Month: November 2022

Jovene, Cyril; Marrot, Jerome; Jasmin, Jean-Philippe; Chugunova, Elena; Goumont, Regis published an article in 2016, the title of the article was A Synthetic Pathway to Substituted Benzofuroxans through the Intermediacy of Sulfonates: The Case Example of Fluoro-Nitrobenzofuroxans.Name: 1-Fluoro-2-methoxybenzene And the article contains the following content:

Benzofuroxans are well known compounds that continue to attract particular attention since the discovery of 4,6-dinitrobenzofuroxan (DNBF) back in 1899. It has been shown that these compounds possess biol. activities that are related to their electronic behaviors and the positioning of substituents borne by the heterocycles. In this paper, we report the first synthesis of 4-fluoro-6-nitrobenzofuroxan and 6-fluoro-4-nitrobenzofuroxan; the altered positions of the substituents enabling us to carry out structural and reactivity comparisons, with DNBF and 4,6-difluorobenzofuroxan. These compounds have been unambiguously characterized through NMR and radiocrystallog. studies. Two main synthetic pathways involving fluoroanisoles and fluorophenols, cheap and easily available chems., have been successfully developed. Finally, benzofurazan analogs have been prepared via deoxygenation of corresponding benzofuroxans with tri-Et phosphite. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to benzofuroxan preparation sulfonate substitution heterocyclization, benzofurazan preparation deoxygenation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ding, Wei; Wang, Chen; Tan, Jie Ren; Ho, Chang Chin; Leon, Felix; Garcia, Felipe; Yoshikai, Naohiko published an article in 2020, the title of the article was Site-selective aromatic C-H λ3-iodanation with a cyclic iodine(III) electrophile in solution and solid phases.Recommanded Product: 321-28-8 And the article contains the following content:

An efficient and site-selective aromatic C-H λ3-iodanation reaction was achieved using benziodoxole triflate (BXT) as an electrophile under room temperature conditions. The reaction tolerated a variety of electron-rich arenes and heteroarenes to afford the corresponding arylbenziodoxoles I [R = 4-OMeC6H4, 2,4-di-MeC6H3, 2-thienyl, etc.] in moderate to good yields. The reaction could also be performed mechanochem. by grinding a mixture of solid arenes and BXT under solvent-free conditions. The arylbenziodoxoles could be used for various C-C and C-heteroatom bond formations and are also amenable to further modification by electrophilic halogenation. DFT calculations suggested that the present reaction proceeded via a concerted λ3-iodanation-deprotonation transition state, where the triflate anion acts as an internal base. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to arylbenziodoxole site selective preparation, arene benziodoxole triflate site selective aromatic iodanation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shiri, Lotfi; Narimani, Hojatollah; Kazemi, Mosstafa published an article in 2018, the title of the article was Synthesis and characterization of sulfamic acid supported on Fe3O4 nanoparticles: A green, versatile and magnetically separable acidic catalyst for oxidation reactions and Knoevenagel condensation.Application In Synthesis of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

Sulfamic acid immobilized on diethylenetriamine functionalized Fe3O4 nanoparticles (SA-DETA-Fe3O4) was successfully prepared and characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermo gravimetric anal. (TGA), X-Ray diffraction (XRD) and SEM (SEM). The sulfamic acid was found as a magnetically separable and highly active catalyst for the oxidative coupling of thiols and oxidation of sulfides. Furthermore, the SA-DETA-Fe3O4 showed high catalytic activity in Knoevenagel condensation of aromatic aldehydes with active methylene compounds (malononitrile and Et cynoacetate). The nanosolid catalyst could be easily recovered by a simple magnetic separation and reused for many cycles without deterioration in catalytic activity. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application In Synthesis of Benzyl(4-bromophenyl)sulfane

The Article related to oxidation thiol sulfide iron oxide sulfamic acid supported catalyst, knoevenagel condensation iron oxide sulfamic acid supported catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Application In Synthesis of Benzyl(4-bromophenyl)sulfane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 15, 2022, Baugh, Simon David Peter; Freeman, Kathryn B.; Pelletier, Jeffrey Claude; Reitz, Allen B.; Scott, Richard W.; Weaver, Damian G.; Whitman, David B. published a patent.Application of 152626-77-2 The title of the patent was Novel heteroaromatic compounds exhibiting antifungal activity and their method of use and preparation. And the patent contained the following:

Pharmaceutical compositions of the invention comprise heteroaromatic compounds of formula I having a disease-modifying action in the treatment of fungal infections and diseases associated with fungal infection. Compounds of formula I wherein A1 is (un)substituted thiazolyl, (un)substituted thiadiazolyl, (un)substituted imidazolyl, (un)substituted pyrazinyl, etc.; A2 is (un)substituted pyrimidinyl, (un)substiuted pyrazinyl, (un)substituted oxadiazolyl, (un)substituted thiadiazolyl, etc.; A3 is (CH2)0-2NHC:NHNH2 and derivatives, (CH2)0-2C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; A4 is (CH2)0-3NHC:NHNH2 and derivatives, (CH2)0-3C:NHNH2 and derivatives, OCH2CH2NHC:NHNH2 and derivatives, etc.; R1 is H, C1-4 alkyl and C3-5 branched alkyl; and enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, are claimed. Example compound II•2TFA was prepared by a multistep procedure (procedure given). The invention compound were evaluated for their antifungal activity (data given). The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Application of 152626-77-2

The Article related to heteroaromatic preparation antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 152626-77-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 7, 2013, Chen, Shaoqing; De Vicente Fidalgo, Javier; Hamilton, Matthew Michael; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Li, Hongju; Lovey, Allen John; Lucas, Matthew C.; Luk, Kin-Chun Thomas; Lynch, Stephen M.; O’Yang, Counde; Padilla, Fernando; Schoenfeld, Ryan Craig; Sidduri, Achyutharao; Soth, Michael; Wang, Ce; Wovkulich, Peter Michael; Zhang, Xiaohu published a patent.Safety of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Pyrrolopyrazines as kinase inhibitors and their preparation. And the patent contained the following:

The invention relates to the use of pyrrolopyrazine derivatives of formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases. Compounds of formula I wherein R is H; R’ is lower alkoxy and (un)substituted alkyl; RR’ can be taken together to form (un)substituted heterocycloalkyl; Q is (un)substituted bicyclic heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their kinase inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.00172 μM. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to pyrrolopyrazine preparation kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 9, 2014, Bair, Kenneth W.; Millan, David S.; Martin, Matthew W.; Tebbe, Mark J.; Lu, Wei; Li, Hongbin; Loch, James published a patent.Application of 1417036-28-2 The title of the patent was Preparation of FASN inhibitors useful for treatment of cancer and other diseases. And the patent contained the following:

The invention relates to compounds of formula I as inhibitors of fatty acid synthase (FASN) useful alone or in combination with other drugs for the treatment of disorders such as cancer, autoimmune diseases, inflammatory disorders, and viral infections. I [wherein R1 is a (un)substituted 5- to 6-membered heterocycloalkyl; L is a (un)substituted 5- to 10-membered monocyclic or bicyclic (hetero)alkyl; A and B are independently O or S; Ar is a (un)substituted 3- to 10-membered monocyclic or bicyclic (hetero)aryl or heterocycloalkyl; R2 is H, a (un)substituted (hetero)aryl, or a (un)substituted (hetero)cycloalkyl] and pharmaceutically acceptable salts thereof are claimed and exemplified. Example compound (R)-II was prepared in a multistep process (preparation given). and evaluated for inhibition of cancer cell proliferation using PC3 cells. From the above assay III was determined to exhibit an IC50 value of <0.5 μM. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Application of 1417036-28-2

The Article related to fatty acid synthase inhibitor preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 1417036-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 14, 2020, Konradi, Andrei W.; Lin, Tracy Tzu-Ling Tang published a patent.Safety of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Preparation of substituted naphthalene-2-carboxamide derivatives useful for treatment of cancer. And the patent contained the following:

Provided herein are compounds of formula I and pharmaceutical compositions comprising said compounds that are useful for treating cancers specifically cancers that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD. Compounds of formula I [wherein X1 and X2 independently = N, NRx, C(=O), or CRx; X3, and X4 independently = N, NRx, C(=O), or CRx, with proviso; each Rx independently = H, halo, nitro, oxo, thioxo, (un)substituted C1-6 alkyl, (un)substituted (hetero)aryl, etc.; R1 = (un)substituted C1-6 alkyl, (un)substituted C1-6 haloalkyl, (un)substituted C3-10 cycloalkyl, etc.; each R2 independently = N3, CN, (un)substituted (hetero)aryl, etc.; n = 0, 1, 2, 3, or 4; each dashed line independently = single or double bond] or pharmaceutically acceptable salts or solvates thereof, are claimed and exemplified. Example compound II was synthesized from a multistep preparation starting from the bromination of 2-naphthylcarboxylic acid (preparation given). Exemplified I were evaluated in a YAP reporter assay from which II demonstrated an IC50 of ≤0.100μM against firefly luciferase activity. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to naphthalene carboxamide derivative preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 1, 2022, Yu, Jingxiong; Liu, Fanggang; Deng, Zefeng; Shi, Zaifa; Zhang, Jiangle; Wang, Qiaolin; Yang, Jing; Hu, Haoquan; Qin, Zhengbo; Tang, Zichao published an article.Category: ethers-buliding-blocks The title of the article was Insights into a Low-Rank Naomaohu Coal Structural Information by Multistage Fractions Coupled with LIAD-VUVPI-TOFMS. And the article contained the following:

In-depth insights into the chem. composition and structural information of coal are an effective way to improve the efficiency of coal utilization. Laser-induced acoustic desorption coupling with vacuum UV photoionization time-of-flight mass spectrometry (LIAD-VUVPI-TOFMS) was applied to structural characterization of cyclohexane extracts of low-rank Naomaohu coal. The characterization of four types (12 model compounds) of mixed coal model compounds (three compounds per category)-saturated hydrocarbons, substitute aromatic hydrocarbons, aromatic hydrocarbons, and aromatic heteroatom rings-demonstrated that the approach can provide intact mol. weight information. The cyclohexanone extract (ECYC) was obtained by microwave-assisted extraction and separated into four group components (F1-4) by column chromatog. to achieve component classification and simplify anal. The mol. weight and structure were obtained by LIAD-VUVPI-TOFMS and synchronous fluorescence spectroscopy, combined with microwave-assisted extraction and column chromatog. to sep. product characteristics. Chem. components of a total of 248 species were observed, of which 46 are derived from aliphatic hydrocarbons embedded in the coal skeleton structure, 132 species are derived from aromatic hydrocarbons embedded in the coal skeleton structure, 61 are derived from possible coal skeleton units (compounds have obvious stacking and bonding effects), and 9 could not be determined (aromatic hydrocarbons or a possible coal skeleton structure unit). The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Category: ethers-buliding-blocks

The Article related to low rank naomaohu coal structure multistage fraction tofms, Fossil Fuels, Derivatives, and Related Products: Coal and Lignite (Brown Coal) Analysis and Properties and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Garcia-Gonzalez, Ma. Carmen; Hernandez-Vazquez, Eduardo; Gordillo-Cruz, Raul E.; Miranda, Luis D. published an article in 2015, the title of the article was Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles.SDS of cas: 887581-09-1 And the article contains the following content:

Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacol. important polyheterocyclic systems through a cascade palladium-catalyzed C-C bond formation processes (tandem reaction). Allyl, homoallyl and propargyl amine led to the formation of benzopyrrolizidinone derivatives, benzoindolizidinone derivatives and pyrazinoisoquinoline derivatives, resp., while benzylamines and o-bromobenzylamine were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindione derivatives Under optimized conditions the synthesis of the target compounds was achieved using dichlorobis(triphenylphosphine)palladium as a catalyst. Starting materials included 2-propen-1-amine (allyl amine), 2-iodobenzoic acid derivatives 2-bromobenzoic acid derivatives, 2-(benzoyloxy)acetaldehyde, isocyanides (isonitriles), 3-buten-1-amine (homoallyl amine). Dehydro amino acid amides (dehydroalanine derivatives) intermediates included N-[1-[[(1,1-dimethylethyl)amino]carbonyl]ethenyl]-2-iodo-N-(phenylmethyl)benzamide, thiophene derivatives, furan derivatives, pyrrole derivatives, indole derivatives The title compounds thus formed included (methylene)(oxo)pyrrolo[2,1-a]isoindolecarboxamides, (methylene)(oxo)pyrido[2,1-a]isoindolecarboxamides, isoindolo[2,1-b]isoquinolinecarboxamides, pyrazino[1,2-b]isoquinolinedione derivatives. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).SDS of cas: 887581-09-1

The Article related to benzopyrrolizidinone benzoindolizidinone pyrazinoisoquinoline pyrazionoisoquinolindione preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2016, Boursalian, Gregory B.; Ham, Won Seok; Mazzotti, Anthony R.; Ritter, Tobias published an article.COA of Formula: C7H7FO The title of the article was Charge-transfer-directed radical substitution enables para-selective C-H functionalization. And the article contained the following:

Efficient C-H functionalization requires selectivity for specific C-H bonds. Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selectivity, but a general strategy for para-selective C-H functionalization has remained elusive. Herein we introduce a previously unappreciated concept that enables nearly complete para selectivity. We propose that radicals with high electron affinity elicit arene-to-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity. We demonstrate with a simple theor. tool that the selectivity is predictable and show the utility of the concept through a direct synthesis of aryl piperazines. Our results contradict the notion, widely held by organic chemists, that radical aromatic substitution reactions are inherently unselective. The concept of radical substitution directed by charge transfer could serve as the basis for the development of new, highly selective C-H functionalization reactions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).COA of Formula: C7H7FO

The Article related to regioselective radical aromatic substitution arene selectfluor, piperazine aryl regioselective preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem