Month: January 2023

Fenitrothion and 3-methyl-4-nitrophenol degradation by two bacteria in natural waters under laboratory conditions was written by Alonso, Jose L.;Sabater, Consuelo;Ibanez, Maria J.;Amoros, Inmaculada;Botella, Maria S.;Carrasco, Jose. And the article was included in Journal of Environmental Science and Health, Part A: Environmental Science and Engineering & Toxic and Hazardous Substance Control in 1997.Related Products of 5367-32-8 This article mentions the following:

The ability of 2 bacterial strains, Flavobacterium strain ATCC 27551, and Arthrobacter aurescens strain TW17, to degrade fenitrothion and the product of its hydrolysis, 3-methyl-4-nitrophenol (MNP), in natural water under laboratory conditions was studied. Fenitrothion was degraded by Flavobacterium whereas MNP was not. In comparison, MNP was metabolized by A. aurescens and fenitrothion was not. Natural microbial populations did not decompose fenitrothion and MNP; however Flavobacterium and A. aurescens degraded these compounds in the presence of the natural microbial population. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Related Products of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Stereoselective synthesis of 3,4-trans-disubstituted γ-lactams by cerium(IV) ammonium nitrate mediated radical cyclization of cinnamamides was written by Nair, Vijay;Mohanan, Kishor;Suja, Tachapully D.;Biju, Akkattu T.. And the article was included in Synthesis in 2007.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A facile synthesis of 3,4-trans-disubstituted γ-lactams, e.g., I, was developed, consisting of the radical cyclization of cinnamamides mediated by cerium(IV) ammonium nitrate. The single-electron-transfer reaction of the methoxystyrenyl moiety mediated by cerium(IV) ammonium nitrate gives rise to a cation radical, whose cyclization followed by reaction with oxygen and methanol generates 3,4-trans-disubstituted γ-lactams. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and herbicidal activity of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives was written by Zhang, Hao;Li, Qibo;Liu, Kechang;Liu, Ruiquan;Li, Qingyang;Wang, Qingmin;Liu, Shangzhong. And the article was included in Youji Huaxue in 2015.Related Products of 1877-75-4 This article mentions the following:

In order to find new herbicidal leading compounds, a series of N-(4-chloro-2-fluoro-5-substituted phenyl)isoindole-1,3-dione derivatives were designed and synthesized via the strategy of linking active sub-structures which are chlorophthalim and phenoxy carboxylic ester. The target compounds were synthesized from starting material 2-chloro-4-fluoro-5-nitrophenol in four steps, and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay results indicated that most compounds exhibited excellent herbicidal activities at 1,500 g/ha in both pre- and post-emergence treatments against Abutilon theophrasti and Amaranthus retroflexus. On the basis of advanced screening tests, compound 6d exhibited 100% inhibitory effect against Abutilon theophrasti and Amaranthus retroflexus at 750 g/ha, compounds 7a and 7i were much more effective against Abutilon theophrasti than com. acifluorfen with 80%-86% inhibitory activity at 22.5 g/ha. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, complexation, and fluorescence behavior of 3,4-dimethylthieno[2,3-b]thiophene carrying two monoaza-15-crown-5 ether groups was written by Wu, Yong-Xiang;Cao, Jing;Deng, Hai-Yan;Feng, Jun-Xiang. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2011.COA of Formula: C10H21NO4 This article mentions the following:

A novel fluoroionophore I based on 3,4-dimethylthieno[2,3-b]thiophene bearing two monoaza-15-crown-5 ethers at the 3- and 4-positions was prepared UV-vis and fluorescence responses of compound I upon the addition of alkali and alk. earth metal cations were evaluated in acetonitrile solution Receptor I showed a unique response for Ba²⁺ due to the formation of an intramol. sandwich complex. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).COA of Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The asarone-derived phenylpropanoids from the rhizome of Acorus calamus var. angustatus Besser was written by Bai, Yajun;Sun, Ying;Xie, Jing;Li, Bin;Bai, Yujun;Zhang, Dongxu;Liang, Jing;Xiao, Chaoni;Zhong, Aiguo;Cao, Yanjun;Zheng, Xiaohui. And the article was included in Phytochemistry (Elsevier) in 2020.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

Phenylpropanoids comprise a broad spectrum of biol. active natural products. As part of our ongoing research on antiepileptic active compounds from traditional Chinese herb, Acorus calamus var. angustatus Besser, three undescribed phenylpropanoids and twenty-two known ones were isolated. All the undescribed structures were determined by a combination of 1D and 2D NMR, HRMS. In addition, γ-asaronol was identified as racemates and its absolute configuration were determined by the modified Mosher′s method and ECD spectral data. Furthermore, some selected isolated compounds were evaluated for their cell viability and neuroprotective activities in H₂O₂-induced SH-SY5Y cells. α-Asaronol, β-asaronol, 3-(2,4,5-trimethoxyphenyl)propan-1-ol and 1,2,4-trimethoxy-5-(3-methoxypropyl)benzene exerted potential protective activity from neuronal oxidative stress in all test concentrations ranging from 0.01 to 100 μM, in which the neuroprotective activity of β-asaronol was the best. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A general method for the synthesis of isatins: preparation of regiospecifically functionalized isatins from anilines was written by Hewawasam, Plyasena;Meanwell, Nicholas A.. And the article was included in Tetrahedron Letters in 1994.Related Products of 56619-93-3 This article mentions the following:

A new method has been developed for regiospecific conversion of substituted anilines to isatins. The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with di-Et oxalate to furnish an α-ketoester. Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Related Products of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Convergent reductive depolymerization of wood lignin to isolated phenol derivatives by metal-free catalytic hydrosilylation was written by Feghali, Elias;Carrot, Geraldine;Thuery, Pierre;Genre, Caroline;Cantat, Thibault. And the article was included in Energy & Environmental Science in 2015.COA of Formula: C11H16O3 This article mentions the following:

The first examples of reductive depolymerization of lignin are reported under metal-free conditions. Using hydrosilanes as reductants and B(C₆F₅)₃ as a Lewis acid catalyst, wood lignin is efficiently converted to a narrow distribution of phenol derivatives at room temperature A three-step methodol. based on the selection of the wood species and the lignin extraction method followed by a convergent reductive depolymerization enables the production of four structurally defined aromatic compounds The phenol products were successfully isolated in 7-24 wt% yield from lignin and 0.5-2.4 wt% yield from wood. The strategy is found to be robust and is applied to 15 different wood plants, including gymnosperm and angiosperm species. The efficiency of this novel methodol. has been evaluated based on spectroscopic characterization of the lignin preparations and isolated yields of mono-aromatic products. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3COA of Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Accurate and simple method for simultaneous determination of restricted ethylene glycol ethers and esters in leather by GC-MS was written by Ma, He-Wei;Luo, Jian-Xun. And the article was included in Journal of the Society of Leather Technologists and Chemists in 2021.Reference of 112-49-2 This article mentions the following:

An anal. approach was developed for the simultaneous determination of the eight ethylene glycol ethers (EGEs) and esters (EGEEs) prohibited by European Union (EU) REACH regulation in leather samples. The analytes were extracted using methanol with ultrasonic assistance within 30 min. The extracts were cleaned up by passing the extraction solution through a cartridge containing alumina-N frits, and the eluate was injected into GC-MS which was fitted with a 60m length capillary DB-WAX column. Excellent separation of the eight EGEs/EGEEs was achieved by the capillary column within 25 min. The clean-up with Alumina-N cartridge presented desired efficiency for removing the co-extractives in the extracts The major advantages of this method are the simplicity and accuracy. Limitation of the detection, linear range, and reproducibility of the method were evaluated. Average recoveries in the range of 91.7%-102.5% (RSD, ≤6.1%) with detection limits at 3.0-9.4mg/kg for the eight targets were obtained. Anal. results showed that ethylene glycol di-Me ether (EGDME), ethylene glycol Et ether (EGEE), and diethylene glycol di-Me ether (DEGDME), were found in 22% of 95 leather samples at the concentration range of 35-82mg/kg, 12-285mg/kg and 28-66mg/kg, resp., while the other five EGEs/EGEEs were not detected. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Reference of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Machine learning-based prediction of toxicity of organic compounds towards fathead minnow was written by Chen, Xingmei;Dang, Limin;Yang, Hai;Huang, Xianwei;Yu, Xinliang. And the article was included in RSC Advances in 2020.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

Predicting the acute toxicity of a large dataset of diverse chems. against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approx. ratio of 1 : 1. Only six mol. descriptors were used to establish the quant. structure-activity/toxicity relationship (QSAR/QSTR) model for 96 h pLC₅₀ through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R² = 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (q_int² = 0.699 and q_ext² = 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six mol. descriptors and a large data set for the test set consisting of 481 compounds In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nucleophilic attack of intramolecular hydroxyl groups on electron-rich aromatics using hypervalent iodine(III) oxidation was written by Hata, Kayoko;Hamamoto, Hiromi;Shiozaki, Yukiko;Caemmerer, Simon B.;Kita, Yasuyuki. And the article was included in Tetrahedron in 2007.Electric Literature of C11H16O3 This article mentions the following:

The hypervalent iodine(III) reagent, phenyliodine bis(trifluoroacetate) (PIFA)-mediated oxidative nucleophilic substitution of electron-rich aromatics involving aromatic cation radical intermediates was utilized in the direct aromatic carbon-oxygen bond formation reaction, and a novel and simple synthetic method for chroman derivatives was developed. E.g., in presence of PIFA, intramol. oxidative cyclization of hydroxy-substituted benzene I gave up to 55% chroman II. As an extension of this methodol., a facile access to spirodienone derivatives was also achieved. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Electric Literature of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Electric Literature of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem