Category: 622-86-6

Li, Aijun published the artcileImproved synthesis of nefazodone from phenol, Related Products of ethers-buliding-blocks, the main research area is nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation.

A route for the synthesis of nefazodone (I) is reported. Nefazodone was obtained with an overall yield of 37.2% from phenol. The key steps involve the improved synthesis of 5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3(2H)-one (II), a key intermediate. The phenol was etherified with 1,2-dichloroethane (75%), followed by iodination-amination with NaI and CH3OH-NH3 (85.7%), acylation with Et chloroformate (95.7%) and cyclization with propionylhydrazine (83.6%).

Transactions of Tianjin University published new progress about nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Morgan, David L. published the artcileEnd-quenching of quasiliving polyisobutylene with phenoxy derivatives for direct chain end functionalization, Product Details of C8H9ClO, the main research area is end quenching quasiliving polyisobutylene phenoxy derivative chain end functionalization.

Various functional alkyl phenoxy derivatives were used to end-quench TiCl4-catalyzed quasiliving isobutylene polymerizations initiated from 2-chloro-2,2,4-trimethylpentane or 5-tert-butyl-1,3-di(2-chloro-2-propyl)benzene at -70°C in 40/60 (volume/volume) hexane/methyl chloride. Quant. end-capping was observed from mono-alkylation of the phenoxy derivatives in para position. The quenching reactions were tolerant of phenoxy derivatives bearing a primary halide, allowing for direct functionalization of polyisobutylene with primary chloride and bromide end groups. Electrophilic aromatic substitution on phenoxy alkyls such as anisole, and subsequent in situ cleavage of the alkyl-oxygen bond, provided single-pot synthesis of phenol telechelic polyisobutylene.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about end quenching quasiliving polyisobutylene phenoxy derivative chain end functionalization. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Duriatti, Albert published the artcileIn vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules, SDS of cas: 622-86-6, the main research area is oxidosqualene sterol cyclase intermediate analog inhibitor; plant oxidosqualene sterol cyclase inhibitor; liver oxidosqualene sterol cyclase inhibitor.

2-Aza-2,3-dihydrosqualene and related mols., a series of new compounds designed as analogs of the transient carbocationic high-energy intermediate occurring in the oxirane ring opening during cyclization of 2,3-oxidosqualene, were tested in vitro as inhibitors of the microsomal 2,3-oxidosqualene cyclase of animals (rat liver) and of higher plants (maize, pea). These mols. proved to be good and specific inhibitors for the cyclases of both phyla. The inhibition is due to pos. charged species and is sensitive to steric hindrance around the N atom. 4,4,10β-Trimethyl-trans-decal-3β-ol and 4,10β-dimethyl-trans-decal-3β-ol, which have previously been described (J. A. Nelson et al., 1978) as inhibitors of the 2,3-oxidosqualene cyclase of CHO cells, were noncompetitive inhibitors of the rat liver microsomal enzyme and presented no activity towards the higher plants cyclases. Aza derivatives of these decalines, which were aimed to mimic the C-8 carbocationic intermediate occurring during later steps of the 2,3-oxidosqualene cyclization did not inhibit the cyclases. This result underlines the theor. limitations of the high-energy analog concept in designing enzyme inhibitors. Among mols. tested, 2,3-epiminosqualene was a reversible, noncompetitive inhibitor of the cyclases; similarly U18666A was a very potent inhibitor of the microsomal cyclases. In contrast, AMO 1618, a known anticholesterolemic agent reported previously to act at the level of the 2,3-oxidosqualene cyclization step, did not appear to act directly on the cyclases.

Biochemical Pharmacology published new progress about Corn. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Leicunaite, Jelena published the artcileLiquid chromatography and characterization of ether-functionalized imidazolium ionic liquids on mixed-mode reversed-phase/cation exchange stationary phase, HPLC of Formula: 622-86-6, the main research area is ether functionalized imidazolium ionic liquid mixed mode liquid chromatog; reversed phase cation exchange HPLC imidazolium ionic liquid.

A new series [CnOmmim]Cl of imidazolium cation-based ionic liquids (ILs), with an ether functional group on the alkyl side-chain, was prepared The possibility of analyzing the ionic liquids by HPLC was studied on mixed-mode reversed/cation exchange stationary phase with the aqueous-acetonitrile mobile phase. Elution parameters, such as retention factor, selectivity and column efficiency, were studied as functions of mobile phase composition and pH. The ILs were characterized by elemental anal., and IR, UV and 1H, 13C NMR spectroscopy.

Comptes Rendus Chimie published new progress about HPLC. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, HPLC of Formula: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bentley, William Henry published the artcileXVIII. – On γ-phenoxy-derivatives of malonic acid and acetic acid, and various compounds used in the synthesis of these acids, Formula: C8H9ClO, the main research area is .

This paper contains a description of a number of compounds which were prepared in the course of a research, not yet completed, on the synthesis of methylisopropyltetramethylenedicarboxylic acid. This acid possesses especial interest from the fact that its formula was for a long time considered as the most probable expression of the constitution of camphoric acid.

Journal of the Chemical Society, Transactions published new progress about Esters. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Singewald, Elizabeth T. published the artcileNovel Hemilabile (Phosphinoalkyl)arene Ligands: Mechanistic Investigation of an Unusual Intramolecular, Arene-Arene Exchange Reaction, Computed Properties of 622-86-6, the main research area is crystal structure rhodium phosphinoethoxybenzene complex; mol structure rhodium phosphinoethoxybenzene complex; intramol exchange free coordinated arene rhodium; phosphinoalkylarene ligand preparation complexation rhodium; phosphinoalkoxyarene ligand preparation complexation rhodium; rhodium phosphinoalkoxyarene phosphinoalkylarene complex preparation; hemilabile phosphinoalkylarene ligand rhodium complex.

The novel, hemilabile (phosphinoalkyl)arene ligands ArX(CH2)2PPh2 (Ar = C6H5, X = O; Ar = C6H5, X = CH2; Ar = 4-FC6H4, X = CH2) were synthesized and complexed to Rh(I) to form the bis(phosphine), η6-arene piano stool complexes [(η6:η1-ArX(CH2)2PPh2)Rh(η1-ArX(CH2)2PPh2)]BF4 (2a-c; shown as I, Y = H, H, F, resp.). Complexes 2a-c were fully characterized in solution, and complex 2a was characterized by single-crystal x-ray diffraction methods. Two of these complexes, 2a and 2c, undergo an unusual, degenerate η6-arene, free arene exchange reaction which was studied by 2-dimensional NMR EXSY experiments A mechanism for the exchange reaction of 2a which involves the formation of a square planar, cis-phosphine, cis-ether Rh(I) complex, [Rh(η2-PhO(CH2)2PPh2)2]BF4, is proposed.

Organometallics published new progress about Crystal structure. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Computed Properties of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ferrando, German published the artcileFacile C(sp2)/OR bond cleavage by Ru or Os, Product Details of C8H9ClO, the main research area is osmium phosphine olefin complex DFT; ruthenium phosphine olefin complex DFT; crystal structure osmium phosphine carbyne complex preparation; mol structure osmium phosphine carbyne complex; isomerization osmium phosphine carbene complex kinetics; olefin osmium ruthenium complex preparation isomerization carbene; carbyne osmium complex preparation DFT; vinylidene osmium ruthenium complex preparation DFT.

Os(H)3ClL2 (L = PiPr3 or PtBu2Me) are shown to be useful “”precursors”” to “”OsHClL2″”, which react with vinyl ethers to form first an η2-olefin adduct and then isomerize to the carbenes, OsHCl[CMe(OR)]L2. Subsequent R- and L-dependent reactions involve C(sp2)-OR bond cleavage, to make either carbyne or vinylidene complexes. The mechanisms of these reactions are explored, and the thermodn. disparity of Ru vs. Os and the influence of the OR group and the spectator phosphine ligands are discussed based on DFT (B3PW91) calculations

Inorganic Chemistry published new progress about C-O bond cleavage. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mizuno, Kazuhiko published the artcileA convenient synthesis of aryl vinyl ethers by use of tetrabutylammonium hydrogen sulfate, Synthetic Route of 622-86-6, the main research area is aryl vinyl ether; dehydrohalogenation haloethoxybenzene.

RC6H4OCH:CH2 (I; R = H, Me, Me3C, MeO, CN, halo, benzo) were prepared by dehydrohalogenation of RC6H4OCH2CH2X (II) in the presence of Bu4N+ HSO4- (III). Thus, 50% aqueous NaOH and 5 mmol III were added to a solution of 5 mmol II (R = 4-Me3C, X = Cl) in C6H6 and the mixture stirred 1 h at room temperature to give 97% I (R = 4-Me3C). Similarly prepared were 10 addnl. I.

Synthesis published new progress about Dehydrohalogenation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Synthetic Route of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kochi, Jay K. published the artcileAlkenes from halides and epoxides by reductive eliminations with chromium(II) complexes, Product Details of C8H9ClO, the main research area is CHROMIUM REDUCTIVE ELIMINATION; COMPLEX; ALKENE FROM ALKYL HALIDE; ALKYL HALIDE ALKENE FROM; REDUCTIVE ELIMINATION HALIDE; EPOXIDE REDUCTIVE ELIMINATION.

A variety of β-substituted alkyl halides and epoxides are reductively eliminated in high yields to alkenes by Cr(II) en at room temperature The reducing agent is easily prepared in situ from chromous salts and ethylenediamine. Reductive elimination and protolytic reduction of β-substituted alkyl halides by chromous reagent proceed by similar mechanisms, and involve free radicals and alkylchromium species as intermediates. In the former process, β-substituents such as OH, OPh, OAc, tosyloxy, Br, Cl, NH2 and trimethylammonium groups are readily eliminated from the β-substituted alkylchromium intermediate to generate alkene. Protolytic reduction of the alkylchromium species is a significant competing reaction only with such β-substituents as CN, benzamido and phthalimido groups. Factors which determine the effect of groups on the relative rates of reductive elimination and protolytic reduction of the alkylchromium species are discussed. The formation of a free radical by an initial ligand transfer of halogen from the alkyl halide to chromous ion is enhanced by β-bromo and trimethylammonium groups. Neighboring group participation by these groups in homolytic processes to form bromine or trimethylammonium-bridged alkyl radicals as intermediates is postulated. Cr(II)en is a more powerful reductant than Cr(II) and the scale of relative reactivity of various halides is compressed in the former relative to the latter. o-Diiodobenzene is reduced by Cr(II)en stepwise to benzene, and benzyne does not appear to be an intermediate in the reaction. 55 references.

Tetrahedron published new progress about Elimination reaction. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Product Details of C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Corsano, S. published the artcileNew pyridazinones: synthesis and correlation between structure and α-blocking activity, COA of Formula: C8H9ClO, the main research area is structure activity correlation pyridazinone adrenoreceptor; piperazinylpyridazinone preparation adrenoreceptor blocking.

The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinones, I (R = H, Me, Ph, R1 = Cl; R = Me, R1 = H), II (R = H, Me, Ph, R1 = Cl, R2 = H, OMe; R = R1 = H, R2 = OMe; R = Me, R1 = H, R2 = H, OMe), III (R2 = H, OMe), has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.

European Journal of Medicinal Chemistry published new progress about Receptors Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, COA of Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem