Application of 398-62-9,Some common heterocyclic compound, 398-62-9, name is 4-Fluoro-1,2-dimethoxybenzene, molecular formula is C8H9FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a chilled solution (0 C.) of 1.0 g (6.4 mmol) of 4-fluoroveratrole in 6.5 mL anhydrous dichloromethane was added 10.5 mL of 1.0 M titanium (IV) chloride (10.5 mmol; in CH2Cl2), over 30 m and under inert atmosphere. Following this, a solution of 0.826 g (7.2 mmol) of dichloromethyl methyl ether in 2.0 mL anhydrous dichloromethane slowly was added to the reaction. After this addition was complete, the ice bath was removed and the reaction stirred at room temperature for an additional 3 h. The reaction then was poured over 25 g crushed ice, and extracted with ether (3×20 mL). The combined organic layers were washed with saturated sodium bicarbonate (3×20 mL) and with brine (1×20 mL), dried over sodium sulfate, and evaporated under reduced pressure. The product was purified using flash chromatography with 15% ethyl acetate in hexanes. The product gave the NMR shown in FIG. 16.
The synthetic route of 398-62-9 has been constantly updated, and we look forward to future research findings.