Month: February 2023

Facile Synthesis of Single Iron Atoms over MoS₂ Nanosheets via Spontaneous Reduction for Highly Efficient Selective Oxidation of Alcohols was written by Li, Zhijun;Li, Honghong;Yang, Zening;Lu, Xiaowen;Ji, Siqi;Zhang, Mingyang;Horton, J. Hugh;Ding, Honghe;Xu, Qian;Zhu, Junfa;Yu, Jin. And the article was included in Small in 2022.Formula: C8H10O2 This article mentions the following:

The facile creation of high-performance single-atom catalysts (SACs) is intriguing in heterogeneous catalysis, especially on 2D transition-metal dichalcogenides. An efficient spontaneous reduction approach to access atomically dispersed iron atoms supported over defect-containing MoS₂ nanosheets is herein reported. Advanced characterization methods demonstrate that the isolated iron atoms situate atop of molybdenum atoms and coordinate with three neighboring sulfur atoms. This Fe SAC delivers exceptional catalytic efficiency (1 atm O₂ @ 120鎺? in the selective oxidation of benzyl alc. to benzaldehyde, with 99% selectivity under almost 100% conversion. The turnover frequency is calculated to be as high as 2105 h^-1. Moreover, it shows admirable recyclability, storage stability, and substrate tolerance. D. functional theory calculations reveal that the high catalytic activity stems from the optimized electronic structure of single iron atoms over the MoS2 support. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Formula: C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Blue-light Induced Iron-Catalyzed 浼?Alkylation of Ketones was written by Abdallah, Marie-Samira;Joly, Nicolas;Gaillard, Sylvain;Poater, Albert;Renaud, Jean-Luc. And the article was included in Organic Letters in 2022.Application In Synthesis of (4-Methoxyphenyl)methanol This article mentions the following:

A visible-light induced iron-catalyzed 浼?alkylation of ketones was reported. The photocatalytic system was based on the single diaminocyclopentadienone iron tricarbonyl complex. Two catalytic intermediates of this complex were able to harvest light allowing the synthesis of substituted aromatic and aliphatic ketones such as RC(O)CH₂CH₂R¹ [R = t-Bu, 4-MeC₆H₄, 2-furyl, etc.; R¹ = Ph, 2-thienyl, 4-BrC₆H₄, etc.] at room temperature using the borrowing hydrogen strategy in the presence of various substituted primary alcs. as alkylating reagents. Preliminary mechanistic studies unveiled the role of light for both the dehydrogenation and reduction step. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Application In Synthesis of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application In Synthesis of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions was written by Pan, Xian-Dao;Han, Rui;Sun, Piao-Yang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human cancer cell lines in vitro. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationships of macrolides against Mycobacterium tuberculosis was written by Zhu, Zhaohai J.;Krasnykh, Olga;Pan, Dahua;Petukhova, Valentina;Yu, Gengli;Liu, Yinghui;Liu, Huiwen;Hong, Saweon;Wang, Yuehong;Wan, Baojie;Liang, Wenzhong;Franzblau, Scott G.. And the article was included in Tuberculosis (Oxford, United Kingdom) in 2008.Safety of 1,1-Diisopropoxycyclohexane This article mentions the following:

Existing 14, 15 and 16-membered macrolide antibiotics, while effective for other bacterial infections, including some mycobacteria, have not demonstrated significant efficacy in tuberculosis. Therefore an attempt was made to optimize this class for activity against Mycobacterium tuberculosis through semisyntheses and bioassay. Approx. 300 macrolides were synthesized and screened for anti-TB activity. Structural modifications on erythromycin were carried out at positions 3, 6, 9, 11, and 12 of the 14-membered lactone ring; as well as at position 4″ of cladinose and position 2′ of desosamine. In general, the synthesized macrolides belong to four subclasses: 9-oxime, 11,12-carbamate, 11,12-carbazate, and 6-O-substituted derivatives Selected compounds were assessed for mammalian cell toxicity and in some cases were further assessed for CYP3A4 inhibition, microsome stability, in vivo tolerance and efficacy. The activity of 11,12-carbamates and carbazates as well as 9-oximes is highly influenced by the nature of the substitution at these positions. For hydrophilic macrolides, lipophilic substitution may result in enhanced potency, presumably by enhanced passive permeation through the cell envelope. This strategy, however, has limitations. Removal of the C-3 cladinose generally reduces the activity. Acetylation at C-2′ or 4″ maintains potency of C-9 oximes but dramatically decreases that of 11,12-substituted compounds Further significant increases in the potency of macrolides for M. tuberculosis may require a strategy for the concurrent reduction of ribosome methylation. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Safety of 1,1-Diisopropoxycyclohexane).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 1,1-Diisopropoxycyclohexane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iridium-Catalyzed Carbonylative Synthesis of Chromenones from Simple Phenols and Internal Alkynes at Atmospheric Pressure was written by Zhu, Fengxiang;Li, Yahui;Wang, Zechao;Wu, Xiao-Feng. And the article was included in Angewandte Chemie, International Edition in 2016.HPLC of Formula: 16356-02-8 This article mentions the following:

A novel procedure on the carbonylative synthesis of chromenones was developed. With simple phenols and internal alkynes as the substrates, various chromenones were isolated in moderate to good yields with excellent regioselectivity and functional-group tolerance by using iridium as the catalyst and copper as the promotor at atm. pressure. Notably, this is the first example on carbonylative annulation of simple phenols and alkynes. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8HPLC of Formula: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total Synthesis and Evaluation of B-Homo Palmatine and Berberine Derivatives as p300 Histone Acetyltransferase Inhibitors was written by Yang, Zhongzhen;Zhang, Yong;Chen, Xin;Li, Weijian;Li, Guo-Bo;Wu, Yong. And the article was included in European Journal of Organic Chemistry in 2018.Related Products of 3929-47-3 This article mentions the following:

Palmatine and berberine, structurally similar isoquinoline alkaloids exhibiting a broad range of biol. activities, were recently found to inhibit p300 histone acetyltransferase (HAT), a potential therapeutic target for treating transcriptional activator-driven malignancies and diseases. Here, we report the first total synthesis of B-homo palmatine and berberine derivatives, which were synthesized from 3,4-dimethoxybenzaldehyde and benzo[d][1,3]dioxole-5-carbaldehyde in nine steps in 13.8% and 16.9% overall yields, resp. A number of other new B-homo palmatine and berberine derivatives were also prepared These derivatives display good inhibitory activity against p300 HAT; compound I manifests the most potent inhibition with an IC₅₀ value of 0.42 娓璏. Cell-based assays revealed that I exhibits certain inhibitory activity against HCG27, HT1080, and Z-138 cell lines, and no visible activity towards other cancer cell lines tested, reflecting that I has low cytotoxicity and acts against some types of cancer cells. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of supramolecular complexes based on tetracrown-substituted zinc porphyrinates was written by Mikhailitsyna, E. A.;Tyurin, V. S.;Beletskaya, I. P.. And the article was included in Protection of Metals and Physical Chemistry of Surfaces in 2010.Computed Properties of C10H21NO4 This article mentions the following:

New metal-porphyrin receptors functionalized by aza-crown-ether groups were synthesized. Main paths of supramol. self-assembly of porphyrin aza-crown-ether conjugates to bis-porphyrin sandwich complexes with metal and ammonium cations were studied using spectral methods of anal. (EAS, ¹H, ¹³CNMR, MALDI-ToF mass spectrometry). Principal regularities of axial coordination of the obtained bis-porphyrin complexes with exobidentate ligands (1,4-diazabicyclo[2.2.2]octane and pyrazine) were studied. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Topological Effects of Dendronized Polymers on Their Thermoresponsiveness and Microconfinement was written by Xu, Gang;Zhang, Jiaxing;Jia, Ruitong;Li, Wen;Zhang, Afang. And the article was included in Macromolecules (Washington, DC, United States) in 2022.SDS of cas: 112-49-2 This article mentions the following:

Topol. structures can provide dendritic polymers with featured properties through cooperative effects beyond their mol. structures. Herein, we report the synthesis of a series of oligoethylene glycol (OEG)-based dendronized polymers, which carry the first generation of 2-fold, 4-fold, or 6-fold dendritic OEG pendants with methoxyl or ethoxyl terminals. Depending on the OEG branching d., these polymers show different mol. thicknesses and exhibit characteristic thermoresponsiveness with phase transition temperatures in the range of 16.6-67.2鎺矯. Furthermore, the higher the OEG branching d., the higher the shielding to the interior parts from the dendritic OEGs cooperatively to exhibit “mol. envelope” effects. This mol. microconfinement formed from the crowded OEG dendrons was further investigated through covalently linked or phys. mixed dye. Topol. structures of the polymers are discovered to play a key role in encapsulation of the dye guest and can modulate its transition within the aggregates through the thermally induced phase transitions. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2SDS of cas: 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.SDS of cas: 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Polypode ligands as phase-transfer catalysts was written by Fornasier, Roberto;Montanari, Fernando;Podda, Gianni;Tundo, Pietro. And the article was included in Tetrahedron Letters in 1976.Related Products of 60221-37-6 This article mentions the following:

Polyethers prepared from sym-trichlorotriazine and decylpentaerythritol were phase-transfer catalysts for substitution reactions of Me(CH2)7Br (I), butylation of PhCH2COMe (II), and reduction of Me(CH2)5COMe (III). E.g., I with KI, II with BuBr, and III with NaBH4 in the presence of the triazine derivative IV gave 85% Me(CH2)7I, 78% PhCHBuCOMe, and 97% Me(CH2)5CH(OH)Me, resp. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Related Products of 60221-37-6).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 60221-37-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue was written by Streeter, Matthew D.;Rowan, Sheldon;Ray, Jason;McDonald, David M.;Volkin, Jonathan;Clark, Jonathan;Taylor, Allen;Spiegel, David A.. And the article was included in ACS Chemical Biology in 2020.Application of 111-77-3 This article mentions the following:

Although there is ample evidence that the advanced glycation end-product (AGE) glucosepane contributes to age-related morbidities and diabetic complications, the impact of glucosepane modifications on proteins has not been extensively explored due to the lack of sufficient anal. tools. Here, the authors report the development of the first polyclonal anti-glucosepane antibodies using a synthetic immunogen that contains the core bicyclic ring structure of glucosepane. The authors study the recognition properties of these antibodies through ELISAs involving an array of synthetic AGE derivatives and determine them to be both high-affinity and selective in binding glucosepane. The authors then employ these antibodies to image glucosepane in aging mouse retinae via immunohistochem. The authors’ studies demonstrate for the first time accumulation of glucosepane within the retinal pigment epithelium, Bruch’s membrane, and choroid: all regions of the eye impacted by age-related macular degeneration. Co-localization studies further suggest that glucosepane colocalizes with lipofuscin, which has previously been associated with lysosomal dysfunction and has been implicated in the development of age-related macular degeneration, among other diseases. The authors believe that the anti-glucosepane antibodies described in this study will prove highly useful for examining the role of glycation in human health and disease. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Application of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem