Category: ethers-buliding-blocks

Walker, James B. published the artcileFurther studies on the mechanism of transamidinase action: transamidination in Streptomyces griseus, Recommanded Product: Formamidine disulfide dihydrochloride, the publication is Journal of Biological Chemistry (1958), 1-9, database is CAplus.

cf. C.A. 51, 8169d. In contrast to mammalian kidney transamidinase, that of S. griseus does not react with glycine. Like the kidney transamidinase, it catalyzes reversible arginine-ornithine and canavanine-ornithine transamidinations. The concept of an enzyme-amidine intermediate in transamidination reactions is supported by (a) the occurrence of the arginine-ornithine exchange reaction, coupled with specificity considerations, and (b) the fact that the formamidine moiety of the intermediate can be trapped with HONH₂ to form hydroxyguanidine. Formamidine disulfide is a potent inhibitor of transamidinase. It is suggested that its inhibitory action results from the formation of a mixed disulfide with an essential sulfhydryl group on the enzyme. A sensitive colorimetric assay for hydroxyguanidine is described.

Journal of Biological Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C11H19N, Recommanded Product: Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wheatley, P. J. published the artcileCrystallography of some cyanine dyes, Product Details of C2H8Cl2N4S2, the publication is Journal of the Chemical Society (1959), 3245-50, database is CAplus.

The cell constants and space groups of some cyanine dyes and their solvates were determined The structure of the unsolvated dye 3,3′-diethylthiacarbocyanine bromide was elucidated from 2 projections. The cation is planar with the conjugated chain in the extended form. The S atoms are cis with respect to this chain. Some curious properties of the crystals are described. The results of the structure determination are correlated with other properties of cyanine dyes.

Journal of the Chemical Society published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C8H10O2, Product Details of C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Williams, D. Lyn H. published the artcileS-Nitrosation of thiourea and thiocyanate ion. Nitrosyl thiocyanate and the S-nitroso-adduct of thiourea as nitrosating agents, Application In Synthesis of 14807-75-1, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1977), 128-32, database is CAplus.

The reaction between H2NCSNH2 (I) and PhN(Me)NO (II) in aqueous acid solution gave PhNHMe (III) and a S-nitroso intermediate (IV) which decomposed to form [(H2N)2C+S]2. The latter two products are the same as those from the reaction of I and HNO2. The nitrosoamine reaction was acid-catalyzed and was first order in both I and II. Added III reduced the reaction rate, showing that the formation of IV was reversible, i.e. it was capable of acting directly as a nitrosating agent. The reactivities (relative to III) of ‘various nitrite’ traps (NH3, H2NN+H3, H2NSO3H, H3N+OH, urea) towards IV were determined, the order of reactivity was the same as for the nitrosating agents NOCl, NOBr, and H2N+O2, but discrimination by IV was greater than for these, implying that IV is a less reactive species. Rate constant ratios obtained for NOSCN are similar to those of IV suggesting that they have almost the same reactivity as nitrosating agents.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C8H11BO2, Application In Synthesis of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yeh, S. Y. published the artcileN-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. New metabolic pathways, Application In Synthesis of 52818-63-0, the publication is Drug Metabolism and Disposition (1990), 18(4), 453-61, database is CAplus and MEDLINE.

N-(2-Dimethylaminoethyl)benzylamine and 2-benzylaminopyridine were identified as two new urinary metabolites of tripelennamine in the rat by GC/MS. 2-(4-Methoxybenzylamino)-pyridine and N-(dimethylaminoethyl)-4-hydroxybenzylamine were identified as new urinary metabolites of pyrilamine by GC/MS. Thus, in addition to N– and O-demethylation, hydroxylation, and glucuronidation, N-debenzylation, N-depyridination and N-dedimethylaminoethylation were shown to be novel pathways for metabolism of tripelennamine and pyrilamine. The mechanism for N-depyridination and N-dealkylation is discussed.

Drug Metabolism and Disposition published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C3H5F3O, Application In Synthesis of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Papez, Maja published the artcileAnorectal drug products for over-the-counter human use, Formula: C17H28ClNO3, the publication is Federal Register (2003), 68(165), 51167-51170, database is CAplus.

The Food and Drug Administration (FDA) is issuing, under the Federal Food, Drug, and Cosmetic Act, a final rule establishing that any over-the-counter (OTC) drug product containing a combination of hydrocortisone and pramoxine hydrochloride (HCl) for anorectal use is not generally recognized as safe and effective and is misbranded. This combination product is not currently marketed OTC. This final rule discusses data on the combination of hydrocortisone and pramoxine HCl that were still under review when an earlier final rule on OTC anorectal drug products was issued. This rule is part of FDA’s ongoing review of OTC drug products.

Federal Register published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C10H13NO2, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Flores-Alamo, Marcos published the artcileAnorectal drug products for over-the-counter human use; tentative final monograph, COA of Formula: C17H28ClNO3, the publication is Federal Register (1988), 53(157), 30756-84, database is CAplus.

Components of over-the-counter anorectal products suitable for external (topical) or intrarectal administration and allowed combinations of active ingredients and their labeling are given under the Federal Food, Drug, and Cosmetic Act. Classes of active ingredients include: local anesthetics, vasoconstrictors, protectants, analgesics, anesthetics, antipruritics, astringents, and/or keratolytic agents.

Federal Register published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C12H10BFO3, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dziaduszek, Jerzy published the artcileAnorectal drug products for over-the-counter human use; final monograph, Synthetic Route of 637-58-1, the publication is Federal Register (1990), 55(150), 31776-83, database is CAplus.

Active ingredients and permitted combinations of active ingredients in over-the-counter anorectal products for external or intrarectal administration are given under the Federal Food, Drug, and Cosmetic Act. Classes of active ingredients include anesthetics, vasoconstrictors, protectants, analgesics, antipruritics, astringents, and keratolytics. Labeling of anorectal drug products is also considered.

Federal Register published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C13H8BrIN2O2S, Synthetic Route of 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Blanpin, Odette published the artcileThe local-anesthetic action of pramoxine hydrochloride (tronothane, Related Products of ethers-buliding-blocks, the publication is Anesthesie, Analgesie, Reanimation (1957), 225-31, database is CAplus.

Pramoxine (or tronothane) is p-butoxyphenyl morpholinopropyl ether-HCl (I). Its pharmacol. properties and toxicity are reported. L.D.₅₀ (intravenous injection into caudal vein of the mouse) 132 mg./kg.; L.D._min. (slow intravenous infusion in guinea pigs) 108.7 ± 2.3 mg./kg.; L.D.₅₀ (subcutaneous injection into the mouse) 1.47 g./kg. A 1% solution of I was used to determine its local tolerance (in the eye of a rabbit) and its effectiveness as a local anesthetic (also on rabbits). I was found to be 3.6 times as effective as cocaine-HCl when used as a local anesthetic on the skin surface and 1.5 times as effective as procaine-HCl (II) in infiltration tests on guinea pigs. In tests determining the reduction of the excitability of a frog muscle preparation (sciatic nerve to the gastrocnemius muscle in Ringer solution, pH 6) a 0.10% solution of I had about the same effect as a 0.01% solution of II. I is, therefore, an excellent surface anesthetic, but its use in eye surgery must be rigorously avoided because of its property of producing necrosis of the mucous membrane and muscle fibers.

Anesthesie, Analgesie, Reanimation published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bolton, Roger published the artcileSulfuryl chloride as an electrophile. IV. Steric hindrance to activation by the methoxy-group, Category: ethers-buliding-blocks, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1970), 1770-2, database is CAplus.

The rates of reactions of sulfuryl chloride with a number of aromatic ethers have been studied in chlorobenzene solution The additivity principle, which holds in a number of examples of this reactions, fails when 2 substituents are placed ortho to the methoxyl group in anisole. 2,3,4,6-Tetramethylanisole substitutes Cl at a similar rate to that of 3-methylanisole, its calculated rate coefficient being 2000 times the exptl. value. Neither increasing the size of the alkyl group attached to the O atom nor using only 1 ortho substituent brought about any detectable effect due to steric factors.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Demir, Hulya published the artcileEvaluation of the chemical profiling, total phenolic composition, the antioxidant and antimicrobial properties of the essential oils of Mentha piperita L., Salvia officinalis L., and Thymus vulgaris L, Application of 2-Isopropylanisole, the publication is Journal of Food Science and Engineering (2018), 8(6), 263-270, database is CAplus.

The purpose of this study was to determine the chem. composition, total phenolic composition, the antioxidant and antimicrobial properties of the essential oils (EOs) of Mentha piperita L., Salvia officinalis L., and Thymus vulgaris L. The essential oils of M. piperita L., S. officinalis L., and T. vulgaris L. were analyzed by means of gas chromatog.-mass spectrometry (GC-MS) to demonstrate their chem. composition The antioxidant properties of the EOs were evaluated with the 2,2-diphenyl-picrylhydrazyl (DDPH) free radical scavenging assay, their total phenolic compound contents were determined by the Folin Ciocalteau method, and their antimicrobial activities were evaluated by the disk diffusion assay. The major compounds in the contents of the essential oils of M. piperita L., S. officinalis L., and T. vulgaris L. were found to be eucalyptol, 1R-α-pinene, and o-cymene, resp. In the 2,2-diphenyl-picrylhydrazyl (DDPH) assay, the EO of M. piperita L. (8,930.01 μMTE/g) demonstrated the highest antioxidant activity, followed by the activities of the EOs of T. vulgaris L. (157.76 μMTE/g) and S. officinalis L. (115.54 μMTE/g). The total phenolic compound contents of M. piperita L., T. vulgaris L., and S. officinalis L. were measured as 135.074, 0.242, and 0.221 mMGAE/g. All essential oils showed antioxidant activities and antimicrobial activities. The highest antimicrobial activity against S. aureus, A. nigeris, and C. albicans was determined in the EO of M. piperita L. within diameters of 42, 32, and 28 mm, resp. These properties of essential oils are used in the pharmaceutical and food industries. The essential oils are approved as official medications in many countries and take place in their pharmacopoeias.

Journal of Food Science and Engineering published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem