In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5111-65-9 as follows. HPLC of Formula: C11H9BrO
The B22 – 1 (1 g, 4.22 mmol) is dissolved in dioxane (5 ml) in, adding three (dibenzylidene acetone) two palladium (97 mg, 0 . 17 mmol) and 2 tert-butyl phosphine 2 ‘, 4′, 6’ – three isopropyl biphenyl (72 mg, 0 . 17 mmol), then adding dissolved in 5 ml water with potassium hydroxide (709 mg, 12 . 66 mmol), heating to 100 C reaction 1.5 hours. After cooling to room temperature by adding 2 N HCl (20 ml), stirring 1 hour after concentrating under reduced pressure, methylene chloride (30 ml * 3) extraction, the combined organic phase, dried with anhydrous sodium sulfate, concentrated under reduced pressure to get the yellow solid (435 mg, 59%).
According to the analysis of related databases, 5111-65-9, the application of this compound in the production field has become more and more popular.