Month: November 2022

Karmel, Caleb; Rubel, Camille Z.; Kharitonova, Elena V.; Hartwig, John F. published an article in 2019, the title of the article was Iridium-catalyzed silylation of five-membered heteroarenes: high sterically derived selectivity from a pyridyl-imidazoline ligand.Name: 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane And the article contains the following content:

The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions that occur with selectivities dictated by steric effects, such as the borylation of C-H bonds, have been poor in many cases. We report that the silylation of five-membered ring heteroarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [Ir(cod)(OMe)]2 and a phenanthroline ligand or a new pyridylimidazoline ligand that further increases the regioselectivity. The silylation reactions with these catalysts produce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H bonds of these rings under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtures of products or products that are unstable. The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate heteroarenes that bear halogen, aryl and perfluoroalkyl substituents. The experimental process involved the reaction of 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073339-22-6).Name: 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The Article related to heteroarene heptamethyltrisiloxane bispinacolatodiboron iridium catalyst pyridyl imidazoline ligand, regioselective chemoselective silylation borylation hiyama coupling, Heterocyclic Compounds (One Hetero Atom): Other 5-Membered Rings and other aspects.Name: 2-(4-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 29, 2020, Kang, Chengjun; Zhang, Zhaoqiang; Wee, Vanessa; Usadi, Adam K.; Calabro, David C.; Baugh, Lisa Saunders; Wang, Shun; Wang, Yuxiang; Zhao, Dan published an article.Electric Literature of 150-78-7 The title of the article was Interlayer Shifting in Two-Dimensional Covalent Organic Frameworks. And the article contained the following:

Layer-stacking structures are very common in two-dimensional covalent organic frameworks (2D COFs). While their structures are normally determined under solvent-free conditions, the structures of solvated 2D COFs are largely unexplored. We report herein the in situ determination of solvated 2D COF structures, which exhibit an obvious difference as compared to that of the same COF under dried state. Powder X-ray diffraction (PXRD) data analyses, computational modeling, and Pawley refinement indicate that the solvated 2D COFs experience considerable interlayer shifting, resulting in new structures similar to the staggered AB stacking, namely, quasi-AB-stacking structures, instead of the AA-stacking structures that are usually observed in the dried COFs. We attribute this interlayer shifting to the interactions between COFs and solvent mols., which may weaken the attraction strength between adjacent COF layers. D. functional theory (DFT) calculations confirm that the quasi-AB stacking is energetically preferred over the AA stacking in solvated COFs. All four highly crystalline 2D COFs examined in the present study exhibit considerable interlayer shifting upon solvation, implying the universality of the solvent-induced interlayer stacking rearrangement in 2D COFs. These findings prompt re-examination of the 2D COF structures in solvated state and suggest new opportunities for the applications of COF materials under wet conditions. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Electric Literature of 150-78-7

The Article related to interlayer shifting two dimensional covalent organic framework, Physical Properties of Synthetic High Polymers: Polymer Structure and other aspects.Electric Literature of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 12, 2014, Resta, Claudio; Di Pietro, Sebastiano; Majeric Elenkov, Maja; Hamersak, Zdenko; Pescitelli, Gennaro; Di Bari, Lorenzo published an article.COA of Formula: C15H24O2 The title of the article was Consequences of Chirality on the Aggregation Behavior of Poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene] (MEH-PPV). And the article contained the following:

Poly[2-methoxy-5(2′-ethylhexoxy)-p-phenylenevinylene] (MEH-PPV) has been for the first time prepared and fully characterized in enantiopure (R) form. If the polymer mol. weight is sufficiently low, (R)-MEH-PPV assumes a helical supramol. structure in the solution aggregates, with consequences on the tendency to aggregation and on the fluorescence quenching, both of which are reduced with respect to the racemic analog. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).COA of Formula: C15H24O2

The Article related to chirality effect aggregation poly methoxy ethylhexyloxy phenylenevinylene, Physical Properties of Synthetic High Polymers: Polymer Structure and other aspects.COA of Formula: C15H24O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 21, 2014, Cheng, Chen; Hartwig, John F. published an article.Application of 1417036-28-2 The title of the article was Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol. And the article contained the following:

Regioselective C-H functionalization of arenes has widespread applications in synthetic chem. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, authors report a catalytic intermol. C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Application of 1417036-28-2

The Article related to rhodium catalyzed intermol carbon hydrogen silylation arene steric regiocontrol, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Application of 1417036-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 10, 2022, Lee, Hiu-Fung; Lacbay, Cyrus M.; Boutin, Rebecca; Matralis, Alexios N.; Park, Jaeok; Waller, Daniel D.; Guan, Tian Lai; Sebag, Michael; Tsantrizos, Youla S. published an article.Safety of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. And the article contained the following:

Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Safety of 1-Fluoro-2-methoxybenzene

The Article related to multiple myeloma antimyeloma liver toxicity thienopyrimidine hggpps inhibitor pharmacokinetics, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Safety of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 29, 2020, Kucinski, Krzysztof; Stachowiak, Hanna; Hreczycho, Grzegorz published an article.Reference of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Silylation of Alcohols, Phenols, and Silanols with Alkynylsilanes – an Efficient Route to Silyl Ethers and Unsymmetrical Siloxanes. And the article contained the following:

The formation of several silyl ethers (alkoxysilanes, R3Si-OR’) and unsym. siloxanes (R3Si-O-SiR’3) can be catalyzed by the com. available potassium bis(trimethylsilyl)amide (KHMDS). The reaction proceeds via direct dealkynative coupling between various alcs. or silanols and alkynylsilanes, with a simultaneous formation of gaseous acetylene as the sole byproduct. The dehydrogenative and dealkenative coupling of alcs. or silanols are well-investigated, while the utilization of alkynylsilanes as silylating agents has never been comprehensively studied in this context. Overall, the presented system allows the synthesis of various attractive organosilicon compounds under mild conditions, making this approach an atom-efficient, environmentally benign, and sustainable alternative to existing synthetic solutions The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Reference of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to silylation alc phenol silanol alkynylsilane green chem, silyl ether unsym siloxane preparation green chem, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Reference of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 20, 2020, Bao, Xia-Zhen; Wang, Qi; Ren, Xiao-Rong; Dai, Fang; Zhou, Bo published an article.Name: 1,4-Dimethoxybenzene The title of the article was A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells. And the article contained the following:

Targeting redox vulnerability of cancer cells by pro-oxidants capable of generating reactive oxygen species (ROS) has surfaced as an important anticancer strategy. Due to the intrinsic narrow therapeutic window and other dangerous side effects of ROS generation, it is highly needed and challenging to develop pro-oxidative anticancer agents (PAAs) with high selectivity for generating ROS in cancer cells. Herein we report a hydrogen peroxide (H2O2)-activated Cu(II) pro-ionophore strategy to develop naphthazarin (Nap) as such type of PAAs based on the H2O2-mediated conversion of boronate to free phenol. The boronate-protected Nap (PNap) can exploit increased levels of H2O2 in HepG2 cells to in situ release Nap followed by its efflux via conjugation with reduced glutathione (GSH), allowing that the Nap-GSH adduct works as a Cu(II) ionophore to induce continuously GSH depletion via a reduction-dependent releasing of Cu(I) by GSH. This strategy endows PNap with the unprecedented ability to hit multi-redox characteristics (increased levels of H2O2, GSH and copper) of HepG2 cells, leading to ROS generation preferentially in HepG2 cells along with their selective death. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Name: 1,4-Dimethoxybenzene

The Article related to hydrogen peroxide copper proionophore naphthazarin preparation cancer, copper, glutathione, hydrogen peroxide, ionophore, reactive oxygen species, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Name: 1,4-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 5, 2021, Neil, Baptiste; Lucien, Franck; Fensterbank, Louis; Chauvier, Clement published an article.Product Details of 321-28-8 The title of the article was Transition-Metal-Free Silylation of Unactivated C(sp2)-H Bonds with tert-Butyl-Substituted Silyldiazenes. And the article contained the following:

Aromatic organosilanes bearing C(sp2)-Si bonds found increasing applications across the chem. science, yet are mostly produced by atom-uneconomical stoichiometric procedures. Catalytic alternatives using hydrosilanes as Si sources also were described, but they display unfavorable thermodn. and are mostly based on expensive catalytic systems, often derived from noble metals, or lack generality. Herein, the authors describe the use of an alternative Si source, the tert-butyl-substituted silyldiazenes (tBu-N:N-SiR3), that are readily accessible from com. available precursors and whose structure enables the C(sp2)-H bond silylation of unactivated heteroaryl and aryl compounds under ambient, transition-metal-free catalytic conditions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8

The Article related to unactivated carbon hydrogen bond heteroaryl aromatic compound silylation silyldiazene, aromatic organosilane preparation, heteroaryl silane preparation, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Product Details of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 25, 2020, Tran, Quoc Khanh; Han, Sangjin; Ly, Hoang Vu; Kim, Seung-Soo; Kim, Jinsoo published an article.Recommanded Product: 91-16-7 The title of the article was Hydrodeoxygenation of a bio-oil model compound derived from woody biomass using spray-pyrolysis-derived spherical γ-Al2O3-SiO2 catalysts. And the article contained the following:

In this study, spherical γ-Al2O3-SiO2 catalysts with various Al/Si ratios were prepared by combining the sol-gel and spray pyrolysis (SP) methods. The effectiveness of the product catalysts was then tested via the hydrodeoxygenation (HDO) of guaiacol, a model compound of bio-oil obtained from the pyrolysis of lignocellulosic biomass. Our results showed that the γ-Al2O3-SiO2 catalyst with a 50:50 Al/Si ratio after calcination at 450°C exhibited the highest guaiacol conversion (81.79%) at a reaction temperature of 300°C, atm. pressure, and a weight hourly space velocity (WHSV) of 6.5 h-1. During guaiacol HDO, the carbon-oxygen cleavage and Me group transfer reactions occurred on the γ-Al2O3-SiO2 catalyst, which converted the guaiacol into the resp. deoxygenated products, including 2,6-xylenol, 2,3,5,6-tetra-Me phenol, pentamethyl benzene, and hexamethyl benzene. The reaction pathways for the conversion of guaiacol HDO were also proposed in this study. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Recommanded Product: 91-16-7

The Article related to alumina silica guaiacol hydrodeoxygenation woody biomass spray pyrolysis, Electrochemical, Radiational, and Thermal Energy Technology: Other and other aspects.Recommanded Product: 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 1, 2021, Sun, Haoran; Luo, Zhongyang; Wang, Wenbo; Li, Simin; Xue, Shuang published an article.Product Details of 91-16-7 The title of the article was Porosity roles of micro-mesostructured ZSM-5 in catalytic fast pyrolysis of cellulolytic enzyme lignin for aromatics. And the article contained the following:

Cellulolytic enzyme lignin could be utilized to produce aromatic-rich bio-oil in the catalytic fast pyrolysis (CFP) process, in which strong-acidic ZSM-5 is often used as the catalyst. The introduction of mesopores into conventional ZSM-5 catalysts can improve the diffusion of heavy components and thus enable the modulation of pyrolysis products. To investigate the effect of mesoporous structure parameters on the diffusion of heavy phenols and the regulation of pyrolysis products by different types of pore structures, three different mesoporous ZSM-5 were prepared (core-shell, hierarchical, composites), with textural properties being compared in detail. The structural parameters were adopted to analyze the relationship between mesopores distribution and catalytic performance, revealing the significant effect of equivalent mesopore size. Among the prepared catalysts, a micro-mesostructured composite zeolite (ZMA) with internal hierarchical pores and ununiform mesolayer shell had a suitable mesostructure, of which the interconnected meso-channels improved the accessibility of inner acidic sites. Also, it was optimum to balance aromatic yield (above 7.5 wt%) and the product distribution (MAHs/PAHs approaching 6), revealing that its moderate equivalent pore size maintained a certain shape-selectivity to suppress PAHs formation. It was further shown that the applicable catalyst to lignin ratio (C/L) ranges differed with various mesostructures, as ZMA and hierarchical samples were suitable for higher and lower ratios, resp. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Product Details of 91-16-7

The Article related to zsm cellulolytic enzyme lignin aromatic catalytic fast pyrolysis porosity, Electrochemical, Radiational, and Thermal Energy Technology: Other and other aspects.Product Details of 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem