Month: December 2022

Friedman, Adam A. published the artcileRh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza-Dihydrodibenzoxepines, Safety of 2-Methoxy-5-methylphenylboronic acid, the main research area is palladium rhodium ligand domino tandem reaction; chemoselectivity; domino catalysis; enantioselectivity; heterocycles; multi-catalytic reactions.

Under optimized reaction conditions, the synthesis of the target compounds was achieved using bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-hydroxydirhodium, palladium(II) acetate and bis(1,1-dimethylethyl)[2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine as catalyst combination. Di-μ-chlorobis(η2-ethene)dirhodium was also used as a catalyst. Reactants included (ethenyl)pyridine derivatives, such as 3-chloro-2-ethenyl-5-(trifluoromethyl)pyridine, 5-chloro-6-ethenyl-3-pyridinecarbonitrile. Reactants inlcuded 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol derivatives The title compounds thus formed included benzoxepinopyridine derivative (I) and related substances [pyrido[3,2-b][1]benzoxepine derivatives]. Par.

Angewandte Chemie, International Edition published new progress about Alkenylation. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Safety of 2-Methoxy-5-methylphenylboronic acid.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Zhendong published the artcile3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is butyl hydroxyanisole liver lipid high fat diet; 3-tert-butyl-4-hydroxyanisole; food antioxidant; lipid homeostasis; nonalcoholic fatty liver disease; obesogen.

3-tert-Butyl-4-hydroxyanisole (3-BHA), one of the widely used food antioxidants, has been found to act as a potential obesogen by promoting adipogenesis in vitro and inducing white adipose tissue development in vivo. Whether 3-BHA-induced visceral obesity was accompanied by a disruption of hepatic lipid homeostasis in mammals remained unclear. In this study, we evaluated the effect of 3-BHA on the development of nonalcoholic fatty liver disease (NAFLD) in male C57BL/6J mice. After 18 wk of oral administration of 10 mg/kg 3-BHA, the mice fed with a high-fat diet (HFD) had higher hepatic triglyceride concentrations (0.32 mg/mg protein) and severer steatosis (1.57 for the NAFLD score) than the control ones. The in vivo hepatic lipid deposition disturbed by 3-BHA was transcriptionally regulated by the genes involved in lipid uptake, de novo lipogenesis, fatty acid oxidation, and lipid export. The in vitro studies further confirmed that 24 h of exposure to 50 μM 3-BHA could induce intracellular oleic acid (OA) uptake and triglyceride accumulation (1.5-fold of the OA control) in HepG2 cells. Lipidomic anal. indicated the perturbation of 3-BHA in the levels of 30 lipid species related to sphingolipids, glycerophospholipids, and glycerolipids under HFD conditions. The findings herein first revealed the disruption effect of 3-BHA on hepatic lipid homeostasis, thus exacerbating the development of HFD-induced NAFLD.

Environmental Science & Technology published new progress about Adipogenesis. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Zhendong published the artcileButylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells, Application In Synthesis of 121-00-6, the main research area is butylated hydroxyanisole isomer adipogenesis; 3T3-L1 cells; Adipogenesis; Butylated hydroxyanisole (BHA) isomers; Lipogenesis; Obesity.

Butylated hydroxyanisole (BHA) isomers, as the widely used anthropogenic antioxidants in food, have been revealed to induce endocrine disrupting effects, while the mechanism how BHA isomers regulate the lipogenic differentiation remains to be elucidated. Using 3T3-L1 differentiation model, the effects of BHA isomers, including 2-tert-butyl-4-hydroxyanisole (2-BHA), 3-tert-butyl-4-hydroxyanisole (3-BHA) and their mixture (BHA), on adipogenesis were tested. The results showed that 3-BHA and BHA promoted adipocyte differentiation and enhanced the cellular lipid accumulation through the regulation of the transcriptional and protein levels of the adipogenetic biomarkers, while 2-BHA had no effect. The effective window for 3-BHA induced lipogenesis was the first four days during 3T3-L1 differentiation. BHA isomers showed no binding affinities for peroxisome proliferator activated receptor γ (PPARγ). Instead, the upstream of PPARγ signaling pathway, i.e. the phosphorylation of cAMP-response element binding protein (CREB), upregulation of CAAT/enhancer-binding proteins β (C/EBPβ) and elevated cell proliferation during postconfluent mitosis stage were induced by 3-BHA exposure. Altogether, this study revealed the adipogenic effect of 3-BHA through interference with the upstream events of the PPARγ signaling pathway. The authorized usage of BHA as food additives and its occurrence in human sera can potentially contribute to the incidence of obesity, which is of high concern.

Journal of Hazardous Materials published new progress about Adipogenesis. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Barghamadi, Marzieh published the artcileIn situ synchrotron XRD and sXAS studies on Li-S batteries with ionic-liquid and organic electrolytes, Product Details of C10H22O5, the main research area is Lithium sulfur batteries ionic liquid electrolytes.

Lithium-sulfur (Li-S) batteries are a promising technol. capable of reaching high energy d. of 500-700 Wh kg-1, however the practically achievable performance is still lower than this value. This hindrance can be attributed to a lack of understanding of the fundamental electrochem. processes during Li-S battery cycling, in particular the so-called redox shuttle effect which is due to the relatively high solubility of polysulfide intermediates in the electrolyte. Herein, the effects of LiNO3 as an additive as well as C4mpyr-based ionic liquids (ILs) in electrolyte formulations for Li-S cells are analyzed using in situ X-ray powder diffraction (XRD) and ex situ soft X-ray absorption spectroscopy (sXAS) techniques. While LiNO3 is known for its protective properties on the lithium anode in Li-S cells, our studies have provided further evidence for suppression of Li2S deposition when using LiNO3 as an additive, as well as affecting the solid electrolyte interphase (SEI) layer at a mol. level. Moreover, the detected sulfur species on the surface of the anode and cathode, after a few cycles are compared for IL and organic-based electrolytes.

Journal of the Electrochemical Society published new progress about Ionic liquids. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Product Details of C10H22O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Inomata, Koya published the artcileRuthenium-catalyzed selective hydrosilylation reaction of allyl-functionalized PEG derivatives, Formula: C9H20O5, the main research area is polyethylene glycol allyl ether derivative ruthenium catalyzed selective hydrosilylation.

Reactions of allyl-functionalized poly(ethylene glycol) (PEG) derivatives with alkoxysilanes proceeded efficiently to furnish the corresponding hydrosilylated products in good to excellent yields using a ruthenium catalyst, [RuCl2(nbd)]n. A preliminary mechanistic study supported the pivotal role of the PEG moiety, which coordinated to the ruthenium atom during the reaction to achieve high reaction selectivity. This method may be applicable to the synthesis of various PEGs with a silyl terminus, which is useful as biocompatible and low toxic silane coupling agents.

Tetrahedron Letters published new progress about Hydrogenation. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Formula: C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Krueger, Peter J. published the artcileAmino group stretching vibrations in primary acid amides, SDS of cas: 16332-06-2, the main research area is AMINO GROUP STRETCHING VIBRATIONS; VIBRATIONS STRETCHING AMINO GROUP; STRETCHING VIBRATIONS AMINO GROUP; AMIDES SPECTRA.

Most primary alkyl, primary α-substituted alkyl, and primary aromatic acid amides exhibit three sharp concentration and temperature dependent absorption bands at 3518 ± 3, 3504 ± 4, and 3486 ± 8 cm.-1, in dilute (0.003M or less) CCl4 solution, just below the fundamental antisymmetric NH2 stretching vibration. These are tentatively assigned to the shifted antisymmetric NH2 stretching vibration in cyclic dimers, cyclic trimers, and cyclic tetramers resp., with increasing NH…O hydrogen bond strength. In all alkyl amides the antisymmetric NH2 band intensity exceeds the symmetric band intensity. Conjugation of the CONH2 group with π-electron systems reverses this intensity relation, except where the acidic NH2 group can form intramol. H bonds. These observations substantiate the previously published views on the nature of the vibrational mechanism of the NH2 group. No evidence is found for enolization of amides in CCl4 solution 31 references.

Canadian Journal of Chemistry published new progress about Hydrogen bond. 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, SDS of cas: 16332-06-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Barekati-Goudarzi, Mohamad published the artcileHeterogeneous and Homogeneous Components in Gas-Phase Pyrolysis of Hydrolytic Lignin, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is homogeneous gas pyrolysis hydrolytic lignin.

Pyrolysis of hydrolytic lignin (HL) in the newly designed, gas phase continuous droplet evaporation (CDE) and continuous atomization (CA) reactors, was studied. The products distribution was strongly dependent on the heterogeneous character of either delivery of lignin solution into CDE reactor (in-situ formation of solid phase) or sampling conditions using quartz wool in both CDE and CA reactors. The effect of residence time, initial concentration of HL solution and injection temperature on products distribution in CDE reactor was investigated and discussed in terms of mass and heat transfer limitation. The exptl. data confirm that at low initial mass delivery rates of lignin (micrograms per s) and by increasing initial lignin concentration (up to 40 times), the formation of phenolics is slightly intensified (6 times). However, the solid surface or any condense phase that forms in-situ during reaction in the gas phase may largely govern the pyrolysis processes. The detailed exptl. examination of homogeneous pyrolysis of lignin in both gas-phase reactors by implication of diverse anal. techniques (GC, GPC, LDI, FTIR, EPR, NMR) revealed break down of HL macromols. into oligomer-fragments after pyrolysis at negligible amounts of phenolics detected. A mechanistic interpretation of primary steps for formation of dominant intermediate products – oligomers and oligomer stable radicals, is represented.

ACS Sustainable Chemistry & Engineering published new progress about Heat transfer. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Masuda, Koichiro published the artcileAerobic Dehydrogenative Coupling of Naphthols and Phenols with a Ru(OH)x/Al2O3 Catalyst under Continuous-Flow Conditions, SDS of cas: 121-00-6, the main research area is binaphthol biphenol preparation green chem continuous flow; naphthol phenol aerobic dehydrogenative coupling alumina ruthenium hydroxide catalyst.

Dehydrogenative coupling reactions of naphthols and phenols were achieved with a heterogeneous catalyst, alumina-supported ruthenium hydroxide (Ru(OH)x/Al2O3), using continuous-flow conditions and aerobic oxygen as the sole oxidant. The reactions were operated continuously for more than 16 h with good reactivity and selectivity. The Ru catalyst could be recycled at least three times by a simple online washing/activation procedure without depackaging the catalyst cartridge. The reaction provided binaphthols and biphenols as valuable products for synthetic purpose and functional materials, while an over-oxidized quinone was obtained with 2,6-Di-tert-butylphenol; combining this reaction with catalytic hydrogenation under continuous-flow conditions enabled smooth conversion of quinone to the 4,4′-biphenol derivative, which is a member of an important class of compounds for liquid crystals, engineering plastics, and other functional materials.

ChemistrySelect published new progress about Flow reactors. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, SDS of cas: 121-00-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sakamoto, Shuhei published the artcileElectrochemical properties of lithium air secondary batteries incorporating manganese salen complex as soluble catalyst for nonaqueous electrolyte solutions, Name: 2,5,8,11,14-Pentaoxapentadecane, the main research area is lithium air secondary battery manganese salen complex electrochem property.

Manganese-containing salen-type complexes of (R,R)-(-)-N,N’-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride (MnSl) were examined as a novel soluble catalyst in nonaqueous electrolyte solutions for lithium air secondary batteries (LABs). The LAB cells with MnSl exhibited a larger first discharge capacity and better cycle performance (893 mAh g-1, 738 mAh g-1 up to 10 cycles) than those without MnSl. Attenuated total reflection Fourier transform IR spectroscopy (ATR-FTIR) conducted during the discharge/charge cycle showed deposition and decomposition of the discharge product, Li2O2, on the surface of the air electrode. Cyclic voltammetry results suggested that MnSl promotes the oxygen reduction reaction and oxygen evolution reaction because of its high reactivity with O2.

Electrochemistry (Tokyo, Japan) published new progress about Decomposition. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Name: 2,5,8,11,14-Pentaoxapentadecane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guan, Khor Hock published the artcileInfluence of tetraglyme towards magnesium salt dissociation in solid polymer electrolyte for electric double layer capacitor, Quality Control of 143-24-8, the main research area is solid polymer electrolyte tetraglyme magnesium elec double layer capacitor.

Most of commercialized elec. double layer capacitors (EDLCs) with liquid electrolyte are bulky, non-flexible and unsafe which require solid polymer electrolyte (SPE) as the replacement. Herein, SPE containing tetraglyme as the ionic conductivity booster was prepared in which polyvinyl alc. (PVA), magnesium trifluoromethane sulfonate (Mg (Tf)2) and tetraglyme (TEDGME) have been utilized as the host polymer, salt and additive, resp. After the addition of TEDGME, the SPE exhibited a significant boost in ionic conductivity from 1.43 x 10-9 to 3.10 x 10-5 S cm-1. This is attributed to the presence of multiple ether oxygen atom functional group from TEDGME that provides more charge carriers. Fourier transform IR spectroscopy authenticates the formation of complex within the SPE systems which indicates the formation of good interaction between the host polymer and the salts. X-ray diffraction anal. demonstrates the reduction in crystallinity of the SPE after the addition of TEDGME which is beneficial for the ion diffusion. The maximum specific capacitance achieved by the EDLC employing the SPE incorporated with TEDGME is 6.34 F/g at 0.04 A/g, with the rate capability of 74.1%.

Journal of Polymer Research published new progress about Crystallinity. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Quality Control of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem