Month: November 2022

First total synthesis of rhuscholide A, glabralide B and denudalide was written by Li, Tian-Ze;Geng, Chang-An;Chen, Ji-Jun. And the article was included in Tetrahedron Letters in 2019.Category: ethers-buliding-blocks The following contents are mentioned in the article:

The first total synthesis of rhuscholide A (I), a benzofuran lactone possessing anti-HIV-1 activity, had been accomplished in 14 linear steps with 10.6% overall yield. In this synthesis, base-mediated phenol ortho-alkylation and piperidine promoted aldol condensation were exploited as key steps. The synthesis was flexible and allowed for the convenient preparation of two analogous natural products glabralide B (II) and denudalide (III). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Category: ethers-buliding-blocks).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Highly potent inhibitors of TNF-α production. Part I. Discovery of new chemical leads and Their structure-Activity relationships was written by Matsui, Toshiaki;Kondo, Takashi;Nishita, Yoshitaka;Itadani, Satoshi;Nakatani, Shingo;Omawari, Nagashige;Sakai, Masaru;Nakazawa, Shuichi;Ogata, Akihito;Mori, Hideaki;Terai, Kouichiro;Kamoshima, Wataru;Ohno, Hiroyuki;Obata, Takaaki;Nakai, Hisao;Toda, Masaaki. And the article was included in Bioorganic & Medicinal Chemistry in 2002.COA of Formula: C9H14ClNO2 The following contents are mentioned in the article:

Discovery of new chem. leads of inhibitors for TNF-α production starting from the chem. modification of 2-(octanoylamino)-2-phenylethyl disodium phosphate (I) is reported. Further biol. studies of I to disclose the site of its action strongly suggested that I inhibits LPS-induced TNF-α expression in the liver and spleen of mice. Structure-activity relationships (SARs) are also discussed and full details including the chem. are reported. This study involved multiple reactions and reactants, such as (R)-2-Amino-2-(3-methoxyphenyl)ethanol hydrochloride (cas: 532987-19-2COA of Formula: C9H14ClNO2).

(R)-2-Amino-2-(3-methoxyphenyl)ethanol hydrochloride (cas: 532987-19-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H14ClNO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic Asymmetric Hydrophosphination as a Valuable Tool to Access Dihydrophosphinated Curcumin and Its Derivatives was written by Teo, Ronald Hong Xiang;Lee, Jeannie Xue Ting;Tan, Wei Ren;Shum, Wen Qian;Li, Yongxin;Pullarkat, Sumod A.;Tan, Nguan Soon;Leung, Pak-Hing. And the article was included in Organometallics in 2021.Recommanded Product: Bisdemethoxycurcumin The following contents are mentioned in the article:

Curcumin and its derivatives were successfully functionalized with secondary phosphines via catalytic asym. dihydrophosphination to give enantioenriched products with up to 95% enantiomeric excess (ee). Subsequently, the medicinal activities of dihydrophosphinated-curcumin Au(I) complexes obtained from the in situ complexation of dihydrophosphinated-curcumin with Au(I) were evaluated using the MKN74 and MCF7 cancer cell lines and compared to existing drugs such as curcumin and cisplatin. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Simple Protocol for the Stereoselective Construction of Enaminyl Sulfonyl Fluorides was written by Leng, Jing;Tang, Wenjian;Fang, Wan-Yin;Zhao, Chuang;Qin, Hua-Li. And the article was included in Organic Letters in 2020.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:

A clickable connective hub 1-bromo-2-triazolethane-1-sulfonyl fluoride (BTESF) was developed and successfully applied for the fluorosulfonylvinylation of a host of primary and secondary cyclic or acyclic amines including amino acids and pharmaceuticals. Further antimicrobial experiments revealed that vinyl sulfonyl fluoride functionalized norfloxacin, ciprofloxacin, and lomefloxacin exhibited 4-fold improved antimicrobial activity against Gram-pos. bacteria compared to their parent drugs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Simple Protocol for the Stereoselective Construction of Enaminyl Sulfonyl Fluorides was written by Leng, Jing;Tang, Wenjian;Fang, Wan-Yin;Zhao, Chuang;Qin, Hua-Li. And the article was included in Organic Letters in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

A clickable connective hub 1-bromo-2-triazolethane-1-sulfonyl fluoride (BTESF) was developed and successfully applied for the fluorosulfonylvinylation of a host of primary and secondary cyclic or acyclic amines including amino acids and pharmaceuticals. Further antimicrobial experiments revealed that vinyl sulfonyl fluoride functionalized norfloxacin, ciprofloxacin, and lomefloxacin exhibited 4-fold improved antimicrobial activity against Gram-pos. bacteria compared to their parent drugs. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyrano-[2,3b]-pyridines as potassium channel antagonists was written by Finlay, Heather J.;Lloyd, John;Nyman, Michael;Conder, Mary Lee;West, Tonya;Levesque, Paul;Atwal, Karnail. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

The design and synthesis of a series of highly functionalized pyrano[2,3-b]pyridines is described. These compounds were assayed for their ability to block the I_Kur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethylbenzenesulfonylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxylic acid N-ethyl-N-phenylamide with an IC₅₀ of 378 nM. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Quality Control of N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of N-(3-Methoxybenzyl)ethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile Hydrogenative Deprotection of N-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon was written by Yamamoto, Yuta;Shimizu, Eisho;Ban, Kazuho;Wada, Yoshiyuki;Mizusaki, Tomoteru;Yoshimura, Masatoshi;Takagi, Yukio;Sawama, Yoshinari;Sajiki, Hironao. And the article was included in ACS Omega in 2020.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Nb₂O₅/C was prepared from activated carbon, H₂O, and NbCl₅; in the presence of a combination of Nb₂O₅/C and Pd/C, benzylamines, benzyl carbamates, and benzyl ethers underwent hydrogenolysis in MeOH to yield amines and alcs. The combination of Nb₂O₅/C and Pd/C was used five times for the debenzylation of N-benzyldioctylamine to give product in 82->97% yield with a decrease in yield in the fourth reaction. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile Hydrogenative Deprotection of N-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon was written by Yamamoto, Yuta;Shimizu, Eisho;Ban, Kazuho;Wada, Yoshiyuki;Mizusaki, Tomoteru;Yoshimura, Masatoshi;Takagi, Yukio;Sawama, Yoshinari;Sajiki, Hironao. And the article was included in ACS Omega in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

Nb₂O₅/C was prepared from activated carbon, H₂O, and NbCl₅; in the presence of a combination of Nb₂O₅/C and Pd/C, benzylamines, benzyl carbamates, and benzyl ethers underwent hydrogenolysis in MeOH to yield amines and alcs. The combination of Nb₂O₅/C and Pd/C was used five times for the debenzylation of N-benzyldioctylamine to give product in 82->97% yield with a decrease in yield in the fourth reaction. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

B(C₆F₅)₃-Catalyzed Sequential Additions of Terminal Alkynes to para-Substituted Phenols: Selective Construction of Congested Phenol-Substituted Quaternary Carbons was written by Chen, Hui;Yang, Mo;Wang, Guoqiang;Gao, Liuzhou;Ni, Zhigang;Zou, Jingxiang;Li, Shuhua. And the article was included in Organic Letters in 2021.Product Details of 103-16-2 The following contents are mentioned in the article:

A borane-catalyzed sequential addition of terminal alkynes to para-substituted phenols, which afforded a wide range of ortho-propargylic alkylated phenols bearing congested quaternary carbons was reported. Control experiments combined with DFT calculations suggested that the reaction undergoes a sequential phenol alkenylation/hydroalkynylation process. Further extension of this strategy to the construction of triaryl-substituted quaternary carbons demonstrates the broad utility of this method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

B(C₆F₅)₃-Catalyzed Sequential Additions of Terminal Alkynes to para-Substituted Phenols: Selective Construction of Congested Phenol-Substituted Quaternary Carbons was written by Chen, Hui;Yang, Mo;Wang, Guoqiang;Gao, Liuzhou;Ni, Zhigang;Zou, Jingxiang;Li, Shuhua. And the article was included in Organic Letters in 2021.SDS of cas: 103-16-2 The following contents are mentioned in the article:

A borane-catalyzed sequential addition of terminal alkynes to para-substituted phenols, which afforded a wide range of ortho-propargylic alkylated phenols bearing congested quaternary carbons was reported. Control experiments combined with DFT calculations suggested that the reaction undergoes a sequential phenol alkenylation/hydroalkynylation process. Further extension of this strategy to the construction of triaryl-substituted quaternary carbons demonstrates the broad utility of this method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2SDS of cas: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem