Month: November 2022

LC-QTOF-MS identification of major urinary cyclopropylfentanyl metabolites using synthesized standards was written by Vikingsson, Svante;Rautio, Tobias;Wallgren, Jakob;Strand, Anna;Watanabe, Shimpei;Dahlen, Johan;Wohlfarth, Ariane;Konradsson, Peter;Wu, Xiongyu;Kronstrand, Robert;Green, Henrik. And the article was included in Journal of Analytical Toxicology in 2019.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

The aim of this studywas to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl along with synthesis routes. In this study, metabolites were identified in 13 post-mortem urine samples using liquid chromatog- raphy quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Samples were analyzed with and without enzymic hydrolysis, and seven potential metabolites were synthesized inhouse to provide the identity of major metabolites. Cyclopropylfentanyl was detected in all samples, and the most abundant metabolite was norcyclo- propylfentanyl (M1) that was detected in 12 out of 13 samples. Reference materials were synthesized (synthesis routes provided) to identify the exact structure of the major metabolites 4-hydroxyphenethyl cyclopropylfentanyl (M8), 3,4-dihydroxyphenethyl cyclopropylfentanyl (M5) and 4-hydroxy-3-methoxyphenethyl cyclopropylfentanyl (M9). These metabolites are suitable urinary markers of cyclopropylfentanyl intake as they are unique and detected in a majority of hydrolyzed urine samples. Minor metabolites included two quinone metabolites (M6 and M7), not previously reported for fentanyl analogs. Interestingly, with the exception of norcyclopropylfentanyl (M1), the metabolites appeared to be between 40% and 90% conjugated in urine. In total, 11 metabolites of cyclo- propylfentanyl were identified, including most metabolites previously reported after hepatocyte incubation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrothermal Co-Liquefaction of Synthetic Polymers and Miscanthus giganteus: Synergistic and Antagonistic Effects was written by Souza dos Passos, Juliano;Glasius, Marianne;Biller, Patrick. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

Synthetic polymers constitute one of the main carbon-containing wastes generated nowadays. In this study, combined hydrothermal liquefaction (co-HTL) is evaluated for 1:1 mixtures of Miscanthus giganteus and different synthetic polymers-including poly-acrylonitrile-butadiene-styrene (ABS), bisphenol-A-based epoxy resin, high-d. polyethylene (HDPE), low-d. polyethylene (LDPE), polyamide 6 (PA6), polyamide 6/6 (PA66), poly(ethylene terephthalate) (PET), polycarbonate (PC), polypropylene (PP), polystyrene (PS), and polyurethane foam (PUR)-using batch HTL at 350°C. Based on oil yields and composition, a comprehensive discussion of observed interactions is presented. The results show that even though polyolefins do not depolymerize under these conditions, the oil products depict that these materials interact with miscanthus biocrude changing its composition Bisphenol-A-based polymers as PC and epoxy resins both contribute to the formation of monomer-like structures in the biocrude. PET increases the presence of carboxyl groups, while polyamides and PUR increase significantly the oil yield, modifying the biocrude composition toward nitrogen-containing mols. PUR co-HTL was found to increase oil, carbon, and energy yields, leading to process improvement when compared to pure miscanthus processing. HTL of synthetic polymers and biomass can be an opportunity for sustainable recycling of chems. in a synergistic, multipurpose process. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrothermal Co-Liquefaction of Synthetic Polymers and Miscanthus giganteus: Synergistic and Antagonistic Effects was written by Souza dos Passos, Juliano;Glasius, Marianne;Biller, Patrick. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Synthetic polymers constitute one of the main carbon-containing wastes generated nowadays. In this study, combined hydrothermal liquefaction (co-HTL) is evaluated for 1:1 mixtures of Miscanthus giganteus and different synthetic polymers-including poly-acrylonitrile-butadiene-styrene (ABS), bisphenol-A-based epoxy resin, high-d. polyethylene (HDPE), low-d. polyethylene (LDPE), polyamide 6 (PA6), polyamide 6/6 (PA66), poly(ethylene terephthalate) (PET), polycarbonate (PC), polypropylene (PP), polystyrene (PS), and polyurethane foam (PUR)-using batch HTL at 350°C. Based on oil yields and composition, a comprehensive discussion of observed interactions is presented. The results show that even though polyolefins do not depolymerize under these conditions, the oil products depict that these materials interact with miscanthus biocrude changing its composition Bisphenol-A-based polymers as PC and epoxy resins both contribute to the formation of monomer-like structures in the biocrude. PET increases the presence of carboxyl groups, while polyamides and PUR increase significantly the oil yield, modifying the biocrude composition toward nitrogen-containing mols. PUR co-HTL was found to increase oil, carbon, and energy yields, leading to process improvement when compared to pure miscanthus processing. HTL of synthetic polymers and biomass can be an opportunity for sustainable recycling of chems. in a synergistic, multipurpose process. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model was written by Orhan, Cemal;Tuzcu, Mehmet;Durmus, Ali Said;Sahin, Nurhan;Ozercan, Ibrahim Hanifi;Deeh, Patrick Brice Defo;Morde, Abhijeet;Bhanuse, Prakash;Acharya, Manutosh;Padigaru, Muralidhara;Sahin, Kazim. And the article was included in Biomedicine & Pharmacotherapy in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Osteoarthritis (OA) is a musculoskeletal disorder mainly found in elderly individuals. Modern treatment of OA, like nonsteroidal anti-inflammatory drugs, corticosteroids, hyaluronic acid injections, etc., is linked to long-term side effects. We evaluated the anti-osteoarthritic properties of a novel joint health formula (JHF) containing Bisdemethoxycurcumin enriched curcumin, 3-O-Acetyl-11-keto-beta-Boswellic acid-enriched Boswellia, and Ashwagandha in monosodium iodoacetate (MIA)-induced knee OA in rats. Twenty-eight female rats were distributed into four groups: Control, OA, OA + JHF (100 mg/kg), and OA + JHF (200 mg/kg). JHF decreased the right joint diameters but increased the paw area and stride length compared to the OA group with no treatment. JHF significantly reduced the arthritic conditions after four weeks of supplementation (p < 0.05). JHF significantly decreased TNF-α, IL-1β, IL-10, COMP, and CRP in the serum of osteoarthritic rats (p < 0.0001). We observed reduced lipid peroxidation but increased SOD, GSH-Px, and CAT activities in response to JHF treatment in OA animals. JHF down-regulated MMP-3, COX-2, and LOX-5 and improved the histol. structure of the knee joint of osteoarthritic rats. JHF demonstrated a protective effect against osteoarthritis, possibly due to anti-inflammatory and antioxidant activity in exptl. induced osteoarthritis in rats, and could be an effective option in the management of OA. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Bisdemethoxycurcumin

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reductive Catalytic Depolymerization of Semi-industrial Wood-Based Lignin was written by Lu, Xiaojia;Lagerquist, Lucas;Eranen, Kari;Hemming, Jarl;Eklund, Patrik;Estel, Lionel;Leveneur, Sebastien;Grenman, Henrik. And the article was included in Industrial & Engineering Chemistry Research in 2021.Recommanded Product: 2380-78-1 The following contents are mentioned in the article:

The current work studies the reductive catalytic depolymerization (RCD) of lignin from a novel semi-industrial process. The aim was to obtain aromatic mono-, di-, tri-, and tetramers for further valorization. The substrate and products were characterized by multiple anal. methods, including high pressure size-exclusion chromatog. (HPSEC), gas chromatog.-mass spectrometry, GC-flame ionization detector (FID), GC-FID/thermal conductivity detector (TCD), and NMR. The RCD was studied by exploring the influence of different parameters, such as lignin solubility, reaction time, hydrogen pressure, reaction temperature, pH, type and loading of the catalyst, as well as type and composition of the organic/aqueous solvent. The results show that an elevated temperature, a redox catalyst, and a hydrogen atm. are essential for the depolymerization and stability of the products, while the reaction medium also plays an important role. The highest obtained mono- to tetramers yield was 98% and mono- to dimers yield over 85% in the liquid phase products. The reaction mechanisms influenced the structure of the aliphatic chain in the monomers, but left the phenolic structure along with the methoxy groups largely unaltered. The current work contributes to the development and debottlenecking of the novel and sustainable overall process, which utilizes efficiently all the fractions of wood, in line with the principles of green engineering and chem. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies was written by Maiti, Panchanan;Manna, Jayeeta;Thammathong, Joshua;Evans, Bobbi;Dubey, Kshatresh Dutta;Banerjee, Souvik;Dunbar, Gary L.. And the article was included in Antioxidants in 2021.Related Products of 33171-05-0 The following contents are mentioned in the article:

Despite its potent anti-amyloid properties, the utility of curcumin (Cur) for the treatment of Alzheimer’s disease (AD) is limited due to its low bioavailability. Tetrahydrocurcumin (THC), a more stable metabolite has been found in Cur-treated tissues. We compared the anti-amyloid and neuroprotective properties of curcumin, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and THC using mol. docking/dynamics, in-silico and in vitro studies. We measured the binding affinity, H-bonding capabilities of these compounds with amyloid beta protein (Aβ). Dot blot assays, photo-induced cross linking of unmodified protein (PICUP) and transmission electron microscopy (TEM) were performed to monitor the Aβ aggregation inhibition using these compounds Neuroprotective effects of these derivatives were evaluated in N2a, CHO and SH-SY5Y cells using Aβ42 (10μM) as a toxin. Finally, Aβ-binding capabilities were compared in the brain tissue derived from the 5x FAD mouse model of AD. We observed that THC had similar binding capability and Aβ aggregation inhibition such as keto/enol Cur and it was greater than BDMC and DMC. All these derivatives showed a similar degree of neuroprotection in vitro and labeled Aβ-plaques ex vivo. Overall, ECur and THC showed greater anti-amyloid properties than other derivatives Therefore, THC, a more stable and bioavailable metabolite may provide greater therapeutic efficacy in AD than other turmeric derivatives This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 33171-05-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of bioremediation and detoxification potentiality for papermaking black liquor by a new isolated thermophilic and alkali-tolerant Serratia sp. AXJ-M was written by An, Xuejiao;Zhong, Bin;Chen, Guotao;An, Weijuan;Xia, Xiang;Li, Hanguang;Lai, Fenju;Zhang, Qinghua. And the article was included in Journal of Hazardous Materials in 2021.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

There is a great need for efficiently treating papermaking black liquor because it can seriously pollute both soil and water ecosystems. In this study, the Plackett-Burman (PB) exptl. design combined with response surface methodol. (RSM) was used for improving the biodegradation efficiency of lignin by a new isolated thermophilic and alkali-tolerant strain Serratia sp. AXJ-M, and the results showed that a biodegradation efficiency of 70.5% was achieved under optimal culture conditions. The bacterium with ligninolytic activities significantly decreased target the parameters (color 80%, lignin 60%, phenol 95%, BOD 80% and COD 80%). The control and treated samples were analyzed by gas chromatog.-mass spectrometer (GC-MS), which showed that the concentrations of a majority of low-mol.-weight compounds were decreased after biol. treatment. Furthermore, toxicol., genotoxicity and phytotoxicity studies have supported the detoxification by the bacterium of black liquor. Finally, the genome sequence of the thermophilic, alkali-tolerant and lignin-degrading bacterium AXJ-M was completed, and the genetic basis of the thermophilic and alkali-resistant properties of AXJ-M was preliminarily revealed. The dyp-type peroxidase was first reported to have the potential to catalyze lignin degradation structurally. These findings suggest that Serratia sp. AXJ-M may be potentially useful for bioremediation applications for papermaking black liquor. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Sensitive Spectrofluorimetric Method for Curcumin Analysis was written by Sravani, Anne Boyina;Mathew, Elizabeth Mary;Ghate, Vivek;Lewis, Shaila A.. And the article was included in Journal of Fluorescence in 2022.Computed Properties of C19H16O4 The following contents are mentioned in the article:

Curcumin (CUR), a natural polyphenolic compound extracted from the rhizomes of Curcuma longa, is used as a pharmaceutical agent, spice in food, and as a dye. Currently, CUR is being investigated for cancer treatment in Phase-II clin. trials. CUR also possesses excellent activities like anti-inflammatory, anti-microbial, and anti-oxidant, therefore quality control is crucial. The present research work was to develop a new, simple, validated and time-saving rapid 96-well plate spectrofluorimetric method for the determination of CUR. The developed method was compared with routinely used high performance liquid chromatog. (HPLC) technique. The developed method were found to be linear in the concentration range of 15 to 3900 ng/mL with R2 ≥ 0.9983 for spectrofluorimetric and 50-7500 ng/mL with R2 ≥ 0.9999 for HPLC method. Accuracy, intraday and interday precision was adequate, with RSD lower than the suggested limits. The limits for the detection and the quantification of CUR were 7 and 15 ng/mL for spectrofluorimetric, and 25 and 50 ng/mL for HPLC resp. The Bland-Altman anal. demonstrated the similarities between the two methods. The 96-well plate method was successfully applied to determine CUR in solid lipid nanoparticles (SLNs) and chitosan nanoparticles (Chi-NPs). The developed spectrofluorimetric method can hence serve as a possible replacement for the HPLC method for the quantification of CUR in healthcare and food products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Computed Properties of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C19H16O4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of storage time on the microbial and physicochemical properties of gamma irradiated turmeric powder under various atmospheres of packaging was written by Esmaeili, Saeideh;Berengi-Ardestani, Samira;Khanniri, Elham;Barzegar, Mohsen;Sahari, Mohammad Ali. And the article was included in Radiation Physics and Chemistry in 2021.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:

Irradiation process has recently found a special place in reducing microbial contamination of foodstuffs. However, there are still ambiguities about the effect of irradiation on the physicochem. properties and bioactive compounds of foods during storage. In this study, the influence of gamma irradiation at doses 0, 5, 10, and 15 kGy on the microbial load and physicochem. properties of turmeric powder were studied during one year storage at room temperature under air and modified atm. (vacuum and N2). The results showed that irradiation effectively reduced the microbial contamination of turmeric powder and it could provide the safety and microbial desirability of the samples for 1 yr at 10 kGy dose. By increasing the storage time and progress of oxidation processes, phenolic compounds (PCs) decreased in all samples. Subsequently, the curcumin, dimethoxycurcumin and bisdemethoxycurcumin contents as curcuminoids were diminished 61.5, 62.1, and 59.1% after one year of storage, resp. The IC50 (DPPH·, FRAP, and ABTS·+) of the extracts were in the range of (117.9-244.5μg/mL), (41.5-85.3μg/mL), and (206.4-505.2μg/mL), resp. during 12 mo of storage and the highest antioxidant activity of the extracts was obtained after four months of storage at a dose of 10 kGy (p < 0.05). These results confirm that the effect of storage time on the physicochem. properties of turmeric powder was higher than the effect of irradiation and packaging atm. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubility of monobenzone in aqueous co-solvent mixtures of several alcohols: Determination, modelling and thermodynamic aspects analysis was written by Zhou, Yanyan;Wu, Jiaxin;Farajtabar, Ali;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2020.SDS of cas: 103-16-2 The following contents are mentioned in the article:

Investigation upon the solubility of monobenzone in aqueous co-solvent mixtures of isopropanol, n-propanol, ethylene glycol (EG) and ethanol was performed via a saturation shake-flask technique at temperatures from 283.15 K to 328.15 K under pressure of p = 101.2 kPa. Exptl. solubility magnitude presented pos. dependence upon the mass fraction of each co-solvent and temperature The greatest solubility value on the mole fraction scale was observed in the neat co-solvents. The equilibrated solids with corresponding co-solvent mixtures were characterized through an X-ray power diffraction (XRD) technique, demonstrating the absence of polymorphic transformation or solvate formation. The Jouyban-Acree model was adopted to math. describe the monobenzone solubility data. The maximum magnitudes of RAD and RMSD were 3.17 × 10^-2 and 7.64 × 10^-4, resp. The local mole fractions of isopropanol (n-propanol, EG or ethanol) and water adjacent monobenzone were quant. studied by the Inverse Kirkwood-Buff integrals method. The parameters of preferential solvation for the isopropanol (n-propanol, EG or ethanol) were pos. in the isopropanol (n-propanol, EG or ethanol) mixtures in intermediate and alc.-rich compositions, indicating that monobenzone was preferentially solvated by the isopropanol (n-propanol, EG or ethanol). Monobenzone mainly acted as a Lewis acid which interacted with proton-acceptor functional group of the alcs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem