Category: 52818-63-0

Yang, Fa-Liu published the artcileAn Efficient Homogenized Ruthenium(II) Pincer Complex for N-Monoalkylation of Amines with Alcohols, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is European Journal of Organic Chemistry (2017), 2017(24), 3481-3486, database is CAplus.

An ionic 2,6-bis(imidazo[1,2-α]pyridin-2-yl)pyridine-based N^N^N pincer ruthenium(II) complex exhibited high efficiency in the C-N bond formation between amines and alcs. by the “borrowing hydrogen” (BH) or “hydrogen autotransfer” (HA) concept. The synthetic protocol selectively generated monoalkylated amines without formation of tertiary amines during the reaction. The unique selectivity enabled the formation of sym. and asym. substituted diamines. This methodol. features several advantages including a low catalyst loading (as low as 0.5 mol-%), a short reaction time (as short as 2 h), and excellent N-monoalkylation selectivity.

European Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is Al2H32O28S3, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chatenoud, Lucienne published the artcilePolyclonal and monoclonal antibodies directed against SK & F 94461, a specific H₁ histamine receptor ligand, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Molecular Pharmacology (1988), 34(2), 136-44, database is CAplus and MEDLINE.

SK & F 944618 an aminopentyl analog of mepyramine, is a recently described H, receptor antagonist. At variance with the other available H₁ receptor ligands, SK & F 94461 offers the possibility of coupling to a protein carrier to render the mol. immunogenic. SK & F 94461 coupled to succinylated bovine serum albumin was used as an immunogen to raise polyclonal antibodies in rabbits and BALB/c mice. In parallel, spleen cells from immunized mice were used to produce hybridomas by somatic cell fusion. Thus, 6 different murine monoclonal antibodies sharing anti-SK & F 94461 specificity were selected for further detailed characterization of their binding properties. Pharmacol. studies of competitive inhibition by using a set of 11 histaminergic agents allowed anal. of the fine specificity of anti-SK & F 94461 antibodies. Both polyclonal and monoclonal anti-SK & F 94461 antibodies showed very high affinity for the immunizing mol. (i.e., K_a values for monoclonal antibodies 8 and 12 were, resp., 3 × 10¹⁰ and 1.4 × 10¹⁰ M^-1). Both types of antibodies bound with high affinity (IC₅₀ ranging from 10^-10-10^-12 M) to mepyramine, which has a chem. structure closely resembling that of SK & F 94461. Moreover, these antibodies displayed clear-cut stereoselectivity inasmuch as they bound the d-configuration of chlorpheniramine with higher affinity than the l-form. Thus, all 6 monoclonal antibodies showed IC₅₀ values 1-6 log units lower for d– than for l-chlorpheniramine. For some monoclonal antibodies, spectroscopic and fluorescence spectra studies showed that their different binding capacities correlated with their optical properties. Similarly, polyclonal anti-SK & F 94461 antibodies showed a 500-fold lower affinity for l– than for d-chlorpheniramine. All these results indicate that the polyclonal and the majority of monoclonal anti-SK & F 94461 antibodies recognized with high-affinity structural configurations known to be important for the pharmacol. activity of H₁ ligands, namely the presence of the dimethylaminoethyl side chain and, with stereochem. selectivity, the d-configuration of chlorpheniramine. These data extend for the 1st time to an H₁ histamine receptor ligand results reported in other hormone systems.

Molecular Pharmacology published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pilania, Meenakshi published the artcileCu-Catalyzed Expeditious Synthesis of N-Benzylaminoheterocycles Using N-Tosylhydrazones and Aminoheteroarenes, Quality Control of 52818-63-0, the publication is ChemistrySelect (2016), 1(20), 6368-6373, database is CAplus.

N-Tosylhydrazones were successfully coupled in the presence of CuI (10 mol%) with various heterocyclic amines to develop a convenient and high yielding protocol for the preparation of N-benzylaminoheterocycles under microwave irradiation This ligand-free new methodol. used readily available starting materials and a cheaper copper catalyst. A wide range of O, N and S containing heteroarylamines and o-phenylenediamine were explored to prepare N-benzylaminoheterocycles and 1,2-disubstituted benzimidazoles. The protocol was equally effective with N-tosylhydrazones derived from aldehydes and ketones, especially ferrocene aldehyde to prepare an array of N-benzylaminoheterocycles in good to excellent yields. Finally, the identified reaction conditions were utilized to prepare drug-like mols. namely pyrido[1,2-a]benzimidazole and N-substituted-2-amino-thiazole derivative as antitubercular agents.

ChemistrySelect published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Quality Control of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bird, Ian published the artcileSynthesis of pyrilamine-d₆, Related Products of ethers-buliding-blocks, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1985), 22(2), 109-15, database is CAplus.

Pyrilamine-d₆ (I) was synthesized from N-2-[(4-methoxyphenyl)methyl]aminopyridine and (D₃C)₂NCH₂CH₂Cl in 83% yield. The alkyl chloride was prepared in 37% overall yield in a three step reaction from p-MeC₆H₄SO₂N(CD₃)₂.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Costa, Roberta L. da published the artcileSynthesis of phenanthridinone derivatives by direct arylation. Characterization of the absorption and emission spectra for representative examples, HPLC of Formula: 52818-63-0, the publication is Quimica Nova (2016), 39(3), 310-319, database is CAplus.

Phenanthridinones were prepared by reductive amination of anilines or pyridinamines, benzoylation, ortho-iodination and direct arylation. The phenanthridinone heterocyclic system has attracted considerable attention in recent years due to the diverse array of phys., chem. and pharmacol. properties demonstrated by natural and synthetic derivatives As a consequence there has been considerable development of synthetic methodol. for the synthesis of this and related heterocyclic ring systems. The synthetic literature is discussed and is compared with a direct arylation methodol. for the intramol. cyclization of tertiary (2-iodo)benzoylamides to generate the biaryl bond of these compounds The efficient methodol. allowed the synthesis of a number of previously unknown phenanthridinone products. The photoluminescent properties of representative examples were characterized and it is proposed that the previously unknown compound 1s reveals dual fluorescence in a manner similar to the known compound 1r.

Quimica Nova published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vellakkaran, Mari published the artcileAn Efficient and Selective Nickel-Catalyzed Direct N-Alkylation of Anilines with Alcohols, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is ACS Catalysis (2017), 7(12), 8152-8158, database is CAplus.

Herein, we developed an efficient and selective nickel-catalyzed monoalkylation of various primary alcs. with aryl and heteroaryl amines together with diols and amino alc. derivatives Notably, the catalytic protocol consisting of an earth-abundant and non-precious NiBr₂/L1 (L1 = 1,10-phenanthroline) system enables the transformations in the presence of hydroxyl, alkene, nitrile, and nitro functionalities. As a highlight, we have demonstrated the alkylation of diamine, intramol. cyclization to N-heterocycles, and functionalization of complex vitamin E, an (±)-α-tocopherol derivative Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate-determining step.

ACS Catalysis published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C18H35NO, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Panigrahi, Ahwan published the artcileZnBr₂ Mediated C-N Bond Formation using Cinnamyl Alcohol and 2-Amino Pyridines, Application of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is European Journal of Organic Chemistry (2021), 2021(21), 3054-3058, database is CAplus.

A simple method for C-N bond formation is disclosed by using cinnamyl alcs. and 2-amino pyridine derivatives in the presence of stoichiometric amount of zinc bromide. This reaction works with a wide range of substrates, and is compatible with primary, secondary, and homoallylic alcs. To the best of our knowledge, this is the first report for C-N bond formation using cinnamyl alc. and 2-amino pyridines using zinc bromide as a Lewis acid.

European Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Application of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Moutaoukil, Zakaria published the artcileN-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes, Formula: C13H14N2O, the publication is Organic & Biomolecular Chemistry (2022), 20(4), 831-839, database is CAplus and MEDLINE.

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands.

Organic & Biomolecular Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ge, Chenyang published the artcileUnsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water, Formula: C13H14N2O, the publication is Green Chemistry (2018), 20(8), 1805-1812, database is CAplus.

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its Ir complex supported on hydrotalcite was characterized via x-ray power diffraction (XRD), XPS, energy dispersive X-ray (EDX) spectroscopy and TEM. This new heterogeneous catalyst bearing the unsym. indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in H₂O. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, this catalyst system showed good recovery performance in H₂O. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Green Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sakya, Subas M. published the artcileEfficient synthesis of 5-alkyl amino and thioether substituted pyrazoles, Synthetic Route of 52818-63-0, the publication is Tetrahedron Letters (2003), 44(41), 7629-7632, database is CAplus.

Nucleophilic substitution reactions of 1-(4-methylsulfonyl-2-pyridyl)-5-chloro pyrazoles with various substitutions at the 4 position with amine nucleophiles and thiols occur under mild conditions to provide the 5-alkylamino and thioether pyrazoles in high yields. Reaction products of 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde with piperazine derivatives, benzenethiol, 1H-imidazole, cyclohexanethiol, 2(1H)-pyridinethione, etc. were reported. A similar reaction of 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile, 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Me ester and 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide with amines was also reported.

Tetrahedron Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Synthetic Route of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem