Month: November 2022

Metabolomics-based profiling for quality assessment and revealing the impact of drying of Turmeric (Curcuma longa L.) was written by Salem, Mohamed A.;El-Shiekh, Riham A.;Fernie, Alisdair R.;Alseekh, Saleh;Zayed, Ahmed. And the article was included in Scientific Reports in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:

Turmeric, the rhizomes of Curcuma longa L., is one of the top selling spices, food preservatives, and food colorants. In addition, it exhibits health promoting benefits owing to its unique phytochem. composition Nevertheless, it is commonly subjected to heat drying, hence, the dried powder is the most used form and can easily be adulterated with allied species. Therefore, our research aimed to profile the phytochem. composition and investigate the impact of drying of turmeric. Extraction and fractionation followed by LC- and GC-MS anal. resulted in the identification of a total of 161 metabolites belonged to various phytochem. classes. Moreover, multivariate data anal. identified curcuminoids, terpecurcumins, and organic acids as potential markers for drying. Based on the applied anal. techniques in combination with chemometrics, these investigations have succeeded to provide good coverage of the metabolome of turmeric in both fresh and dried forms. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce c-MYC Protein Levels in Cells was written by Medina, Jesus R.;Tian, Xinrong;Li, William H.;Suarez, Dominic;Mack, James F.;LaFrance, Louis;Martyr, Cuthbert;Brackley, James;Di Marco, Christina;Rivero, Ralph;Heerding, Dirk A.;McHugh, Charles;Minthorn, Elisabeth;Bhaskar, Aishwarya;Rubin, Jacob;Butticello, Michael;Carpenter, Christopher;Nartey, Eldridge N.;Berrodin, Thomas J.;Kallal, Lorena A.;Mangatt, Biju. And the article was included in Journal of Medicinal Chemistry in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacol. inhibitors that directly target MYC have not yet yielded a drug-like mol. due to the lack of any known small mol. binding pocket in the protein, which could be exploited to disrupt MYC function. We have recently described a strategy to target MYC indirectly, where a screening effort designed to identify compounds that can rapidly decrease endogenous c-MYC protein levels in a MYC-amplified cell line led to the discovery of a compound series that phenocopies c-MYC knockdown by siRNA. Herein, we describe our medicinal chem. program that led to the discovery of potent, orally bioavailable c-MYC-reducing compounds The development of a min. pharmacophore model based on empirical structure activity relationship as well as the property-based approach used to modulate pharmacokinetics properties will be highlighted. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave-assisted synthesis of silver nanoprisms/nanoplates using a “modified polyol process” was written by Darmanin, Thierry;Nativo, Paola;Gilliland, Douglas;Ceccone, Giacomo;Pascual, Cesar;De Berardis, Barbara;Guittard, Frederic;Rossi, Francois. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2012.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

In this paper, we report a novel, efficient and versatile process to produce high concentrations of silver nanoprisms, while controlling their size (prism height) and size dispersity, using a “modified polyol process” (microwave-assisted process). If the formation of silver spherical particles, nanocubes or nanowires has already been reported using the classical polyol process (reduction of AgNO₃ by ethylene glycol and in presence of PVP), here we show that the production of silver nanoprisms/nanoplates is possible by a careful choice in the process parameters and in particular in the reducing agent (ethylene glycol should be replaced by a reducing agent containing only one hydroxyl reducing group such as ethylene glycol monoalkyl ethers). The synthesis, characterization, the influence of parameters and the mechanism of formation are discussed in order to correlate the operational conditions with the shape and the dimension of the nanoparticles. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Safety of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Asymmetric Synthesis of 3-Pyrrolines through an Aryne-Induced Domino Process was written by Hwu, Jih Ru;Panja, Avijit;Gupta, Nitesh K.;Huang, Wen-Chieh;Hu, Yu-Chen;Lin, Chun-Cheng;Hwang, Kuo-Chu;Chan, Wei-Jen;Tsay, Shwu-Chen. And the article was included in Asian Journal of Organic Chemistry in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

Here, the accomplishment of a newly developed domino reaction was reported for synthesizing optically active 3-pyrrolines I [R¹ = H, OMe, OCH₂O; R² = H, p-Me, p-OMe, m-Br; R³ = OMe, CN, CO₂Me; R⁴ = CO₂Me, CO₂Et; R⁵ = H, CO₂Me, CO₂Et], a class of compounds with various biol. properties. The reaction involved the use of (trimethylsilyl)aryl triflates, Schiff bases, and alkynes in the presence of a chiral catalyst (R)-(-)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate. The key features of this new reaction include the generation of a single product in very good yields (75-85%) with high stereo- and enantio-selectivity; the enantiomeric ratio reaches as high as 98.5 : 1.5. Moreover, it involved an aryne-induced domino reaction and an unusual 1,4-intramol. proton transfer, which overwhelms the well-established 1,5-proton transfer. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer was written by Sun, Dejuan;Yang, Zijian;Zhen, Yongqi;Yang, Yushang;Chen, Yanmei;Yuan, Yong;Zhang, Lan;Zeng, Xiaoxi;Chen, Lixia. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

5-Bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives were synthesized and evaluated as ULK1 inhibitors in non-small cell lung cancer. Among all the obtained ULK1 inhibitors, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine, was the most active one. The docking anal. was conducted to compare 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine and SBI-0206965, which further elucidated the roles of the H-bond donor. This compound inhibited the proliferation of A549 cells and showed strong inhibitory activity against ULK1 kinase. Moreover, we found that 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine could induce apoptosis while simultaneously blocking autophagy. Collectively, these findings shed new light on 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine that would be utilized as a promising candidate drug for the future NSCLC therapy. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer was written by Sun, Dejuan;Yang, Zijian;Zhen, Yongqi;Yang, Yushang;Chen, Yanmei;Yuan, Yong;Zhang, Lan;Zeng, Xiaoxi;Chen, Lixia. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

5-Bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives were synthesized and evaluated as ULK1 inhibitors in non-small cell lung cancer. Among all the obtained ULK1 inhibitors, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine, was the most active one. The docking anal. was conducted to compare 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine and SBI-0206965, which further elucidated the roles of the H-bond donor. This compound inhibited the proliferation of A549 cells and showed strong inhibitory activity against ULK1 kinase. Moreover, we found that 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine could induce apoptosis while simultaneously blocking autophagy. Collectively, these findings shed new light on 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine that would be utilized as a promising candidate drug for the future NSCLC therapy. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kraft lignin depolymerization in sub- and supercritical water using ultrafast continuous reactors. Optimization and reaction kinetics was written by Abad-Fernandez, Nerea;Perez, Eduardo;Martin, Angel;Cocero, Maria J.. And the article was included in Journal of Supercritical Fluids in 2020.Quality Control of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Kraft lignin was rapidly depolymerised in a continuous reactor using sub- and supercritical water. The reaction yielded an aromatic oil rich in high value aromatic monomers such as guaiacol, vanillin, acetovanillone and homovanillic acid. Different temperatures between 300 and 400°C and reaction times from 60 ms were studied. An increment in reaction time at every temperature studied promoted secondary reactions of repolymn. of the lignin products. Those undesired reactions were more relevant as temperature increased. An optimal temperature of 386°C at a reaction time of 170 ms was found, with a maximum yield in phenolic compounds obtained. At those conditions, a bio-oil containing low mol. weight compounds was obtained with a yield of 44.6%. A selectivity to the four cited monomers of 9.9% was achieved, with little formation of solid residue (3.5%). A simple kinetic model was proposed to describe the yield for the different fractions and fitted to exptl. data. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Quality Control of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction was written by Pan, Na;Xinen Lee, Maegan;Bunel, Louis;Grimaud, Laurence;Vitale, Maxime R.. And the article was included in ACS Organic & Inorganic Au in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Oxidative isocyanide-based multicomponent reactions (oxidative IMCRs) are very useful tools for the rapid construction of mol. diversity starting from readily available and stable substrates. Despite all their benefits, such multicomponent reactions are underdeveloped and strictly limited to 3-component processes. Indeed, in the presence of several reaction partners, the oxidation event needs to be rigorously chemoselective, which becomes incredibly more intricate as the number of reactive components increases. Nonetheless, authors could overcome this significant pitfall and reach the first oxidative Ugi-type 4-IMCR by capitalizing on a very mild and green TEMPO-catalyzed electro-oxidation process. Employing alcs. as aldehyde surrogates and in the notable absence of any supporting electrolyte, this transformation proved to be extremely chemoselective in the presence of an amine and was compatible with a wide range of alcs., amines, isocyanides, and carboxylic acids. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of chain length in ethoxylated and sulfonate surfactants upon the limiting diffusion coefficients in water at 25.0°C was written by Ortona, Ornella;D’Errico, Gerardino;Ciccarelli, Donato;Vitagliano, Vincenzo. And the article was included in Physical Chemistry Chemical Physics in 2000.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

Limiting diffusion coefficients of ethoxylated surfactants of general formula CH₃(CH₂)_p-1(OCH₂CH₂)_qOH (C_pE_q) and sulfonate surfactants of formula CH₃(CH₂)_p-1SO₃^– Na⁺(C_pSO₃Na) were measured at 25°C by the Taylor dispersion technique. The series C₆E_q, with 0≤q≤5, was studied to evaluate the effect of the length of ethoxylic chain, (-OCH₂CH₂-)_q, on the mobility of the surfactant, the series C_pE₅ with 0≤p≤8 was studied to evaluate the effect of the length of the hydrophobic group, (-CH₂-)_p. The series C_pSO₃Na was also studied to compare the exptl. results with the intradiffusion coefficients obtained by the NMR-PGSE technique and with the data computed by the Nernst-Hartley equation. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synbiotic Musa acuminata skin extract and Streptococcus salivarius K12 inhibit candida species biofilm formation was written by Rismayuddin, Nurul Alia Risma;Mohd Badri, Puteri Elysa Alia;Ismail, Ahmad Faisal;Othman, Noratikah;Bandara, H. M. H. N.;Arzmi, Mohd Hafiz. And the article was included in Biofouling in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:

This study aimed to determine the effect of synbiotic Musa acuminata skin extract (MASE) and Streptococcus salivarius K12 (K12) on Candida species biofilm formation. Liquid chromatog. quadrupole time-of-flight (LC-Q-TOF-MS) was conducted to characterize MASE. To determine the effect of synbiotic on Candida biofilm, 200 μL of RPMI-1640 containing Candida, K12, and MASE were pipetted into the same well and incubated at 37 °C for 72 h. A similar protocol was repeated with K12 or MASE to determine the probiotic and prebiotic effects, resp. Dimorphism, biofilm biomass, and Candida total cell count (TCC) were determined A total of 60 compounds were detected in MASE. C. albicans (ALT5) and Candida lusitaniae exhibited the highest reduction in biofilm biomass when co-cultured with prebiotic (77.70 ± 7.67%) and synbiotic (97.73 ± 0.28%), resp. All Candida spp. had decreased TCC and hyphae when co-cultured with synbiotic. In conclusion, MASE and K12 inhibit Candida biofilm formation. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C19H16O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem