Electric Literature of 102-52-3, These common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 2 (5.0 g, 35.4 mmol) is added into 20 ml glacial acetic acid and 5 ml anhydrous ethanol mixed solution, then dropwise 1, 1, 3, 3 – tetramethoxy propane (6.4 ml, 38.9 mmol), heating to 90 C, reaction 10 h, turns on lathe eliminates ethanol, ethyl acetate extraction, the combined organic phase, saturated sodium bicarbonate solution to wash, anhydrous MgSO4Drying, filtering, turns on lathe does solvent, column chromatography purification to obtain white solid 5.2 g, yield 83%.
Statistics shows that 1,1,3,3-Tetramethoxypropane is playing an increasingly important role. we look forward to future research findings about 102-52-3.