Month: November 2022

Beyond Directed ortho Metalation: Ru-Catalyzed C_Ar-O Activation/Cross-Coupling Reaction by Amide Chelation was written by Zhao, Yigang;Snieckus, Victor. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane The following contents are mentioned in the article:

Disclosed is a new, catalytic, and general methodol. for the chem. synthesis of biaryl, heterobiaryl, and polyaryl mols. by the cross-coupling of o-methoxybenzamides with aryl boroneopentylates. The reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH₂(CO)(PPh₃)₃ conditions. A one-step, base-free coupling process is thereby established that has the potential to supersede the useful two-step directed ortho metalation/ cross-coupling reaction involving cryogenic temperature and strong base conditions. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, min. waste, and convenient scale-up make these reactions suitable for industrial applications. Thus, e.g., treatment of N,N-diethyl-2-methoxybenzamide with 2-phenyl-5,5-dimethyl-1,3,2-dioxaborinane in presence of RuH₂(CO)(PPh₃)₃ afforded N,N-diethyl-2-biphenylcarboxamide (96%). This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synthesis and characterization of giant Calixarenes was written by Guerineau, Vincent;Rollet, Marion;Viel, Stephane;Lepoittevin, Benedicte;Costa, Ludovic;Saint-Aguet, Pascale;Laurent, Regis;Roger, Philippe;Gigmes, Didier;Martini, Cyril;Huc, Vincent. And the article was included in Nature Communications in 2019.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:

Calixarenes are cyclic oligomers obtained by condensation of suitable p-functionalized phenols with formaldehyde, usually allowing for the synthesis of the well known small calixarenes (including up to eight phenolic subunits). We report here the discovery of much larger members of this family, exhibiting sizes up to 90 phenolic subunits: the giant calixarenes. These macrocycles are obtained according to simple, easily scalable processes, in yields up to 65%. We show that the formation of these giant macrocycles is favored by an oxygen-containing-group at the para-position of the starting phenol, high concentrations of heavy alk. bases (rubidium or cesium hydroxides) and long reaction times. A mechanism is proposed to rationalize these observations. These giant macrocycles can also be obtained in the quasi-solid state, opening interesting perspectives in the field of calixarenes chem. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synthesis and characterization of giant Calixarenes was written by Guerineau, Vincent;Rollet, Marion;Viel, Stephane;Lepoittevin, Benedicte;Costa, Ludovic;Saint-Aguet, Pascale;Laurent, Regis;Roger, Philippe;Gigmes, Didier;Martini, Cyril;Huc, Vincent. And the article was included in Nature Communications in 2019.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Calixarenes are cyclic oligomers obtained by condensation of suitable p-functionalized phenols with formaldehyde, usually allowing for the synthesis of the well known small calixarenes (including up to eight phenolic subunits). We report here the discovery of much larger members of this family, exhibiting sizes up to 90 phenolic subunits: the giant calixarenes. These macrocycles are obtained according to simple, easily scalable processes, in yields up to 65%. We show that the formation of these giant macrocycles is favored by an oxygen-containing-group at the para-position of the starting phenol, high concentrations of heavy alk. bases (rubidium or cesium hydroxides) and long reaction times. A mechanism is proposed to rationalize these observations. These giant macrocycles can also be obtained in the quasi-solid state, opening interesting perspectives in the field of calixarenes chem. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production was written by Ricelli, Alessandra;Gionfra, Fabio;Percario, Zulema;De Angelis, Martina;Primitivo, Ludovica;Bonfantini, Veronica;Antonioletti, Roberto;Bullitta, Simonetta Maria;Saso, Luciano;Incerpi, Sandra;Pedersen, Jens Zacho. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alc. (HA). HT has aroused much interest due to its antioxidant activity as a radical scavenger, whereas only a few studies have been made on the HA mol. Both chem. synthesis and extraction techniques have been developed to obtain these mols., with each method having its advantages and drawbacks. In this study, we report the use of tyrosol from olive mill wastewaters as a starting mol. to synthesize HT and HA, using a sustainable procedure characterized by high efficiency and low cost. The effects of HT and HA were evaluated on two cell lines, THP-1 human leukemic monocytes and L-6 myoblasts from rat skeletal muscle, after treating the cells with a radical generator. Both HT and HA efficiently inhibited ROS production In particular, HT inhibited the proliferation of the THP-1 leukemic monocytes, while HA protected L-6 myoblasts from cytotoxicity. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Optimization and modeling of microwave-assisted extraction of curcumin and antioxidant compounds from turmeric by using natural deep eutectic solvents was written by Doldolova, Khadija;Bener, Mustafa;Lalikoglu, Melisa;Asci, Yavuz Selim;Arat, Refik;Apak, Resat. And the article was included in Food Chemistry in 2021.Reference of 33171-05-0 The following contents are mentioned in the article:

Natural deep eutectic solvents (NADES) have recently come to the fore as new green solvents for foods, cosmetics and pharmaceuticals due to their unique solvation power and low toxicity. Turmeric extracts were prepared using the microwave assisted extraction method (MAE) using five NADES containing binary combinations of choline chloride, lactic acid, fructose, and sucrose. The MAE method was optimized and modeled by using response surface methodol. to obtain maximum total antioxidant capacity (TAC) and curcumin contents (CC) in extracts for each NADES. All NADES extracts, except NADES-1 containing fructose and cholin chloride, exhibited higher TAC and CC than those in 80% methanol:water which was the preferred solvent in literature. NADES solvents did not interfere with subsequent antioxidant capacity measurements using the CUPRAC method. The proposed MAE is a potentially efficient and sustainable procedure in pharmaceutical and food industries for the extraction of antioxidants and curcumin from turmeric. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

One-pot bio-derived ionic liquid conversion followed by hydrogenolysis reaction for biomass valorization: A promising approach affecting the morphology and quality of lignin of switchgrass and poplar was written by Carrozza, Chiara Francesca;Papa, Gabriella;Citterio, Attilio;Sebastiano, Roberto;Simmons, Blake A.;Singh, Seema. And the article was included in Bioresource Technology in 2019.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The use of bio-derived ionic liquids (e.g., cholinium lysinate) in a one-pot process was evaluated on overall sugar and lignin yields as a function of two model woody and herbaceous feedstocks, switchgrass and poplar, with emphasis on the study of phys. and chem. alterations in lignin structure, by performing a detailed mass balance anal. and chem. characterization. Multiple chromatog. and spectroscopic anal. techniques were applied tracking lignin reactivity and partitioning during the ionic liquid one-pot conversion. Depolymerization efficiency of the lignin-rich residue derived from the whole process was investigated as a function of different temperatures and pressures during catalytic hydrogenolysis by Ni(SO)₄. This study validates the potential of ionic liquid one pot process as an integrated approach for full exploitation of lignocellulosic feedstocks. The insights gained will contribute to the design of future conversion routes for efficient biomass deconstruction and lignin valorization. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COVID-19: an In Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters was written by Khasamwala, Rukaiya Hasani;Ranjani, S.;Nivetha, S. Sai;Hemalatha, S.. And the article was included in Applied Biochemistry and Biotechnology in 2022.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:

Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this world. Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system as herbal remedies. India is famous for traditional medicinal formulations which includes ‘Trikadu’-a combination of three acrids, namely Zingiber officinale, Piper nigrum and Piper longum which have antioxidant properties that boost the immune system hence acting as a strong preventive measure. In this study, AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA-dependent polymerase protein and enveloped protein of the SARS-CoV-2 virus. Anal. of the results showed that coumarin, coumaperine and bisdemethoxycurcumin showed strong bonding interactions with both the proteins. They can conclude that Trikadu has the potential mols.; hence, it can be incorporated in the diet to boost the immune system as a preventive measure against the virus. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A New Family of Renewable Thermosets: Kraft Lignin Poly-adipates was written by Di Francesco, Davide;Rigo, Davide;Reddy Baddigam, Kiran;Mathew, Aji P.;Hedin, Niklas;Selva, Maurizio;Samec, Joseph S. M.. And the article was included in ChemSusChem in 2022.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Thermosetting polymeric materials have advantageous properties and are therefore used in numerous applications. In this study, it was hypothesized and ultimately shown that thermosets could be derived from comparably sustainable sub-components. A two-step procedure to produce a thermoset comprising of Kraft lignin (KL) and the cross-linker adipic acid (AdA) was developed. The crosslinking was activated by means of an acetylating agent comprising isopropenyl acetate (IPA) to form a crosslinking mixture (CLM). The crosslinking was confirmed by FTIR and solid-state NMR spectroscopy, and the esterification reactions were further studied using model compounds When the KL lignin was mixed with the CLM, partial esterification occurred to yield a homogeneous viscous liquid that could easily be poured into a mold, as the first step in the procedure. Without any additions, the mold was heated and the material transformed into a thermoset by reaction of the two carboxylic acid-derivatives of AdA and KL in the second step. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethanol/1,4-dioxane/formic acid as synergistic solvents for the conversion of lignin into high-value added phenolic monomers was written by Wu, Zhen;Zhao, Xinxu;Zhang, Jun;Li, Xun;Zhang, Yu;Wang, Fei. And the article was included in Bioresource Technology in 2019.Recommanded Product: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

In this study, a mixture solvent of ethanol/1,4-dioxane/formic acid (FA) is firstly reported to efficaciously depolymerize industrial lignin to produce high-value added phenolic monomers, in which 1,4-dioxane acts as lignin solvent, ethanol acts as solvent, reactant and in situ hydrogen donor, and FA acts as acid catalyst and in situ hydrogen donor. The effects of solvent composition and reaction conditions on the lignin conversion and product yields were explored, resulting in a low residue yield of 6.57% and a high phenolic monomers yield of 22.4% at 300 °C for 2 h when Kraft lignin was depolymerized in the mixture solvent of ethanol/1,4-dioxane/FA (10:10:2, volume/volume). Moreover, possible reaction mechanism on lignin depolymerization in the mixture solvent was illustrated, suggesting a favorable synergistic effect among the three components of the mixture solvent. In addition, the satisfactory applicability of the mixture solvent was approved through the feedstock adaptability and recyclability experiments This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Enzymatic hydrolysis of corn stover lignin by laccase, lignin peroxidase, and manganese peroxidase was written by Zhang, Sitong;Dong, Zijian;Shi, Jia;Yang, Chengrui;Fang, Yi;Chen, Guang;Chen, Huan;Tian, Chunjie. And the article was included in Bioresource Technology in 2022.Formula: C9H12O3 The following contents are mentioned in the article:

Lignin of high purity and structural integrity was isolated from the enzymic residue of corn stover. Degradation of the lignin by laccase, lignin peroxidase, and manganese peroxidase was investigated. Structural changes in the lignin after degradation were characterized by SEM, nitrogen adsorption and Fourier transform IR spectroscopy, and the enzymic products were systematically analyzed by gas chromatog. mass spectrometry. The highest percentage of lignin degradation was obtained with a mixture of three enzymes (25.79%): laccase (Lac), the starting enzyme of the mixed enzyme reaction, worked with lignin peroxidase (LiP), and manganese peroxidase (MnP) to further degrade lignin. This degradation destroyed the macromol. structure of lignin, broke its key chem. bonds, and opened benzene rings, thus producing more acidic compounds This study elucidated the concept of degrading lignin from corn stover using the Lac, LiP and MnP enzymes synergistically, thus providing a theor. basis for the biodegradation of lignin. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem