In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4342-46-5, name is 4-Methoxycyclohexanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H15NO
DIPEA (3.24 mL, 18.58 mmol) was added to ethyl 2,4-dichloropyrimidine-5-carboxylate (3.42 g, 15.5 mmol) and 4-methoxycyclohexan-l -amine (2.0 g, 15.5 mmol) in acetonitrile (80 mL) at 0C. The reaction mixture was stirred at rt for 16 h. The solvent was removed under reduced pressure. The crude product was purified by fee, eluting with 0 – 5% EtOAc in petroleum ether, to afford the title compound (3.60 g, 74%) as a white solid; NMR(400 MHz, CDCls) 1.26 – 1.50 (4H, m), 1.38 (3H, t), 2.02 – 2.18 (4H, m), 3.15 – 3.27 (1H, m), 3.37 (3H, s), 4.04 – 4.18 (1H, m), 4.35 (2H, q), 8.34 (1H, d), 8.66 (1H, s); mJz MH+314.
The synthetic route of 4342-46-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
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