Category: 2674-34-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 2674-34-2

A flame dried RBF was charged with l,4-dibromo-2,5-dimethoxybenzene (1) (10.3 g, 39.6 mmol, 1.0 equiv.), phenylboronic acid (9.92 g, 81.4 mmol, 2.05 equiv.), potassium carbonate (19.2 g, 139 mmol, 3.5 equiv.), toluene (80 mL), deionized water (40 mL), and a stir bar. Pd(PPh3)4 (457 mg, 0.395 mmol, 1 mol%) was added last to the flask before the reaction mixture was lowered into a bath that was preheated to 90 C and stirred for l2h with a condenser. Upon completion, the reaction was diluted with water, extracted 3 times with DCM, dried on MgS04, and concentrated via rotary evaporation. The solid was then recrystallized in EtOH to provide 9.01 g (31.1 mmol, 78% yield) of white needles. NMR (500 MHz, CDCb): d 7.61-7.59 (m, 4H), 7.46-7.43 (m, 4H), 7.38-7.34 (m, 2H), 6.99 (s, 2H), 3.80 (s, 6H). 13C NMR (125 MHz, CDCb): d 150.6, 138.3, 130.4, 129.4, 128.1, 127.1, 114.8, 56.4. HRMS (TOF-EI, m/z) calcd. for C20H18O2 [M]+: 290.1307; found: 290.1300.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LEHIGH UNIVERSITY; CHEN, Mark; WEHRMANN, Caleb; CHARLTON, Ryan; (58 pag.)WO2019/226678; (2019); A2;,
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Application of 2674-34-2,Some common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A dry and nitrogen-flushed 25 ml Schlenk tube equipped with a magnetic stirrer, Mg(3.5 mmol, 3.5 equiv) and dry LiCl (3 mmol, 3.0 equiv) were covered with dry THF(3 mL) and activated by the addition of a few drops of TMSCl. After stirring for 30min, L1 (0.05 mmol, 0.05 equiv) and NiI (0.05 mmol, 0.05 equiv) were added. Thereaction mixture was stirred at 0oC. A solution of aryl bromine (1.0 mmol, 1.0 equiv)and allyl bromide (3.0 mmol, 3.0 equiv) in THF (2 mL) was added in with a syringepump at 0oC (flow rate was 3 mL/h). The resulting mixture was stirred under nitrogenat 0oC for 12 h before the addition of saturated aqueous NH4Cl solution (10 ml). Theresulting mixture was extracted with ethyl acetate (3 ¡Á 30 mL). The organic fractionswere dried over Na2SO4, concentrated in vacuo and purified by silica gelchromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethoxybenzene, its application will become more common.

Reference:
Article; Zhang, Zhan; Xu, Lijun; Chen, Zhengkai; Liu, Zhubo; Miao, Maozhong; Song, Jinyu; Ren, Hongjun; Synlett; vol. 26; 20; (2015); p. 2784 – 2788;,
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Application of 2674-34-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a freshly prepared solution of PdNPs (10 mL, 0.02 mmol), required amount of K2CO3 (2 mmol) was added followed by aryldihalides/ arylhalide (1 mmol) and arylboronic acid (3 mmol)/diboronic acid (0.75 mmol). Then, the reaction mixture was stirred at room temperature in open atmosphere. The reaction was monitored by TLC and was stopped after the complete consumption of starting material. The desired product got precipitated out which was separated by filtration and extracted with chloroform. The chloroform layer was evaporated to get the terphenyl in pure state.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mandali, Pavan Kumar; Chand, Dillip Kumar; Catalysis Communications; vol. 31; (2013); p. 16 – 20;,
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Some common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2674-34-2

K2CO3 (1.13g, 8.19mmol), boronate ester 17 (800mg, 1.78mmol), and dibromoarene 11 (176mg, 0.593mmol) in toluene (20mL), EtOH (4mL) and H2O (2mL) was sparged with Ar for 1h. Pd(PPh3)4 (73mg, 0.063mmol) was added, the mixture was sparged with Ar for an additional 20min, and then heated 90C for 16h. The reaction mixture was cooled to rt and diluted with 50mL of H2O. The reaction mixture was extracted with Et2O (3¡Á50mL). The combined organics were washed with 150mL of brine, dried with Na2SO4, and the solvents were removed under vacuum. The product was isolated via column chromatography as a white solid (433mg, 99%), mp 248-250C. 1H NMR (CDCl3): delta 8.09 (d, J=1.8Hz, 2H), 7.80 (dd, J=8.0, 1.8Hz, 2H), 7.53 (d, J=8.0Hz, 2H), 7.49 (s, 6H), 6.91 (s, 2H), 3.76 (s, 12H), 1.41 (s, 36H). 13C NMR (CDCl3): delta 169.0, 151.3, 150.3, 141.6, 136.8, 132.2, 131.6, 130.3, 129.9, 128.4, 121.8, 121.7, 112.8, 56.0, 51.8, 35.0, 31.5. FTIR (cm-1): 1720.79. UV-vis (CH2Cl2) lowest E abs lambdamax [nm] ( [M-1cm-1]): 337 (22,801). Em. (CH2Cl2) lambdamax [nm]: 424. Anal. Calcd for C52H62O6: C, 79.76; H, 7.98. Found: C, 77.41; H, 8.18.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2674-34-2, its application will become more common.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
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2674-34-2, These common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of A (146 g, 50 mmol) in 250 ml of THF was slowly added n-butyllithium (50 mL, 2.5 M/L in hexane) at -78 C under argon. The mixture was kept at -78 for 1 hour. Then, pinacol borate (25.3 g, 100 mmol) was added, followed by slowly warming to room temperature, and the mixture was stirred overnight. The mixture was extracted twice with diethyl ether and washed with distilled water and brine. Further purification by silica gel column chromatography using hexane as eluent.A white solid (15 g, yield 80%), i.e., 2,5-dimethoxy-1,4-diborate benzene (B), was obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2674-34-2.

Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Li Xiaojun; Li Yongfang; Pan Fei; Zhang Zhiguo; (21 pag.)CN109748925; (2019); A;,
Ether – Wikipedia,
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2674-34-2, A common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dibromo-2,5-dimethoxybenzene (2.0 g, 6.76 mmol) was added dissolved in THF 35 mL, it was added dropwise a 1.6 M BuLi slowly at -78 . After stirring the reaction solution for 2 hours at -78 , it was added dropwise to DMF (2.8 mL, 33.7 mmol). The reaction solution is stirred at room temperature for 15 hours (20 ). 2 N HCl in a 20 mL reaction mixture was stirred slowly dropping off. The resulting solid was then filtered under reduced pressure, dried to obtain a 2,5-dimethoxyterephthalaldehyde 267 mg (30%).

The synthetic route of 1,4-Dibromo-2,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Korea Research Institute of Chemical Technology; Lee, Jong Chul; Mun, Sang Jin; Sin, Won Suk; Lee, Sang Gyu; (19 pag.)KR101493823; (2015); B1;,
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