Month: November 2022

On April 22, 2010, Hamada, Maiko; Nakamura, Mitsuharu; Kiuchi, Masatoshi; Marukawa, Kaoru; Tomatsu, Ayumi; Shimano, Kyoko; Sato, Noriko; Sugahara, Kunio; Asayama, Mahoko; Takagi, Kan; Adachi, Kunitomo published an article.Recommanded Product: Benzyl(4-bromophenyl)sulfane The title of the article was Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate. And the article contained the following:

A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P1) receptor agonists with potent immunomodulatory activity accompanied by little or no effect on heart rate. Many of the synthesized compounds sufficiently decreased the number of peripheral blood lymphocytes. Some of the phosphates had potent agonism at S1P1 but no agonism at S1P3, which had been reported to be a receptor responsible for heart rate reduction Although high S1P1/S1P3 selectivity was considered to be favorable to reduce the effect on heart rate, almost all the phosphates showed a remarkable heart rate lowering effect in vivo. The results suggest that other factors in addition to S1P3 agonism should be responsible for the heart rate reduction caused by S1P1 agonists. Only 2-amino-2-[2-[2′-fluoro-4′-(4-methylphenylthio)biphenyl-4-yl]ethyl]propane-1,3-diol (6d) was identified as a desired S1P1 receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Recommanded Product: Benzyl(4-bromophenyl)sulfane

The Article related to multiple sclerosis immunomodulators agonists decrease heart rate, Pharmacology: Structure-Activity and other aspects.Recommanded Product: Benzyl(4-bromophenyl)sulfane

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On March 10, 1994, Achard, D.; Truchon, A.; Peyronel, J. F. published an article.Computed Properties of 81616-80-0 The title of the article was Perhydrothiopyranopyrroles derivatives: a novel series of potent and selective nonpeptide NK1 antagonists. And the article contained the following:

The synthesis of RP 73467 (I), a representative of 4,4-di-Ph perhydrothiopyrano[2,3-c]-pyrrole-1-oxides, a new series of potent and selective nonpeptide NK1 Substance P antagonists, is described. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Computed Properties of 81616-80-0

The Article related to perhydrothiopyranopyrrole derivative nk1 receptor antagonist preparation, Pharmacology: Structure-Activity and other aspects.Computed Properties of 81616-80-0

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Ether – Wikipedia,
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Martinez, Antonio Rosales; Enriquez, Lourdes; Jaraiz, Martin; Morales, Laura Pozo; Rodriguez-Garcia, Ignacio; Ojeda, Emilio Diaz published an article in 2020, the title of the article was A concise route for the synthesis of tetracyclic meroterpenoids: (±)-aureol preparation and mechanistic interpretation.SDS of cas: 150-78-7 And the article contains the following content:

A new concise general methodol. for the synthesis of different tetracyclic meroterpenoids was reported, (±)-aureol was the key intermediate for the general route. The synthesis of (±)-aureol were achieved in seven steps (28% overall yield) from (±)-albicanol. The key steps of this reported route included a C-C bond-forming reaction between (±)-albicanal and a lithiated arene unit and a rearrangement involving 1,2-hydride and 1,2-Me shifts promoted by BF3•Et2O as an activator and water as initiator. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).SDS of cas: 150-78-7

The Article related to aureol preparation, aureol, natural products synthesis, tetracyclic meroterpenoids, Terpenes and Terpenoids: General and other aspects.SDS of cas: 150-78-7

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Semple, Graeme; Santora, Vincent J.; Smith, Jeffrey M.; Covel, Jonathan A.; Hayashi, Rena; Gallardo, Charlemagne; Ibarra, Jason B.; Schultz, Jeffrey A.; Park, Douglas M.; Estrada, Scott A.; Hofilena, Brian J.; Smith, Brian M.; Ren, Albert; Suarez, Marissa; Frazer, John; Edwards, Jeffrey E.; Hart, Ryan; Hauser, Erin K.; Lorea, Jodie; Grottick, Andrew J. published an article in 2012, the title of the article was Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).Application In Synthesis of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

The design of a new clin. candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by replacement of the sulfonamide linkage with a sulfone. One compound from this series, APD916 (I) increased wakefulness in rodents as measured by polysomnog. with a duration of effect consistent with its pharmacokinetic properties. The identification of a suitable salt form of I allowed it to be selected for further development. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application In Synthesis of Benzyl(4-bromophenyl)sulfane

The Article related to biaryl sulfone derivative preparation histamine h3 antagonist sar, apd916 h3 antagonist wakefulness, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of Benzyl(4-bromophenyl)sulfane

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On February 1, 2015, Kurata, Haruto; Gentry, Patrick R.; Kokubo, Masaya; Cho, Hyekyung P.; Bridges, Thomas M.; Niswender, Colleen M.; Byers, Frank W.; Wood, Michael R.; Daniels, J. Scott; Conn, P. Jeffrey; Lindsley, Craig W. published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges. And the article contained the following:

This Letter describes the continued optimization of the MLPCN probe ML375, a highly selective M5 neg. allosteric modulator (NAM), through a combination of matrix libraries and iterative parallel synthesis. True to certain allosteric ligands, SAR was shallow, and the matrix library approach highlighted the challenges with M5 NAM SAR within in this chemotype. Once again, enantiospecific activity was noted, and potency at rat and human M5 were improved over ML375, along with slight enhancement in physiochem. properties, certain in vitro DMPK parameters and CNS distribution. Attempts to further enhance pharmacokinetics with deuterium incorporation afforded mixed results, but pretreatment with a pan-P 450 inhibitor (1-aminobenzotriazole; ABT) provided increased plasma exposure. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene

The Article related to enantiospecific activity, m(5), matrix library, muscarinic receptor, negative allosteric modulator, pharmacokinetics, Pharmacology: Structure-Activity and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nomura, Sayaka; Endo-Umeda, Kaori; Makishima, Makoto; Hashimoto, Yuichi; Ishikawa, Minoru published an article in 2016, the title of the article was Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists.SDS of cas: 157869-15-3 And the article contains the following content:

Liver X receptor (LXR) agonists are candidates for the treatment of atherosclerosis via induction of ABCA1 (ATP-binding cassette A1) gene expression, which contributes to reverse cholesterol transport (RCT) and to cholesterol efflux from the liver and intestine. However, LXR agonists also induce genes involved in lipogenesis, such as SREBP-1c (sterol regulatory binding element protein 1c) and FAS (fatty acid synthase), thereby causing an undesirable increase in plasma and hepatic triglyceride (TG) levels. Recent studies indicate that LXRα contributes to lipogenesis in liver, and selective LXRβ activation improves RCT in mice. Therefore, LXRβ-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. However, the ligand-binding domains in the two LXR isoforms α/β share high sequence identity, and few LXR ligands show subtype selectivity. In this study the authors identified a tetrachlorophthalimide analog as an LXRβ-selective agonist. Structural development led to (E)-4,5,6,7-tetrachloro-2-(2-styrylphenyl)isoindoline-1,3-dione (I), which shows potent and selective LXRβ agonistic activity in reporter gene assays. In binding assays, compound I bound to LXRβ preferentially over LXRα. It also induced the expression of ABCA1 mRNA but not SREBP-1c mRNA in cells. Compound I appears to be a promising lead compound for therapeutic agents to treat atherosclerosis without the side effects induced by LXRα/β dual agonists. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to tetrachlorophthalimide liver x receptor beta agonist, abca1, srebp-1c, agonists, atherosclerosis, liver x receptor (lxr), Pharmacology: Structure-Activity and other aspects.SDS of cas: 157869-15-3

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Ether – Wikipedia,
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On October 1, 2022, Gabriella, Santagata; Tiziana, Di Renzo; Salvatore, Mallardo; Anna, Reale; Giovanni, Cascone; Floriana, Boscaino; Grazia, Volpe Maria published an article.Product Details of 578-58-5 The title of the article was Innovative technologies optimizing the production process of “Castagne del Prete”: Impact on microstructure and volatile compounds. And the article contained the following:

“Castagne del Prete” are traditional processed chestnuts from the Campania Region obtained through a treatment involving a drying, roasting and rehydration phase. The last one is a long, costly and non-standardized treatment that is therefore in need of improvement. In the present study, different technologies (heat treatment, steam and thermosonication) were evaluated to optimize the chestnuts rehydration phase. To this end, microstructure, thermal properties and volatile organic compounds (VOCs) of “Castagne del Prete” obtained by different rehydration methods were evaluated. Results highlighted that thermosonication strongly influenced the starch gelatinization process, responsible for the total destructuration and denaturation of the crystalline network. VOCs anal. showed that the samples rehydrated by thermosonication with chestnuts/water ratio 1:5 had a volatile compounds pattern very similar to the control sample obtained by classic rehydration method. In addition, the time for obtaining “Castagne del Prete” by using thermosonication (approx. 5 h) as rehydration treatment was significantly reduced in comparison to the classic method which took approx. 7 days. Thus, thermosonication emerged as the most promising technique among those investigated for the production of “Castagne del Prete”, as it saves energy and time, while guaranteeing the flavor and structural characteristics of the finished products. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Product Details of 578-58-5

The Article related to microstructure drying gelatinization rehydration, Food and Feed Chemistry: Analysis and other aspects.Product Details of 578-58-5

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On October 21, 2021, Pancrazzi, Francesco; Maestri, Giovanni; Maggi, Raimondo; Viscardi, Rosanna published an article.Formula: C11H10O The title of the article was Oxidative Dearomatization of Phenols and Polycyclic Aromatics with Hydrogen Peroxide Triggered by Heterogeneous Sulfonic Acids. And the article contained the following:

Authors report herein a method for the oxidative dearomatization of phenols and bare polycyclic arenes into the corresponding quinoid derivatives using hydrogen peroxide. The reaction is catalyzed by sulfonic acids and best results were achieved using heterogenized species. The best results using phenols were achieved using a hybrid material, namely a perfluorinated polymer functionalized with sulfonic acid groups supported on silica. The dearomatization of polycyclic aromatic hydrocarbons performed better using the polymeric acid catalyst. These methods operate under mild conditions, using mild and benign oxidants and thus minimizing the formation of waste. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Formula: C11H10O

The Article related to quinoid preparation heterogeneous sulfonic acid, phenol polycyclic aromatic hydrogen peroxide oxidative dearomatization, Alicyclic Compounds: Cyclohexanes and other aspects.Formula: C11H10O

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On March 30, 2021, De Flaviis, Riccardo; Sacchetti, Giampiero; Mastrocola, Dino published an article.HPLC of Formula: 91-16-7 The title of the article was Wheat classification according to its origin by an implemented volatile organic compounds analysis. And the article contained the following:

Food volatile organic compounds (VOCs) anal. is a useful tool in authentication and classification processes, but, to date, the anal. of wheat VOCs is still little explored. In this study a method of anal. based on solid phase microextraction coupled with gas chromatog.-mass spectrometry was optimized by testing different types of fibers, sample preparation methods and amounts, extraction temperatures and times, desorption times and oven programs. The anal. was applied to six wheat cultivars harvested in different areas, and permitted to identify 158 VOCs, of which 98 never found before. A principal component anal. performed on the dataset showed that the area of cultivation accounted for the highest source of variability. Partial least squares anal. permitted to correctly classify wheats based on their cultivation area and species, and to identify the most discriminant VOCs. These results are promising for the study of the influence of geog. origin on wheat quality. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).HPLC of Formula: 91-16-7

The Article related to ethanol hexanal acetic acid classification wheat quality, gc–ms, pedoclimatic conditions, spme, volatile organic compounds, wheat species, Food and Feed Chemistry: Analysis and other aspects.HPLC of Formula: 91-16-7

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On April 15, 2022, Ma, Lijuan; Peng, Yuxi; Du, Liping; Zhang, Linqi; Tong, Wenzhe; Weng, Yanru; Xiao, Dongguang; Zhang, Huiling; Huang, Jihong published an article.Related Products of 91-16-7 The title of the article was Effect of main taste compounds on the release of methoxyphenolic compounds in Pu-erh tea. And the article contained the following:

As a typical Chinese tea, Pu-erh tea attracts much attention due to its unique flavor formed by taste and aroma compounds To study the effects of taste compounds on the aroma release, model solutions containing five typical methoxyphenolic compounds (MCs) and main taste compounds with different concentrations were prepared based on the anal. of Pu-erh tea samples. GC-MS results indicated that the release of five MCs was inhibited by theabrownin, tea polysaccharide, tea polyphenol and catechins. The release of 1,2-dimethoxybenzene, 3,4-dimethoxytoluene and 1,2,3-trimethoxy-5-methyl-benzene was promoted by gallic acid under a low concentration (≤4 mg/g). Statistically, gallic acid had the most significant effect on the release of MCs. Isothermal titration calorimetry suggested that hydrogen bonds and hydrophobic effects had potential contributions to the interaction between taste and aroma compounds This work will provide the research basis for revealing the formation mechanism of tea flavor. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Related Products of 91-16-7

The Article related to puerh tea methoxyphenolic taste aroma hydrophobicity, Food and Feed Chemistry: Beverages and other aspects.Related Products of 91-16-7

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