321-28-8, A common heterocyclic compound, 321-28-8, name is 1-Fluoro-2-methoxybenzene, molecular formula is C7H7FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of the selected anisole or biphenyl (13.0mmol) in 30mL of dry CH2Cl2 at 0 C, p-toluoylchloride (2g, 13.0mmol), and AlCl3 (3g, 22.05mmol) were added and the mixture was stirred at rt overnight. After addition of ice, the mixture was diluted with CH2Cl2, washed with NaHCO3 saturated solution, dried and evaporated to dryness.
The synthetic route of 321-28-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gobbi, Silvia; Hu, Qingzhong; Foschi, Giacomo; Catanzaro, Elena; Belluti, Federica; Rampa, Angela; Fimognari, Carmela; Hartmann, Rolf W.; Bisi, Alessandra; Bioorganic Chemistry; vol. 86; (2019); p. 401 – 409;,
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