Related Products of 102-52-3, A common heterocyclic compound, 102-52-3, name is 1,1,3,3-Tetramethoxypropane, molecular formula is C7H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 150 mL of CH2Cl2, 5 mL of 1,1,3,3-tetramethoxypropane and 5 mL of trifluoroacetic acid was stirred in an ice bath for 40 min and then 5 g (17.0 mmol) of L-Trp-OBzl was added thereto. After the reaction mixture was stirred for 14 h, TLC (CH2Cl2:CH3OH, 30:1) showed point disappearing. The reaction solution was washed with saturated NaHCO 3 solution three times, saturated NaC solution three times, combined with CH2Cl2 layer, dried over anhydrous NaSO 4 , filtered under reduced pressure, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CH2Cl2 :CH3OH, 100: 1) 5.9 g (87%) of the title compound was obtained as a brown-red oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Capital University of Medical Sciences; Peng Shiqi; Zhao Ming; Wang Yuji; Wu Jianhui; Li Ze; (8 pag.)CN107686483; (2018); A;,
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