Month: November 2022

On August 3, 1995, Grisoni, Serge; Huon, Christian; Peyronel, Jean-Francois published an article.HPLC of Formula: 81616-80-0 The title of the article was 4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists. And the article contained the following:

The synthesis of 4,4-diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolones, a new series of substance P antagonists with high affinity for rat and human NK1 receptors is described. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).HPLC of Formula: 81616-80-0

The Article related to diphenylperhydrothiapyranopyrrolone substance p receptor antagonists, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 2, 2018, Ouyang, Xuan-Hui; Tan, Fang-Lin; Song, Ren-Jie; Deng, Wei; Li, Jin-Heng published an article.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Palladium-Catalyzed Oxidative [2 + 2 + 1] Annulation of 1,7-Diynes with H2O: Entry to Furo[3,4-c]quinolin-4(5H)-ones. And the article contained the following:

A novel cascade annulation of 1,7-diynes I [R2 = R3 = Ph, R4 = H, Y = NBn; R2 = R3 = Ph, R4 = H, Y = O; R2 = Ph, 4-MeOC6H4, 4-BrC6H4, 2-thiophenyl, cyclopropyl, R3 = Ph, 4-MeOC6H4, 4-ClC6H4 R4 = H, Y = NMe; R2 = Ph, R3 = Ph, R4 = Me, Cl, Y = NMe] with water has been developed for the synthesis of furo[3,4-c]quinolin-4(5H)-one skeletons II with high atom- and step-economy. The transformation was enabled by a palladium catalyst in the presence of copper salt as the promoter, involving the formation of one C-C bond and two C-O bonds. Moreover, the reaction exhibits good tolerance of functional groups and broad substrate scope. Notably, the control experiments support the incorporation of the new oxygen atom from water. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to preparation furoquinolinone palladium catalyzed cascade oxidative annulation diyne water, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dagar, Anuradha; Guin, Soumitra; Samanta, Sampak published an article in 2018, the title of the article was AgSbF6-Catalyzed Tandem Reaction of 2-Alkynylanilines with Cyclic Enynones: Efficient access to 3-Furo[3,2-c]chromenylindoles and Related Scaffolds.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A simple, mild, catalytic and efficient method for the straightforward synthesis of an interesting class of a range of 2-aryl/alkyl-substituted-3-(2-aryl/alkyl-4H-furo[3,2-c]chromen-4-yl)-1H-indoles I [R = H, Bn; R1 = C6H5, (CH2)3CH3, 4-CH3C6H4, etc.; R2 = C6H5, (CH2)3CH3, 4-CH3C6H4, etc.; X = H, F, OCH3; Y = H, F, CH3, OCH3] in good to high yields is reported for the first time. This atom-efficient method proceeds via AgSbF6-catalyzed one-pot sequential intramol. hydroamination (C-N bond formation) of 2-alkynylanilines 5-X-2-R1CCC6H3NHR followed by Friedel-Crafts alkylation/oxa-cyclization (creation of new C-C and C-O bonds) reaction between in situ generated 2-substituted indoles and several cyclic enynones II and 2-(phenylethynyl)cyclohex-2-enone. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to furochromenylindole preparation, alkynylaniline enynone heterocyclization silver catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Rui-Juan; Wang, Peng-Fei; Yuan, Wen-Kui; Wen, Li-Rong; Li, Ming published an article in 2017, the title of the article was Nickel Catalysis Enables Hetero [2+2+1] Cycloaddition between Yne-Isothiocyanates and Isonitriles with Low Catalyst Loading.Electric Literature of 157869-15-3 And the article contains the following content:

Nickel(II) can be used to catalyze the hetero [2+2+1] cycloaddition of 2-alkynylaryl isothiocyanates and isonitriles in 2-methyltetrahydrofuran (2-MeTHF) to give a wide array of thieno[2,3-b]indoles in excellent yields. The reaction is featured by employing as little as 0.3 mol% nickel(II) acetylacetonate [Ni(acac)2] under air conditions in the absence of any additives (addnl. reducing agents and external ligands). This is the first successful example to apply nickel(II) directly in hetero [2+2+1] cycloadditions The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to alkynylaryl isothiocyanate isonitrile nickel hetero cycloaddition catalyst, thienoindole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 19, 1992, Achard, Daniel; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Electric Literature of 81616-80-0 The title of the patent was Preparation and reactions of thiopyranopyrroles and oxide derivatives. And the patent contained the following:

Title compounds I [R = H, allyl, or CR1R2R3, where R1 and R2 are H, (un)substituted Ph (with halo, alkyl, alkyloxy, NO2), and R3 is defined as for R1 or R2 or alkyl or alkyloxyalkyl, where at least one R1-3 is (un)substituted Ph, and n = 0-2], and isomers, are prepared by N-deprotection of the appropriate perhydrothiopyranopyrrole. Salts, isomers, and mixtures of isomers of these compounds are claimed. The above compounds are reacted with alkanoic acids R4CHR5CO2H [e.g., (2-methoxyphenyl)acetic acid] or with an imide analog to give claimed compounds N-substituted I [R = C(:Z)CHR4R5, n = 0-2, Z = O or NH, R4 = (un)substituted Ph (with halo, amino, alkylamino, etc., R5 = H, halo, OH, alkyl, etc.]. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0

The Article related to thiopyranopyrrole oxide perhydro preparation reaction, perhydrothiopyranopyrrole oxide preparation reaction, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 19, 1992, Achard, Daniel; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Product Details of 81616-80-0 The title of the patent was Preparation of thiopyranopyrrole derivatives as substance P antagonists. And the patent contained the following:

The preparation of perhydrothiopyranopyrroles and oxide derivatives I [Z = O, NH; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, heterocyclyl; R2 = H, halo, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxy, alkoxycarbonyl, benzyloxycarbonyl, amino, acylamino; n = 0-2], stereoisomers and their mixtures, and salts is claimed. The compounds are particularly interesting as substance P antagonists. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Product Details of 81616-80-0

The Article related to thiopyranopyrrole perhydro preparation antagonist substance p, perhydrothiopyranopyrrole preparation antagonist substance p, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Qian; Zhou, Peng; Liu, Feng; Hao, Wen-Juan; Yao, Changsheng; Jiang, Bo; Tu, Shu-Jiang published an article in 2015, the title of the article was Cobalt(II)/silver relay catalytic isocyanide insertion/cycloaddition cascades: a new access to pyrrolo[2,3-b]indoles.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

The combination of Co(acac)2 and AgOTf enables the bimetallic relay catalysis reaction of 2-ethynylanilines and isocyanides, allowing easy and low-cost access to new densely functionalized pyrrolo[2,3-b]indoles. The reaction pathway involves a Co(acac)2-catalyzed double isocyanide insertion followed by a silver-enabled 1,3-dipolar cycloaddition [e.g., 2-(phenylethynyl)aniline + isocyanocyclohexane in 1:2 molar ratio → pyrrolo[2,3-b]indole I (up to 86%, under aerobic conditions)]. The synthetic utility of these bicycloaddn. reactions results in subsequent C-C and C-N bond-forming events to rapidly build up mol. complexity. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to cobalt silver relay catalytic isocyanide insertion cycloaddition cascade, ethynylanaline reaction isocyanide pyrroloindole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 19, 2016, Hao, Wen-Juan; Wu, Ya-Nan; Gao, Qian; Wang, Shu-Liang; Tu, Shu-Jiang; Jiang, Bo published an article.Recommanded Product: 157869-15-3 The title of the article was Dual cobalt(II)/silver catalysis: synthesis of aryliminated pyrrolo[2,3-b]indoles via multicomponent bicyclization cascades. And the article contained the following:

Dual cobalt(II)/silver catalysis enables multicomponent bicyclization cascades of 2-ethynylanilines, tert-Bu isocyanide, and arylamines, resulting in subsequent multiple bond-forming events to rapidly build up aryliminated pyrrolo[2,3-b]indoles such as I. The reaction pathway involves bimetal-catalyzed isocyanide insertion/1,3-dipolar cycloaddition/imination substitution sequence. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 157869-15-3

The Article related to aryliminated pyrroloindole preparation, ethynylaniline tert bu isocyanide arylamine multicomponent bicyclization cascade, cobalt silver catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Capozzi, Maria Annunziata M.; Centrone, Caterina; Fracchiolla, Giuseppe; Naso, Francesco; Cardellicchio, Cosimo published an article in 2011, the title of the article was A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts.Name: Benzyl(4-bromophenyl)sulfane And the article contains the following content:

A series of experiments was performed to test a theor. model that we have recently proposed to explain the highly enantioselective oxidation of aryl benzyl sulfides with tert-Bu hydroperoxide in the presence of a complex between titanium and (S,S)- or (R,R)-hydrobenzoin. The studied variations involved the sulfides, the ligands, and the order of addition of reactants. The reaction path predicted by our model was confirmed in every experiment In particular, aryl benzyl sulfides behaved as the ideal substrate for this type of asym. oxidation, which yields synthetically useful, enantiopure aryl benzyl sulfoxides in a straightforward manner. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Name: Benzyl(4-bromophenyl)sulfane

The Article related to enantioselective oxidation aryl benzyl sulfide chiral titanium catalyst, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Name: Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 19, 2019, Zhang, Shanshan; Chen, Fei; He, Yan-Mei; Fan, Qing-Hua published an article.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine The title of the article was Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts. And the article contained the following:

An efficient Ru-catalyzed asym. hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to asym hydrogenation dibenzoazepine derivative ruthenium diamine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem