On October 4, 2022, Zhang, Hao-Ran; Feng, Cong-Cong; Chen, Ning; Zhang, Song-Lin published an article.Quality Control of 1,4-Dimethoxybenzene The title of the article was Direct Arene Trifluoromethylation Enabled by a High-Valent CuIII-CF3 Compound. And the article contained the following:
Direct C-H trifluoromethylation of arenes and heteroarenes poses an important synthetic challenge that is highly desirable. High-valent CuIII-CF3 compounds have often been invoked in copper-mediated trifluoromethylation reactions, but the fundamental reactivity toward arenes is elusive. Herein, direct C-H trifluoromethylation of arenes/heteroarenes by a high-valent CuIII-CF3 compound is disclosed for the first time. The CuIII-CF3 compound serves CF3 radical and a CuII oxidant by homolytic cleavage of a CuIII-CF3 bond, which engage synergistically in a SEAr type reaction with arenes. The presence of K2S2O8 co-oxidant can significantly improve the reaction yields. This reaction shows good efficiency, broad functional group tolerance, and the potential in late-stage functionalization. The reactivity of high-valent CuIII-CF3 compounds disclosed in this study represents an important progress in organofluorine and CuIII chem. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Quality Control of 1,4-Dimethoxybenzene
The Article related to arene heteroarene trifluoromethylation copper, arenes, c−h functionalization, high-valent copper species, radical reaction, trifluoromethylation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1,4-Dimethoxybenzene
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Ether | (C2H5)2O – PubChem