Month: November 2022

On October 1, 2013, Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei published an article.Formula: C8H10BrNO The title of the article was Copper-catalyzed sequential N-arylation and aerobic oxidation: synthesis of quinazoline derivatives. And the article contained the following:

A novel and efficient copper-catalyzed cascade method for the synthesis of quinazoline derivatives was developed. The protocol uses readily available substituted (2-bromophenyl)methanamines and amidine hydrochlorides as the starting materials, inexpensive CuBr as the catalyst, and economical and environment friendly air as the oxidant, and the corresponding quinazoline derivatives were obtained in moderate to good yields. The procedure underwent sequential intermol. N-arylation, intramol. nucleophilic substitution and aerobic oxidation The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Formula: C8H10BrNO

The Article related to bromobenzylamine amidine hydrochloride cascade arylation copper catalyst, quinazoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C8H10BrNO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aleksandrova, Maiia I.; Ivanov, Alexander Yu.; Dilman, Alexander D.; Vasilyev, Aleksander V. published an article in 2019, the title of the article was Electrophilic Activation of 1-Aryl-3-bromo-2,2-difluoropropan-1-ones by Triflic Acid in Reactions with Arenes.SDS of cas: 321-28-8 And the article contains the following content:

The reactions of 1-aryl-3-bromo-2,2-difluoropropan-1-ones [Ar(CO)CF2CH2Br] with various arenes Ar’H in the superacid TfOH at room temperature for 1-7 h result in the formation of products of hydroarylation of the carbonyl group, 1,1-diaryl-3-bromo-2,2-difluoropropan-1-ols [ArAr’C(OH)CF2CH2Br], in yields up to 85 %. The reaction with benzene goes deeper and leads to 1-aryl-3-bromo-2,2-difluoro-1,1-diphenylpropanes [ArCPh2CF2CH2Br] in good yields. Mainly, the bromomethyl group (CH2Br) of starting ketones remains untouched under the superacidic conditions. Cationic intermediates of the reaction have been studied by means of NMR spectroscopy. Plausible reaction mechanism is discussed. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to arene ketone trifluoromethanesulfonic acid electrophilic aromatic substitution cation, alc preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.SDS of cas: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hashimoto, Riichi; Hanaya, Kengo; Sugai, Takeshi; Higashibayashi, Shuhei published an article in 2022, the title of the article was 1,2-Rearrangement from o-Quinols to Multisubstituted Catechols via Retro Diels-Alder Reaction of o-Quinol Dimers.SDS of cas: 578-58-5 And the article contains the following content:

The 1,2-rearrangement of o-quinols has been a long-standing unsolved problem since 1958. Although the rearrangement is expected to be useful for syntheses of catechol derivatives, it is hampered by many competing reactions and has not been developed as a useful methodol. Here, authors succeeded in settling this problem by a first systematic thorough investigation, establishing the 1,2-rearrangement as a cascade reaction with a retro Diels-Alder reaction from o-quinol dimers. This is a useful strategy for syntheses of substituted catechols used as synthetic building blocks for bioactive compounds and material mols. o-Quinol dimers were synthesized by improved oxidative hydroxylation of substituted phenols followed by spontaneous Diels-Alder reaction. The dimers then underwent the retro Diels-Alder reaction to regenerate the o-quinols followed by 1,2-rearrangement under neutral heating conditions at an appropriate temperature depending on the migratory substituent, furnishing substituted catechols in good yields. The competing reactions such as an elimination of a substituent or α-ketol rearrangement were minimized by controlling the reaction temperature The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).SDS of cas: 578-58-5

The Article related to quinol dimer catechol preparation regioselective, phenol hydroxylation retro diels alder rearrangement, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.SDS of cas: 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 7, 2010, Marsilje, Thomas H., III; Lu, Wenshuo; Chen, Bei; He, Xiaohui; Lee, Christian Cho-Hua; Jiang, Songchun; Yang, Kunyong published a patent.Synthetic Route of 152626-77-2 The title of the patent was Preparation of substituted 2-(phenylamino)pyrimidin-4-amine as IGF-1 receptor and anaplastic lymphoma kinase inhibitors for treating proliferative disorders. And the patent contained the following:

The invention is related to the preparation of pyrimidine derivatives I [ring E may optionally contain a double bond; one of Z1-3 = NR6, N(R6)(:O) or S(O)1-2 and the others are CR2; R6 = H, azetidin-3-yl, 1,1-dioxo-2H-thiopyran-4-yl,, (un)substituted alk(en/yn)yl, 4-(pyrrolidin-1-yl)-1-oxobutyl, 3-morpholinopropylsulfonyl, etc.; R2 = (un)substituted 2-oxo-1,2-dihydropyridin-3-yl, 2-oxoazepan-3-yl, 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S; R1 = halo, optionally halogenated alkyl; R3, R4 = H; R5 = halo, OH, alkyl, alkoxy, CN, etc.; X = Y = (CH)0-1; m = 2-4] and their physiol. acceptable salts which may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK), and to their pharmaceutical compositions Thus, monoamination of 2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine (preparation given) with tert-Bu 4-(4-amino-5-fluoro-2-methylphenyl)piperidine-1-carboxylate (preparation given) and reductive amination of formaldehyde gave II. Selected I had IC50 values in the range of 1 nM – 1 μM for the inhibition of IGF-1R. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Synthetic Route of 152626-77-2

The Article related to phenylaminopyrimidineamine preparation igf1r anaplastic lymphoma kinase inhibitor antiproliferative neoplasm, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 152626-77-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 16, 2020, Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Seok Beom; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Hong, Suckchang; Kim, In Su published an article.Application In Synthesis of 2-Methylanisole The title of the article was Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates. And the article contained the following:

The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, and N-methoxyamides. Complete site-selectivity and functional group tolerance are observed Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application In Synthesis of 2-Methylanisole

The Article related to aryl quinazolinone nitrene surrogate regioselective rhodium amidation, functionalized quinazolinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 18, 2018, Wang, Xu; He, Dandan; Huang, Yubing; Fan, Qihang; Wu, Wanqing; Jiang, Huanfeng published an article.Product Details of 157869-15-3 The title of the article was Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen. And the article contained the following:

A copper-catalyzed process for the synthesis of substituted quinazolines from benzonitriles and 2-ethynylanilines using mol. oxygen (O2) as sole oxidant is described. The mild catalytic system enabled the effective cleavage of the C-C triple bond and construction of new C-N and C-C bonds in one operation. Furthermore, the compound N,N-dimethyl-4-(2-(4-(trifluoromethyl)phenyl)quinazolin-4-yl)aniline (3dj) exhibited obvious aggregation-induced emission phenomenon, and the fluorescence quantum yield (ΦF,film) and lifetime (τfilm) were measured to be 45.5% and 5.8 ns in thin films state, resp. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to copper catalyzed cyclization benzonitrile ethynylaniline carbon bond cleavage oxygen, diphenyl quinazoline preparation crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 25, 2009, Ryu, Jung-Yi; Lee, Tae-Hoon; Kim, Tae-Hoon; Koo, Chul-Whoi; Son, Se-Mo published an article.SDS of cas: 146370-51-6 The title of the article was Mobility characteristics of novel oligomer structuralized by biphenyl conjugated with electron donating units. And the article contained the following:

Oligomers containing biphenyl backbone were prepared by using Wittig reaction and their optical properties were characterized. The drift mobility of oligomers was measured by using TOF method. The drift mobility showed elec. field-dependent character and coincidence with Poole-Frankel relation. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).SDS of cas: 146370-51-6

The Article related to electron mobility biphenyl conjugated electron donating unit oligomer, Physical Properties of Synthetic High Polymers: Physical Interactions Of Polymers and other aspects.SDS of cas: 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 1, 2020, Zhou, Jingjing; Su, Zhengzhou; Wang, Mingqi; Wang, Yufei; Wang, Jianping; Zhang, Baoliang; Zhang, Qiuyu published an article.Computed Properties of 929-37-3 The title of the article was Thiolactone-based conjugation assisted magnetic imprinted microspheres for specific capturing target proteins. And the article contained the following:

Protein imprinted materials receive considerable attention in biol. scope but restricted about practical use for the lack of adsorption efficiency and rebinding specificity. To approach the dearth, imprinted polymers or ligands capable of designable structure, herein, the facile thiolactone-based conjugates accompanied by multiple functional units, were put forward into imprinting system as protein anchors by click chem. Due to the simple implementation and flexible reconstitution of this conjugation strategy, a series of thiol-ene-amine segments were fabricated to capture bovine serum albumin (BSA) for generating imprinting cavities through dopamine self-polymerization on well-defined hollow magnetic substrates. Among them, the BSA-imprinted microspheres based on thiol-ene-MA conjugates (MA referred as 3-morpholinopropylamine) not only exhibited remarkable rebinding ability (adsorption capacity: 209.22 mg/g, imprinting factor: 4.59) and efficient saturation adsorption (30 min), but also presented satisfactory selectivity in the individual and competitive protein samples. Assisted with thiol-ene-amine conjugation, the elaborate magnetic imprinted materials for specific separating target macromols. hold great promising in applications. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Computed Properties of 929-37-3

The Article related to thiolactone conjugation magnetic imprinted microsphere capturing target protein, Biochemical Methods: Miscellaneous Separations (Not Covered At Other Subsections) and other aspects.Computed Properties of 929-37-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 30, 2000, Pan, Jiang-Qing; Chen, Zi-Kuan; Xiao, Yang; Huang, Wei published an article.HPLC of Formula: 146370-51-6 The title of the article was Synthesis and characterization of fully soluble polyphenylenevinylene. And the article contained the following:

Fully soluble poly[2-(2-ethylhexyloxy)-5-methoxy-p-phenylenevinylene] was synthesized by the polymerization of 2-(2-ethylhexyloxy)-5-methoxy-1,4-xylylene dibromide with addition of mol. weight modifiers (chain stopper, free radical scavengers) to a polymerization system containing monomer, catalyst, and solvent. The polymers synthesized in this work were characterized by IR, NMR, and UV-visible spectroscopy, and gel-permeation chromatog. Results show that the weight-average mol. weight of the polymer can be controlled by the addition of chain stopper (benzyl bromide) and radical inhibitor (BHT). The polymerization mechanism in the presence of these additives was also discussed. A dual mechanism involving carbene for the polymerization was proposed. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).HPLC of Formula: 146370-51-6

The Article related to polyphenylenevinylene preparation solubility, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.HPLC of Formula: 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 12, 2022, Kleybolte, Moritz E.; Vagin, Sergei I.; Rieger, Bernhard published an article.Application of 146370-51-6 The title of the article was High-Molecular-Weight Bisalkoxy-Substituted Poly(para)phenylenes by Kumada Polymerization. And the article contained the following:

Substituted poly(para)phenylenes (PPPs) are conjugated polymers with an attractive application potential in various fields of materials science. They are synthesized nearly exclusively using catalytic cross-coupling polymerization reactions based on Pd- or Ni-catalysts. Among these synthetic approaches to access alkoxy-substituted PPPs, Kumada catalyst transfer polymerization (KCTP or GRIM polymerization) would offer certain economic advantages over Suzuki-type polymerization as it relies on the utilization of a non-precious metal for catalysis. It also results in less total costs of the utilized reagents, avoiding addnl. preparative steps such as synthesis, isolation, and purification of boronic acid derivatives necessary for the Suzuki reaction. In fact, KCTP is nowadays the state-of-the-art method for the synthesis of polythiophenes. However, the application of KCTP for the synthesis of alkoxy-substituted PPPs leads to polymers with low mol. weights, limiting their practical applicability. Here, we developed a synthesis protocol that resulted in MEH-PPP with a mol. weight of Mn = 133 kg/mol and BHex-PPP with Mn = 153 kg/mol relative to polystyrene, outperforming the previous state of the art by a factor more than 5. Also, a tetra(ethylene glycol)-substituted PPP has been prepared by this procedure, with a mol. weight exceeding the previously reported results for analogous structures. Such mol. weights can be obtained in a reasonable reaction time (5 days) using low concentrations of an N-heterocyclic carbene-coordinated Ni complex. The polymerization kinetics suggested a chain-growth mechanism with a chain transfer step. The latter is caused most likely by a bimol. interaction of the Ni-species at the polymer chain ends. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to bisalkoxy polyphenylene kumada polymerization, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Application of 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem