Month: November 2022

On February 29, 2020, Aukland, Miles H.; Siauciulis, Mindaugas; West, Adam; Perry, Gregory J. P.; Procter, David J. published an article.Synthetic Route of 93-04-9 The title of the article was Metal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation. And the article contained the following:

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Synthetic Route of 93-04-9

The Article related to arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction, heterobiaryl preparation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Aukland, Miles H.; Siauciulis, Mindaugas; West, Adam; Perry, Gregory J. P.; Procter, David J. published an article.Recommanded Product: 321-28-8 The title of the article was Metal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation. And the article contained the following:

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction, heterobiaryl preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tota, Arianna; Zenzola, Marina; Chawner, Stephen J.; John-Campbell, Sahra St; Carlucci, Claudia; Romanazzi, Giuseppe; Degennaro, Leonardo; Bull, James A.; Luisi, Renzo published an article in 2017, the title of the article was Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.Electric Literature of 53136-21-3 And the article contains the following content:

Direct synthesis of NH-sulfoximines from sulfides were achieved through O and NH transfer in the same reaction, occurring with complete selectivity. The reaction was mediated by bisacetoxyiodobenzene under simple conditions and employs inexpensive N-sources. Preliminary studies indicated that NH-transfer was likely to be first, followed by oxidation, but the reaction proceedes successfully in either order. A wide range of functional groups and biol. relevant compounds were tolerated. The use of AcO15NH4 affords 15N-labeled compounds The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Electric Literature of 53136-21-3

The Article related to sulfide preparation ammonium carbamate bisacetoxyiodobenzene oxidation imination, sulfoximine chemoselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 7, 2022, Ito, Tasuku; Seidel, Falk William; Jin, Xiongjie; Nozaki, Kyoko published an article.Category: ethers-buliding-blocks The title of the article was TEMPO as a Hydrogen Atom Transfer Catalyst for Aerobic Dehydrogenation of Activated Alkanes to Alkenes. And the article contained the following:

2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) has been extensively utilized as a radical scavenger or an oxidation catalyst. In contrast, TEMPO as a hydrogen atom transfer (HAT) catalyst has rarely been studied. Here, authors report that TEMPO, as the HAT catalyst, homolytically cleaves benzylic or allylic C-H bonds to give the corresponding alkyl radicals. Benefiting from the dual roles played by TEMPO as the HAT catalyst and the radical scavenger, the highly challenging aerobic dehydrogenation of activated alkanes to alkenes is successfully developed. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Category: ethers-buliding-blocks

The Article related to alkene preparation tempo hydrogen atom transfer catalyst, activated alkane transition metal free aerobic dehydrogenation, General Organic Chemistry: Synthetic Methods and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 26, 2020, Yin, Dehang; Su, Dengquan; Jin, Jian published an article.SDS of cas: 91-16-7 The title of the article was Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids. And the article contained the following:

Here, a mild and practical method that allows for the direct C-H trifluoromethylation, perfluoroalkylation, and chlorodifluoromethylation of (hetero)arenes such as mesitylene, 1-tosyl-1H-pyrrole, N-(thiophen-3-yl)acetamide, etc. using TFA and the related carboxylic acids RC(O)OH (R = CF3, C5F11, CF2Cl, etc.) was reported. A diverse array of arenes and heteroarenes was successfully transformed into valued fluoroalkylated compounds e.g., I. The combination of photoredox catalysis and a bis(4-chlorophenyl) sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).SDS of cas: 91-16-7

The Article related to fluoroalkyl compound preparation, trifluoroacetic acid arene trifluoromethylation perfluoroalkylation photoredox catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ong, Derek Yiren; Tejo, Ciputra; Xu, Kai; Hirao, Hajime; Chiba, Shunsuke published an article in 2017, the title of the article was Hydrodehalogenation of Haloarenes by a Sodium Hydride-Iodide Composite.Application of 53136-21-3 And the article contains the following content:

A simple protocol for hydrodebromination and -deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application of 53136-21-3

The Article related to haloarene hydrodehalogenation sodium hydride iodide, dft calculations, haloarenes, hydrodehalogenation, reduction, sodium hydride, General Organic Chemistry: Synthetic Methods and other aspects.Application of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 4, 2022, Zhang, Hao-Ran; Feng, Cong-Cong; Chen, Ning; Zhang, Song-Lin published an article.Quality Control of 1,4-Dimethoxybenzene The title of the article was Direct Arene Trifluoromethylation Enabled by a High-Valent CuIII-CF3 Compound. And the article contained the following:

Direct C-H trifluoromethylation of arenes and heteroarenes poses an important synthetic challenge that is highly desirable. High-valent CuIII-CF3 compounds have often been invoked in copper-mediated trifluoromethylation reactions, but the fundamental reactivity toward arenes is elusive. Herein, direct C-H trifluoromethylation of arenes/heteroarenes by a high-valent CuIII-CF3 compound is disclosed for the first time. The CuIII-CF3 compound serves CF3 radical and a CuII oxidant by homolytic cleavage of a CuIII-CF3 bond, which engage synergistically in a SEAr type reaction with arenes. The presence of K2S2O8 co-oxidant can significantly improve the reaction yields. This reaction shows good efficiency, broad functional group tolerance, and the potential in late-stage functionalization. The reactivity of high-valent CuIII-CF3 compounds disclosed in this study represents an important progress in organofluorine and CuIII chem. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Quality Control of 1,4-Dimethoxybenzene

The Article related to arene heteroarene trifluoromethylation copper, arenes, c−h functionalization, high-valent copper species, radical reaction, trifluoromethylation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1,4-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 4, 2022, Zhang, Hao-Ran; Feng, Cong-Cong; Chen, Ning; Zhang, Song-Lin published an article.Application of 91-16-7 The title of the article was Direct Arene Trifluoromethylation Enabled by a High-Valent CuIII-CF3 Compound. And the article contained the following:

Direct C-H trifluoromethylation of arenes and heteroarenes poses an important synthetic challenge that is highly desirable. High-valent CuIII-CF3 compounds have often been invoked in copper-mediated trifluoromethylation reactions, but the fundamental reactivity toward arenes is elusive. Herein, direct C-H trifluoromethylation of arenes/heteroarenes by a high-valent CuIII-CF3 compound is disclosed for the first time. The CuIII-CF3 compound serves CF3 radical and a CuII oxidant by homolytic cleavage of a CuIII-CF3 bond, which engage synergistically in a SEAr type reaction with arenes. The presence of K2S2O8 co-oxidant can significantly improve the reaction yields. This reaction shows good efficiency, broad functional group tolerance, and the potential in late-stage functionalization. The reactivity of high-valent CuIII-CF3 compounds disclosed in this study represents an important progress in organofluorine and CuIII chem. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Application of 91-16-7

The Article related to arene heteroarene trifluoromethylation copper, arenes, c−h functionalization, high-valent copper species, radical reaction, trifluoromethylation, General Organic Chemistry: Synthetic Methods and other aspects.Application of 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 19, 2022, Ritu; Das, Saikat; Tian, Ya-Ming; Karl, Tobias; Jain, Nidhi; Konig, Burkhard published an article.Electric Literature of 93-04-9 The title of the article was Photocatalyzed Dehydrogenation of Aliphatic N-Heterocycles Releasing Dihydrogen. And the article contained the following:

Author’s report the iridium-nickel dual photocatalytic acceptorless and redox neutral dehydrogenation of aliphatic heterocycles yielding cyclic alkenes without overoxidn. at room temperature Excitation of the iridium photocatalyst initiates the formation of a nickel hydride intermediate that yields alkenes and H2 via β-hydride elimination. The reaction proceeds regioselectively and the scope was demonstrated by the synthesis of 12 biol. relevant mols. and drugs. In addition, com. and easily available N-heterocyclic alkane starting materials were converted into functionalized alkenes of high synthetic and com. value using the method. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Electric Literature of 93-04-9

The Article related to cyclic enamide enecarbamate preparation regioselective photochem, aliphatic heterocycle dehydrogenation hydride elimination iridium nickel catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Lingling; Li, Yiming; Jiang, Xuefeng published an article in 2020, the title of the article was Visible-light-promoted oxidative halogenation of (hetero)arenes.Name: 2-Methoxynaphthalene And the article contains the following content:

Herein, a compatible oxidative halogenation of (hetero)arenes such as 4-phenylmorpholine, 1,3,5-trimethoxybenzene, imidazo[1,2-a]pyrazine, etc. with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure) was described. Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Name: 2-Methoxynaphthalene

The Article related to haloarene preparation regioselective, arene oxidative halogenation, halo heteroarene preparation regioselective, heteroarene oxidative halogenation, General Organic Chemistry: Synthetic Methods and other aspects.Name: 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem