Month: December 2022

Nikl, Joachim published the artcileDirect Metal- and Reagent-Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis, COA of Formula: C11H16O2, the main research area is hydroxyarylsulfone preparation electrochem green chem; phenol sodium benzenesulfinate anodization cross coupling sulfonylation; C−H activation; cross-coupling; electrochemistry; oxidation; sustainable chemistry.

A novel electrochem. strategy for the synthesis of arylsulfones R1SO2R2 (R1 = 3-tert-butyl-2-hydroxy-5-methoxyphenyl, 2-hydroxy-5-methoxy-3-methylphenyl, 4-hydroxy-3,5-dimethoxyphenyl, 2-hydroxy-3-methoxy-5-methylphenyl; R2 = Me, Ph, 4-fluorophenyl, etc.) by direct sulfonylation of phenols with sodium sulfinates NaOS(O)R2 has been developed. The C,S-coupling products are of particular interest for chem. synthesis, material sciences and pharmaceutical sciences. By using this metal- and reagent-free electrochem. method, aryl and diaryl sulfones can be obtained directly in good yields. The established one-step protocol is easy to perform, scalable, and inherently safe, and enables a broad scope, which is not limited by quinoid-forming substrates.

Chemistry – A European Journal published new progress about Anodization. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rao, Zi-Kun published the artcileDual thermo-responsive amphiphilic alternating copolymers: one-pot synthesis and the temperature-induced self-assembly, Application of 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is copolymer self assembly.

Abstract: Synthesis and self-assembly of stimuli-responsive amphiphilic alternating copolymers (AAC) are an emerging land of tremendous possibilities. Herein, by combining backbone polyethylene glycol (PEG) with pendent oligo-polyglycol simultaneously, two alternating LCST segments are knitted through enzymic synthesis, giving a series of alternating poly[(PEG400-a-succinic acid)-co-(diol(3EG)-a-succinic acid)] (PPSDS) for the first time. All the PPSDSs show only one-step sharp temperature responsiveness in transmittance-temperature curve owing to stabilization effect of PEG400. The cloud points can be linearly controlled by simply adjusting the feeding ratio of PEG400/diol-3EG. Referring to published works and 1H-NMR spectra in D2O, all the obtained AAC formed penetrable nanovesicles under 4°C. The TEM and 1H-NMR results confirmed that when heated to 18°C, PPSDS of “”9/1″” transformed from nanovesicles to large-compound micelles due to large hydrophobic volume, while other PPSDS of “”8/2, 7/3, 6/4″” retained the vesicle structures, except that the hydrophilic layer turned from PEG400 + diol(3EG) to PEG400 alone, leading to the size reduction The temperature-controlled size “”expansion and contraction”” of nanovesicles was unique for AAC, which was potentially good for enhancing loading rate. Further heating above cloud point resulted in the destruction of nanostructures and irregular intermol. aggregations. The first reported dual temperature-responsive AAC was innovative in structure design, providing a potential opportunity for the design and synthesis of controllable self-assemble structures and smart biomacromols. in biomedical applications.

Journal of Materials Science published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Application of 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hu, An published the artcileA Consequence of Dispersity on the Self-Assembly of Amphiphilic Homopolymers Containing Main-Chain Azobenzene, Synthetic Route of 23783-42-8, the main research area is self assembly amphiphilic homopolymer azobenzene.

The self-assembly of amphiphilic oligomers/polymers is a versatile and promising approach for creating nonspherical polymeric nanoparticles. Discrete amphiphilic oligomers/polymers with molecularly defined structures are ideal candidates for fabricating smart nanoparticles and for achieving a deeper understanding of structure-controlled self-assembly. Herein, discrete and disperse amphiphilic homopolymers of PAZOnTEG2n, with hydrophobic azobenzene are designed and synthesized as the main chains tethered with hydrophilic tetraethylene glycol monomethyl ether (TEG) units, to accurately investigate the impact of dispersity on their self-assembly in solution The discrete-PAZO8TEG16 in DMF/water and in THF/water results in the formation of 2D lamellae, while the dispersed counterpart prefers to self-assemble into spherical micelles. The significant difference is due to their distinction between interior structures of assembly. Furthermore, photoisomerization of azobenzene triggers dissociation/reassembly for discrete polymeric nanoparticles but no obvious change for the dispersed counterparts under irradiation with UV/vis light. This work reveals the influence of dispersity on the self-assembly of amphiphilic polymers and stimuli-responsive properties of their nanomaterials, which is desirable for universal applicability in fabricating smart 2D lamellas.

Macromolecular Chemistry and Physics published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Synthetic Route of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Han, Jianxiong published the artcileRu-Se Coordination: A New Dynamic Bond for Visible-Light-Responsive Materials, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is ruthenium terpyridine biquinoline selenoether complex preparation amphiphilicity photodissociation; UV vis spectra ruthenium terpyridine biquinoline selenoether amphiphilic complex.

Photodynamic bonds are stable in the dark and can reversibly dissociate/form under light irradiation Photodynamic bonds are promising building blocks for responsive or healable materials, photoactivated drugs, nanocarriers, extracellular matrixes, etc. However, reactive intermediates from photodynamic bonds usually lead to side reactions, which limit the use of photodynamic bonds. Here, we report that the Ru-Se coordination bond is a new photodynamic bond that reversibly dissociates under mild visible-light-irradiation conditions. We observed that Ru-Se bonds form via the coordination of a selenoether ligand with [Ru(tpy)(biq)(H2O)]Cl2 (tpy = 2,2′:6′,2”-terpyridine, biq = 2,2′-biquinoline) in the dark, while the Ru-Se bond reversibly dissociates under visible-light irradiation No side reaction is detected in the formation and dissociation of Ru-Se bonds. To demonstrate that the Ru-Se bond is applicable to different operating environments, we prepared photoresponsive amphiphiles, surfaces, and polymer gels using Ru-Se bonds. The amphiphiles with Ru-Se bonds showed reversible morphol. transitions between spherical micelles and bowl-shaped assemblies for dark/light irradiation cycles. The surfaces modified with Ru-Se-bond-containing compounds showed photoswitchable wettability. Polymer gels with Ru-Se cross-links underwent photoinduced reversible sol-gel transitions, which can be used for reshaping and healing. Our work demonstrates that the Ru-Se bond is a new type of dynamic bond, which can be used for constructing responsive, reprocessable, switchable, and healable materials that work in a variety of environments.

Journal of the American Chemical Society published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Dapeng published the artcileOne-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is ionizable amphiphilic Janus dendrimer delivery system mRNA.

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mech. properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the “”PEG dilemma””, and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodol. and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technol. often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5°C and demonstrated higher transfection efficiency than pos. control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.

Journal of the American Chemical Society published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Czysch, Christian published the artcileNontoxic N-Heterocyclic Olefin Catalyst Systems for Well-Defined Polymerization of Biocompatible Aliphatic Polycarbonates, COA of Formula: C9H20O5, the main research area is heterocyclic olefin catalyst biocompatible aliphatic polycarbonate ring opening polymerization; nanocarrier drug delivery system.

Herein, N-heterocyclic olefins (NHOs) are utilized as catalysts for the ring-opening polymerization (ROP) of functional aliphatic carbonates. Aiming for the polymerization of monomers with high side chain functionality, six-membered carbonates derived from 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) served as model compounds Tuning the reactivity of NHO from predominant side chain transesterification at room temperature toward ring-opening at lowered temperatures (-40°C) enables controlled ROP. These refined conditions give narrowly distributed polymers of the hydrophobic carbonate 5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one (MTC-OBn) (D < 1.30) at (pseudo)first-order kinetic polymerization progression. For the active ester monomer 5-methyl-5-pentafluorophenyloxycarbonyl-1,3-dioxane-2-one (MTC-PFP) with elevated side chain reactivity, a cocatalysis system consisting of NHO and the Lewis acid magnesium iodide is required to retune the reactivity from side chains toward controlled ROP. The broad feasibility of our findings was further demonstrated by the synthesis of block copolymers for bioapplications and their successful nanoparticular assembly. The polycarbonate block copolymer mPEG44-b-poly(MTC-OBn) enables phys. entrapment of hydrophobic dyes in sub-20 nm micelles, whereas the active ester block copolymer mPEG44-b-poly(MTC-PFP) is postfunctionalizable by covalent dye attachment. Both block copolymers thereby serve as platforms for phys. or covalent modification of nanocarriers for drug delivery. ACS Polymers Au published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, COA of Formula: C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guazzelli, Elisa published the artcileSingle-chain folding and self-assembling of amphiphilic polyethyleneglycol-modified fluorinated styrene homopolymers in water solution, Name: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is amphiphilic polyethyleneglycol modified fluorinated styrene homopolymer self assembling.

Amphiphilic tetrafluorostyrene monomers (EFSn) carrying in the para position a polyethyleneglycol (PEG) chain with varied lengths (n = 3-13) were synthesized and polymerized by ARGET-ATRP to obtain the corresponding amphiphilic homopolymers pEFSn-x with controlled and tailored polymerization degrees (x = 8-135). All polymers presented a reversible thermoresponsive LCST-type behavior, in water/methanol mixture when n ≤ 4 or in pure water when n ≥ 8, with a cloud point (Cp) temperature in the range 30-40°C strictly dependent on the length of the PEG side chain. Combined small angle X-scattering (SAXS) and dynamic light scattering (DLS) measurements were used to study the self-assembly behavior in water of the water-soluble amphiphilic homopolymers. SAXS confirmed the formation of compact-sized and spherical single-chain self-folded nanostructures below Cp, that generally presented small hydrodynamic diameters (Dh ≤ 11 nm) as proven by DLS anal. Above Cp, much larger multi-chain aggregates were formed (Dh ≥ 800 nm), that reversibly turned back to collapsed nanostructures on cooling below the Cp temperature By contrast, the polymers were not able to self-assemble in THF or DMF solutions, in which they adopted conventional random coil conformations.

Polymer published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Name: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Meiyu published the artcileSelf-assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy, Application In Synthesis of 23783-42-8, the main research area is amphiphilic porphyrin preparation PDT cancer nanoparticle; amphiphilic; nanoparticles; photodynamic therapy; self-assembly; triphenylphosphine.

Hydrophobic photosensitizers greatly affect cell permeability and enrichment in tumors, but they cannot be used directly for clin. applications because they always aggregate in water, preventing their circulation in the blood and accumulation in tumor cells. As a result, amphiphilic photosensitizers are highly desirable. Although nanomaterial-based photosensitizers can solve water solubility, they have the disadvantages of complicated operation, poor reproducibility, low drug loading, and poor stability. In this work, an efficient synthesis strategy is proposed that converts small mols. into nanoparticles in 100% aqueous solution by mol. assembly without the addition of any foreign species. Three photosensitizers with triphenylphosphine units and ethylene glycol chains of different lengths, TPP-PPh3, TPP-PPh3-2PEG and TPP-PPh3-4PEG, were synthesized to improve amphiphilicity. Of the three photosensitizers, TPP-PPh3-4PEG is the most efficient (singlet oxygen yield: 0.89) for tumor photodynamic therapy not only because of its definite constituent, but also because its amphiphilic structure allows it to self-assemble in water.

Chemistry – A European Journal published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Application In Synthesis of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Jiali published the artcileHydrogen-bond super-amphiphile based drug delivery system: design, synthesis, and biological evaluation, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is hydrogen bond amphiphile drug delivery system.

Drug delivery systems (DDSs) show great application prospects in tumor therapy. So far, phys. encapsulation and covalent grafting were the two most common strategies for the construction of DDSs. However, phys. encapsulation-based DDSs usually suffered from low drug loading capacity and poor stability, and covalent grafting-based DDSs might reduce the activity of original drug, which greatly limited their clin. application. Therefore, it is of great research value to design a new DDS with high drug loading capacity, robust stability, and original drug activity. Herein, we report a super-amphiphile based drug delivery system (HBS-DDS) through self-assembly induced by hydrogen bonds between amino-substituted N-heterocycles of the 1,3,5-triazines and hydrophilic carmofur (HCFU). The resulting HBS-DDS had a high drug loading capacity (38.1%) and robust stability. In addition, the drug delivery system exhibited pH-triggered size change and release of drugs because of the pH responsiveness of hydrogen bonds. In particular, the anticancer ability test showed that the HBS-DDS could be efficiently ingested by tumor cells, and its half-maximal inhibitory concentration (IC50 = 3.53μg mL-1) for HeLa cells was close to that of free HCFU (IC50 = 5.54μg mL-1). The hydrogen bond-based DDS represents a potential drug delivery system in tumor therapy.

RSC Advances published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cid, Jose Maria published the artcileDiscovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor, HPLC of Formula: 622-86-6, the main research area is metabotropic glutamate mGluR2 PAM modulator allosteric; pyridone derivative SAR preparation; PAM; allosteric; glutamate; mGluR2; metabotropic; modulators.

A series of 1,5-disubstituted pyridones was identified as pos. allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several compounds with improved in vitro activity. Lead compound 8 (I) was further profiled and found to attenuate the increase in PCP induced locomotor activity in mice.

ACS Chemical Neuroscience published new progress about Allosterism. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, HPLC of Formula: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem