Month: February 2023

Synthesis and Photophysics of Fully 锜?Conjugated Heterobis-Functionalized Polymeric Molecular Wires via Suzuki Chain-Growth Polymerization was written by Elmalem, Einat;Biedermann, Frank;Johnson, Kerr;Friend, Richard H.;Huck, Wilhelm T. S.. And the article was included in Journal of the American Chemical Society in 2012.Electric Literature of C14H21BO4 This article mentions the following:

Fully 锜?conjugated polymers of 2-bromo-9,9-dioctylfluoren-2-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane with with d.p. up to 23 and near quant. (>95%) heterobis-functionalization are prepared by a controlled Suzuki chain-growth polymerization, with control over mol. weight, narrow polydispersity, and ability to define polymer end groups. The first end group is introduced through the initiator metal complex tert-Bu₃PPd(X)Br (X = aryl), while the second end group is added by quenching of the chain-growth polymerization with the desired boronic esters. In all cases, polymers obtained at 50% conversion showed excellent end group fidelity and high purity following a simple workup procedure, as determined by MALDI-TOF, GPC, and ¹H and 2D NMR. End group functionalization altered the optoelectronic properties of the bridge polymer. Building on a common fluorene backbone, and guided by DFT calculations, donor and acceptor end groups introduced to create polymeric mol. wires exhibiting charge transfer and energy transfer as characterized by fluorescence, absorption, and transient absorption spectroscopy as well as by fluorescence lifetime measurements. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Electric Literature of C14H21BO4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Electric Literature of C14H21BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study was written by Thanigaimalai, Pillaiyar;Konno, Sho;Yamamoto, Takehito;Koiwai, Yuji;Taguchi, Akihiro;Takayama, Kentaro;Yakushiji, Fumika;Akaji, Kenichi;Kiso, Yoshiaki;Kawasaki, Yuko;Chen, Shen-En;Naser-Tavakolian, Aurash;Schon, Arne;Freire, Ernesto;Hayashi, Yoshio. And the article was included in European Journal of Medicinal Chemistry in 2013.Formula: C9H10O4 This article mentions the following:

This work describes the design, synthesis, and evaluation of low-mol. weight peptidic SARS-CoV 3CL protease inhibitors. The inhibitors were designed based on the potent tripeptidic Z-Val-Leu-Ala(pyrrolidone-3-yl)-2-benzothiazole (I) (K_i = 4.1 nM), in which the P3 valine unit was substituted with a variety of distinct moieties. The resulting series of dipeptide-type inhibitors displayed moderate to good inhibitory activities against 3CL^pro. In particular, compounds (II) (R¹ = OMe, R² = H and R¹ = H, R² = OMe) exhibited good inhibitory activities with K_i values of 0.39 and 0.33 娓璏, resp. These low-mol. weight compounds are attractive leads for the further development of potent peptidomimetic inhibitors with pharmaceutical profiles. Docking studies were performed to model the binding interaction of the compound II (R¹ = OMe, R² = H) with the SARS-CoV 3CL protease. The preliminary SAR study of the peptidomimetic compounds with potent inhibitory activities revealed several structural features that boosted the inhibitory activity: (i) a benzothiazole warhead at the S1′ position, (ii) a 绾?lactam unit at the S1-position, (iii) an appropriately hydrophobic leucine moiety at the S2-position, and (iv) a hydrogen bond between the N-arylglycine unit and a backbone hydrogen bond donor at the S3-position. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo was written by Samara, Pinelopi;Christoforidou, Nikoleta;Lemus, Christelle;Argyropoulou, Aikaterini;Ioannou, Kyriaki;Vougogiannopoulou, Konstantina;Aligiannis, Nektarios;Paronis, Efthimios;Gaboriaud-Kolar, Nicolas;Tsitsilonis, Ourania;Skaltsounis, Alexios-Leandros. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 3929-47-3 This article mentions the following:

Oleuropein is a glucosylated seco-iridoid present in olive fruits and leaves. Due to its broad spectrum of biol. activities, including anticancer properties, oleuropein has attracted scientific attention for the past 20 years. The promising antiproliferative activity of an olive leaf extract enriched in oleuropein against a series of human cancer cell lines, prompted us to proceed with the semi-synthesis of 51 analogs of oleuropein. Following their initial screening against the estrogen receptor neg. breast cancer cell line SKBR3, 7 analogs were shown to display significant cytotoxicity and were further tested against 6 addnl. solid tumor-derived and leukemic cell lines. The analog with the most promising antitumor activity (24) was selected for more detailed studies. 24 was non-toxic to peripheral blood mononuclear cells derived from healthy blood donors when tested at concentrations close to its half maximal inhibitory concentration In vivo administration of 24 in melanoma-bearing mice resulted in reducing tumor size in a dose-dependent manner and in inducing anti-melanoma-reactive immune responses. Our results suggest that analog 24, emerging from the initial structure of oleuropein, represents a promising lead structure for further optimization. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Anti-inflammatory effects of an optimized PPAR-绾?agonist via NF-榄廈 pathway inhibition was written by Ju, Zhiran;Su, Mingzhi;Hong, Jongki;Kim, Eun La;Jung, Jee H.. And the article was included in Bioorganic Chemistry in 2020.Formula: C5H12O3 This article mentions the following:

In our previous study, a PPAR-绾?agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico anal. showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr⁴⁷³ of PPAR-绾?LBD (ligand binding domain). To facilitate addnl. hydrogen bonding with Tyr⁴⁷³, a more polar head group was introduced to the structure of (+)-(R,E)-6a1, and we also attempted to synthesize enzymically stable derivatives Of the synthetic derivatives, compound (+)-(R,E)-5f showed highest PPAR-绾?transcriptional activity and reasonable metabolic stability. Compound (+)-(R,E)-5f suppressed the expression of pro-inflammatory mediators such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), and tumor necrosis factor-浼?(TNF-浼?. Reduction of nitric oxide (NO), and ROS was also observed Compound (+)-(R,E)-5f was found to suppress the NF-榄廈 pathway by inhibiting phosphorylation of IKK (I榄廈 kinase), and this may lead to subsequent inhibition of I榄廈浼?(inhibitor of NF-榄廈浼? phosphorylation and inhibition of NF-榄廈 activation. These results indicate that (+)-(R,E)-5f exerts anti-inflammatory activity via NF-榄廈 pathway inhibition, and may serve as a potential anti-inflammatory lead. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate was written by Mo, Wenyan;Shi, Yanxia;He, Junbo;Li, Baoju;Peng, Hao;He, Hongwu. And the article was included in Journal of Heterocyclic Chemistry in 2016.Related Products of 1877-75-4 This article mentions the following:

A series of novel Et 4-(methyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates I [R¹ = 4-CH₃, 4-OCH₃, 4-Cl, etc.] and Et 4-(trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates II [R¹ = H, 4-CH₃, 4-OCH₃, 4-Cl] were synthesized, and their structures were confirmed by IR, ¹H-NMR, MS spectra and elemental anal. The results of preliminary bioassays show that some of the title compounds exhibited moderate to good herbicidal activities. Compared with the fluorine free compounds I [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F], the compounds bearing fluorine II [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F] showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds II were tested for fungicidal activity against Pseudoperonospora cubensis at 500 娓璯/mL. Compounds II [R¹ = H, 4-F] showed the best fungicidal activity with more than 80% inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcumin Recognizes a Unique Binding Site of Tubulin was written by Chakraborti, Soumyananda;Das, Lalita;Kapoor, Neha;Das, Amlan;Dwivedi, Vishnu;Poddar, Asim;Chakraborti, Gopal;Janik, Mark;Basu, Gautam;Panda, Dulal;Chakrabarti, Pinak;Surolia, Avadhesha;Bhattacharyya, Bhabatarak. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: 6972-61-8 This article mentions the following:

Although curcumin is known for its anticarcinogenic properties, the exact mechanism of its action or the identity of the target receptor is not completely understood. Studies on a series of curcumin analogs, synthesized to investigate their tubulin binding affinities and tubulin self-assembly inhibition, showed that: (i) curcumin acts as a bifunctional ligand, (ii) analogs with substitution at the diketone and acetylation of the terminal phenolic groups of curcumin are less effective, (iii) a benzylidiene derivative, compound 7, is more effective than curcumin in inhibiting tubulin self-assembly. Cell-based studies also showed compound 7 to be more effective than curcumin. Using fluorescence spectroscopy we show that curcumin binds tubulin 32 鑴?away from the colchicine-binding site. Docking studies also suggests that the curcumin-binding site to be close to the vinblastine-binding site. Structure-activity studies suggest that the tridented nature of compound 7 is responsible for its higher affinity for tubulin compared to curcumin. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective Production of Diethyl Maleate via Oxidative Cleavage of Lignin Aromatic Unit was written by Cai, Zhenping;Long, Jinxing;Li, Yingwen;Ye, Lin;Yin, Biaolin;France, Liam John;Dong, Juncai;Zheng, Lirong;He, Hongyan;Liu, Sijie;Tsang, Shik Chi Edman;Li, Xuehui. And the article was included in Chem in 2019.Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:

Green production of bulk chems. traditionally obtained from fossil resources is of great importance. One potential route toward realizing this goal is through the utilization of renewable lignin; however, current techniques generally lead to low product specificity because of the structural diversity of this recalcitrant biopolymer. Herein, we devised a new catalytic system to promote selectively oxidative lignin in air, and di-Et maleate was formed at impressively high yield of 404.8 mg g^-1 and selectivity of 72.7% over the polyoxometalate ionic liquid of [BSmim]CuPW₁₂O₄₀. This high catalytic activity is ascribed to a five-coordinated Cu⁺ species, which, through the formation of end-on dioxygen species in vacant orbitals, facilitates the selective oxidation of basic lignin aromatic units (phenylpropane C₉ units). Therefore, these results represent significant progress toward the realization of an industrially applicable and highly selective lignin oxidation process for the generation of value-added and bulk chems. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heat capacity of six glymes in N,N-dimethylformamide + water mixtures. Solvation of glymes was written by Jozwiak, Malgorzata;Komudzinska, Marlena;Tyczynska, Magdalena;Marczak, Wojciech;Jozwiak, Andrzej. And the article was included in Journal of Molecular Liquids in 2022.Formula: C8H18O4 This article mentions the following:

The paper presents the heat capacities of glyme solutions: monoglyme, diglyme, triglyme, tetraglyme, pentaglyme and hexaglyme, in binary solvents N,N-dimethylformamide + water at four temperatures (293.15 K, 298.15 K, 303.15 K, 308.15 K) obtained using differential calorimeter Micro DSC III, Setaram – France. The concentration of glymes was approx. 0.25 mol/kg. On the basis of the obtained exptl. results, the apparent isobaric heat capacities of the glymes were calculated It was noted that the larger the glyme mol. was, the more pronounced the increase in the value of the apparent molar heat capacity function with the increase in water content in the two-component solvent. The observed changes in apparent isobaric heat capacity as a function of the water content in the mixed solvent are discussed in terms of the hydrophobic nature of the glymes. Moreover, it was shown that the apparent molar isobaric heat capacity of the glymes in pure solvents, i.e. in water and in N,N-dimethylformamide, increases linearly with the increase in the number of oxygen atoms in the glyme mols. i.e. with the size of glyme mols. Furthermore, a linear correlation was observed between the apparent isobaric molar heat capacity and the enthalpic effect of the hydrophobic hydration of the studied glymes at 298.15 K. The results obtained in this paper are compare with the same obtained for selected cyclic ethers. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Formula: C8H18O4).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Formula: C8H18O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photolytic and photocatalytic decomposition of fenitrothion by PW₁₂O₄₀^3- and TiO₂: a comparative study was written by Kormali, P.;Dimoticali, D.;Tsipi, D.;Hiskia, A.;Papaconstantinou, E.. And the article was included in Applied Catalysis, B: Environmental in 2004.Category: ethers-buliding-blocks This article mentions the following:

The photocatalytic degradation of fenitrothion under UV and near visible light in the presence of the polyoxometallate (POM) photocatalyst PW₁₂O₄₀^3- in aqueous solutions has been studied and compared with the photodegradation by TiO₂ suspensions. Fenitrothion is effectively degraded in the presence of both photocatalysts following pseudo-first-order kinetics. Complete mineralization of fenitrothion is achieved using both photocatalysts, leading to the formation of CO₂ and inorganic ions (PO₄^3-, SO₄^2-, NO₂^–, and NO₃^–) as final products. Various intermediates, identical in the presence of both photocatalysts, have been detected and identified using HPLC and gas chromatog.-mass spectrometry (GC-MS) techniques. The similarity of the intermediates by these two methods, i.e., PW₁₂O₄₀^3- and TiO₂, tends to suggest that the photodegradation mechanism of fenitrothion in as other cases as well takes place mainly via a common reagent, i.e., OH radicals. A photodegradation mechanism is proposed. Photolysis of fenitrothion, i.e., in the absence of catalysts, is very slow and far from producing complete mineralization. A relatively large number of intermediates is observed, most of which are not detected in the photocatalytic processes. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Category: ethers-buliding-blocks).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging was written by Andres, Jose-Ignacio;De Angelis, Meri;Alcazar, Jesus;Iturrino, Laura;Langlois, Xavier;Dedeurwaerdere, Stefanie;Lenaerts, Ilse;Vanhoof, Greet;Celen, Sofie;Bormans, Guy. And the article was included in Journal of Medicinal Chemistry in 2011.Related Products of 63071-12-5 This article mentions the following:

We have recently reported the phosphodiesterase 10A (PDE10A) inhibitor 2-[4-[1-(2-[¹⁸F]fluoroethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenoxymethyl]-quinoline (I) as a promising candidate for in vivo imaging using positron emission tomog. (PET). We now describe the synthesis and biol. evaluation of a series of related pyridinyl analogs II (R¹ = FCH₂CH₂, FCH₂CH₂CH₂, F₃CCH₂; R² = 3,5-di-Me, 5-methoxy, 6-bromo, etc.) that exhibit high potency and selectivity as PDE10A inhibitors. The most interesting compounds were injected in rats to measure their levels of PDE10A occupancy through an in vivo occupancy assay. The 3,5-dimethylpyridine derivative II (R¹ = FCH₂CH₂, R² = 3,5-di-Me) and the 5-methoxypyridine derivative II (R¹ = FCH₂CH₂, R² = 5-methoxy) showed a comparable level of occupancy to that of I. Because these derivatives showed lower in vitro activity and are slightly less lipophilic than I, we hypothesized that they could behave as better PET imaging ligands. Compounds II (R¹ = ¹⁸FCH₂CH₂, R² = 3,5-dimethyl; R¹ = ¹⁸FCH₂CH₂, R² = 5-methoxy; R¹ = FCH₂CH₂, R² = 5-¹¹CH₃O) were radio synthesized and subjected to biodistribution studies in rats for a preliminary evaluation as candidate PET radioligands for in vivo imaging of PDE10A in the brain. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Related Products of 63071-12-5).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 63071-12-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem