Category: ethers-buliding-blocks

These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 645-36-3

4-(2-bromoethyl)heptane (4.14 g, 1.0 eq, 20 mmol) was dissolved in 30 mL of DMF and the amino acetal was added(2.66 g, 1.0 eq, 20 mmol) and K2CO3 (5.5 g, 2.0 eq, 40 mmol).After the reaction solution was reacted at 100 C. for 6 hours, the reaction was completed by TLC (PE:EA=1:1).The reaction solution was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3).The combined reaction solution was washed successively with saturated aqueous NH 4 Cl (50 mL×3), water (30 mL) and saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to give the product as a yellow oil (4.2 g, Y=81.1%). .

The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 645-36-3, name is 2,2-Diethoxyethanamine, A new synthetic method of this compound is introduced below., Formula: C6H15NO2

Dissolve N- (2-chloropyrimidine-4-substituted) -4-fluorobenzamide (5g, 19.9mmol) in toluene (50mL), cool to 0 C, and slowly drop in dichlorosulfoxide under nitrogen protection (7.1 g, 59.8 mmol), transferred to room temperature for 1 hour, and then refluxed overnight. TLC monitoring, after the reaction was completed, the solvent and dichlorosulfoxide were removed to obtain (Z) -N- (2-chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride.Dissolve aminoacetaldehyde diethanol (3.5 g, 23.9 mmol) and TEA (4.0 g, 39.8 mmol) in dichloromethane (100 mL), cool to 0 C, and obtain (Z) -N- (2-Chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride was dissolved in dichloromethane (100 mL), and the solution was slowly added dropwise. The mixture was naturally warmed to room temperature and stirred overnight. Monitored by TLC. After the reaction was completed, the mixture was washed with a saturated ammonium chloride aqueous solution and a saturated saline solution, dried over anhydrous Na2SO4, filtered, and dried. Purification by silica gel column chromatography gave a yellow solid (7 g, 95.7%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(Trifluoromethoxy)aniline

General procedure: Under nitrogen atmosphere, dry CH2Cl2 (30 mL), amine (0.02 mol), and Et3N (0.05 mol) wereadded to a three-necked round bottom ask and stirred for 0.5 h, then chloroacetyl chloride droppedslowly and reacted for 3 h at room temperature. Then, the solution was washed with 2 mol L1hydrochloric acid (30 mL), saturated aq NaHCO3 solution (30 mL), and brine (40 mL), successively,then dried over anhydrous Na2SO4 and filtered. After evaporating CH2Cl2 in vacuum, the obtainedcrude product was rened by recrystallization using ethyl acetate/petroleum ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1535-75-7, its application will become more common.

Synthetic Route of 588-96-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 588-96-5, name is p-Bromophenetole, This compound has unique chemical properties. The synthetic route is as follows.

Example I.1 2-{-4-[1-(4-Ethoxy-phenyl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide 60 mg (0.23 mmol) N-Ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide (VI.1) are added to a mixture of 46 mg (0.23 mmol) 1-bromo-4-ethoxy-benzene, 91 mg (97%, 0.92 mmol) sodium tert-butyrat, 28 mg (0.09 mmol) 2-(di-tert-butylphosphino)biphenyl and 21 mg (0.02 mmol) tris-(dibenzylidenaceton)-dipalladium(0) in 1.0 mL 1,4-dioxane. The mixture is stirred for 1.5 h at 120 C. in a microwave oven. After that time, the solvent is removed in vacuo and the residue is purified by HPLC (column: Waters XBridge 50; eluent A: water+0.3% NH4OH, eluent B: MeOH) to yield the desired product. C24H32N2O2 (M=380.5 g/mol) ESI-MS: 381 [M+H]+Rt (HPLC): 2.15 min (method C)

The chemical industry reduces the impact on the environment during synthesis p-Bromophenetole. I believe this compound will play a more active role in future production and life.

Reference of 929-75-9,Some common heterocyclic compound, 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, molecular formula is C8H20N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 20 mL round-bottomed flask, 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid (prepared as described in US20100152190A1, 200 mg, 324 mumol) and HATU (136 mg, 357 mumol) combined with dry tetrahydrofuran (2 mL) to give an off-white suspension at room temperature. It was stirred for 30 min at room temperature. The reaction mixture was slowly added dropwise to a solution of 1,11-diamino-3,6,9-trioxaundecane (312 mg, 304 muL, 1.62 mmol) in dry tetrahydrofuran (1.5 mL) at 0 C. The reaction was done after stirring at room temperature for 20 min. It was filtered and injected into Gilson reverse-phase high-performance liquid chromatography for purification. The desired fractions was converted to free base and lyophilized to afford (2R,3S,4R,5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid [4-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethylcarbamoyl)-2-methoxy-phenyl]-amide as a white solid (169 mg, 66% yield). LCMS (ES+) m/z calcd. for C39H47Cl2F2N5O6[(M+H)+]: 790. found: 790

The synthetic route of 929-75-9 has been constantly updated, and we look forward to future research findings.

Related Products of 36805-97-7, A common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, molecular formula is C11H25NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of 4-bromo-3-methylbenzoic acid (10 g, 46.5 mmol) was heated to 80 C. and N,N-dimethylformamide di-tert-butyl acetal (44.6 mL, 186.0 mmol) was added dropwise over 30 minutes under a nitrogen atmosphere; stirring was continued at this temperature for 1.5 h. The reaction mixture was allowed to cool and then washed with water (1*), saturated NaHCO3 (1*), and brine (1*). The organic layer was dried (Na2SO4) and concentrated to afford tert-Butyl 4-bromo-3-methylbenzoate (as an off-white oil (8.8 g, 70%). ESI-MS m/e 311.9 (M+CH3CN+1).

The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89521-55-1, name is 3-(Benzyloxy)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

To a stirred solution of 3- benzyloxybenzene-1,2 -diamine (1 g, 4.67 mmol) in AcOH (20 mL) was added with tetramethoxymethane (0.95 g, 7 mmol) in one portion at 20 oC. The solution was stirred overnight. Then the mixture was concentrated in vacuo. The residue was purified by prep-HPLC (neutral condition) to afford 4-benzyloxy-2- methoxy-1H- benzimidazole (0.7 g, 56%) as a white powder. LCMS (M+H+) m/z: Calcd: 255.11; Found: 255.1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 398-62-9,Some common heterocyclic compound, 398-62-9, name is 4-Fluoro-1,2-dimethoxybenzene, molecular formula is C8H9FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a chilled solution (0 C.) of 1.0 g (6.4 mmol) of 4-fluoroveratrole in 6.5 mL anhydrous dichloromethane was added 10.5 mL of 1.0 M titanium (IV) chloride (10.5 mmol; in CH2Cl2), over 30 m and under inert atmosphere. Following this, a solution of 0.826 g (7.2 mmol) of dichloromethyl methyl ether in 2.0 mL anhydrous dichloromethane slowly was added to the reaction. After this addition was complete, the ice bath was removed and the reaction stirred at room temperature for an additional 3 h. The reaction then was poured over 25 g crushed ice, and extracted with ether (3×20 mL). The combined organic layers were washed with saturated sodium bicarbonate (3×20 mL) and with brine (1×20 mL), dried over sodium sulfate, and evaporated under reduced pressure. The product was purified using flash chromatography with 15% ethyl acetate in hexanes. The product gave the NMR shown in FIG. 16.

The synthetic route of 398-62-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1535-75-7,Some common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A Schlenk tube was charged with dibromides (0.3 mmol), Pd2dba3(0.0075 mmol), DPEPhos (0.03 mmol), and Cs2CO3 (0.75 mmol). The tube was evacuated and backfilled with argon before amine (0.36 mmol) and 2 mL toluene was added. The reaction mixture was stirred at 120 oC for 8-24h. After the reaction mixture was diluted with EtOAc and washed with water and brine, the solution was dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluting with 50:1 petroleum ether/ethyl acetate) to provide the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethoxy)aniline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 20469-65-2, name is 1-Bromo-3,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20469-65-2, Recommanded Product: 20469-65-2

(1a) 3-Bromo-5-methoxyphenol Commercially available 1-bromo-3,5-dimethoxybenzene (18.74 g, 86.3 mmol) was dissolved in 1-methyl-2-pyrrolidone (100 mL), and sodium thiomethoxide (6.74 g, 96.2 mmol) was added, followed by stirring at 100C for 3 hours under nitrogen atmosphere. The reaction solution was cooled to room temperature, 1N hydrochloric acid (200 mL) was added, and extraction was carried out with diethyl ether (500 mL). The organic layer was washed with saturated brine, and subsequently dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=20%-25%) to afford the desired compound (15.03 g, yield 86%) as a white solid. 1H-NMR (CDCl3, 400 MHz): delta 3.77 (3H, s), 4.82 (1H, s), 6.33 (1H, t, J=2.4 Hz), 6.61 (1H, t, J=2.0 Hz), 6.66 (1H, t, J=2.0 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.