Reference of 60792-79-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60792-79-2, name is 2,2′-Oxybis(ethylamine) dihydrochloride, This compound has unique chemical properties. The synthetic route is as follows.
Preparation of 1-((3R,5R)-7-(2-(2-(4Z,7Z,1OZ,13Z,16Z,19Z)-docosa-4,7,1O,13,16,19- hexaenamidoethoxy)ethylamino)-3 ,5-dihydroxy-7-oxoheptyl)-5-(4-fluorophenyl)-2- isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide (1-32):1) EDCIH2NNH2 H2NNHBoc2) HCIOH OH 0H / N NH2/[0239j In a typical run, sodium hydroxide (400 mg, 10 mmol) is dissolved in MeOH (70 mL) and 2-(2-aminoethoxy)ethanamine dihydrochloride (1.0 g, 5.65 mmol) is added. The resulting reaction mixture is stirred at room temperature for 30 mm. A solution containing Boc2O (740 mg, 3.40 mmol) in THF (15 mL) is then added dropwise, at room temperature, over a period of 15 mm. The resulting reaction mixture is stirred at room temperature for 18 h and then concentrated under reduced pressure. The resulting residue is taken up in CH2C12 (200 mL) and stirred vigorously at room temperature for 4 h. The mixture is filtered and the filtrate is concentrated under reduced pressure to afford 850 mg of tert-butyl 2-(2- aminoethoxy)ethylcarbamate (74% yield).
The chemical industry reduces the impact on the environment during synthesis 2,2′-Oxybis(ethylamine) dihydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CATABASIS PHARMACEUTICALS, INC.; JIROUSEK, Michael, R.; MILNE, Jill, C.; TING, Amal; WENSLEY, Allison; VU, Chi, B.; WO2013/166176; (2013); A1;,
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