Month: November 2022

Production and characterization of bio-oil and biochar from ablative pyrolysis of lignocellulosic biomass residues was written by Khuenkaeo, Nattawut;Tippayawong, Nakorn. And the article was included in Chemical Engineering Communications in 2020.Reference of 2380-78-1 The following contents are mentioned in the article:

Agricultural residues are one of the large untapped sources of bio-energy in Thailand, with over 30 million tons available per yr. They may be utilized to generate renewable liquid and solid fuels. In this work, pyrolysis of lignocellulosic biomass residues (corncobs, coconut shells, and bamboo residue) was carried out in an ablative pyrolysis reactor with rotating blades. Influences of inert carrier gas flows (5-15 L/min) and rotating frequency (4-8 Hz) at a fixed hot plate temperature of 500 °C on generating bio-oil were investigated. Characterization of bio-oil as well as biochar products was performed. Maximum bio-oil yield was found to be about 50% weight/weight for coconut shell at 5 L/min of flowrate and 8 Hz of the rotating frequency, and 45% weight/weight for bamboo residues at the same condition. For corncob, the highest bio-oil yield was 72% weight/weight at 5 L/min of flowrate and 6 Hz of the rotating frequency. Solid char yields were around 23-28% weight/weight The heating values of the liquid oil and solid char were about 20-25 and 23-30 MJ/kg, resp. Rotating blade ablative reactor was able to generate high yields of bio-oil for agricultural residues. The main compounds of the bio-oil obtained were phenolics, including furfuran, organic acids, aldehydes, alcs., ethers, and ketones. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Reference of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Development of a degrader against oncogenic fusion protein FGFR3-TACC3 was written by Shibata, Norihito;Cho, Nobuo;Koyama, Hiroo;Naito, Mikihiko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Electric Literature of C3H9NO The following contents are mentioned in the article:

Fibroblast growth factor receptor 3-transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3), which has been identified in many cancers such as glioblastoma and bladder cancer, is a potent oncogenic fusion protein that induces constitutive activation of FGFR signaling, resulting in uncontrolled cell proliferation. Although several tyrosine kinase inhibitors against FGFR are currently under development, resistance to such types of inhibitors in patients has become a concern. In this study, a chimeric mol. SNIPER(TACC3)-11 I was developed and found to reduce FGFR3-TACC3 levels effectively. Compound I conjugated KHS108 (a TACC3 ligand) to an LCL161 derivative II (an inhibitor of apoptosis protein [IAP] ligand) with a PEG linker (n = 2). Mechanistical anal. showed that cellular IAP1 was required for the reduction of FGFR3-TACC3 levels. Consistent with the decrease in FGFR3-TACC3 levels, compound I suppressed the growth of FGFR3-TACC3 pos. cells. Thus, compound I is a candidate therapeutic with a novel drug modality against cancers that exhibit FGFR3-TACC3-dependent proliferation and exerts pharmacol. effects distinct from FGFR3 kinase inhibitors because it lacks substructures crucial for kinase inhibition. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Electric Literature of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

One-Pot Conversion of Lignin into Naphthenes Catalyzed by a Heterogeneous Rhenium Oxide-Modified Iridium Compound was written by Li, Xinxin;Zhang, Bo;Pan, Xiaoli;Ji, Jianwei;Ren, Yujing;Wang, Hua;Ji, Na;Liu, Qiying;Li, Changzhi. And the article was included in ChemSusChem in 2020.Safety of 4-Benzyloxyphenol The following contents are mentioned in the article:

The direct transformation of lignin into fuels and chems. remains a huge challenge because of the recalcitrant and complicated structure of lignin. In this study, rhenium oxide-modified iridium supported on SiO₂ (Ir-ReO_x/SiO₂) is employed for the one-pot conversion of various lignin model compounds and lignin feedstocks into naphthenes. Up to 100% yield of cyclohexane from model compounds and 44.3% yield of naphthenes from lignin feedstocks are achieved. 2 D HSQC NMR spectroscopy before and after the reaction confirms the activity of Ir-ReO_x/SiO₂ in the cleavage of the C-O bonds and hydrodeoxygenation of the depolymerized products. H₂ temperature-programmed reduction, temperature-programmed desorption of NH₃, IR spectroscopy of pyridine adsorption, XPS, X-ray absorption fine structure anal., and control experiments reveal that a synergistic effect between Ir and ReO_x in Ir-ReO_x/SiO₂ plays a crucial role in the high performance; ReO_x is mainly responsible for the cleavage of C-O bonds, whereas Ir is responsible for hydrodeoxygenation and saturation of the benzene rings. This methodol. opens up an energy-efficient route for the direct conversion of lignin into valuable naphthenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Safety of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

One-Pot Conversion of Lignin into Naphthenes Catalyzed by a Heterogeneous Rhenium Oxide-Modified Iridium Compound was written by Li, Xinxin;Zhang, Bo;Pan, Xiaoli;Ji, Jianwei;Ren, Yujing;Wang, Hua;Ji, Na;Liu, Qiying;Li, Changzhi. And the article was included in ChemSusChem in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

The direct transformation of lignin into fuels and chems. remains a huge challenge because of the recalcitrant and complicated structure of lignin. In this study, rhenium oxide-modified iridium supported on SiO₂ (Ir-ReO_x/SiO₂) is employed for the one-pot conversion of various lignin model compounds and lignin feedstocks into naphthenes. Up to 100% yield of cyclohexane from model compounds and 44.3% yield of naphthenes from lignin feedstocks are achieved. 2 D HSQC NMR spectroscopy before and after the reaction confirms the activity of Ir-ReO_x/SiO₂ in the cleavage of the C-O bonds and hydrodeoxygenation of the depolymerized products. H₂ temperature-programmed reduction, temperature-programmed desorption of NH₃, IR spectroscopy of pyridine adsorption, XPS, X-ray absorption fine structure anal., and control experiments reveal that a synergistic effect between Ir and ReO_x in Ir-ReO_x/SiO₂ plays a crucial role in the high performance; ReO_x is mainly responsible for the cleavage of C-O bonds, whereas Ir is responsible for hydrodeoxygenation and saturation of the benzene rings. This methodol. opens up an energy-efficient route for the direct conversion of lignin into valuable naphthenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Impact of cooking and drying operations on color, curcuminoids, and aroma of Curcuma longa L. was written by Yin, Molika;Weil, Mathieu;Avallone, Sylvie;Lebrun, Marc;Conejero, Genevieve;In, Sokneang;Bohuon, Philippe. And the article was included in Journal of Food Processing and Preservation in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:

Effects of cooking and drying on color, curcuminoids, essential oil, and aroma compounds of Curcuma longa L. were assessed. Sliced fresh turmeric rhizomes were air-dried at 60°C directly or after cooking at 95°C for 3 or 90 min. Microscopic observations showed that curcuminoids and essential oil are located in different dedicated cells. Curcuminoids and essential oil of dried turmeric were both around 10% db. After processing, curcuminoids were dispersed throughout the matrix. Drastic cooking and drying operations decreased chromatic values more than smooth cooking. Cooking had no impact on curcuminoid and essential oil contents and slightly modified the aromatic profile of essential oils. Drying decreased the curcuminoid (<38%) and essential oil (<13%) contents. Turmeric starchy matrix preserves the curcuminoids and essential oil during the process. We recommend a preliminary smooth cooking step to reduce the drying time, save energy consumption and preserve turmeric quality. Our study brings us to propose better practices for turmeric processing. A smooth cooking (95°C/3 min) before drying is recommended to preserve the quality of the turmeric as the curcuminoids and essential oil are preserved during cooking. This protection could be linked to the starchy structure of the turmeric matrix. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of didodecyldimethylammonium bromide on the phase behavior of nonionic surfactant-silicone oil microemulsions was written by Silas, James A.;Kaler, Eric W.;Hill, Randal M.. And the article was included in Langmuir in 2001.Computed Properties of C10H22O3 The following contents are mentioned in the article:

The effects of adding didodecyldimethylammonium bromide (DDAB) to mixtures of n-alkyl polyglycol ether (C_iE_j), water, and silicone oil are systematically studied. In mixtures of C₈E₃ and C₁₂E₆ with water, small amounts of DDAB cause the upper miscibility gap to vanish and be replaced by a high-temperature lamellar phase. In mixtures of C₁₂E₅ with octamethylcyclotetrasiloxane (D₄), the addition of DDAB makes the surfactant mixture more hydrophilic and expands the lower miscibility gap by increasing the (pseudo)-critical temperature In ternary mixtures of C_iE_j, D₄, and water, adding DDAB increases the surfactant efficiency by a factor of ≤3, expanding the single-phase microemulsion region to higher temperatures and lower surfactant concentrations The temperature limits of the single-phase microemulsion correlate with changes in the pseudo-binary phase diagrams upon addition of DDAB. Addnl., the surfactant mixture stabilizes liquid crystalline regions, but at temperatures that do not obscure the gains in surfactant efficiency offered by the ionic-nonionic surfactant mixture Similar results are reported for 2 linear silicone oils, hexamethyldisiloxane, and decamethyltetrasiloxane. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Virtual screening and drug repurposing experiments to identify potential novel selective MAO-B inhibitors for Parkinson’s disease treatment was written by Crisan, Luminita;Istrate, Daniela;Bora, Alina;Pacureanu, Liliana. And the article was included in Molecular Diversity in 2021.Related Products of 103-16-2 The following contents are mentioned in the article:

The main study’s purpose is to detect novel natural products (NPs) that are potentially selective MAO-B inhibitors and, addnl., to computationally reposition the marketed drugs with a new therapeutic role for Parkinson’s disease. To reach the goals, 3D similarity search, docking, ADMETox, and drug repurposing approaches were employed. Thus, an unbiased benchmarking dataset was built including selective and nonselective inhibitors for MAO-B compliant with both ligand- and structure-based virtual screening approaches. A retrospective and prospective mining scenario was applied to SPECS NP and DrugBank databases to detect novel scaffolds with potential benefits for Parkinson’s disease patients. Out of the three best selected natural products, cardamomin showed excellently predicted drug-like properties, superior pharmacol. profile, and specific interactions with MAO-B active site, indicating a potential selectivity over MAO-B. Two marketed drugs, fenamisal and monobenzone, were proposed as promising candidates repurposed for Parkinson’s disease. The application of shape, physicochem., and electrostatic similarity searches protocol emerged as a plausible solution to explore MAO-B inhibitors selectivity. This protocol might serve as a rewarding tool in early drug discovery and can be extended to other protein targets. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Virtual screening and drug repurposing experiments to identify potential novel selective MAO-B inhibitors for Parkinson’s disease treatment was written by Crisan, Luminita;Istrate, Daniela;Bora, Alina;Pacureanu, Liliana. And the article was included in Molecular Diversity in 2021.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

The main study’s purpose is to detect novel natural products (NPs) that are potentially selective MAO-B inhibitors and, addnl., to computationally reposition the marketed drugs with a new therapeutic role for Parkinson’s disease. To reach the goals, 3D similarity search, docking, ADMETox, and drug repurposing approaches were employed. Thus, an unbiased benchmarking dataset was built including selective and nonselective inhibitors for MAO-B compliant with both ligand- and structure-based virtual screening approaches. A retrospective and prospective mining scenario was applied to SPECS NP and DrugBank databases to detect novel scaffolds with potential benefits for Parkinson’s disease patients. Out of the three best selected natural products, cardamomin showed excellently predicted drug-like properties, superior pharmacol. profile, and specific interactions with MAO-B active site, indicating a potential selectivity over MAO-B. Two marketed drugs, fenamisal and monobenzone, were proposed as promising candidates repurposed for Parkinson’s disease. The application of shape, physicochem., and electrostatic similarity searches protocol emerged as a plausible solution to explore MAO-B inhibitors selectivity. This protocol might serve as a rewarding tool in early drug discovery and can be extended to other protein targets. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway was written by Kaushik, Hitaishi;Kaul, Deepak;Kumaran, Muthu Sendhil;Parsad, Davinder. And the article was included in Journal of Dermatological Science in 2020.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:

This study was attempt to understand miR-2909 RNomics in vitiligo pathogenesis using MBEH treated primary melanocytes as an archetype cellular model because MBEH causes pathol. features indistinguishable from clin. vitiligo. Primary melanocytes were treated with MBEH and 4-TBP and the role of miR-2909 RNomics at transcriptional and translational level was explored through qRT-PCR, western blot anal., flow cytometry, immunocytochem., immunohistochem. and in silico binding affinities. 4 mm punch biopsies were also obtained from lesional sites of vitiligo patients to validate the results observed in cell culture experiments MBEH induced miR-2909 RNomics led to downregulation of MITF, TYR, TYRP1, and TYRP2 leading to decreased melanin synthesis which in turn is a characteristic trait of vitiligo. On the other hand, 4-TBP increased TGF-β which also has the intrinsic capacity to downregulate MITF leading to decreased melanin synthesis and thereby initiation of vitiligo. Based upon our results we propose a mol. pathway which has the inherent capacity to resolve the mechanism through which these chems. may induce vitiligo. This mechanism was also found to be involved in the lesional biopsies of vitiligo patients. These results could be exploited in better understanding the pathogenesis as well as in treatment of vitiligo. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway was written by Kaushik, Hitaishi;Kaul, Deepak;Kumaran, Muthu Sendhil;Parsad, Davinder. And the article was included in Journal of Dermatological Science in 2020.Formula: C13H12O2 The following contents are mentioned in the article:

This study was attempt to understand miR-2909 RNomics in vitiligo pathogenesis using MBEH treated primary melanocytes as an archetype cellular model because MBEH causes pathol. features indistinguishable from clin. vitiligo. Primary melanocytes were treated with MBEH and 4-TBP and the role of miR-2909 RNomics at transcriptional and translational level was explored through qRT-PCR, western blot anal., flow cytometry, immunocytochem., immunohistochem. and in silico binding affinities. 4 mm punch biopsies were also obtained from lesional sites of vitiligo patients to validate the results observed in cell culture experiments MBEH induced miR-2909 RNomics led to downregulation of MITF, TYR, TYRP1, and TYRP2 leading to decreased melanin synthesis which in turn is a characteristic trait of vitiligo. On the other hand, 4-TBP increased TGF-β which also has the intrinsic capacity to downregulate MITF leading to decreased melanin synthesis and thereby initiation of vitiligo. Based upon our results we propose a mol. pathway which has the inherent capacity to resolve the mechanism through which these chems. may induce vitiligo. This mechanism was also found to be involved in the lesional biopsies of vitiligo patients. These results could be exploited in better understanding the pathogenesis as well as in treatment of vitiligo. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem