Category: ethers-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 19056-40-7, name is 4-Bromo-3-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19056-40-7, Application In Synthesis of 4-Bromo-3-methoxyaniline

The mixture of 4-bromo-3-methoxyaniline (2-111, 1 g, 4.97 mmol), pyridine (785mg, 9.94 mmol) and cyclopropanesulfonyl chloride (696 mg, 4.97 mmol) in DCM (20 mL)was stirred at 40 °C rt for 16 h. Upon reaction completion, the resulting mixture was filtered,concentrated to remove the solvent. The resulting residue was purified by silica gelchromatography (Pet Ether/ethyl acetate = 1/1) to obtain title compound 2-112 (yellow solid,1.2 g, 79percent yield). LCMS: 306 [M + Hj .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 134364-69-5, name is 2,3-Difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: ethers-buliding-blocks

Step 2) 2.Og 3-Isobutoxy-4,5,6,6a-tetrahydro-3aH-pentalen-l -one was dissolved in 40 ml DCM. 2.47g Br2 was added drop wise and the mixture was stirred at rt for 20 min. The reaction mixture was cooled to O0C and 3.12 g TEA was slowly added. The cooling bath was removed and the mixture was stirred at rt for 1 h. Filtration and concentration gave a crude product which was purified on silica using 2% MeOH in DCM to produce 2.26 g l-Bromo-2,3-difluoro-4-methoxy-benzene.

The synthetic route of 134364-69-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 366-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-butanone (14.40 g, 200 mmol), Acetic acid (1.8 g, 30 mmol), and Sodium triacetoxyborohydride (6.36 g, 30 mmol) were added to a solution of 3-Fluoro-4-methoxyaniline (2.82 g, 20 mmol) in DCM (120 mL) and the mixture was stirred at RT for 12 hr. Water was added to quench the reaction and the mixture was extracted with DCM. The solvent was removed under and the residue was purified by silica gel chromatography to afford N-(sec-Butyl)-3-fluoro-4-methoxyaniline (2.6 g, 66percent yield). MS m/z=198 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 53087-13-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53087-13-1 name is 1-(Benzyloxy)-3-bromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-Benzyloxy-3-bromobenzene (10.56 g, 40.13 mmol), 3,5-dimethoxybenzaldehyde (7.34 g, 44.14 mmol), and n-butyl lithium (17.66 ml, 44.14 mmol) were treated in the same manner as described above for the synthesis of (2,3-dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanol. The crude material was purified via flash column chromatography (10% EtOAc in hexane gradient to 40% EtOAc in hexane in about 40 min.) to give (3-Benzyloxy-phenyl)-(3,5-dimethoxy-phenyl)-methanol as an oil (11.54 g, 82%): 1H-NMR (CDCl3) 7.43-7.21 (m, 6H, Ar), 7.04-6.85 (m, 3H, Ar), 6.54 (d, J=2 Hz, 2H, Ar), 6.36 (t, J=2 Hz, 1H, Ar), 5.72 (d, J=3 Hz, 1H, CHOH), 5.04 (s, 2H, CH2), 3.76 (s, 6H, 2OCH3), 2.21 (d, J=3 Hz, 1H, OH). The product was carried over to the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Benzyloxy)-3-bromobenzene, and friends who are interested can also refer to it.

Electric Literature of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2- [1- (2- {4- [1- (4,4-dimethyl-4,5-211-oxazol-2-yl) -1-methyl-ethyl] } -piperidin-4-yl] -1H-benzimidazole was dissolved in 60 mL of THF, and 620 mg of sodium methoxide was added in portions to produce a large amount of air bubbles. The solution was clouded by clarification, After 2 h of reaction, the mixture was heated to 70 C, 2032 muL 2-bromoethyl ether was added, Reaction 2 h, TLC monitoring reaction, After stopping the reaction, add a small amount of water to quench the reaction, concentrate out of THF, add methylene chloride and wash with saturated NaCl solution three times, the organic layer was concentrated with the appropriate amount of dichloromethane to dissolve it, adding n-hexane beating to obtain light yellow solid, Filtration and drying gave solid 2. 0 g, yield 90%

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.

Electric Literature of 18800-30-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18800-30-1, name is 1-Bromo-4-(2-bromoethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: b) 52.0 g (186 mmol) of 1 -bromo-4-(2-bromoethoxy)benzene is added to 300 ml THF and chilled to 0 C. Within 30 min 25.0 g (223 mmol) KOtBu are added to this mixture in several portions. The cooling bath is removed and the reaction mixture is stirred at r.t. over night. The reaction is queched by the addition of water. The resulting mixture is extracted with EtOAc (2x). The org. phases are combined, washed with sat. aq. NaCI solution, dried with MgSO4 and the solvent is removed in vacuo. The resulting product is used without further purification.

The synthetic route of 1-Bromo-4-(2-bromoethoxy)benzene has been constantly updated, and we look forward to future research findings.

Synthetic Route of 50868-73-0,Some common heterocyclic compound, 50868-73-0, name is 2-Methoxy-6-methylaniline, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2-methoxy-6-methylphenylaniline (137 mg) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to a solution of triphosgene (119 mg) in anhydrous dichloromethane (5 mL) at room temperature. After the dropwise addition was completed, a solution of 1-(2-methoxy-5-methyl-phenyl)-3-(4-piperazin-1-yl-phenyl)-urea (340 mg) obtained in Example (47a) and diisopropylethylamine (0.38 mL) in anhydrous dichloromethane (5 mL) was added dropwise slowly to the reaction mixture at room temperature. After 3 hours, the reaction mixture was concentrated and diluted with ethyl acetate and water. The deposited solid was collected by filtration, washed with hexane and ethyl acetate and dried under reduced pressure, and 361 mg (72%) of the title compound was obtained as a white powder. 1H-NMR spectrum (400MHz,DMSO-d6):delta(ppm)=9.10(1H, s), 8.07(1H, s), 7.99(1H, d, J=1.5Hz), 7.77(1H, s), 7.34(2H, d, J=8.6Hz), 7.10(1H, dd, J=7.9 and 7.9Hz), 6.96(2H, d, J=9.0Hz), 6.96(1H, d, J=9Hz), 6.88(1H, dd, J=7.4 and 7.4Hz), 6.82(1H, dd, J=8.4 and 8.4Hz), 6.72(1H, d, J=8.2Hz), 3.84(3H, s), 3.73(3H, s), 3.59(4H, t, J=4.1Hz), 3.07(4H, t, J=5.1Hz), 2.23(3H, s), 2.12(3H, s). MS(FAB) m/z:504 (M + H)+. Melting point: 200-203C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxy-6-methylaniline, its application will become more common.

Synthetic Route of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a round bottomed flask, diol 7 (1.03 g 8.8 mmol) was dissolved in 90 mL of DCM. Triethylorthobenzoate (3.0 mL,13.5 mmol) and p-toluenesulfonic acid (32.0 mg 2 molpercent) were added. The reaction mixture was stirred at room temperature for one hour. Water (0.4 mL) was added and the mixture stirred vigorously for an additional 40 minutes. The solvent was removed in vacuo, and the residue waspurified by silica gel column chromatography using 25percent ethyl acetate/hexanes as the eluent. Benzoate 10(1.02 g, 52percent) was obtained as a yellow oil. 1H-NMR (500 MHz, CDCl3): delta 2.15-2.20 (t, J=6.0 Hz, 1H),3.71-3.78 (dd, J=6.0, 12.0 Hz, 1H), 3.78-3.84 (dd, J= 5.0, 12.0 Hz, 1H), 3.86-3.93 (quin, J=5.0 Hz, 1H),4.44-4.51 (dd, J=7.0, 12.0 Hz, 1H), 4.53-4.59 (dd, J=4.5, 12.0 Hz, 1H), 7.44-7.50 (dd, J=5.0 Hz, 7.0 Hz,2H), 7.57-7.62 (t, J=7.5 Hz, 1H), 8.03-8.09 (d, J=7.5 Hz, 2H).

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Application of 67191-35-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

A flame-dried Schlenk reaction flask is charged with a stir bar and put under an Ar atmosphere. 923 mg [Dichloro-(3-phenyl-1H-inden-1-ylidene)-bis-(tricyclohexyl-phosphine)-ruthenium(II)] 2a (1.0 mmol; Umicore AG & Co KG, Hanau), 173 mg 2-isopropoxystyrene (1.05 mmol; 1.05 equiv.; Aldrich) and 1026 mg Amberlyst 15-A resin in dry form (4.0 mmol, 4 equiv.; Rohm and Haas Co., Philadelphia, USA) are loaded into the reaction flask and 25 mL dichloromethane (DCM) is added. The reaction is stirred at 40 C. for 75 minutes and the solution colored from red to brown. Subsequently, the reaction mixture is sent through a Pasteur pipette equipped with a cotton plug to remove the Amberlyst resin. Evaporation of all volatiles, suspending the residue in 20 mL n-hexane and subsequent filtration and drying of the precipitate in vacuo afforded 548 mg of the desired compound 3a (yield: 91%)

The chemical industry reduces the impact on the environment during synthesis 1-Isopropoxy-2-vinylbenzene. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5111-65-9 as follows. HPLC of Formula: C11H9BrO

The B22 – 1 (1 g, 4.22 mmol) is dissolved in dioxane (5 ml) in, adding three (dibenzylidene acetone) two palladium (97 mg, 0 . 17 mmol) and 2 tert-butyl phosphine 2 ‘, 4′, 6’ – three isopropyl biphenyl (72 mg, 0 . 17 mmol), then adding dissolved in 5 ml water with potassium hydroxide (709 mg, 12 . 66 mmol), heating to 100 C reaction 1.5 hours. After cooling to room temperature by adding 2 N HCl (20 ml), stirring 1 hour after concentrating under reduced pressure, methylene chloride (30 ml * 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, concentrated under reduced pressure to get the yellow solid (435 mg, 59%).

According to the analysis of related databases, 5111-65-9, the application of this compound in the production field has become more and more popular.