Author: Jessica.F

Adding a certain compound to certain chemical reactions, such as: 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2132-62-9, HPLC of Formula: C16H14O2

In a clean quartz reactor, add acetophenone oxime (27.0 mg, 0.20 mmol), bis (4-methoxyphenyl) acetylene (57.1 mg, 0.24 mmol), and bis(2-methylallyl) (1,5-cyclooctadiene)ruthenium(II) (3.2 mg, 0.01 mmol), water (0.5 mL), polyethylene glycol 400 (0.5 mL), high-pressure mercury lamp as the photochemical reaction device of the light generating device Stir at room temperature for 24 hours. After the reaction was completed, saturated brine (10 mL) and ethyl acetate (5 mL ¡Á 3) were added for extraction. The ethyl acetate layer was collected, the solvent was removed under reduced pressure, and the residue was separated and purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1, v / v) to obtain the target product 62.9 mg, a yellow solid in 89% yield .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-methoxyphenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sichuan University; Hai Li; Wu Yong; Guan Mei; Lv Songyang; He Maoyao; Yang Zengbao; (8 pag.)CN111039867; (2020); A;,
Ether – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1706-12-3, name is 1-Methyl-4-phenoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Methyl-4-phenoxybenzene

A moderate stirrer was placed in a dry reaction tube (20 ml), palladium hydroxide/carbon (30 mol%), NaBH4 (1.5 equivalents) was added, and then the reaction tube was evacuated, filled with argon gas, and repeatedly replaced three times. A solution of 4-methyldiphenyl ether (0.2 mmol) and tetrahydropyrrole (0.7 mmol) dissolved in a solvent was slowly added to the reaction tube with a syringe under an argon atmosphere, and 10 uL was added to the reaction tube using a micro-injector. Water, then 1 mL of air was added to the reaction tube with a syringe, and the reaction tube was placed in an oil bath at 160 C to heat and stir the reaction. After 24 hours, the reaction was stopped, the reaction tube was taken out from the oil bath, cooled to room temperature, diluted with ethyl acetate, and then filtered over Celite, and the yield of benzene in the gas phase was 74%. The filtrate was concentrated and separated by an activated thin layer chromatography chromatography plate (eluent: n-hexane/ethyl acetate = 100/1).The final product was obtained in 5g and 4g. Product 5g (yield: 62%)

According to the analysis of related databases, 1706-12-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lanzhou University; Zeng Huiying; Cao Dawei; Li Chaojun; (19 pag.)CN109553592; (2019); A;,
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Synthetic Route of 175278-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175278-17-8, name is 2-Bromo-4-(trifluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 2-bromo-4-trifluoromethoxyaniline (0.500 g), cupper iodide (I) (18.6 mg), bis(triphenylphosphine)palladium (II) dichloride (68.5 mg), triethylamine (0.817 mL) and tetrahydrofuran (7.8 mL) was added phenylacetylene (0.279 mL) at room temperature under stirring, and the mixture was stirred at 80 C. for 16 hours. The reaction mixture was cooled to room temperature, diluted with diethyl ether (30 mL) and then filtered through celite (registered trademark). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (206 mg).1H-NMR (CDCl3) delta ppm:4.32 (2H, br s), 6.70 (1H, d, J=8.8 Hz), 6.95-7.10 (1H, m), 7.20-7.30 (1H, m), 7.30-7.45 (3H, m), 7.45-7.60 (2H, m).

The synthetic route of 2-Bromo-4-(trifluoromethoxy)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KISSEI PHARMACEUTICAL CO., LTD.; US2012/129890; (2012); A1;,
Ether – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 104197-14-0, name is 4-Bromo-2,6-difluoroanisole, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104197-14-0, Formula: C7H5BrF2O

Example 27; Dicyclopropylmethyl [9-(3,5-difluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine Dicyclopropylmethyl-^, 8-dimethyl-9H-purin-6-yl)-amine (0.05Og , 0.194 mmol), 4-bromo-2,6- difluoroanisole (0.087g , 0.388 mmol), Copper(l) Iodide (0.055g , 0.291 mmol), Cesium carbonate (0.158g , 0.485 mmol) and 1 ,10-Phenanthroline (0.070 g , 0.388 mmol) was dissolved in 2.0 ml of anhydrous DMF in a microwave vial with a septum cap. It was degassed alternatively with vacuum and nitrogen 3 times and then heated at 13O0C overnight in an oil bath. The crude was partitioned between 2 ml of water and 3 x 2 ml of DCM through a phase separating cartridge. Combined organics were dried under reduced pressure to yield a dark liquid which was purified by flash column chromatography in the ISCO system with 12g silica cartridge and a gradient of 0 to 40% EtOAc in heptane with sample loading in DCM. Fractions bearing product were combined to yield a transparent oil which was further purified by preparative HPLC method c. Fractions combined to yield the title compound as a solid (6.4mg, 8%).1H NMR (400MHz, CDCI3) delta = 0.39-0.60 (m, 8H), 1.07 (m, 2H), 2.47 (s, 3H), 3.52 (s, 3H), 4.90 (s, 3H),6.99 (d, 2H).LCMS (System 4): 2.90 mins m/z (APCI) = 401 [MH+], m/z (ES) = 401 [MH+]

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2,6-difluoroanisole, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
Ether – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 16728-64-6, name is 3-(Benzyloxy)propan-1-amine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16728-64-6, HPLC of Formula: C10H15NO

.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Benzyloxy)propan-1-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; EP1174431; (2002); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36449-75-9, name is 1-(2-Bromoethyl)-2-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 36449-75-9

General procedure: General synthetic procedure for the final products.The appropriately substituted 4-phenethylpiperidine (6)(0.5 mmol) was dissolved in acetonitrile (5 mL) and K2CO3(0.75 mmol) and the appropriate phenethyl bromide (7) (0.5 mmol) added. The reaction mixture was refluxedfor 8 h.After completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature and filtered through a Celite pad. The filtrate was concentrated under vacuum to obtain the desired crude product. The crude product was further purified by column chromatography (silica gel: 3-5% methanol in dichloromethane) to afford the corresponding 1,4-diphenethylpiperidine (8a-8y) in good yield (75-80 %), which was then converted to hydrochloride salt by treatment with 2M HCl in diethyl ether.Compounds12a-12dwere synthesized using the same procedure as above, except that an appropriately substituted 4-benzylpiperidine (11) was utilized in place of compound6.

The synthetic route of 36449-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nickell, Justin R.; Culver, John P.; Janganati, Venumadhav; Zheng, Guangrong; Dwoskin, Linda P.; Crooks, Peter A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 2997 – 3000;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22236-10-8, name is 4-(Difluoromethoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-(Difluoromethoxy)aniline

To a solution of 4-difluoromethoxyphenylamine (0.99 g, 6.30 mmol) in EtOH (4.5 mL) at 20 C was added under stirring an aqueous HNO3 solution (67%, d=1.4, 0.43 mL, 6.30 mmol) followed by the addition of cyanamide (0.45 g,10.6 mmol). The resulting solution was stirred at reflux for 12 h. Then the mixture was cooled down to rt, concentrated at reduced pressure and diluted with MTBE (15 mL) to induce crystallization of the product. The resulting suspension was stirred at 20 C for 15 min. The formed precipitate was filtered off, washed with a cold mixture of MTBE/EtOH (3:1, 5 mL) followed by MTBE (5 mL), and air-dried to afford the product (0.95 g, 58%) as a white solid;

According to the analysis of related databases, 22236-10-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kubas, Holger; Meyer, Udo; Krueger, Bjoern; Hechenberger, Mirko; Vanejevs, Maksims; Zemribo, Ronalds; Kauss, Valerjans; Ambartsumova, Raisa; Pyatkin, Ilya; Polosukhin, Alexey I.; Abel, Ulrich; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4493 – 4500;,
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Reference of 18638-99-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18638-99-8 name is (3,4,5-Trimethoxyphenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a 25 mL of round bottom flask, a solution of di-tert-butyldicarbonate (1 mmol) and Diphenyglycouril (10 mol %) were addedin 10 mL of ethanol. A turbid solutionwas obtained. In that solution1 mmol of Amine (1a-y) was added. Reaction mixture was stirredfor 30 min at room temperature. After total consumption of thestarting material (determination by TLC), the solvent was removedin vacuo, and the residue was isolated by column chromatographyon silica gel to get the pure product 3a-y as solid or oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3,4,5-Trimethoxyphenyl)methanamine, and friends who are interested can also refer to it.

Reference:
Article; Awasthi, Amardeep; Mukherjee, Anagh; Singh, Mandeep; Rathee, Garima; Vanka, Kumar; Chandra, Ramesh; Tetrahedron; vol. 76; 23; (2020);,
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Synthetic Route of 19500-02-8,Some common heterocyclic compound, 19500-02-8, name is 3-Methoxy-2-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 3-methoxy-2-methyl aniline(2.74 g, 20 mmol), water (6 mL) and 48percent aqueous solution of hydrobromic acid (2.4 mL) were added. To this sodium nitrite (2.76 g, 40 mmol) in water (1.20 mL) was added dropwise at 0¡ãC for 10 minutes. After adding acetone (24 mL) to the reaction mixture, copper bromide (5.64 g, 40 mmol) was added at 0¡ãC and stirred for 3hours. The reaction mixture was warmed to room temperature and concentrated. The residue was diluted with dichloromethane and washed with a mixture of saturated aqueous sodium hydrogen carbonate and aqueous ammonia. The organic layer was dried over anhydrous sodium sulfate and the filtrate was concentrated to obtain the title compound (2.5 g, yield : 62percent); m/z (ES+) : 201 [M+H]+.

The synthetic route of 19500-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEO PHARMA A/S; BLADH, Haakon; FELDING, Jakob; ZHOU, Ding; CAI, Zhen-wei; S?RENSEN, Morten Dahl; WO2015/24878; (2015); A1;,
Ether – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H15NO

DIPEA (3.24 mL, 18.58 mmol) was added to ethyl 2,4-dichloropyrimidine-5-carboxylate (3.42 g, 15.5 mmol) and 4-methoxycyclohexan-l -amine (2.0 g, 15.5 mmol) in acetonitrile (80 mL) at 0C. The reaction mixture was stirred at rt for 16 h. The solvent was removed under reduced pressure. The crude product was purified by fee, eluting with 0 – 5% EtOAc in petroleum ether, to afford the title compound (3.60 g, 74%) as a white solid; NMR(400 MHz, CDCls) 1.26 – 1.50 (4H, m), 1.38 (3H, t), 2.02 – 2.18 (4H, m), 3.15 – 3.27 (1H, m), 3.37 (3H, s), 4.04 – 4.18 (1H, m), 4.35 (2H, q), 8.34 (1H, d), 8.66 (1H, s); mJz MH+314.

The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem