Some common heterocyclic compound, 2734-70-5, name is 2,6-Dimethoxyaniline, molecular formula is C8H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2734-70-5
Trimethylalurninum (4.7 mL, 9.4 mmol) was added dropwise to a solution of 2,6-dimethoxyaniline (1.2 g, 7.8 mmol) and Compound lb (0.80 g, 9.4 mmol) in toluene (10mL) while cooling in an ice bath. After addition was complete, the reaction mixture was warmed to 110 °C and was stirred at this temperature for l4hrs. The cooled reaction mixture was partitioned between a saturated solution of Rochelle?s salt and EtOAc. The organic phase was separated, dried over MgSO4, filtered and concentrated under reducedpressure. The resulting residue was added to a silica gel (120 g) colunm and was eluted with 0-20percent of 20percent MeOH/DCM in 0.5percent TEA/DCM to give Compound lc (1.1 g, 4.5 mmol, 57 percent) as a brown liquid. MS ,n/z 239.0 (M+H). 1H NMR (500M1-lz, CDC13) 67.01(t, J 8.3 Hz, 1H), 6,62 (d, J= 7.7 Hz, 2H), 5.32 (s, 2H), 4.88 (hr s, 2H), 4.31 (s,2H), 3.82 (s, 6H), 3.62-3.73 (m, 2H), 1.19-1.33 (m, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2734-70-5, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHAO, Hannguang J.; FINLAY, Heather; LAWRENCE, R., Michael; MYERS, Michael C.; (154 pag.)WO2017/96130; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem