Category: 2235-01-0

Leonard, Nicholas M.;Oswald, Matthew C.;Freiberg, Derek A.;Nattier, Bryce A.;Smith, Russell C.;Mohan, Ram S. published 《A Simple and Versatile Method for the Synthesis of Acetals from Aldehydes and Ketones Using Bismuth Triflate》 in 2002. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Product Details of 2235-01-0 The article mentions the following:

Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformates and the corresponding alc. in the presence of 0.1 mol % Bi(OTf)₃·4H₂O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolanes using ethylene glycol is also catalyzed by Bi(OTf)₃·4H₂O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Product Details of 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sorlin, Alexandre M.;Mixdorf, Jason C.;Rotella, Madeline E.;Martin, Robert T.;Gutierrez, Osvaldo;Nguyen, Hien M. published 《The Role of Trichloroacetimidate To Enable Iridium-Catalyzed Regio- and Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study》 in 2019. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Related Products of 2235-01-0 The article mentions the following:

Asym. allylic fluorination has proven to be a robust and efficient methodol. with potential applications for the development of pharmaceuticals and practical synthesis for ¹⁸F-radiolabeling. A combined computational (dispersion-corrected DFT) and exptl. approach was taken to interrogate the mechanism of the diene-ligated, iridium-catalyzed regio- and enantioselective allylic fluorination. Our group has shown that, in the presence of an iridium(I) catalyst and nucleophilic fluoride source (Et₃N·3HF), allylic trichloroacetimidates undergo rapid fluoride substitution to generate allylic fluoride products with excellent levels of branched-to-linear ratios. Mechanistic studies reveal the crucial role of the trichloroacetimidate as a potent leaving group and ligand to enable conversion of racemic allylic trichloroacetimidates to the corresponding enantioenriched allylic fluorides, via a dynamic kinetic asym. transformation (DYKAT), in the presence of the chiral bicyclo[3.3.0]octadiene-ligated iridium catalyst. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Related Products of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Fei;Yi, Junyi;Nishimoto, Yoshihiro;Yasuda, Makoto published 《Homologation of Alkyl Acetates, Alkyl Ethers, Acetals, and Ketals by Formal Insertion of Diazo Compounds into a Carbon-Carbon Bond》. The research results were published in《Synthesis》 in 2021.Name: Dimethoxydiphenylmethane The article conveys some information:

Homologation of alkyl acetates, alkyl ethers, acetals, and ketals was accomplished via formal insertion of diazo esters into carbon-carbon σ-bonds. The combined Lewis acid InI₃ with Me₃SiBr catalyzed the homologation of alkyl acetates and alkyl ethers. That of acetals and ketals was catalyzed solely by the use of InBr₃. The key point of the homologation mechanism is that the indium-based Lewis acids have the appropriate amount of Lewis acidity to achieve both the abstraction and release of leaving groups. The abstraction of a leaving group by an indium-based Lewis acid and the electrophilic addition of carbocation or oxonium intermediates to diazo esters followed by the rearrangement of carbon substituents provide the corresponding cation intermediates. Finally, the leaving group that is captured by the Lewis acid bonds with cation intermediates to furnish the homologated products. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Name: Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lusi, Robert F.;Sennari, Goh;Sarpong, Richmond published 《Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy》. The research results were published in《Nature Chemistry》 in 2022.Computed Properties of C15H16O2 The article conveys some information:

Natural product total synthesis inspires the development of synthesis strategies to access important classes of mols. In the 1960s, Corey and coworkers demonstrated a visionary preparation of the terpenoid longifolene, using ‘strategic bond anal.’ to craft a synthesis route. This approach proposes that efficient synthesis routes to bridged, polycyclic structures should be formulated to introduce the bulk of the target’s topol. complexity at a late stage. Subsequently, similar strategies have proved general for the syntheses of a wide variety of bridged, polycyclic mols. Here, we demonstrate that an orthogonal strategy where topol. complexity is introduced at the outset leads to the short synthesis of the longifolene-related terpenoid longiborneol. To implement this strategy, we access a bicyclo[2.2.1] starting material through scaffold remodelling of readily available (S)-carvone. We also employ a variety of late-stage C-H functionalization tactics in divergent syntheses of many longiborneol congeners. Our strategy may prove effective for the preparation of other topol. complex natural products that contain the bicyclo[2.2.1] framework. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Computed Properties of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of Dimethoxydiphenylmethane《Torquoselective 6π-Electron Electrocyclic Ring Closure of 1-Azatrienes Containing Acyclic Chirality at the C-Terminus》 was published in 2006. The authors were Sydorenko, Nadiya;Hsung, Richard P.;Vera, Eymi L., and the article was included in《Organic Letters》. The author mentioned the following in the article:

Torquoselective pericyclic ring closures of 1-azatrienes that contain acyclic chirality at the C-terminus are described herein. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Quality Control of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Braslau, Rebecca;Burrill, Leland C. II;Chaplinski, Vladimir;Howden, Rodney;Papa, Patrick W. published 《Studies in the stereoselective trapping of prochiral carbon radicals by optically active camphoxyl nitroxides》 in 1997. The article was appeared in 《Tetrahedron: Asymmetry》. They have made some progress in their research.Computed Properties of C15H16O2 The article mentions the following:

Optically active camphoxyl nitroxides, e.g. I, derived from camphene react with prochiral carbon radicals to give diastereomeric coupling products, e.g. II. The diastereomeric ratio can be conveniently measured by ¹H-NMR spectroscopy, in contrast to previous work employing steroidal nitroxides. The structure of the camphoxyl radical was modified and all couplings resulted in modest diastereoselectivity.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Computed Properties of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ranu, Brindaban C.;Jana, Ranjan;Samanta, Sampak published 《A simple, efficient and general procedure for acetalization of carbonyl compounds and deprotection of acetals under the catalysis of indium(III) chloride》 in 2004. The article was appeared in 《Advanced Synthesis & Catalysis》. They have made some progress in their research.Related Products of 2235-01-0 The article mentions the following:

Indium(III) chloride efficiently catalyzed the protection of a variety of aldehydes and ketones to their corresponding 1,3-dioxolanes and dialkyl acetals in refluxing cyclohexane. However, deprotection of acetals was also achieved in refluxing aqueous MeOH under the catalysis of In(III) chloride. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Related Products of 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schmidt, Matthias;Ungvari, Johannes;Gloede, Julia;Dobner, Bodo;Langner, Andreas published 《New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance》 in 2007. The article was appeared in 《Bioorganic & Medicinal Chemistry》. They have made some progress in their research.Formula: C15H16O2 The article mentions the following:

Multidrug resistance (MDR) to antitumor agents represents a major obstacle to a successful chemotherapy of cancer. Overexpression of P-glycoprotein (p-gp) seems to be the major factor responsible for MDR. A large number of chem. unrelated compounds are known to interact with p-gp resulting in a decreasing resistance. In our efforts related to structure-activity studies of new potential MDR reversal agents we synthesized a series of compounds that differ in the aromatic core structure, the linker, and the basic moiety. For our search of new aromatic core structures we synthesized novel 2,2-diphenyl-1,3-dioxolane, 2,2-diphenyl-1,3-dioxane, and 4,5-diphenyl-1,3-dioxolane derivatives A range of lipophilic linker structures and protonable basic moieties were synthesized and investigated to optimize the structure of the potential MDR-modulators. The compounds were tested in vitro using human Caco-2 cells. Both the cytotoxicity of the synthons and their ability to resensitize the cells were determined with a MTT assay. The results show that at low concentration various substances reverse tumor cell MDR. Some of the new structures show better effects than established modulators like trifluoperazine. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Formula: C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gros, Philippe;Le Perchec, Pierre;Senet, Jean-Pierre published 《Silica-supported guanidinium chloride-acetyl chloride as an efficient deprotecting reagent for acetals》 in 1995. The article was appeared in 《Journal of Chemical Research, Synopses》. They have made some progress in their research.HPLC of Formula: 2235-01-0 The article mentions the following:

Acetals have been treated with acetyl chloride in the presence of catalytic amounts of silica-supported guanidinium chloride to produce the corresponding aldehydes and ketones in good yields under neutral conditions. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. HPLC of Formula: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Castan, Alejandro;Badorrey, Ramon;Galvez, Jose A.;Diaz-de-Villegas, Maria D. published 《Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins》 in 2017. The article was appeared in 《Beilstein Journal of Organic Chemistry》. They have made some progress in their research.Category: ethers-buliding-blocks The article mentions the following:

New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Category: ethers-buliding-blocks The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem