Category: ethers-buliding-blocks

Application of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Indolinone 1 (1000 mg, 52.3 mmol) was suspended in acetic anhydride (10 mL) and refluxed at 130 C for 8 h. The reaction mixture was allowed to cool to 50 C and (triethoxymethyl)benzene (2930 mg, 131 mmol) was added. The resulting reaction mixture was stirred at 120 C for 6 h. Then, volatiles were removed in vacuo and petroleum ether was added to the obtained residue. After triturating for 15 min, the separated solids were filtered and washed with petroleum ether and then dried under vacuum to afford 974 mg (51percent) of title compound.

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 16618-68-1, name is 3-Bromo-5-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16618-68-1, HPLC of Formula: C7H8BrNO

To a solution of 3-bromo-5-methoxyaniline (5.0 g, 25 mmol) stirred in acetone (100 mL) at room temperature, benzoyl isothiocyanate (3.95 mL, 27.2 mmol) was added. The reaction mixture was stirred for 1 hour before the acetone was removed by evaporation. The crude residue obtained was washed with hexanes and collected by filtration to give N-((3-bromo-5-ethoxyphenyl)carbamothioyl)benzamide as a yellow solid (8.0 g, 89 %). LC (Method B): 2.351 min. MS (APCI): calcd for Ci5Hi4BrN202S [M+H]+ m/z 365.0, 367.0, found 365.0, 367.0. 1H NMR (DMSO-d6, 400 MHz) 5 ppm 12.57 (br s, 1H), 11.64 (br s, 1H), 7.98 (d, J = 7.4 Hz, 2H), 7.67 (t, J = 7.4 Hz, 1H), 7.60 (br s, 1H), 7.55 (t, J = 7.8 Hz, 2H), 7.34 (br s, 1H), 7.08 (t, J = 2.0 Hz, 1H), 3.79 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-5-methoxyaniline, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 701-56-4, name is 4-Methoxy-N,N-dimethylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Methoxy-N,N-dimethylaniline

The second step, 28.2 grams of oil,200 ml of toluene,27 grams of anhydrous aluminum chloride was added to a 500 ml three-neck bottle.The temperature was refluxed for 6 hours in an oil bath.Cool down to 80 C,Slowly add 100 ml of saturated sodium bicarbonate solution.Produce a solid,Continue to stir for 10 minutes.Filter out the insoluble matter while hot,After filtration, hot liquid separation,Add 50 ml of water to the toluene.Warmed up to 80 C together,Stir for 10 minutes,Liquid separation,The toluene phase is dried,Then use an oil pump to decompress and distill.Curing to obtain 20.8 grams of product,99.8% purity,The yield was 81%.

The synthetic route of 701-56-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 171290-52-1,Some common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Procedure A: To a solution of alkyne (1.3equiv.) and (E)-4-azido-bis(POM)-but-2-enylphosphonate 22 (0.11mmol, 1.0equiv.) in t-BuOH/ H2O (1:1 ratio, 400muL) were added Cu powder (11.6mg, 0.40mmol, 5.0equiv.) and CuSO4 (5.0mg, 0.020mmol, 0.25equiv.). The resulting suspension was stirred 8h at room temperature, then the crude mixture was diluted in EtOAc (1mL), and directly transferred on a preparative thin layer silica plate to give (E)-4?-(1,2,3-triazol-1-yl)-bis(POM)-but-2?-enylphosphonate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethoxyphenylacetylene, its application will become more common.

These common heterocyclic compound, 63057-72-7, name is 1-(Benzyloxy)-4-bromo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-(Benzyloxy)-4-bromo-2-methoxybenzene

A solution of 2 (4.0 g, 13.7 mmol) in dry THF (40 mL) at -78 C. was treated with n-BuLi (2.5 M, 6.0 mL, 15.0 mmol) for 15 min to produce 3. To this solution, 5 (3.1 g, 12.2 mmol) in dry THF (40 mL) was added slowly over a 10 min period. The reaction mixture turned light brown in color and stirring was continued for 1 h. The reaction was quenched by the addition of saturated aqueous NH4Cl (10 mL) and the organic layer was separated. The aqueous layer was extracted with EtOAc (3×25 mL) and the combined organic layer was washed with brine (15 mL). Volatiles were evaporated under reduced pressure and the crude residue was purified by column chromatography using 20% acetone/hexane as the eluent to afford the title compound 6 as a white solid (2.6 g, 46%).

The synthetic route of 1-(Benzyloxy)-4-bromo-2-methoxybenzene has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4179-19-5, name is 3,5-Dimethoxytoluene, A new synthetic method of this compound is introduced below., name: 3,5-Dimethoxytoluene

General procedure: A 25mL round-bottom flask equipped with a magnetic barand a water condenser was charged with propargylic alcohol1 (1.0mmol), arene 2 (1.1mmol), MeCN (2.0mL) andPTSA (10mol%) in air atmosphere. The flask was placedinto a constant temperature oil-bath at 80C and the progressof the reaction was monitored by TLC. After completionof the reaction, the solvent was removed under reducedpressure and the crude reaction mixture was purified by columnchromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 352-67-0, name is 1-Fluoro-4-(trifluoromethoxy)benzene, molecular formula is C7H4F4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 352-67-0

Boron trifluoride etherate (0.453 ml, 3.89 mmol) and trimethyl borate (0.867 ml, 7.77 mmol) were stirred in anhydrous tetrahydrofuran (THF, 10 ml) for 10 minutes to form dimethoxyfluoroborane in situ.To a solution of the 4-fluoro(trifluoromethoxy)benzene (2.0 g, 11.1 mmol) in dry THF (30 ml) at -780C, was added ethylenediaminetetraacetic acid (EDTA, 1.36 g, 11.7 mmol) followed by a 1.4 M solution of sec-butyllithium in cyclohexane (8.33 ml, 11.7 mmol) and the reaction stirred for 2 hours under nitrogen. To this reaction mixture at – 780C, was then added dropwise the preformed dimethoxyfluoroborane mixture. The reaction was stirred at -780C for 30 minutes, warmed to room temperature for 30 minutes, and then quenched with water (10 ml). The volume of the reaction mixture was reduced in vacuo, then the residue dissolved in diethyl ether (10 ml) and washed with an aqueous solution of 10% NaOH (50 ml). The aqueous layer was acidified and extracted with ethyl acetate (3 x 40 ml). The combined ethyl acetate extracts were dried over MgSO4 and concentrated in vacuo to afford the title compound as a single regioisomer (1.51 g).LCMS Rt = 1.38 minMS m/z 223 [M]-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 352-67-0, its application will become more common.

Reference of 14227-17-9, A common heterocyclic compound, 14227-17-9, name is 2,4,6-Trimethoxyaniline, molecular formula is C9H13NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE U N-(2,4,6-Trimethoxyphenyl)-2-bromoacetamide In a process analogous to Example T using 2,4,6-trimethoxyaniline in place of 2,6-diisopropylaniline, the title compound is obtained as a solid; mp 160-161 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1535-73-5, name is 3-Trifluoromethoxyaniline, A new synthetic method of this compound is introduced below., Formula: C7H6F3NO

General procedure: 2-Chloro-4,6-dimethoxy-1,3,5-triazine (1 mmol) (2), substituted aniline (1 mmol)/heterocyclic amines (3) (1 mmol), anhydrous K2CO3 (2 mmol) were added in dry THF (5 mL) taken in a round bottom flask. The reaction mixture was refluxed at 70 °C for 4 h. After completion of the reaction the product is confirmed on thin-layer chromatography (TLC) using eluent (2:8 mL,ethyl acetate-hexane). The reaction mixture was quenched with water and the crude product was extracted with ethyl acetate (3 times) and organic layer was separated and dried over anhydrous Na2SO4. The solvent evaporated on rotavapour. The Crude material was purified by column chromatography (ethylacetate-n-hexane) and product 4(a-x) with good yield (70-75 percent) were obtained (Scheme-II).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 93-04-9,Some common heterocyclic compound, 93-04-9, name is 2-Methoxynaphthalene, molecular formula is C11H10O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A flame dried Schlenk flask was charged with Bi(OTf)3 (13.1 mg,0.020 mmol), alkyl aryl ethers (0.40 mmol), alcohols or thiols (1.2 mmol) andCH2ClCH2Cl (0.20 mL), and then the resulting mixture was stirred at 110 C (or 130 C forthe synthesis of 1m) for 24 h. The solvent was removed under the reduced pressure, andthe residue was subjected to flash column chromatography on silica gel with hexane /AcOEt as eluents to afford the corresponding aryl ethers or aryl thioethers

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxynaphthalene, its application will become more common.