Category: 2734-70-5

Application of 2734-70-5,Some common heterocyclic compound, 2734-70-5, name is 2,6-Dimethoxyaniline, molecular formula is C8H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of benzoic acids 4 (7) (4 mmol),1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (4.8 mmol) and N-hydroxybenzotrizole (0.48 mmol) wereadded amines (4.8 mmol) at room temperature. The reaction mixture was stirredfor overnight and washed with water successively. The organic layer was driedover anhydrous sodium sulfate. Then the solvent was removed in vacuo to affordcrude compounds 5 (8).

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Jiling; Wu, Dang; Xu, Xiaoyong; Huang, Jin; Shao, Xusheng; Li, Zhong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 13; (2016); p. 3064 – 3066;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 2734-70-5, name is 2,6-Dimethoxyaniline, molecular formula is C8H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2734-70-5

Trimethylalurninum (4.7 mL, 9.4 mmol) was added dropwise to a solution of 2,6-dimethoxyaniline (1.2 g, 7.8 mmol) and Compound lb (0.80 g, 9.4 mmol) in toluene (10mL) while cooling in an ice bath. After addition was complete, the reaction mixture was warmed to 110 °C and was stirred at this temperature for l4hrs. The cooled reaction mixture was partitioned between a saturated solution of Rochelle?s salt and EtOAc. The organic phase was separated, dried over MgSO4, filtered and concentrated under reducedpressure. The resulting residue was added to a silica gel (120 g) colunm and was eluted with 0-20percent of 20percent MeOH/DCM in 0.5percent TEA/DCM to give Compound lc (1.1 g, 4.5 mmol, 57 percent) as a brown liquid. MS ,n/z 239.0 (M+H). 1H NMR (500M1-lz, CDC13) 67.01(t, J 8.3 Hz, 1H), 6,62 (d, J= 7.7 Hz, 2H), 5.32 (s, 2H), 4.88 (hr s, 2H), 4.31 (s,2H), 3.82 (s, 6H), 3.62-3.73 (m, 2H), 1.19-1.33 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2734-70-5, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHAO, Hannguang J.; FINLAY, Heather; LAWRENCE, R., Michael; MYERS, Michael C.; (154 pag.)WO2017/96130; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 2734-70-5,Some common heterocyclic compound, 2734-70-5, name is 2,6-Dimethoxyaniline, molecular formula is C8H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Thymol (1.0 eq, 33.3mmol) and methyl 5-(chloromethyl)-2-furoate (1.0 eq, 33.3mmol) were dissolved in nitromethane (120mL, 0.2M). Aluminum trichloride (1.0 eq, 33.3mmol) dissolved in 25mL nitromethane was added to the above solution under nitrogen and heated to slow reflux over 10 min. The heat was turned off and left under nitrogen overnight. The reaction was quenched with 100mL of water and exctracted with dichloromethane. The crude mixture was evaporated to dryness and loaded onto plug chromatography column (1g crude/100g silica gel ratio). The column was eluted with 7 and 11percent ethyl acetate/hexanes to yield the desired product (2.9 g, 30percent). The ester was hydrolyzed to acid by lithium hydroxide in THF/MeOH/H2O (35/25/25). To a solution containing the 5-(4-hydorxy-5-isopropyl-2-methylbenzyl)-2-furoic acid (1.0eq, 3.6 mmol, 0.5M), and 2,6-dimethoxyaniline (1.0eq, 3.6mmol) were dissolved in DMF. To this mixture, HATU (1.0 eq, 3.6 mmol) and di-isopropyl ethyl amine (1.0 eq, 3.6 mmol) were added and stirred overnight. The mixture was heated for 10min at 45°C. The solution was placed into ethyl acetate (3x volume) and washed with water. The organic layer was evaporated to syrup and eluted on plug column chromatography (1:100 g crude/g silicagel) with 30 and 50 percent ethyl acetate/hexane to yield: N-(2,6-dimethoxyphenyl)-5-(4-hydroxy-5-isopropyl-2-methylbenzyl)-2furamide (820 mgs, 55percent yield). 1HNMR (CDCl3) 7.22ppm (1H, t, J=8.68 Hz), 7.08ppm (1H, d, J=3.40 Hz), 6.99ppm (1H,s), 6.64ppm (2H, d, J=8.68 Hz), 6.61ppm (1H, s), 5.97 ppm (1H, d, J=3.40 Hz), 3.95ppm, (2H,s), 3.85ppm, (6H,s), 3.17ppm, (1H,pentet, J=6.8 Hz) 2.23ppm, (3H,s), 1.25 ppm(3H,s), and 1.23ppm (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dimethoxyaniline, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2734-70-5, name is 2,6-Dimethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Weigh 0.5 mmol of amide III-1, 1percent molar amount of palladium catalyst, 1 mmol of potassium carbonate, 0.75 mmol of 2,5-dimethoxyaniline in a Schlenk reaction tube, double-tube tube was purged with nitrogen, repeated three times, and then opened again. Nitrogen valve, add 2 ml of freshly distilled tetrahydrofuran, and close the valve. The tube was stirred at room temperature for 10 minutes and then placed at 110 ° C for 24 hours. After the completion of the reaction, TLC was plated, THF was evaporated, water was added, and water was added, and the mixture was extracted three times with ethyl acetate, and dried over anhydrous magnesium sulfate, and then evaporated to dryness to give the product white crystals: 0.385 mmol (104.5 mg). The product was N-(2,6-dimethoxyphenyl)-3-methylbenzamide in 77percent yield.

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2734-70-5, Quality Control of 2,6-Dimethoxyaniline

Acetic anhydride (2.97 mL, 31.45 mmol) was added to a solution of aniline 51 (2.19 g, 14.3 mmol) in dry dichloromethane (50 mL) under inert atmosphere. The reaction was stirred at room temperature for 24 hours. Upon completion, the reaction mixture was washed with a saturated solution of sodium carbonate, the organic layer dried over MgSO4 and the solvent removed under reduced pressure. The acetanilide 52 was obtained as a white solid (1.67 g, 60percent) after crystallization from Et2O; mp (Et2O) 128-130 °C; TLC Rf (EtOAc) = 0.37; 1H NMR (CDCl3, 400 MHz) delta (ppm) 2.20 (large s, 3H, NHCOCH3), 3.84 (s, 6H, 2OCH3), 6.42 (large s, 1H, NHCOCH3), 6.59 (d, J = 8.4 Hz, 2H, ArH), 7.20 (t, J = 8.2 Hz, 1H, ArH). 13C NMR (CDCl3, 100 MHz) delta 23.3 (CH3), 55.9 (2CH3), 104.3 (2CH), 107.4 (C), 127.8 (CH), 155.6 (2C), 172.9 (C). IR nu cm-1: 1104, 1253, 1437, 1474, 1537, 1590, 1651, 3184, 3256. Calcd. for C10H13O3N: C, 61.53; H, 6.71; N, 7.17. Found: C, 61.36; H, 6.94; N, 7.01.

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Application of 2734-70-5, The chemical industry reduces the impact on the environment during synthesis 2734-70-5, name is 2,6-Dimethoxyaniline, I believe this compound will play a more active role in future production and life.

To a solution of 2,6-dimethoxyaniline (500 g, 3.25 mol, 1 eq) in DCM (5.0 L) was added 2,6-lutidine (1.5 L, 13.0 mol, 4 eq). The reaction mixture was cooled to 0 C (internal temperature) and CSC12 (374 mL, 4.88 mol, 1.5 eq) was added dropwise. The reaction mixture was then stirred for 2 h. The solvent was evaporated under reduced pressure and the material thus obtained was purified by SiC column to provide the title compound, 2-isothiocyanato-l,3-dimethoxybenzene, Example 82.0 as a white solid (1.06g, 2.80 mol, 86%). LCMS (ESI pos. ion) m/z: (M+H)+ = 196. NMR (400 MHz, CDCI3) delta 7.16 (t, J= 8.48 Hz, 1H), 6.55 (d, J = 8.48 Hz, 2H), 3.90 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DEBENEDETTO, Mikkel V.; DRANSFIELD, Paul John; HARVEY, James S.; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; SHARMA, Ankit; (321 pag.)WO2018/93576; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2734-70-5

Equipped with a mechanical stirrer, a condenser and a nitrogen gas through the mouth of the three-necked flask, were added 61.28g (0.40mol) 2,6- dimethoxy aniline and 135.00mL distilled water, stir under a nitrogen atmosphere.40.50mL slowly added dropwise concentrated hydrochloric acid (37percent mass fraction), the temperature of the system was maintained at 35 , then portionwise added 28.14g (0.21mol) 3,5- dimethylbenzaldehyde.System under reflux with vigorous stirring After 6h, the reaction system temperature was lowered to 50 , added in portions with stirring 16.40g sodium hydroxide powder.The solution was subjected to steam distillation, after suction filtration to obtain a solid powder.A solid powder with hot water, and dried dioxane was recrystallized, and dried to give alpha, alpha- bis (4-amino-3,5-dimethoxyphenyl) -1- (3 ‘, 5’-A phenyl) methane solid powder 77.56g (92percent yield)

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China National Offshore Oil Corporation; CNOOC Research Institute; Zhai, Lei; Zhang, Jian; Jing, Bo; Tan, Guorong; Xue, Xinsheng; (12 pag.)CN103864648; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 2734-70-5, The chemical industry reduces the impact on the environment during synthesis 2734-70-5, name is 2,6-Dimethoxyaniline, I believe this compound will play a more active role in future production and life.

To a solution of 2,6-dimethoxyaniline (500 g, 3.25 mol, 1 eq) in DCM (5.0 L) was added 2,6-lutidine (1.5 L, 13.0 mol, 4 eq). The reaction mixture was cooled to 0 C (internal temperature) and CSC12 (374 mL, 4.88 mol, 1.5 eq) was added dropwise. The reaction mixture was then stirred for 2 h. The solvent was evaporated under reduced pressure and the material thus obtained was purified by SiC column to provide the title compound, 2-isothiocyanato-l,3-dimethoxybenzene, Example 82.0 as a white solid (1.06g, 2.80 mol, 86%). LCMS (ESI pos. ion) m/z: (M+H)+ = 196. NMR (400 MHz, CDCI3) delta 7.16 (t, J= 8.48 Hz, 1H), 6.55 (d, J = 8.48 Hz, 2H), 3.90 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DEBENEDETTO, Mikkel V.; DRANSFIELD, Paul John; HARVEY, James S.; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; SHARMA, Ankit; (321 pag.)WO2018/93576; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2734-70-5

Equipped with a mechanical stirrer, a condenser and a nitrogen gas through the mouth of the three-necked flask, were added 61.28g (0.40mol) 2,6- dimethoxy aniline and 135.00mL distilled water, stir under a nitrogen atmosphere.40.50mL slowly added dropwise concentrated hydrochloric acid (37percent mass fraction), the temperature of the system was maintained at 35 , then portionwise added 28.14g (0.21mol) 3,5- dimethylbenzaldehyde.System under reflux with vigorous stirring After 6h, the reaction system temperature was lowered to 50 , added in portions with stirring 16.40g sodium hydroxide powder.The solution was subjected to steam distillation, after suction filtration to obtain a solid powder.A solid powder with hot water, and dried dioxane was recrystallized, and dried to give alpha, alpha- bis (4-amino-3,5-dimethoxyphenyl) -1- (3 ‘, 5’-A phenyl) methane solid powder 77.56g (92percent yield)

The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China National Offshore Oil Corporation; CNOOC Research Institute; Zhai, Lei; Zhang, Jian; Jing, Bo; Tan, Guorong; Xue, Xinsheng; (12 pag.)CN103864648; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2734-70-5, The chemical industry reduces the impact on the environment during synthesis 2734-70-5, name is 2,6-Dimethoxyaniline, I believe this compound will play a more active role in future production and life.

To an ice-cooled solution of 2,6-dimethoxyaniline (Amfinecom Inc., 1.2 g, 7.8 mmol) in DCM (20 mL) was added N,N-diisopropylethylamine (2.73 mL, 15.7 mmol) via syringe followed by a solution of 1,3-thiazole-2-carbonyl chloride (Maybridge, 1.16 g, 7.9 mmol) in DCM (27 mL) slowly via cannula. The resulting brown solution was allowed to warm to RTand stirred for 19 h. The reaction was then partitioned between water (80 mL) and DCM (2X). The combined organic layers were washed with brine (2X), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent: 10-100percent EtOAc in hexanes) to provide 396.1 (1.30 g, 63percent yield) as a light yellow solid. LCMS-ESI (pos.) m/z: 265.2 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem