Category: 102-52-3

Related Products of 102-52-3, A common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, molecular formula is C7H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 150 mL of CH2Cl2, 5 mL of 1,1,3,3-tetramethoxypropane and 5 mL of trifluoroacetic acid was stirred in an ice bath for 40 min and then 5 g (17.0 mmol) of L-Trp-OBzl was added thereto. After the reaction mixture was stirred for 14 h, TLC (CH2Cl2:CH3OH, 30:1) showed point disappearing. The reaction solution was washed with saturated NaHCO 3 solution three times, saturated NaC solution three times, combined with CH2Cl2 layer, dried over anhydrous NaSO 4 , filtered under reduced pressure, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CH2Cl2 :CH3OH, 100: 1) 5.9 g (87%) of the title compound was obtained as a brown-red oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Capital University of Medical Sciences; Peng Shiqi; Zhao Ming; Wang Yuji; Wu Jianhui; Li Ze; (8 pag.)CN107686483; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 102-52-3,Some common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, molecular formula is C7H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

70.67 grams of piperidine are condensed with 1,1,3,3-tetramethoxypropane in acetic acid, concentrated and treated with 59.72 grams of 2-ethoxyethyl cyanoacetate cyanoacetate in the presence of an organic base and a solvent. After silica gel column chromatography (eluent: toluene/acetone) the pure product is obtained yielding dark yellow crystals. Melting point: 66-67 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,3,3-Tetramethoxypropane, its application will become more common.

Reference:
Patent; L’OREAL; Richard, Herve; Marat, Xavier; L’Alloret, Florence; Candau, Didier; Songeur-Geney, Julie; Grumelard, Julie; Winkler, Barbara; Huglin, Dietmar; US2014/294743; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-52-3, name is 1,1,3,3-Tetramethoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1,1,3,3-Tetramethoxypropane

a) Add 2 mol of 1,1,3,3-tetramethoxypropane to the reaction vessel at room temperature and add under stirring0.4 mol mass fraction of 12% hydrochloric acid, the reaction temperature was controlled at 40 C., and the reaction was stirred for 2 h.

The synthetic route of 102-52-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 102-52-3, These common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 2 (5.0 g, 35.4 mmol) is added into 20 ml glacial acetic acid and 5 ml anhydrous ethanol mixed solution, then dropwise 1, 1, 3, 3 – tetramethoxy propane (6.4 ml, 38.9 mmol), heating to 90 C, reaction 10 h, turns on lathe eliminates ethanol, ethyl acetate extraction, the combined organic phase, saturated sodium bicarbonate solution to wash, anhydrous MgSO4Drying, filtering, turns on lathe does solvent, column chromatography purification to obtain white solid 5.2 g, yield 83%.

Statistics shows that 1,1,3,3-Tetramethoxypropane is playing an increasingly important role. we look forward to future research findings about 102-52-3.

Application of 102-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-52-3 as follows.

Preparation of 5-(3-methoxy-4-(1H-pyrazol-1-yl)phenyl)oxazole (IIe) To a suspension of intermediate IId (1.834 g, 8.94 mmol) in EtOH (30 ml) were added malonaldehyde bis(dimethyl acetal) (1.63 ml, 9.84 mmol) and conc.HCl (1 ml). The reaction mixture was stirred at 70 C. for 2 hours. The cooled mixture was evaporated to dryness, diluted saturated solution of NaHCO3 and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaCl, dried over MgSO4, filtered and evaporated. The final product was purified by silica gel chromatography using 0 to 30% EtOAc/cyclohexane as eluent to give intermediate IIe (1.380 g, 64%). 1H NMR (500 MHz, CDCl3) delta 8.12 (d, J=2.1 Hz, 1H), 7.94 (s, 1H), 7.85 (d, J=8.3 Hz, 1H), 7.72 (d, J=1.4 Hz, 1H), 7.40 (s, 1H), 7.36 (dd, J=8.3, 1.8 Hz, 1H), 7.32 (d, J=1.7 Hz, 1H), 6.46-6.43 (m, 1H), 3.97 (s, 3H).

According to the analysis of related databases, 102-52-3, the application of this compound in the production field has become more and more popular.

Electric Literature of 102-52-3, A common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, molecular formula is C7H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of intermediate lId (1.834 g, 8.94 mmol) in EtOH (30 ml) were added malonaldehyde bis(dimethyl acetal) (1.63 ml, 9.84 mmol) and conc.HC1 (1 ml). The reaction mixture was stilTed at 70C for 2 hours. The cooled mixture was evaporated todryness, diluted saturated solution of NaHCO3 and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaC1, dried over MgSO4, filtered and evaporated. The final product was purified by silica gel chromatography using 0 to 30 % EtOAc/cyclohexane as eluent to give intermediate lie(1.380 g, 64%). ?H NMR (500 MHz, CDC13) oe 8.12 (d, J= 2.1 Hz, 1H), 7.94 (s, 1H), 7.85 (d, J= 8.3 Hz, 1H), 7.72 (d, J= 1.4 Hz, 1H), 7.40 (s, 1H), 7.36 (dd, J= 8.3, 1.8 Hz, 1H),7.32 (d, J= 1.7 Hz, 1H), 6.46-6.43 (m, 1H), 3.97 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

102-52-3, name is 1,1,3,3-Tetramethoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 102-52-3

Example 1: Ethyl fl2-Amino-3-chloro-6,7,10,ll-tetrahydro-7,ll- methanocycloocta[61 quinolin-9-yl)acetate (HUP 1)Preparation of tetramethyl 3,7-Dihydroxybicyclo[3.3.11nona-2,6-diene-2,4,6,8- tetracarboxylateA mixture of 1,1,3,3 tetramethoxypropane (32.8 g, 0.20 mol) and 2 M HC1(100 mL) was stirred for 1.5 h at room temperature. To this mixture cooled at 0C was added successively and carefully an aqueous solution of 5 M NaOH within 30 min (pH = 8) and MeOH (100 mL). At 0C, dimethyl-3-oxoglutarate (69.6 g, 0.40 mol) was added, followed by addition of MeOH (70 mL). The reaction mixture was allowed to warm to room temperature and stirred for 3 days. The reaction mixture was acidified to pH = 3 with 10 M HC1. Filtrating fractionwise, washing with water and drying at the dessicator afford the desired tetra ester as a white solid (39.2 g, 51%).

The synthetic route of 102-52-3 has been constantly updated, and we look forward to future research findings.

Related Products of 102-52-3, These common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 6Preparation of Bromomalonaldehyde (9); De-ionized water (2.080 L) was added to a 12-L, four-neck flask under a nitrogen atmosphere and equipped with a thermocouple. Concentrated HCl (88 mL) was added to the water. Malonaldehyde bis-dimethylacetal (2006 mL, 2.0 kilogram (kg), 12.18 moles) was added dropwise over a period of 45 to 60 minutes while the temperature was maintained between 5 C. and 25 C. Bromine (1.912 g, 619 mL; 12 moles; 1 equivalent.) was added dropwise over 1 hour, while the temperature was maintained between 5 C. and 20 C. The reaction was monitored by HPLC for completion. After completion of the reaction (2 to 4 hours), the reaction mixture was concentrated on a rotary evaporator at 45 C. and 100 torr. The resultant mixture was stirred for 1 hour at room temperature, filtered, and washed with cold water (2¡Á1.0 liter). The isolated solids were dried in a forced-air dryer for 2 days. The weight of the product (9) obtained was 1.008 kg, with a 430 g second crop from the filtrate, giving a combined 76% yield. The second crop of crystals was obtained by concentrating the mother liquor to half its original volume and filtering off the resulting crystals. Mass spectrometry (M+H): 150.97 and 151.96 amu.

Statistics shows that 1,1,3,3-Tetramethoxypropane is playing an increasingly important role. we look forward to future research findings about 102-52-3.

Reference:
Patent; Wyeth; US2009/18332; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102-52-3, name is 1,1,3,3-Tetramethoxypropane, A new synthetic method of this compound is introduced below., Computed Properties of C7H16O4

In a 1 L reaction flask, 100 g of tetramethoxypropane was charged successively,58.8 g of N-methylaniline, stirred for 10 minutes,Control the internal temperature below 30 , drop 22g 20% hydrochloric acid,Dripping at about 24 C for 2.5 hours, adding 200 g of toluene,Control in 30 below the drop of 20% of the liquid caustic so that the water layer pH 6 ~ 7,The layers were separated and the aqueous layer was extracted with toluene and the organic layers were combined.Washed with saturated brine three times, and then separated to separate the water layer, the organic layer first vacuum recovery solvent,And then collecting 60 to 70 C / 40 mmHg fraction,To give 3- (N-methyl-N-phenyl) aminopropenal83.1g content of 99.6%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jiangsu Jingye Pharmaceutical Co., Ltd.; Chu, Zhewei; Yue, Bo; Ye, Yin; (4 pag.)CN106431942; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-52-3, name is 1,1,3,3-Tetramethoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 102-52-3

Example A4: Preparation of the compound of formula 70.67 grams of piperidine are condensed with 1 ,1 ,3,3-tetramethoxypropane in acetic acid, concentrated and treated with 59.72 grams of 2-ethoxyethyl cyanoacetate cyanoacetate in the presence of an organic base and a solvent. The following base/solvent combinations are used: Example Base Solvent Example A4.1 DBU (1 ,8-diazabicyclo[5.4.0]undec-7-ene) dimethylformamide Example A4.2 DBN (1 ,5-diazabicyclo[ 4.3.0]non-5-ene) dimethylacetamide Example A4.3 DBN (1 ,5-diazabicyclo[ 4.3.0]non-5-ene) 1 -methylpyrrolidone Example A4.4 DBN (1 ,5-diazabicyclo[ 4.3.0]non-5-ene) dimethylsulfoxide Example A4.5 DBU (1 ,8-diazabicyclo[5.4.0]undec-7-ene) dimethylformamide Example A4.6 piperidine dimethylacetamide Example A4.7 piperidine 1 -methylpyrrolidone Example A4.8 sodium methylate dimethylsulfoxide The desired product (104) is obtained in yields of 91 % (96.5 grams) as an orange powder. After silica gel column chromatography (eluent: toluene/acetone) the pure product (104) is obtained yielding dark yellow crystals. Melting point: 66-67C.

The synthetic route of 102-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; WINKLER, Barbara; HUeGLIN, Dietmar; EICHIN, Kai; EHRSAM, Larissa; MARAT, Xavier; RICHARD, Herve; KIENZLE, Ilona Marion; SCHROeDER, Ute; BASF (CHINA) COMPANY LIMITED; WO2013/11480; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem