New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo was written by Samara, Pinelopi;Christoforidou, Nikoleta;Lemus, Christelle;Argyropoulou, Aikaterini;Ioannou, Kyriaki;Vougogiannopoulou, Konstantina;Aligiannis, Nektarios;Paronis, Efthimios;Gaboriaud-Kolar, Nicolas;Tsitsilonis, Ourania;Skaltsounis, Alexios-Leandros. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 3929-47-3 This article mentions the following:
Oleuropein is a glucosylated seco-iridoid present in olive fruits and leaves. Due to its broad spectrum of biol. activities, including anticancer properties, oleuropein has attracted scientific attention for the past 20 years. The promising antiproliferative activity of an olive leaf extract enriched in oleuropein against a series of human cancer cell lines, prompted us to proceed with the semi-synthesis of 51 analogs of oleuropein. Following their initial screening against the estrogen receptor neg. breast cancer cell line SKBR3, 7 analogs were shown to display significant cytotoxicity and were further tested against 6 addnl. solid tumor-derived and leukemic cell lines. The analog with the most promising antitumor activity (24) was selected for more detailed studies. 24 was non-toxic to peripheral blood mononuclear cells derived from healthy blood donors when tested at concentrations close to its half maximal inhibitory concentration In vivo administration of 24 in melanoma-bearing mice resulted in reducing tumor size in a dose-dependent manner and in inducing anti-melanoma-reactive immune responses. Our results suggest that analog 24, emerging from the initial structure of oleuropein, represents a promising lead structure for further optimization. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem