2674-34-2, These common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of A (146 g, 50 mmol) in 250 ml of THF was slowly added n-butyllithium (50 mL, 2.5 M/L in hexane) at -78 C under argon. The mixture was kept at -78 for 1 hour. Then, pinacol borate (25.3 g, 100 mmol) was added, followed by slowly warming to room temperature, and the mixture was stirred overnight. The mixture was extracted twice with diethyl ether and washed with distilled water and brine. Further purification by silica gel column chromatography using hexane as eluent.A white solid (15 g, yield 80%), i.e., 2,5-dimethoxy-1,4-diborate benzene (B), was obtained.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2674-34-2.
Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Li Xiaojun; Li Yongfang; Pan Fei; Zhang Zhiguo; (21 pag.)CN109748925; (2019); A;,
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