Month: January 2023

Dehydrative Cross-Coupling for C-N Bond Construction under Transition-Metal-Free Conditions was written by Xing, Huicong;Chen, Meijuan;Zhang, Dong;Geng, Zhishuai;Xie, Peizhong;Loh, Teck-Peng. And the article was included in Organic Letters in 2022.SDS of cas: 105-13-5 This article mentions the following:

A transition-metal-free catalytic system was designed to address the dehydrative cross-coupling of unactivated primary/secondary alcs. with amines/amides under environmentally benign conditions. Mg²⁺ and counteranion (PF₆^–) worked synergistically to realize C-OH bond cleavage and concomitant C-N bond formation. A wide range of allylic alcs. and amines/amides were tolerated well in this transformation, which allowed C-N bond construction with high efficiency. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).SDS of cas: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The use of coenzyme Q0 as a template in the development of a molecularly imprinted polymer for the selective recognition of coenzyme Q10 was written by Contin, Mario;Flor, Sabrina;Martinefski, Manuela;Lucangioli, Silvia;Tripodi, Valeria. And the article was included in Analytica Chimica Acta in 2014.SDS of cas: 605-94-7 This article mentions the following:

In this work, a novel molecularly imprinted polymer (MIP) for use as a solid phase extraction sorbent was developed for the determination of coenzyme Q10 (CoQ10) in liver extract CoQ10 is an essential cofactor in mitochondrial oxidative phosphorylation and a powerful antioxidant agent found in low concentrations in biol. samples. This fact and its high hydrophobicity make the anal. of CoQ10 tech. challenging. Accordingly, a MIP was synthesized using coenzyme Q0 as the template, methacrylic acid as the functional monomer, acetonitrile as the porogen, ethylene glycol dimethacrylate as the crosslinker and benzoyl peroxide as the initiator. Various parameters affecting the polymer preparation and extraction efficiency were evaluated. Morphol. characterization of the MIP and its proper comparison with C18 as a sorbent in solid phase extraction were performed. The optimal conditions for the molecularly imprinted solid phase extraction (MISPE) consisted of 400 μL of sample mixed with 30 mg of MIP and 600 μL of water to reach the optimum solution loading. The loading was followed by a washing step consisting of 1 mL of a 1-propanol solution (1-propanol:water, 30:70,volume/volume) and elution with 1 mL of 1-propanol. After clean-up, the CoQ10 in the samples was analyzed by high performance liquid chromatog. The extraction recoveries were higher than 73.7% with good precision (3.6-8.3%). The limits of detection and quantification were 2.4 and 7.5 μg g^-1, resp., and a linear range between 7.5 and 150 μg g^-1 of tissue was achieved. The new MISPE procedure provided a successful clean-up for the determination of CoQ10 in a complex matrix. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7SDS of cas: 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A simple and efficient procedure for the synthesis of ketone di-sec-alkyl acetals was written by Ono, Fumiaki;Takenaka, Hirotaka;Eguchi, Yuko;Endo, Masato;Sato, Tsuneo. And the article was included in Synlett in 2009.SDS of cas: 1132-95-2 This article mentions the following:

Ketone di-sec-alkyl acetals were obtained in good to excellent yields by treatment of ketones with tri-sec-alkyl orthoformate and the corresponding alc. in the presence of a catalytic amount of cerium(III) trifluoromethanesulfonate. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2SDS of cas: 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.SDS of cas: 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The amide C-N bond of isatins as the directing group and the internal oxidant in Ru-catalyzed C-H activation and annulation reactions: access to 8-amido isocoumarins was written by Kaishap, Partha Pratim;Sarma, Bipul;Gogoi, Sanjib. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene This article mentions the following:

The use of the amide C-N bond of isatins as the oxidizing directing group for the Ru(II)-catalyzed redox-neutral C-H activation and annulation reactions with alkynes which afford 8-amido isocoumarins were reported. The reaction also featureed excellent regioselectivity with alkyl aryl substituted alkynes. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydroboration of substituted alkynes using a solid polymeric carboxylic acid catalyst was written by Hoyt, Caroline B.;Sarazen, Michele L.;Jones, Christopher W.. And the article was included in Journal of Catalysis in 2019.Safety of 1,4-Dimethoxy-2-butyne This article mentions the following:

A polymer-supported benzoic acid catalyst for the hydroboration of substituted alkynes with pinacolborane is reported. The robustness of the heterogenous catalyst is demonstrated through catalyst recycle, with comparable reactivity to the homogeneous catalyst. A mechanistic investigation that includes determination of a reaction rate law, ¹H and ¹¹B NMR studies, as well elucidation of the H/D kinetic isotope effect is used to identify the pathway through which product formation occurs. The polymer support provided a recoverable handle, with the active sites in close proximity to promote a two-site reaction pathway with the identification of key boryl species through ¹¹B NMR. The activated alkynyl species is converted through a concerted hydroboration mechanism, supported by inverse KIE values, releasing product and regenerating the active site. Kinetic studies, where initial rates are proportional to the concentration of both the pinacolborane and the catalyst, but become inhibited by the alkyne at higher concentrations, suggest that the catalytic cycle can be described by a two-site rate expression with alkyne-derived surface species present during catalysis. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Safety of 1,4-Dimethoxy-2-butyne).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 1,4-Dimethoxy-2-butyne

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Eosin Y photocatalyzed access to Biginelli reaction using primary alcohols via domino multicomponent cascade: an approach towards sustainable synthesis of 3,4-dihydropyrimidin-2(1H)-ones was written by Kumar, Gobind;Bhargava, Gaurav;Kumar, Yogesh;Kumar, Rupesh. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.SDS of cas: 105-13-5 This article mentions the following:

The Eosin Y photocatalyzed Biginelli protocol has been established by a cascade one-pot three-component reaction of primary alcs., α-ketoester, and urea to provide pharmacol. promising 3,4-dihydropyrimidin-2(1H)-ones in high yields. The key benefits of the present scheme are the capability to allow operational simplicity, readily available substrates, straightforward workup and high yields. This Eosin Y based photocatalytic approach can permit conquering traditional metal-catalyzed reactions in a sustainable manner, thus delivering economic and environmental rewards. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile synthesis of TEG-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine and PET imaging agent [F]florbetapir ([F]AV-45) was written by Yao, Tuo;Li, Zhi. And the article was included in Synthetic Communications in 2018.Recommanded Product: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

Triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine, which can serve as key precursor for many monodentate and multidentate imaging agents for Aβ plaques in human brain, has been readily synthesized with cost-effective starting materials. The important non-radioactive monodentate positron emission tomog. agent [F]florbetapir ([F]AV-45) has also been prepared by this new method. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Recommanded Product: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Exploitation of distillation for energy-efficient and cost-effective environmentally benign process of waste solvents recovery from semiconductor industry was written by Lee, Aejin;Naquash, Ahmad;Lee, Moonyong;Chaniago, Yus Donald;Lim, Hankwon. And the article was included in Science of the Total Environment in 2022.Category: ethers-buliding-blocks This article mentions the following:

The waste solvent is unavoidably generated from the high solvent dependable processes. One of them is the semiconductor industry. The waste solvent is frequently incinerated to eliminate hazardous waste and this practice raises the issue of environmental and treatment costs. Thus, recovery of waste solvent is a substantial environmental mitigation option. This study explores the recovery of multicomponent waste solvents from the semiconductor industry. To achieve a greener and energy-efficient process, the recovery process is proposed through investigation of mixture thermodn. behavior, process design, optimization, economics, and integration of renewable energy for environmental advantages. Herein, Distillation, a practical technol. option for solvent recovery, with green solvent for extractive distillation and a new approach using renewable energy in waste solvent recovery are explored. As the result, waste solvent recovery by distillation with conventional energy exhibits bold advantages to cost and lower carbon process compared to waste disposal. The integration of renewable energy with about 37% share of conventional energy as the backup indicates the highest annual cost-saving and reduces about 89.4% of annual carbon emission compared to carbon emission from waste disposal. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Category: ethers-buliding-blocks).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ru Doped Hydrotalcite Catalyzed Borrowing Hydrogen-Mediated N-Alkylation of Benzamides, Sulfonamides, and Dehydrogenative Synthesis of Quinazolinones was written by Sardar, Bitan;Jamatia, Ramen;Samanta, Arup;Srimani, Dipankar. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 105-13-5 This article mentions the following:

An efficient Ru doped hydrotalcite catalyzed N-alkylation of benzamides and sulfonamides with alcs. via borrowing hydrogen catalysis is illustrated. Various primary alcs., including benzyl, heteroaryl, and aliphatic alcs., were alkylated in good to excellent yields. To shed light on the mechanistic details, several control studies and deuterium labeling experiments were performed. Mechanistic studies underpin that the reaction is going via a borrowing hydrogen pathway rather than an S_N1 type mechanism. The reaction can be easily scaled up without any detrimental effect on the yield. The catalyst is also capable of synthesizing quinazolinone directly from 2-aminobenzamide and alcs. Successful recyclability and high reactivity highlight the practical applicability of the catalyst. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Characterization of the chemical differences between solvent extracts from Pu-erh tea and Dian Hong black tea by CP-Py-GC/MS was written by Gong, Jia-shun;Tang, Chao;Peng, Chun-xiu. And the article was included in Journal of Analytical and Applied Pyrolysis in 2012.Recommanded Product: 20324-33-8 This article mentions the following:

Solvent extracts from a type of Pu-erh tea and Dian Hong black tea were characterized by Curie-point pyrolysis-gas chromatog.-mass spectroscopy (CP-Py-GC/MS). The ethyl-acetate extracts from both teas showed similar CP-Py-GC/MS results, with main pyrolytic products of carbon dioxide, caffeine, o-phenols, and phthalate esters. During pyrolysis, the n-butanol extract from Pu-erh tea formed carbon dioxide (38.92% of total pyrolytic products), alkaloids (49.7%), and nitrogen oxides (8.38%), as well as a small fraction of esters. The n-butanol extract from Dian Hong tea formed mainly alcs., amines, esters, phenols, carboxylic acids, and alkaloids. The raw theabrownin extracts (ethanol precipitates) from the two teas produced substantially different CP-Py-GC/MS results. The raw theabrownin extract from Pu-erh tea formed mostly carbon dioxide during pyrolysis, whereas the counterpart extract from Dian Hong tea formed mainly carbon dioxide (48.23%) and nitrogen oxides (35.39%). The 3.5-100 kDa fractions separated from the theabrownin extracts of the two teas showed similar CP-Py-GC/MS results, whereas the fractions <3.5 kDa and >100 kDa formed substantially different pyrolytic products. These results showed that solvent extracts from Pu-erh tea and Dian Hong tea had substantially different chem. compositions and structures. The study suggested that CP-Py-GC/MS can be used to effectively identify chem. differences between tea extracts In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Recommanded Product: 20324-33-8).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 20324-33-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem