Month: November 2022

Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor was written by Rao, Priyashi;Goswami, Dweipayan;Rawal, Rakesh M.. And the article was included in Scientific Reports in 2021.HPLC of Formula: 33171-05-0 The following contents are mentioned in the article:

Emergence of vector borne diseases has continued to take toll on millions of lives since its inception. The use of insecticides began as vector control strategy in the early 1900′s but the menace of insects is still prevalent. Addnl., the inadequate use of organophosphates and carbamates which target acetylcholine esterase (AChE), are known to develop resistance amongst vectors of transmission and are toxic to humans. In this study, extensive computational screening was performed using homol. modeling, mol. docking, mol. dynamics (MD) simulation and free energy change calculation, which highlighted curcumin as a lead mol. out of ∼ 1700 phytochems. against Culex pipiens AChE. In vivo larvicidal activity was carried out along with in vivo and in vitro AChE inhibition assay to determine the biochem. efficacy of curcumin. Our study reveals that curcumin induces mortality in Cx. pipiens at an early stage of its life cycle by AChE inhibition. This also underlines the use of curcumin as a coming-age natural product insecticide. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0HPLC of Formula: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nutrition during pregnancy and lactation: New evidence for the vertical transmission of extra virgin olive oil phenolic compounds in rats was written by Lopez-Yerena, Anallely;Grases-Pinto, Blanca;Zhan-Dai, Sonia;Perez-Cano, Francisco J.;Lamuela-Raventos, Rosa M.;Rodriguez-Lagunas, Maria J.;Vallverdu-Queralt, Anna. And the article was included in Food Chemistry in 2022.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Maternal breast milk provides the newborn with passive immunity and stimulates the maturation of the infant immune system. The aim of the present study was to evaluate the vertical transmission of phenolic compounds and their metabolites to offspring in rats fed with extra virgin olive oil (EVOO) during pregnancy and lactation. For this purpose, plasma and lactic serum from dams and plasma from offspring were analyzed by LC-ESI-LTQ-Orbitrap-MS. Both enzymic and microbial metabolites of hydroxytyrosol and tyrosol were detected in dam plasma and lactic serum. In addition, significant levels of phenolic compounds and their metabolites were found in offspring plasma. The concentration and number of hydroxytyrosol derivatives was higher than those of tyrosol and the microbial metabolites were found in the highest concentration The observed vertical transmission of EVOO phenolic compounds, whose health benefits are widely reported, provides further support for the importance of the maternal diet during pregnancy and lactation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic hydrothermal liquefaction of lignin for production of aromatic hydrocarbon over metal supported mesoporous catalyst was written by Feng, Li;Li, Xuhao;Wang, Zizeng;Liu, Bingzhi. And the article was included in Bioresource Technology in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:

Catalytic hydrothermal liquefaction (HTL) of lignin was examined at various temperature (250-310°C) and reaction time in the presence of different solvents (water, methanol and ethanol) with different metal supported on MCM-41 mesoporous catalyst. In case of ethanol solvent, the maximum bio-oil yield of 56.2 wt% was obtained with Ni-Al/MCM-41. However in case of water, bio-oil yield was (44.3 wt%); while significantly improves bio-oil yield for methanol solvent (48.1 wt%). It is indicated that alc. solvents promoted the lignin decomposition, while in the presence of catalyst; water solvent significantly improves lignin degradation Loading of Ni and Al on MCM-41, the acid strength of the catalyst increased, which enhanced lignin degradation From the GC-MS anal., the main G-type (ca.54%) phenolic compounds were produced with higher percentage of aromatic hydrocarbon compounds CHNS and GPC anal. showed that catalytic liquefaction encouraged hydrodeoxygenation, which produced lower oxygen content bio-oil with lower mol. weight This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The Chiral Twist-Bend Nematic Phase (N*_TB) was written by Walker, Rebecca;Pociecha, Damian;Storey, John M. D.;Gorecka, Ewa;Imrie, Corrie T.. And the article was included in Chemistry – A European Journal in 2019.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

The twist-bend nematic, N_TB, phase has been observed for chiral materials in which chirality is introduced through a branched 2-methylbutyl terminal tail. The chiral twist-bend nematic phase, N*_TB, is completely miscible with the N_TB phase of the standard achiral material, CB6OCB. The N*_TB phase exhibits optical textures with lower birefringence than those observed for the achiral N_TB phase, suggesting an addnl. mechanism of averaging mol. orientations. The N*-N*_TB transition temperatures for the chiral materials are higher than the N_TB-N transition temperatures seen for the corresponding racemic materials. This suggests the double degeneracy of helical twist sense in the NTB* phase is removed by the intrinsic mol. chirality. A square lattice pattern is observed in the N* phase over a temperature range of several degrees above the N*_TB-N phase transition, which may be attributed to a non-monotonic dependence of the bend elastic constant This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer’s disease was written by Pan, Long-Fei;Wang, Xiao-Bing;Xie, Sai-Sai;Li, Su-Yi;Kong, Ling-Yi. And the article was included in MedChemComm in 2014.COA of Formula: C10H15NO The following contents are mentioned in the article:

Considering the complex pathogenesis factors of Alzheimer’s disease (AD), the multitarget-directed ligand strategy is expected to provide superior effects to fight AD, instead of the classic one-drug-one-target strategy. Resveratrol, exhibiting important properties against AD, was suggested to be used as a starting compound for the treatment of AD. Based on these reasons, a series of resveratrol derivatives were designed, synthesized and biol. evaluated. Among them, compound 6r, exhibiting moderate cholinesterase inhibition activity (AChE, IC₅₀ = 6.55 μM; BuChE, IC₅₀ = 8.04 μM; SI = 1.23), significant inhibition of Aβ₄₂ aggregation (57.78%, at 20 μM) and acceptable inhibitory activity against monoamine oxidases (MAO-A, IC₅₀ = 17.58 μM; MAO-B, IC₅₀ = 12.19 μM), was a potential anti-Alzheimer agent with balanced activities. Consequently, this study provided useful information for further development of resveratrol derivatives as multitarget-directed agents for AD therapy. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of sulfated oligosaccharide glycosides having high anti-HIV activity and the relationship between activity and chemical structure was written by Katsuraya, Kaname;Nakashima, Hideki;Yamamoto, Naoki;Uryu, Toshiyuki. And the article was included in Carbohydrate Research in 1999.SDS of cas: 112-59-4 The following contents are mentioned in the article:

Sulfated laminara-oligosaccharide glycosides having high anti-human immunodeficiency virus (HIV) activities were synthesized from laminara-tetraose, -pentaose and -hexaose. The oligosaccharide glycosides were synthesized by treating peracetylated β-oligosaccharides with various alcs. and Lewis acid catalysts. The effects of the number of glucose residues and the alkyl chain-length on anti-HIV activity were examined The anti-HIV activity of sulfated dodecyl laminara-pentaosides and -hexaosides increased with increasing degree of sulfation (DS) and the pentaoside having an almost fully-sulfated saccharide portion had the highest activity, whereas for the hexaoside a somewhat lower DS manifested the highest activity. Sulfated laminara-oligosaccharide glycosides having fluoroalkyl-containing aglycons of high hydrophobicity showed potent inhibitory effects against HIV infection. In contrast, hydrophilic substituents containing oligo(ethyleneoxy) groups as aglycons in the sulfated oligosaccharides did not show high anti-HIV activity. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4SDS of cas: 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Memantine nanoemulsion: a new approach to treat Alzheimer’s disease was written by Kaur, Atinderpal;Nigam, Kuldeep;Srivastava, Sukriti;Tyagi, Amit;Dang, Shweta. And the article was included in Journal of Microencapsulation in 2020.Formula: C10H22O3 The following contents are mentioned in the article:

A nanoemulsion loaded with memantine for intranasal delivery to bypass the blood-brain barrier for the treatment of Alzheimer disease. The nanoemulsion was prepared using homogenisation and ultrasonication methods. The developed nanoemulsion was characterised, in vitro release and antioxidant potential was analyzed. The in vivo studies were carried out by radiolabelling the memantine with technetium pertechnetate. The finalised NE showed particle-size of ~11 nm and percentage transmittance of ~99%. The in vitro release studies showed 80% drug release in simulated nasal fluid. The nanoemulsion showed 98% cell viability and antioxidative assays confirmed that the encapsulation of memantine in a nanoemulsion sustained its antioxidative potential. Gamma images and biodistribution results also confirmed higher uptake of formulation with %radioactivity of 3.6 ± 0.18%/g at 1.5 h in brains of rats administered intranasally. The developed nanoemulsion could be used as a potential carrier of memantine for a direct nose to brain delivery. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Formula: C10H22O3).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C10H22O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solvents for Processing Stable Tin Halide Perovskites was written by Di Girolamo, Diego;Pascual, Jorge;Aldamasy, Mahmoud H.;Iqbal, Zafar;Li, Guixiang;Radicchi, Eros;Li, Meng;Turren-Cruz, Silver-Hamill;Nasti, Giuseppe;Dallmann, Andre;De Angelis, Filippo;Abate, Antonio. And the article was included in ACS Energy Letters in 2021.Application of 109-85-3 The following contents are mentioned in the article:

Tin is one of the most promising alternatives to lead to make lead-free halide perovskites for optoelectronics. However, the stability of tin-based perovskites is hindered by the oxidation of Sn(II) to Sn(IV). Recent works established that DMSO, which is one of the best-performing solvents for processing perovskite, is the primary source of tin oxidation The quest for a stable solvent could be a game-changer in the stability of tin-based perovskites. Starting from a database of over 2000 solvents, we identified a series of 12 new solvents suitable for the processing of formamidinium tin iodide perovskite (FASnI3) by investigating (1) the solubility of the precursor chems. FAI and SnI₂, (2) the thermal stability of the precursor solution, and (3) the possibility of forming perovskite. Finally, we demonstrate a new solvent system to produce solar cells outperforming those based on DMSO. Our work provides guidelines for further identification of new solvents or solvent mixtures for preparing stable tin-based perovskites. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion was written by Vezina-Dawod, Simon;Angelbello, Alicia J.;Choudhary, Shruti;Wang, Kye Won;Yildirim, Ilyas;Disney, Matthew D.. And the article was included in ACS Medicinal Chemistry Letters in 2021.Quality Control of 2-Methoxyethylamine The following contents are mentioned in the article:

RNA contributes to disease pathobiol. and is an important therapeutic target. The downstream biol. of disease-causing RNAs can be short-circuited with small mols. that recognize structured regions. The discovery and optimization of small mols. interacting with RNA is, however, challenging. Herein, we demonstrate a massively parallel one-bead-one-compound methodol., employed to optimize the linker region of a dimeric compound that binds the toxic r(CUG) repeat expansion [r(CUG)^exp] causative of myotonic dystrophy type 1 (DM1). Indeed, affinity selection on a 331,776-member library allowed the discovery of a compound with enhanced potency both in vitro (10-fold) and in DM1-patient-derived myotubes (5-fold). Mol. dynamics simulations revealed addnl. interactions between the optimized linker and the RNA, resulting in ca. 10 kcal/mol lower binding free energy. The compound was conjugated to a cleavage module, which directly cleaved the transcript harboring the r(CUG)^exp and alleviated disease-associated defects. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Quality Control of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solubilization and extraction of curcumin from Curcuma Longa using green, sustainable, and food-approved surfactant-free microemulsions was written by Degot, Pierre;Huber, Verena;Hofmann, Evamaria;Hahn, Maximilian;Touraud, Didier;Kunz, Werner. And the article was included in Food Chemistry in 2021.Related Products of 33171-05-0 The following contents are mentioned in the article:

Curcumin is a powerful coloring agent widely used in the food industry. Its extraction from the plant Curcuma longa is commonly done with aqueous solvent solutions In contrast to the conventional extraction methods, the present study aimed to compare two different green and bio-based surfactant-free microemulsion (SFME) extraction systems, which are approved for food and yield a higher extracting power of curcuminoids. Two SFMEs, water/ethanol/triacetin and water/diacetin/triacetin, were investigated via dynamic light scattering. Curcumin solubility in binary mixtures consisting of ethanol/triacetin or diacetin/triacetin was studied both exptl. and theor. using UV-Vis measurements and COSMO-RS. The SFMEs were further examined and compared to a common ethanol/water (80/20) extraction mixture with respect to their extracting ability using high performance liquid chromatog. The SFMEs containing ethanol were found to extract ~18% more curcuminoids than the SFMEs containing diacetin and ~53% more than the ordinary ethanol/water mixture This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem