Application of 2674-34-2,Some common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A dry and nitrogen-flushed 25 ml Schlenk tube equipped with a magnetic stirrer, Mg(3.5 mmol, 3.5 equiv) and dry LiCl (3 mmol, 3.0 equiv) were covered with dry THF(3 mL) and activated by the addition of a few drops of TMSCl. After stirring for 30min, L1 (0.05 mmol, 0.05 equiv) and NiI (0.05 mmol, 0.05 equiv) were added. Thereaction mixture was stirred at 0oC. A solution of aryl bromine (1.0 mmol, 1.0 equiv)and allyl bromide (3.0 mmol, 3.0 equiv) in THF (2 mL) was added in with a syringepump at 0oC (flow rate was 3 mL/h). The resulting mixture was stirred under nitrogenat 0oC for 12 h before the addition of saturated aqueous NH4Cl solution (10 ml). Theresulting mixture was extracted with ethyl acetate (3 ¡Á 30 mL). The organic fractionswere dried over Na2SO4, concentrated in vacuo and purified by silica gelchromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethoxybenzene, its application will become more common.
Reference:
Article; Zhang, Zhan; Xu, Lijun; Chen, Zhengkai; Liu, Zhubo; Miao, Maozhong; Song, Jinyu; Ren, Hongjun; Synlett; vol. 26; 20; (2015); p. 2784 – 2788;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem