Month: November 2022

Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis was written by Fernandes, Sara;Ribeiro, Catarina;Paiva-Martins, Fatima;Catarino, Cristina;Santos-Silva, Alice. And the article was included in Food & Function in 2020.Formula: C9H12O3 The following contents are mentioned in the article:

The consumption of extra virgin olive oil (EVOO) has been associated with a lower incidence of cardiovascular diseases partly due to its polyphenol content. The metabolites hydroxytyrosol sulfate and hydroxytyrosol acetate sulfate were shown to be the most concentrated polyphenol metabolites found in plasma after EVOO consumption. Therefore, the capacity of hydroxytyrosol, hydroxytyrosol acetate, homovanillyl alc., homovanillyl alc. acetate and tyrosol sulfate metabolites, to protect red blood cells (RBCs) from oxidative injury induced by the radical initiator 2,2′-azo-bis(2-amidinopropane) dihydrochloride (AAPH) was evaluated. In the presence of AAPH, all non-sulfated compounds and the hydroxytyrosol and hydroxytyrosol acetate monosulfate metabolites showed a significant protective activity against RBCs induced oxidative hemolysis. Moreover, even at 5μM, the protection was highly significant for hydroxytyrosol acetate, hydroxytyrosol and hydroxytyrosol acetate 3′ and 4′ monosulfates. The morphol. changes of RBC and the nature of their Hb were in accordance with the hemolysis assay. Results showed that a free phenolic hydroxyl group is needed for the antioxidant protection given by compounds Hydroxytyrosol metabolites present as phase II sulfate conjugates are actually able to protect RBC from oxidative injury by a non-transcriptional mechanism and are likely to contribute for the anti-atherosclerosis properties of regular EVOO consumption. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Green Extraction of Cork Bioactive Compounds Using Natural Deep Eutectic Mixtures was written by Freitas, David S.;Rocha, Diana;Castro, Tarsila G.;Noro, Jennifer;Castro, Vania I. B.;Teixeira, Marta A.;Reis, Rui L.;Cavaco-Paulo, Artur;Silva, Carla. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

Quercus suber cork generates bioactive components, such as phenolic acids, terpenoids, and tannins, with excellent biol. properties, including antioxidant, anti-inflammatory, and antiaging activities. Aiming to design environmentally benign processes to eliminate, or reduce, the use of toxic chems., we propose the green extraction of bioactives from cork using natural deep eutectic solvents (NADES). Several deep eutectic mixtures were developed, through the mixture of natural compounds, namely, lactic acid, glycerol, ethylene glycol, sodium citrate, and sodium lactate, chosen according to their origin, toxicity, biocompatibility, polarity, and pH. The results revealed higher extraction yields when using NADES instead of harsh solvents like dioxane, with the extraction process governed by several phys.-chem. parameters, including pH, polarity, viscosity, and d., and also by the method of extraction Acidic NADES composed of lactic acid and glycerol, or sodium citrate, extracted a greater amount of aromatic compounds, terpenoids, and fatty acids and their derivatives More basic eutectic mixtures, composed of sodium lactate and a polyol (ethylene glycol or glycerol), extracted predominantly low mol. weight polar compounds The extracts range encompassed by the developed NADES, together with the associated nontoxicity, low price, and ease of preparation, establish these solvents as a green approach to extract high added-value compounds from cork. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemical composition, antioxidative and antimicrobial activities of turmeric spent oleoresin was written by Joshi, Priyanka;Joshi, Sushil;Semwal, Deepak Kumar;Bisht, Akansha;Sharma, Swapnil;Dwivedi, Jaya. And the article was included in Industrial Crops and Products in 2021.Application of 33171-05-0 The following contents are mentioned in the article:

Disposal of the turmeric waste commonly known as turmeric spent oleoresin (TSO) left after separation of curcuminoids has been considered as serious concern and has attracted scientific community at large for its sustainable utilization. The fractionation of TSO was achieved using column chromatog. and the fractions thus obtained were characterized using HPLC and LCMS-qToF techniques. The isolated fractions and turmeric were examined for their antioxidant activity employing standard procedures such as DPPH scavenging assay, ABTS scavenging assay, FRAP assay and Phosphomolybdate assays. Antimicrobial potential of TSO and isolates was performed against different microbial strains using the broth dilution method. Chem. characterization of TSO revealed the presence of ferulic acid, myristicin, furanodience, cyclocurcumin, 6-methoxy-2-[2-(3methoxyphenyl) ethyl] chromone, dihydrocurcumin, bisabolocurcumin ether, terpecurcumin Q, curcumin, cyclobisdesmethoxycurcumin, and bisdemethoxycurcumin. The highest antimicrobial activity was recorded for Fraction 1 (F1) (Inhibitory zone diameter (IZD) = 25.33 ± 0.33 mm), Fraction 6 (F6) (IZD = 23.67 ± 0.33 mm), Fraction 7 (F7) (IZD = 22.67 ± 0.33 mm), Fraction 9 (F9) (IZD = 24.00 ± 00 mm) and Fraction 11 (F11) (IZD = 22.33 ± 0.67 mm) against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), Candida albicans (C. albicans), and Salmonella abony (S. abony) resp. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quantitative analysis of aqueous phases of bio-oils resulting from pyrolysis of different biomasses by two-dimensional comprehensive liquid chromatography was written by Lazzari, Eliane;Arena, Katia;Caramao, Elina B.;Herrero, Miguel. And the article was included in Journal of Chromatography A in 2019.Application of 2380-78-1 The following contents are mentioned in the article:

Agrifood byproducts are perfect candidates to be further processed under the concept of circular economy, in order to produce their valorization. Although significant amounts of food-related wastes that are discarded are produced worldwide, these might still be rich in valuable compounds A strategy to further valorize agrifood-related byproducts is based on pyrolysis processes. The result of this process is a liquid product termed bio-oil which is composed of an organic phase and an aqueous phase. This bio-oil is rich on a variety of components and its anal. implies several challenges. In this work, quant. online comprehensive two-dimensional liquid chromatog. (LC × LC) is proposed for the first time to characterize several aqueous phases of different bio-oils. Rice husk, peanut shell, spent coffee grounds, peach core and Eucalyptus sawdust biomasses were analyzed. The developed quant. LC × LC method presented very good linearity, precision, reproducibility, recovery and LODs and LOQs as low as 0.05 μg mL^-1 and 0.16 μg mL^-1, resp. As much as 28 components were simultaneously separated and quantified in those samples. Our results found that the composition of these bio-oils was different but strongly related to the agrifood byproduct submitted to pyrolysis. The developed methodol. is foreseen as a valuable tool for the quant. study of other bio-oils, considering the great complexity and high dimensionality of these samples. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic depolymerization of alkaline lignin to value-added phenolic-based compounds over Ni/CeO₂-ZrO₂ catalyst synthesized with a one-step chemical reduction of Ni species using NaBH₄ as the reducing agent was written by Totong, Sansanee;Daorattanachai, Pornlada;Laosiripojana, Navadol;Idem, Raphael. And the article was included in Fuel Processing Technology in 2020.Recommanded Product: 2380-78-1 The following contents are mentioned in the article:

Alk. lignin obtained from paper manufacturing is a potential feedstock for upgrading to produce value-added chems. This study demonstrates the efficiencies of synthesized Ni supported CeO₂-ZrO₂ catalysts to convert this low-cost alk. lignin into value-added phenolic-based chems. for further com. applications. Lignin depolymerization was performed under mild reaction conditions, namely, reaction temperature of 200-300°C, and reaction time of 1-5 h. Three different catalyst preparation methods (simple wet-impregnation, wet-impregnation assisted reduction in H₂ atmosphere and one-step chem. reduction) were investigated and used to evaluate possible correlations between the active Ni phase and catalytic performance in lignin depolymerization The active Ni phase was successfully formed by one-step chem. reduction method which showed a significant improvement on product yield, especially lignin oil. The best result obtained in lignin depolymerization was by using 10%Ni/CeO₂-ZrO₂-red catalyst which resulted in producing a high yield of lignin oil (46.8%) from lignin feedstock under mild condition of 250°C. The major phenolic compounds in lignin oil were: guaiacol, methyl-guaiacol, ethyl-guaiacol, vanillin, acetovanillone, and homovanillic acid. Furthermore, the reaction temperature affected the product yield and product distribution resulting in higher diversity of phenolic compounds in lignin oil. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mechanism Study on Depolymerization of the α-O-4 Linkage Lignin Model Compound in Supercritical Ethanol System was written by Jiang, Weikun;Wu, Shubin. And the article was included in Waste and Biomass Valorization in 2019.Computed Properties of C13H12O2 The following contents are mentioned in the article:

The aim of this study was to explore the conversion mechanism of α-O-4 linkage lignin dimer model compound (monobenzone) in supercritical ethanol. The decomposition processes of monobenzone were investigated at different reaction time (0-12 h), conversion temperature (250-310 °) and initial concentrations (0.01-0.03 g/mL). The reaction mechanism and pathways were proposed based on the distribution of products, the bond dissociation energies and the free radical theory. The results showed almost complete degradation was achieved in supercritical ethanol system. A higher temperature, a longer reaction time and a higher initial concentration significantly promoted the formation of solid residue due to the condensation reactions of the degradation intermediates/products. Based on the formation mechanism of products, the conversion products were classified into three types: (1) its own fragmentation compounds, (2) condensation compounds of its intermediates and (3) the second fragmentation compounds of its intermediates. A depolymerization reaction mechanism of monobenzone that primarily involved homolytic cleavage of the C_α-O linkage was proposed. In addition, the bibenzyl were an important and unstable intermediate product, it can continue to produce many different radical species that can participate in a variety of reaction mechanisms, resulting in complex reaction pathways and products distribution, even forming higher-mol. weight solid residue. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Potential of Thai herbal extracts on lung cancer treatment by inducing apoptosis and synergizing chemotherapy was written by Poofery, Juthathip;Khaw-on, Patompong;Subhawa, Subhawat;Sripanidkulchai, Bungorn;Tantraworasin, Apichat;Saeteng, Somcharoen;Siwachat, Sopon;Lertprasertsuke, Nirush;Banjerdpongchai, Ratana. And the article was included in Molecules in 2020.Name: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The incidence of lung cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. In this study we determined the effects of three different Thai herbs on lung cancer. Bridelia ovata, Croton oblongifolius, and Erythrophleum succirubrum were extracted by Et acetate and 50% ethanol. The cytotoxicity was tested with A549 lung cancer cell line. We found four effective extracts that exhibited toxic effects on A549 cells. These extracts included Et acetate extracts of B. ovata (BEA), C. oblongifolius (CEA), and E. succirubrum (EEA), and an ethanolic extract of E. succirubrum (EE). Moreover, these effective extracts were tested in combination with chemotherapeutic drugs. An effective synergism of these treatments was found specifically through a combination of BEA with methotrexate, EE with methotrexate, and EE with etoposide. Apoptotic cell death was induced in A549 cells by these effective extracts via the mitochondria-mediated pathway. Addnl., we established primary lung cancer and normal epithelial cells from lung tissue of lung cancer patients. The cytotoxicity results showed that EE had significant potential to be used for lung cancer treatment. In conclusion, the four effective extracts possessed anticancer effects on lung cancer. The most effective extract was found to be E. succirubrum (EE). This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Name: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans was written by Aleman-Jimenez, Carolina;Dominguez-Perles, Raul;Medina, Sonia;Prgomet, Iva;Lopez-Gonzalez, Ivan;Simonelli-Munoz, Agustin;Campillo-Cano, Maria;Aunon, David;Ferreres, Federico;Gil-Izquierdo, Angel. And the article was included in European Journal of Nutrition in 2021.Reference of 2380-78-1 The following contents are mentioned in the article:

Abstract: Purpose: Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption and biovailability of dietary hydroxytyrosol and the influence of the dietary food-containing hydroxytyrosol on it. Methods: A double-blind study was performed including 20 volunteers who ingested 5 mg of hydroxytyrosol through diverse food matrixes, to discover the influence on pharmacokinetics and bioavailability of HT metabolites (hydroxytyrosol acetate, 3,4-dihydroxyphenylacetic acid (DOPAC), tyrosol, and homovanillic alc.) of the distinct matrixes by UHPLC-ESI-QqQ-MS/MS. Results: The HT pharmacokinetics after consumption of different food matrixes was strongly dependent on the food matrix. In this aspect, the intake of extra virgin olive exhibited significantly higher plasma concentrations after 30 min of oral intake (3.79 ng/mL) relative to the control. Regarding the hydroxytyrosol bioavailability, the intake of extra virgin olive oil, as well as fortified refined olive, flax, and grapeseed oils provided significantly higher urinary contents (0.86, 0.63, 0.55, and 0.33μg/mg creatinine, resp.) compared with basal urine, whereas hydroxytyrosol metabolites showed no significant changes. No differences were found between men and women. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Reference of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of Pyrolysis Temperature on the Characteristics of Wood Vinegar Derived from Chinese Fir Waste: A Comprehensive Study on Its Growth Regulation Performance and Mechanism was written by Lu, Xincheng;Jiang, Jianchun;He, Jing;Sun, Kang;Sun, Yunjuan. And the article was included in ACS Omega in 2019.Related Products of 2380-78-1 The following contents are mentioned in the article:

As a high value-added product from biomass pyrolysis, wood vinegar (WV) has been used as a growth regulator for many plant species in agriculture based on the diverse active chem. compounds present. To reveal the relationship between chem. constituents and regulation performance, four kinds of WVs were prepared by slow pyrolysis from Chinese fir waste at different temperature ranges. The chem. constituents of WVs were analyzed by gas chromatog.-mass spectrometry, and the regulation performance of WVs was investigated from the aspects of seed germination and root growth of wheat. The results indicated that the chem. constituents of WVs were affected obviously by pyrolysis temperature and the major components were acids and phenols. All types of WVs showed regulation performance but with different effects and levels. The WV collected from 20 to 150°C exhibited a promoting effect and other three WVs exhibited inhibiting effects. It was considered that the regulation performance of WV was relevant to acids and phenols through a synergy mechanism. Acids caused intercellular acidification and increased root activity, which promoted the seed germination and root growth, while phenols increased the content of malonaldehyde, indicating that phenols caused the oxidative stress to damage cell structure and inhibit growth. All these results could be a reference for further utilization of WVs as a sustainable alternative to chems. for plant growth regulation in agriculture. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Related Products of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Preparation and antimicrobial activities of new piperidine substituted benzothiazole derivatives was written by Shafi, S. Syed;Rajesh, R.;Subaash, R.;Gopinath, S.. And the article was included in Heterocyclic Letters in 2021.Electric Literature of C3H9NO The following contents are mentioned in the article:

Synthesis of piperidine substituted benzothiazole derivatives I [R = 1-piperidyl, (2-methoxyethylamino), (4-bromoanilino), etc.] was reported. The synthesis was done by the reaction of Et 2-aminobenzo[d]thiazole-6-carboxylate with copper (II) bromide followed by the addition of piperidine and get Et 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylate. The reaction of Et 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylate with NaOH produced 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylic acid. The intermediate 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylic acid was isolated as stable compounds The chem. structures of synthesized compounds were established based on spectral data of ¹H-NMR, ¹³C-NMR, and IR. The mass of the novel compounds was established with the help of the LCMS test. The biol. studies of synthesized compounds I showed that the piperidine, amine, and bromine substituted aniline substituted compounds had good antibacterial activity. The compound amine substituted compound exhibited good antifungal activity. The formation of the crystal was confirmed by powder XRD and the average crystalline size was 54 nm. The photoluminescence data explain the optical property of the compound The biol. studies of synthesized compounds showed that compound I [R = 4-bromoanilino] possesses good antibacterial activity and compound I [R = 2-methoxyethylamino] had good antifungal activity. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Electric Literature of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem