Category: ethers-buliding-blocks

One-pot bio-derived ionic liquid conversion followed by hydrogenolysis reaction for biomass valorization: A promising approach affecting the morphology and quality of lignin of switchgrass and poplar was written by Carrozza, Chiara Francesca;Papa, Gabriella;Citterio, Attilio;Sebastiano, Roberto;Simmons, Blake A.;Singh, Seema. And the article was included in Bioresource Technology in 2019.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

The use of bio-derived ionic liquids (e.g., cholinium lysinate) in a one-pot process was evaluated on overall sugar and lignin yields as a function of two model woody and herbaceous feedstocks, switchgrass and poplar, with emphasis on the study of phys. and chem. alterations in lignin structure, by performing a detailed mass balance anal. and chem. characterization. Multiple chromatog. and spectroscopic anal. techniques were applied tracking lignin reactivity and partitioning during the ionic liquid one-pot conversion. Depolymerization efficiency of the lignin-rich residue derived from the whole process was investigated as a function of different temperatures and pressures during catalytic hydrogenolysis by Ni(SO)₄. This study validates the potential of ionic liquid one pot process as an integrated approach for full exploitation of lignocellulosic feedstocks. The insights gained will contribute to the design of future conversion routes for efficient biomass deconstruction and lignin valorization. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Optimization and modeling of microwave-assisted extraction of curcumin and antioxidant compounds from turmeric by using natural deep eutectic solvents was written by Doldolova, Khadija;Bener, Mustafa;Lalikoglu, Melisa;Asci, Yavuz Selim;Arat, Refik;Apak, Resat. And the article was included in Food Chemistry in 2021.Reference of 33171-05-0 The following contents are mentioned in the article:

Natural deep eutectic solvents (NADES) have recently come to the fore as new green solvents for foods, cosmetics and pharmaceuticals due to their unique solvation power and low toxicity. Turmeric extracts were prepared using the microwave assisted extraction method (MAE) using five NADES containing binary combinations of choline chloride, lactic acid, fructose, and sucrose. The MAE method was optimized and modeled by using response surface methodol. to obtain maximum total antioxidant capacity (TAC) and curcumin contents (CC) in extracts for each NADES. All NADES extracts, except NADES-1 containing fructose and cholin chloride, exhibited higher TAC and CC than those in 80% methanol:water which was the preferred solvent in literature. NADES solvents did not interfere with subsequent antioxidant capacity measurements using the CUPRAC method. The proposed MAE is a potentially efficient and sustainable procedure in pharmaceutical and food industries for the extraction of antioxidants and curcumin from turmeric. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production was written by Ricelli, Alessandra;Gionfra, Fabio;Percario, Zulema;De Angelis, Martina;Primitivo, Ludovica;Bonfantini, Veronica;Antonioletti, Roberto;Bullitta, Simonetta Maria;Saso, Luciano;Incerpi, Sandra;Pedersen, Jens Zacho. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alc. (HA). HT has aroused much interest due to its antioxidant activity as a radical scavenger, whereas only a few studies have been made on the HA mol. Both chem. synthesis and extraction techniques have been developed to obtain these mols., with each method having its advantages and drawbacks. In this study, we report the use of tyrosol from olive mill wastewaters as a starting mol. to synthesize HT and HA, using a sustainable procedure characterized by high efficiency and low cost. The effects of HT and HA were evaluated on two cell lines, THP-1 human leukemic monocytes and L-6 myoblasts from rat skeletal muscle, after treating the cells with a radical generator. Both HT and HA efficiently inhibited ROS production In particular, HT inhibited the proliferation of the THP-1 leukemic monocytes, while HA protected L-6 myoblasts from cytotoxicity. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synthesis and characterization of giant Calixarenes was written by Guerineau, Vincent;Rollet, Marion;Viel, Stephane;Lepoittevin, Benedicte;Costa, Ludovic;Saint-Aguet, Pascale;Laurent, Regis;Roger, Philippe;Gigmes, Didier;Martini, Cyril;Huc, Vincent. And the article was included in Nature Communications in 2019.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Calixarenes are cyclic oligomers obtained by condensation of suitable p-functionalized phenols with formaldehyde, usually allowing for the synthesis of the well known small calixarenes (including up to eight phenolic subunits). We report here the discovery of much larger members of this family, exhibiting sizes up to 90 phenolic subunits: the giant calixarenes. These macrocycles are obtained according to simple, easily scalable processes, in yields up to 65%. We show that the formation of these giant macrocycles is favored by an oxygen-containing-group at the para-position of the starting phenol, high concentrations of heavy alk. bases (rubidium or cesium hydroxides) and long reaction times. A mechanism is proposed to rationalize these observations. These giant macrocycles can also be obtained in the quasi-solid state, opening interesting perspectives in the field of calixarenes chem. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synthesis and characterization of giant Calixarenes was written by Guerineau, Vincent;Rollet, Marion;Viel, Stephane;Lepoittevin, Benedicte;Costa, Ludovic;Saint-Aguet, Pascale;Laurent, Regis;Roger, Philippe;Gigmes, Didier;Martini, Cyril;Huc, Vincent. And the article was included in Nature Communications in 2019.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:

Calixarenes are cyclic oligomers obtained by condensation of suitable p-functionalized phenols with formaldehyde, usually allowing for the synthesis of the well known small calixarenes (including up to eight phenolic subunits). We report here the discovery of much larger members of this family, exhibiting sizes up to 90 phenolic subunits: the giant calixarenes. These macrocycles are obtained according to simple, easily scalable processes, in yields up to 65%. We show that the formation of these giant macrocycles is favored by an oxygen-containing-group at the para-position of the starting phenol, high concentrations of heavy alk. bases (rubidium or cesium hydroxides) and long reaction times. A mechanism is proposed to rationalize these observations. These giant macrocycles can also be obtained in the quasi-solid state, opening interesting perspectives in the field of calixarenes chem. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Beyond Directed ortho Metalation: Ru-Catalyzed C_Ar-O Activation/Cross-Coupling Reaction by Amide Chelation was written by Zhao, Yigang;Snieckus, Victor. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane The following contents are mentioned in the article:

Disclosed is a new, catalytic, and general methodol. for the chem. synthesis of biaryl, heterobiaryl, and polyaryl mols. by the cross-coupling of o-methoxybenzamides with aryl boroneopentylates. The reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH₂(CO)(PPh₃)₃ conditions. A one-step, base-free coupling process is thereby established that has the potential to supersede the useful two-step directed ortho metalation/ cross-coupling reaction involving cryogenic temperature and strong base conditions. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, min. waste, and convenient scale-up make these reactions suitable for industrial applications. Thus, e.g., treatment of N,N-diethyl-2-methoxybenzamide with 2-phenyl-5,5-dimethyl-1,3,2-dioxaborinane in presence of RuH₂(CO)(PPh₃)₃ afforded N,N-diethyl-2-biphenylcarboxamide (96%). This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis and cytotoxicity evalufation of substituted benzimidazole conjugated 1,3,4-oxadiazoles was written by Quy, Nguyen Phu;Hue, Bui Thi Buu;Do, Kiep Minh;Quy, Ha Thi Kim;De, Tran Quang;Phuong, Tran Thi Bich;Trang, Pham Cong;Quoc, Nguyen Cuong;Morita, Hiroyuki. And the article was included in Chemical & Pharmaceutical Bulletin in 2022.Application of 109-85-3 The following contents are mentioned in the article:

Two series of 2-substituted benzimidazole conjugated 1,3,4-oxadiazole derivatives were designed, synthesized and evaluated for their cytotoxic activities against the three human cancer cell lines (cervical cancer (HeLa), breast cancer (MCF-7) and lung cancer (A549)). As the results 14 compounds demonstrated consistent to stronger cytotoxicities compared to the control 5-fluorouracil (5-FU) towards the tested cell lines including 4c (HeLa); 4b, 4e, 4h, 7i-j, 7m-n, 7s (MCF-7); 7b (MCF-7, A549); 7h (HeLa, MCF-7); and 4d, 4i, 7c (HeLa, MCF-7, A549), with the IC₅₀ ranging from 2.7 to 38 μM. Notably, compound 4b illustrated almost 5-fold activity against the MCF-7 while 4d, 4i were 9- and 8-fold (HeLa), 4.5- and 13-fold (MCF-7), 4.7- and 4-fold (A549) increase in activity compared to 5-FU, resp., and were found as lead compounds These findings suggest that compounds 4b, 4d and 4i merit further characterization and can serve as promising scaffolds in the discovery of new potent anticancer agents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethanol treatment suppresses the yellowing of fresh-cut yam by repressing the phenylpropanoid pathway and bisdemethoxycurcumin biosynthesis was written by Guo, Shuang;Zhao, Xiaoyan;Ma, Yue;Zhang, Yan;Wang, Dan. And the article was included in Postharvest Biology and Technology in 2021.Application of 33171-05-0 The following contents are mentioned in the article:

An ethanol treatment (10% volume/volume) inhibited the yellowing of fresh-cut yam during storage. The ethanol treatment also prevented bisdemethoxycurcumin formation, and reduced the contents of metabolites in fresh-cut yam during storage at 25°C. Ethanol treatment also inhibited the activities of key enzymes in the phenylpropanoid pathway, including phenylalanine ammonia lyase (PAL), cinnamic acid-4-hydroxylase (C4H), and 4-coumarate-CoA ligase (4CL), and decreased the transcription level expressions of PAL, C4H, and 4CL compared to the control. The expressions of diketide-CoA synthase, curcumin synthase 3, and curcumin synthase were also reduced by ethanol treatment compared to the control, in agreement with the absence of bisdemethoxycurcumin in fresh-cut yam treated with ethanol. These findings suggest that ethanol can be used to attenuate the yellowing of fresh-cut yam stored at 25°C, which may be related to ethanol inhibition of the phenylpropanoid pathway and bisdemethoxycurcumin biosynthesis. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gene expression programming strategy for estimation of flash point temperature of non-electrolyte organic compounds was written by Gharagheizi, Farhad;Ilani-Kashkouli, Poorandokht;Farahani, Nasrin;Mohammadi, Amir H.. And the article was included in Fluid Phase Equilibria in 2012.Reference of 112-59-4 The following contents are mentioned in the article:

The accuracy and predictability of correlations and models to determine the flammability characteristics of chem. compounds are of drastic significance in various chem. industries. In the present study, the main focus is on introducing and applying the gene expression programming (GEP) math. strategy to develop a comprehensive empirical method for this purpose. This work deals with presenting an empirical correlation to predict the flash point temperature of 1471 (non-electrolyte) organic compounds from 77 different chem. families. The parameters of the correlation include the mol. weight, critical temperature, critical pressure, acentric factor, and normal b.p. of the compounds The obtained statistical parameters including root mean square of error of the results from DIPPR 801 data (8.8, 8.9, 8.9 K for training, optimization and prediction sets, resp.) demonstrate improved accuracy of the results of the presented correlation with respect to previously-proposed methods available in open literature. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Reference of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M^pro) inhibitors to unveil a hope against COVID-19 was written by Adem, Sevki;Eyupoglu, Volkan;Ibrahim, Ibrahim M.;Sarfraz, Iqra;Rasul, Azhar;Ali, Muhammad;Elfiky, Abdo A.. And the article was included in Computers in Biology and Medicine in 2022.SDS of cas: 33171-05-0 The following contents are mentioned in the article:

SARS-CoV-2, a rapidly spreading new strain of human coronavirus, has affected almost all the countries around the world. The lack of specific drugs against SARS-CoV-2 is a significant hurdle towards the successful treatment of COVID-19. Thus, there is an urgent need to boost up research for the development of effective therapeutics against COVID-19. In the current study, we investigated the efficacy of 81 medicinal plant-based bioactive compounds against SARS-CoV-2 Mpro by using various in silico techniques. The interaction affinities of polyphenolic compounds towards SARS-CoV-2 Mpro was assessed via intramol. (by Quantum Mechanic), intermol. (by Mol. Docking), and spatial (by Mol. Dynamic) simulations. Our obtained result demonstrate that Hesperidin, rutin, diosmin, and apiin are most effective compounds agents against SARS-CoV-2 Mpro as compared to Nelfinavir (pos. control). This study will hopefully pave a way for advanced exptl. research to evaluate the in vitro and in vivo efficacy of these compounds for the treatment of COVID-19. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0SDS of cas: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem