Month: January 2023

Cheeseright, Timothy J. et al. published their research in Journal of Medicinal Chemistry in 2009 | CAS: 1877-75-4

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 1877-75-4

Novel Lead Structures for p38 MAP Kinase via FieldScreen Virtual Screening was written by Cheeseright, Timothy J.;Holm, Melanie;Lehmann, Frank;Luik, Sabine;Gottert, Marcia;Melville, James L.;Laufer, Stefan. And the article was included in Journal of Medicinal Chemistry in 2009.Related Products of 1877-75-4 This article mentions the following:

The p38 MAP kinase has received considerable interest in the pharmaceutical industry and remains a valid and interesting target for the treatment of inflammation. To discover novel p38 inhibitors, the ligand-based virtual screening technique, FieldScreen, was applied to 1.2 million com. available compounds Fifty-eight diverse compounds were selected for biol. anal., using mol. field similarity to known inhibitors, while explicitly removing any structure that shared a scaffold with previously reported p38 inhibitors. Of these, 11 (19%) showed ≥20% inhibition of p38 at 10 μM. Analogs of two distinct chem. series were prepared, resulting in a potential lead compound with pIC50 of 6.4. Modeling of SAR using FieldAlign, a ligand alignment protocol, was used to rationalize the SAR of the series of thiadiazole based inhibitors. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palframan, Matthew J. et al. published their research in Synlett in 2011 | CAS: 3929-47-3

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Radical addition of silanes to alkenes followed by oxidation was written by Palframan, Matthew J.;Parsons, Andrew F.;Johnson, Paul. And the article was included in Synlett in 2011.Category: ethers-buliding-blocks This article mentions the following:

Phenyldimethylsilane and trichlorosilane are shown to undergo efficient radical hydrosilylation reactions, on reaction with various alkenes, using triethylborane as the initiator. Adducts from the trichlorosilane reactions can be oxidized to afford alcs. in good yields. This two-step process leads to the anti-Markovnikov hydration of alkenes. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Stubing, D. B. et al. published their research in Organic & Biomolecular Chemistry in 2016 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

Crowned spiropyran fluoroionophores with a carboxyl moiety for the selective detection of lithium ions was written by Stubing, D. B.;Heng, S.;Abell, A. D.. And the article was included in Organic & Biomolecular Chemistry in 2016.Category: ethers-buliding-blocks This article mentions the following:

The absorbance and fluorescence spectra of carboxylated spiropyrans containing methyl-1-aza-12-crown-4, methyl-1-aza-15-crown-5, methyl-1-aza-18-crown-6 moieties are compared. Characteristic changes in spectra after addition of the alkali metal salts of Li+, Na+, K+ and Cs+ were observed Chromism induced by the binding of the metal cations was observed as an increase in absorbance and fluorescence. Of these metal cations, the Li+ ion produced the largest change in all three spiropyran systems. Reversible photoswitching of the spiropyran-metal complexes was observed on irradiation with alternating 352 nm UV and white light. This results in reversible fluorescence based sensing of lithium ions with potential for use in a biol. sensor device. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Category: ethers-buliding-blocks).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Le Corre, M. et al. published their research in Tetrahedron in 1985 | CAS: 5367-32-8

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 5367-32-8

New access to indoles by ylide-amide condensation was written by Le Corre, M.;Hercouet, A.;Le Stanc, Y.;Le Baron, H.. And the article was included in Tetrahedron in 1985.Related Products of 5367-32-8 This article mentions the following:

o-Acylaminobenzylidenephosphoranes lead to indoles in good yield by an intramol. Wittig reaction with the amide carbonyl group. Mechanistic aspects are discussed. A general method is described for the synthesis of indoles from o-nitrobenzyl bromides and o-aminobenzyl alcs. Thus, o-AcNHC6H4CH2PPh3, prepared in 3 steps from 2-O2NC6H4Me, was treated with base to give the indole I in 96% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Related Products of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kerzhentsev, Mikhail et al. published their research in Catalysis Today in 1996 | CAS: 5367-32-8

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 3-Methyl-4-nitroanisole

Photocatalytic pollutant removal in water at room temperature: case study of the total degradation of the insecticide fenitrothion (phosphorothioic acid O,O-dimethyl-O- (3-methyl-4-nitro-phenyl) ester) was written by Kerzhentsev, Mikhail;Guillard, Chantal;Herrmann, Jean-Marie;Pichat, Pierre. And the article was included in Catalysis Today in 1996.Application In Synthesis of 3-Methyl-4-nitroanisole This article mentions the following:

The photocatalytic purification of water containing fenitrothion was performed in TiO2 aqueous suspensions. Mineralization into CO2, H2PO4–, SO42-, NO3– was achieved. Several intermediates were identified by HPLC and gas chromatog.-mass spectrometry. They illustrate the transformation of P:S into P:0, the splitting between the P part and the aromatic moiety, and the transfer of Me or methoxy groups. Formate ions, principally produced from the CH3O and CH3 groups, and acetate ions were also detected as intermediate products. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Application In Synthesis of 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gurumurthy, R. et al. published their research in Oxidation Communications in 1993 | CAS: 1877-75-4

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Formula: C9H10O4

Ruthenium(III)-catalyzed oxidation of phenoxyacetic acids by aqueous phenyliodoso acetate was written by Gurumurthy, R.;Karunakaran, K.;Sathiyanarayanan, K.. And the article was included in Oxidation Communications in 1993.Formula: C9H10O4 This article mentions the following:

The kinetics of oxidation of phenoxyacetic acid and its derivatives (19 compounds) by phenyliodoso acetate has been studied in 60% (volume/volume) aqueous acetic acid. The reaction is first order with respect to both phenoxyacetic acid and phenyliodoso acetate and is catalyzed by hydrogen ions. Catalysis by Ru(III) is observed A Hammett ρ value of -2.62 at 35° indicates an electron-deficient transition state. The oxidation rates of ortho-substituted compounds have been analyzed by applying Taft’s steric energy parameters. A suitable mechanism has been proposed. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Long, Wei et al. published their research in Arabian Journal of Chemistry in 2022 | CAS: 105-13-5

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Computed Properties of C8H10O2

A switchable-oxidative cellulose filter paper bearing immobilized Mn(III)-salen complex for alcohol oxidation was written by Long, Wei;Sevbitov, Andrei;Abdalkareem Jasim, Saade;Kravchenko, Olga;Al-Gazally, Moaed E.;Chupradit, Supat;Kzar, Hamzah H.;Kazemnejadi, Milad. And the article was included in Arabian Journal of Chemistry in 2022.Computed Properties of C8H10O2 This article mentions the following:

Surface modifications of polysaccharide filter papers can alter their catalytic properties significantly. In particular, polysaccharides have gained increasing interest in the development of heterogeneous catalysts. This wok introduces a new approach to the heterogeneous/ sustainable catalytic system preparation based on a catalytic filter paper modified by silylation followed by immobilization of a Mn(III)-salen complex as a novel “catalytic filtration” or “portable catalysis”. Oxidation of alcs. as well as direct conversion of alcs. to Schiff bases and oximes were performed by filtration and passing the reactants through the modified filter paper. Oxidation of benzyl alc. in the presence of mol. oxygen and NaOCl, selectively leads to aldehydes and carboxylic acids, resp. The direct conversion of alcs. to Schiff bases and oximes resulted in the formation of insoluble products on the filter paper. Another advantage of the modified filter paper was its stability and reusability for several times with preservation of the catalytic activity and swellability, which no shrinkage during consecutive wetting-drying cycles was observed Also, a deep study was conducted over mechanism, reusability/stability, and control experiments of the alc. oxidation This study gave new insights into the catalytic propensities of a cellulose filter paper via filtration of reactants. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Computed Properties of C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Computed Properties of C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Duan, Yongli et al. published their research in Journal of Physical Chemistry B in 2022 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 66943-05-3

Controlling the Isomerization of Photoresponsive Molecules through a Limiting Tautomerization Strategy was written by Duan, Yongli;Zhao, Haiquan;Xue, Guodong;Sun, Fanxi;Stricker, Friedrich;Wang, Zhen;Mao, Lijun;He, Chao;de Alaniz, Javier Read;Zheng, Yonghao;Wang, Dongsheng. And the article was included in Journal of Physical Chemistry B in 2022.Related Products of 66943-05-3 This article mentions the following:

Controlling the multistage photoresponsivity remains a challenge, in part, due to the spontaneous tautomerization between isomers. Herein, we present a strategy to access three independent states (linear, cyclic keto, and cyclic enolate) of crown ether (CE)-substituted donor-acceptor Stenhouse adducts (DASAs) by limiting the tautomerization of the closed isomers. The linear-cyclic keto isomerization is reversibly triggered by treatment with metal ions (Na+ or K+) and CE, while the linear-cyclic enolate isomerization is induced by green light and heat. D. functional theory and mol. dynamics calculation results suggest that the steric effect and supramol. interaction between the electron-donating and electron-withdrawing moieties play an important role in hindering the tautomerization between cyclic keto and cyclic enolate DASA-CE. The strategy to influence key steps in the photoswitching process inspires well-controlled multistage isomerization of photoresponsive mols. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Related Products of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Moriuchi, Toshiyuki et al. published their research in Chemistry Letters in 2017 | CAS: 16356-02-8

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Oxidative bromination reactions in aqueous media by using Bu4NBr/TFA/H2O2 system was written by Moriuchi, Toshiyuki;Fukui, Yasuhiro;Sakuramoto, Takashi;Hirao, Toshikazu. And the article was included in Chemistry Letters in 2017.Category: ethers-buliding-blocks This article mentions the following:

Metal-free oxidative bromination reactions in aqueous media were performed using combination of tetrabutylammonium bromide as a a bromide source, trifluoroacetic acid as an acid and hydrogen peroxide as an oxidant under mild conditions. Oxidative bromination reaction of alkenes R1CH:CHR2 [R1 = HO(CH2)4, n-C8H17, PhCH2, R2 = H; R1 = Ph, R2 = HOCH2] and alkynes R3CCR4 (R3 = Ph, R4 = Me; R3 = R4 = MeOCH2) afforded the corresponding vicinal dibromides R1CHBrCHBrR2 and (E)-R3CBr:CR4Br, resp. Furthermore, this oxidative bromination system was applicable to the oxidative bromination of arenes, i.e. 2,6-dimethylphenol and 1,3,5-trimethoxybenzene, and 3,4-dihydronaphthalen-1(2H)-one. A gram-scale bromination reaction was also performed successfully. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Category: ethers-buliding-blocks).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gonzalez, Juan A. et al. published their research in Journal of Solution Chemistry in 2020 | CAS: 112-49-2

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 112-49-2

Volumetric and Viscosimetric Measurements for Methanol + CH3-O-(CH2CH2O)n-CH3 (n = 2, 3, 4) Mixtures at (293.15-303.15) K and Atmospheric Pressure: Application of the ERAS Model was written by Gonzalez, Juan A.;Martinez, Francisco J.;Sanz, Luis F.;Hevia, Fernando;de la Fuente, Isaias Garcia;Cobos, Jose C.. And the article was included in Journal of Solution Chemistry in 2020.Application of 112-49-2 This article mentions the following:

Abstract: Densities, ρ, and kinematic viscosities, ν, have been determined at atm. pressure and at 293.15-303.15 K for binary mixtures formed by methanol and one linear polyether of the type CH3-O-(CH2CH2O)n-CH3 (n = 2, 3, 4). Measurements on ρ and ν were carried out, resp., using an Anton Paar DMA 602 vibrating-tube densimeter and an Ubbelohde viscosimeter. The ρ values were used to compute excess molar volumes, VEm, and, together with the ν results, dynamic viscosities (η). Deviations from linear dependence on mole fraction for viscosity, Δη, are also provided. Different semi-empirical equations have been employed to correlate viscosity data. Particularly, the equations used are the: Grunberg-Nissan, Hind, Frenkel, Katti-Chaudhri, McAllister and Heric. Calculations show that better results are obtained from the Hind equation. The VEm values are large and neg. and contrast with the pos. excess molar enthalpies, HEm, available in the literature, for these systems. Methanol + CH3-O-(CH2CH2O)n-CH3 mixtures have been treated in the framework of the ERAS model. Results for HEm are acceptable, while the composition dependence of the VEm curves is poorly represented. This has been ascribed to the existence of strong dipolar and structural effects in the present solutions In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem