Month: January 2023

Synthesis, Structure, and Properties of the 2-[5-(Aryloxyacetyl)-Amino-1,3,4-Thiadiazol-2-Ylthio] Propionate Derivatives was written by Hu, Bing;Zhai, Yue-Yuan;Zhang, Ling;Zhang, You-Ming;Wei, Tai-Bao. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2014.Quality Control of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A series of novel 2-[5-(aryloxyacetyl)-amino-1,3,4-thiadiazol-2-ylthio] propionate derivatives were synthesized in high yield, and their structures were characterized by IR, ¹H NMR, ¹³C NMR, and elemental anal., coupled with one selected single-crystal x-ray structure determination The herbicidal activities of target compounds were assessed. The preliminary bioassay results showed that some compounds exhibited moderate to strong herbicidal symptoms in preemergence and postemergence tests. At 150 g/ha, S. tritici. show tolerance, while E. crus-galli L., E. Dahuricus, A. retroflexus, and C. glaucum L. were killed or severely injured. The activity of some compounds was comparable to the com. herbicide 2,4-D. A suitable electron-withdrawing substituent at the 2- and/or 4-position of the Ph ring was essential for high herbicidal activity. Moreover, the antifungal activities of the compounds were studied. The compounds were found to possess broad-spectrum antifungal activity. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Quality Control of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Market surveillance: analysis of perfuming products for presence of allergens and prohibited substances was written by Sevcik, Vaclav;Andrascikova, Maria;Vavrous, Adam;Moulisova, Alena;Vrbik, Karel;Bendova, Hana;Jirova, Dagmar;Kejlova, Kristina;Hlozek, Tomas. And the article was included in Chemical Papers in 2022.Category: ethers-buliding-blocks This article mentions the following:

The market surveillance study was based on chem. anal. of 166 com. available perfuming products in order to identify the presence of 24 regulated allergens and 21 prohibited substances. For this purpose, several GC methods were tested. The anal. approach for determination of 24 regulated allergens was based on GC-MS and GC-MS/MS anal. Analyses were performed on two different GC columns to avoid potentially overestimated results due to matrix component co-elutions. Allergens determined by the chem. analyses were compared with the allergens declared on the product label to verify whether these products comply with the requirements of the Regulation No 1223/2009 of the European Parliament and of the Council. A specific proportion of the tested cosmetic products (43%) was found as non-compliant either due to a missing list of ingredients or due to the presence of undeclared allergens that were found to be present in the product above limits (0.001%) for required labeling. The GC-MS/MS anal. of 21 prohibited substances did not reveal any of the prohibited compounds in a concentration above LOQ except safrole, which was found in 12 out of 166 tested samples. The concentration of safrole did not exceed the concentration limit permitted by legislation for the presence from natural sources in any of these samples. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Category: ethers-buliding-blocks).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Efficient Polymer Supported Palladium Catalyst for ortho Selective C-H Olefination of Anilides was written by Saranya, Thachora Venu;Sruthi, Pambingal Rajan;Ayana, Nambokkil;Anas, Saithalavi. And the article was included in ChemistrySelect in 2021.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The development of a novel heterogeneous polymer supported palladium catalyst for the oxidative C-H olefination of anilides was described. The catalyst was realized by immobilizing palladium acetate over ethylene diamine modifiedpolyacrylonitrile (PAN) and characterized by means of FTIR, XRD and XPS analyses which evidenced the complexation of Pd(OAc)₂ with the chelating groups in the polymer. The resulting supported complex (en-PAN-Pd) was then explored as an efficient and reusable heterogeneous catalyst for ortho selective C-H activation of anilides on reaction with a number of alkyl acrylates. This reaction protocol served as a useful and greener method for the synthesis of o-alkenyl anilides under mild reaction conditions. The catalyst also exhibited good recyclability and reusability without losing much catalytic activity. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

TiO₂ supported-reduced graphene oxide co-doped with gallium and sulfur as an efficient heterogeneous catalyst for the selective photochemical oxidation of alcohols; DFT and mechanism insights was written by Khavar, Amir Hossein Cheshme;Khazaee, Zeynab;Mahjoub, Ali Reza;Nejat, Razieh. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Recommanded Product: 105-13-5 This article mentions the following:

Achieving organic transformation reactions using green synthesis methods under mild conditions is always an aspiration of scientists. In this study, Ga, S co-doped TiO₂/reduced graphene oxide (GaxSy@TRG) nanocomposite was synthesized by an innovative surfactant-free ultrasonic-assisted solvothermal method and used to catalyze the selective photocatalytic oxidation of benzyl alc. under visible light irradiation The prepared photocatalyst was analyzed via XRD, FT-IR, Raman, N₂ adsorption-desorption, SEM, TEM, EDX, ICP-MS, UV-Vis absorption, and electrochem. impedance spectroscopy (EIS) measurement. The characterization outcomes indicated the prepared co-doped TiO₂ nanoparticles with anatase crystal structure possessed a mesoporous texture and were uniformly distributed on the RGO surface. The conversion of GO to RGO was confirmed through FT-IR and Raman spectra. The prepared nanocomposites were examined for their ability in artificial photocatalysis and displayed remarkable catalytic activity for the selective oxidation of alcs. into benzaldehyde. The co-doped catalysts showed significantly enhanced photocatalytic ability, due to improved photogenerated electrons transfer, enhanced charge carriers separation and extended optical absorption to the visible light range. Moreover, the synergistic effect of dopants that could act as electron trapping centers and RGO as a powerful acceptor material efficiently reduced photogenerated electron-hole recombination and promoted charge migration. A high conversion rate of 85% was obtained over the Ga_5.0S_10.0@TRG photocatalyst after 110 min under visible light irradiation The results from d. functional theory (DFT) calculations revealed that the hybridization of Ga 4s and S 3p orbitals with valance band can remarkably affect the decreasing of band gap energy. The mechanism of photocatalytic oxidation of benzyl alc. under visible light irradiation was proposed using the combination of exptl. and computational methods. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Probing Electrochemical Mg-Ion Activity in MgCr_2-xV_xO₄ Spinel Oxides was written by Kwon, Bob Jin;Lau, Ka-Cheong;Park, Haesun;Wu, Yimin A.;Hawthorne, Krista L.;Li, Haifeng;Kim, Soojeong;Bolotin, Igor L.;Fister, Timothy T.;Zapol, Peter;Klie, Robert F.;Cabana, Jordi;Liao, Chen;Lapidus, Saul H.;Key, Baris;Vaughey, John T.. And the article was included in Chemistry of Materials in 2020.Quality Control of 2,5,8,11-Tetraoxadodecane This article mentions the following:

Mg migration in oxide spinels is impeded by strong affinity between divalent Mg and O, suggesting a necessity of exploring new chem. of solid lattices for functional Mg-ion electrode materials. Cationic mobility with a suitable activation energy in Cr spinels is evidenced by theor. and exptl. results, while redox potentials of V are appropriate to operate with currently limited candidates of nonaqueous electrolytes. By controlling the structure, composition, and complexity, a largely solid-solution MgCrVO₄ spinel was synthesized, which, unlike nanocomposites, can bring together the advantages of each transition metal in the lattice. The spinel was successfully synthesized by a simple solid-state reaction with minor inactive Cr- or V-rich components, which was confirmed via ²⁵Mg MASNMR and high-resolution x-ray diffraction analyses. A thermally and anodically stable Mg(TPFA)₂/triglyme electrolyte was used for high-temperature electrochem. and lowering kinetic barriers at and across interfaces so as to observe intercalation behavior of Mg in the designed lattice. Multimodal characterization confirmed an apparent bulk demagnesiation from MgCrVO₄ with partial reversibility by probing evolution of the local and long-range structure as well as V and Cr electronic states within the lattice. Characterization experiments also provided a direct evidence for (de)intercalation reactions that occurred without any major competitive conversion reactions or insertion of protons into the lattice, except for the formation of a surface rock salt phase upon charge. These findings in Mg-ion activity expand opportunities to design Mg spinel oxide materials while highlighting the need to identify the origins of reversibility challenges due to, but not limited to, phase stability, particularly for the charged states, barriers at the interface, electrolyte stabilities, and desolvation phenomena, collectively hindering practical use as cathode materials. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Quality Control of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Step- and atom-economical synthesis of 2-aryl benzimidazoles via the sulfur-mediated redox condensation between o-nitroanilines and aryl methanols was written by Le, Huy X.;Nguyen, Khoa D.;Phan, Nam T. S.;Le, Ha V.;Nguyen, Tung T.. And the article was included in Tetrahedron in 2022.Name: (4-Methoxyphenyl)methanol This article mentions the following:

2-Nitroanilines and arylmethanols were used in the preparation of 2-aryl benzimidazoles I [R = 6-Me, 4-Me, etc.; R¹ = Ph, 4-ClC₆H₄, etc.] in the presence of elemental sulfur and an amine. Mechanistic results indicated a dual role of sulfur as both oxidizing and reducing agents in this synthetic pathway. A variety of benzimidiazoles containing halogens, as well as trifluoromethyl, methoxy, and cyano groups, plus heterocycles were prepared in moderate-to-good yields. The utilization of more stable and available substrates in the absence of transition metals and other solvents offers a rapid and green synthesis of benzimidazoles. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Name: (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Name: (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of activated carbons derived from avocado shells as cathode materials for lithium-sulfur batteries was written by Fawaz, Wissam;Mosavati, Negar;Abdelhamid, Ehab;Simon Ng, K. Y.. And the article was included in SN Applied Sciences in 2019.Related Products of 112-49-2 This article mentions the following:

Abstract: Novel mesoporous carbon cathode material for Lithium-Sulfur battery were successfully synthesized from the shells of the avocado fruit. The crystalline structure of the formed carbon was characterized via X-Ray diffraction while SEM was used to observe the morphol. The electronic conductivity was determined as a function of pressure and the COOH functional group were quantified via a titration The mesoporous structure of the formed carbon network allows for good sulfur penetration which is translated by decent electrochem. performance both in terms of cycle life and rate capability. Carbons prepared from waste avocado shells and functionalized with HNO₃ offer a good performance in terms of capacity retention (500 mAh/g of sulfur after 100 cycles). This favorable performance may be attributed to the role of functional COOH groups on the surface of the activated carbon. Graphical abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Related Products of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Related Products of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium Nanoflowers Stabilized by a Nitrogen-Rich PEG-Tagged Substrate as Recyclable Catalyst for the Stereoselective Hydrosilylation of Internal Alkynes was written by Guo, Wusheng;Pleixats, Roser;Shafir, Alexandr;Parella, Teodor. And the article was included in Advanced Synthesis & Catalysis in 2015.SDS of cas: 16356-02-8 This article mentions the following:

Morphol. and size controllable Rh nanoparticles stabilized by a N-rich polyoxyethylenated derivative were prepared by reduction of RhCl₃ with NaBH₄ in H₂O at room temperature and fully characterized. The flower-like Rh NPs are effective and recyclable catalysts for the stereoselective hydrosilylation of challenging internal alkynes and diynes, affording the (E)-vinylsilanes in quant. yields for a wide range of substrates. The insolubility of the nanocatalyst in Et₂O allows its easy separation and recycling. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8SDS of cas: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.SDS of cas: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Transfer hydrogenation of aldehydes and ketones catalyzed using an aminophosphinite POCN^H pincer complex of Ni(II) was written by Segizbayev, Medet;Oztopcu, Ozgur;Hayrapetyan, Davit;Shakhman, Dinmukhamed;Lyssenko, Konstantin A.;Khalimon, Andrey Y.. And the article was included in Dalton Transactions in 2020.Category: ethers-buliding-blocks This article mentions the following:

The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes RCHO (R = Ph, thiophen-2-yl, 3-methoxyphenyl, etc.) and ketones R¹C(O)R² (R¹ = Et, Ph, 2-methoxypyridin-6-yl, etc.; R² = Me, Ph, 2-phenylethyl, Et; R¹R² = -(CH₂)₅-) with 2-propanol and KOtBu as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceed via the metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)NiII species. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Category: ethers-buliding-blocks).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury was written by Panel, Mathieu;Ruiz, Isaac;Brillet, Rozenn;Lafdil, Fouad;Teixeira-Clerc, Fatima;Nguyen, Cong Trung;Calderaro, Julien;Gelin, Muriel;Allemand, Fred;Guichou, Jean-Francois;Ghaleh, Bijan;Ahmed-Belkacem, Abdelhakim;Morin, Didier;Pawlotsky, Jean-Michel. And the article was included in Gastroenterology in 2019.Application In Synthesis of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:

Hepatic ischemia/reperfusion injury is a complication of liver surgery that involves mitochondrial dysfunction resulting from mitochondrial permeability transition pore (mPTP) opening. Cyclophilin D (PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates mPTP opening in the inner mitochondrial membrane. We investigated whether and how recently created small-mol. inhibitors of CypD prevent opening of the mPTP in hepatocytes and the resulting effects in cell models and livers of mice undergoing ischemia/reperfusion injury. We measured the activity of 9 small-mol. inhibitors of cyclophilins in an assay of CypD activity. The effects of the small-mol. CypD inhibitors or vehicle on mPTP opening were assessed by measuring mitochondrial swelling and calcium retention in isolated liver mitochondria from C57BL/6J (wild-type) and Ppif-/- (CypD knockout) mice and in primary mouse and human hepatocytes by fluorescence microscopy. We induced ischemia/reperfusion injury in livers of mice given a small-mol. CypD inhibitor or vehicle before and during reperfusion and collected samples of blood and liver for histol. anal. The compounds inhibited peptidyl-prolyl isomerase activity (half maximal inhibitory concentration values, 0.2-16.2 μmol/L) and, as a result, calcium-induced mitochondrial swelling, by preventing mPTP opening (half maximal inhibitory concentration values, 1.4-132 μmol/L) in a concentration-dependent manner. The most potent inhibitor (C31) bound CypD with high affinity and inhibited swelling in mitochondria from livers of wild-type and Ppif-/- mice (indicating an addnl., CypD-independent effect on mPTP opening) and in primary human and mouse hepatocytes. Administration of C31 in mice with ischemia/reperfusion injury before and during reperfusion restored hepatic calcium retention capacity and oxidative phosphorylation parameters and reduced liver damage compared with vehicle. Recently created small-mol. inhibitors of CypD reduced calcium-induced swelling in mitochondria from mouse and human liver tissues. Administration of these compounds to mice during ischemia/reperfusion restored hepatic calcium retention capacity and oxidative phosphorylation parameters and reduced liver damage. These compounds might be developed to protect patients from ischemia/reperfusion injury after liver surgery or for other hepatic or nonhepatic disorders related to abnormal mPTP opening. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Application In Synthesis of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem