Ethers-buliding-blocks

Related Products of 888327-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 77 Preparation of: 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-3-methyl-5-(3-methylphenyl)- 3,5-dihydro-4H-imidazol-4-oneStep 1 : 1-(difluoromethoxy)-2-(2-fluoroethyl)-4-(phenylethvnyl)benzene; In a 50 mL round-bottomed flask was placed 4-bromo-1-(difluoromethoxy)-2- methylbenzene (0.8 g, 3.37 mmol) and DMF (6.75 mL) was added to give a colorless solution.1-Ethynyl-3-methylbenzene (0.436 mL, 3.37 mmol) and triethylamine (2.352 mL, 16.87 mmol) were added. The reaction was degassed by bubbling with N2.Bis(triphenylphosphine)palladium(ll) chloride (0.118 g, 0.169 mmol) was added and N2 bubbling was continued. Copper iodide (0.032 g, 0.169 mmol) was added. The reaction was heated to 60 C for 12h. The reaction was cooled and partitioned between ether (70 mL) and 1MHCI (50 mL). The organic was washed with 1 M HCI (50 mL) and brine (2 x 50 mL). The organic layer was dried over Na2SO4. The crude was purified by flash chromatography (100% hexanes) to provide 1-(difluoromethoxy)-2-methyl-4-(m-tolylethynyl)benzene (0.88 g, 3.23 mmol, 96% yield) as a yellow oil with minor impurities.1H NMR (400 MHz, DMSO-d6) § 7.05-7.70 (m, 7H), 7.18 (t, JH.F = 74 Hz, 1H), 2.30 (s, 3H), 2.20(s, 3H)

The synthetic route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
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Reference of 707-07-3,Some common heterocyclic compound, 707-07-3, name is (Trimethoxymethyl)benzene, molecular formula is C10H14O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Nitroaniline derivative (1 mmol) was added to a mixture of indium powder (574 mg, 5.0 mmol for 2-nitroaniline, 918 mg 8.0 mmol for 1,2-dinitroarene), and acetic acid (0.572 mL, 10 mmol) in ethyl acetate (2 mL), followed by the addition of trimethyl orthoester (2.0 mmol) in ethyl acetate (3 mL for 2-nitroaniline; 8 mL for 1,2-dinitroarene). The reaction mixture was stirred at reflux under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL), filtered through Celite, poured into 10% NaHCO3 (30 mL), and then extracted with ethyl acetate (30 mL×3). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The residue was eluted with ethyl acetate/hexane (v/v=10/90) for 2-phenylbenzimidazole derivatives or methanol/dichloromethane (v/v=1/99) for 2-methylbenzimidazole derivatives through a silica gel column to give the corresponding benzimidazoles. The structures of the benzimidazoles were characterized by 1H NMR, 13C NMR, FTIR, and GC-MS, and were mostly known compounds. HRMS data were reported in addition for unknown compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Trimethoxymethyl)benzene, its application will become more common.

Reference:
Article; Kim, Jaeho; Kim, Jihye; Lee, Hyunseung; Lee, Byung Min; Kim, Byeong Hyo; Tetrahedron; vol. 67; 41; (2011); p. 8027 – 8033;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1579-40-4 as follows. category: ethers-buliding-blocks

Chlorosulfonic acid diluted (14.11g, 121.1mmol) in dichloromethane 30ml, was cooled in an ice water bath to 5 .This solution, di (para-tolyl) ether (10.0g, 50.44mmol) in dichloro-methane and then added dropwise to a solution (20ml), The reaction solution is warmed to room temperature was stirred for 2 hours.Was added dropwise distilled water (10ml) to the reaction solution was distilled off dichloromethane to the evaporator.Dropping the resulting solution into a saturated sodium chloride solution of 500ml, and then recovering the resultant precipitate was separated by filtration, and was dissolved by heating in distilled water 400ml.By cooling in ice water and this solution was filtered recovering the resulting precipitate.The resulting solid was dissolved in 50ml of methanol and adding Amberlite IR120 be small (Aldrich Co.) 20g, were stirred at room temperature for 30 minutes.Next, the reaction solution was filtered, concentrated by drying the obtained filtrate, to give a compound A1-1 (4.7g, 14.23mmol)

According to the analysis of related databases, 1579-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG CHEMICAL CO., LTD; PARK, JONG HO; SAH, KONG CHUN; KIM, SUNG HYUN; BAEK, GYUNG LIM; RYU, CHANG HYUN; (91 pag.)KR2015/128789; (2015); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1,1-Di-tert-butoxy-N,N-dimethylmethanamine

Preparation of compound (6); A solution of (S)-(+)-Z-4- amino-2-hydroxybutyric acid (5) (5 g, 19.74 mmol) in toluene (38 mL) containing N,N-dimethylformamide di-tert-butyl acetal (18.92 mL, 78.96 mmol) was heated to 95C for 3 h. The solvent was then evaporated and the crude product was purified by flash chromatography on silica gel (n-hexane/EtOAc = 7:4) to give (6) (3.4 g, 55.7 % yields) as yellow solid. Mp 42-44C; [alpha]20D= – 5.9 (c= 10.1 mg/ml, CHC13) 1H-NMR (CDCl3) delta: 1.47 (s, 9H); 1.76-1.85 (m, 1H); 1.94-2.09 (m, 1H); 2.74 (br s, 1H); 3.36 (dd, J= 6.04 Hz, J= 11.99 Hz, 2H); 4.10 (dd, J= 4.02 Hz, J= 8.05 Hz, 1H); 5.09 (s, 2H); 5.21 (br s, 1H); 7.31-7.37 (m, 5H) Anal. Calcd. for C16H23NO5: C, 62.12; H, 7.49; N, 4.53. Found: C, 62.22; H, 7.48; N, 4.53.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 36805-97-7.

Reference:
Patent; Bracco S.P.A.; EP1972617; (2008); A1;,
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Reference of 1515-81-7, A common heterocyclic compound, 1515-81-7, name is 1-Methoxy-4-(methoxymethyl)benzene, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The reactions were carried out a ~40 mL, Teflon-lined, stainlesssteelautoclave. AcOH (2 mL), TEMPO (0.25 mmol), HNO3 (0.25mmol), the appropriate benzylic methyl ether (0.5 mmol), andNH4OAc (1.5 mmol) were added sequentially to the autoclave.Subsequently, the autoclave was pressurized to 1 MPa with O2,and the reaction mixture was heated with magnetic stirring at50 C for 20 h, then cooled to r.t. The mixture was then dilutedwith Et2O (15 mL) and H2O (5 mL), and adjusted to pH 7-8 with2 M aq NaOH. The two layers were separated, and the aqueouslayer was extracted with Et2O (3 × 15 mL). The organic layerswere combined, dried (Na2SO4), filtered, and concentrated to avolume of approximately 3 mL in a rotary evaporator. GC analysisof the concentrated organic phase, with biphenyl or 1,2,4,5-tetramethylbenzene as internal standard, provided the GC yieldof the product. The crude product in the concentrated organicphase from another parallel experiment was purified bycolumn chromatography [silica gel (200-300 mesh), EtOAc-PE].

The synthetic route of 1515-81-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tian, Xinzhe; Ren, Yun-Lai; Ren, Fangping; Cheng, Xinqiang; Zhao, Shuang; Wang, Jianji; Synlett; vol. 29; 18; (2018); p. 2444 – 2448;,
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Electric Literature of 25245-34-5,Some common heterocyclic compound, 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, molecular formula is C8H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 214 1,2-Dihydro-9-methoxy-2,2,4-trimethyl-5-coumarino[3,4-f]quinoline (Compound 314, structure 41 of Scheme XI, where R1 =H, R2 =methoxy) 2,5-Dimethoxyphenylboronic acid (structure 37 of Scheme XI, where R1 =H, R2 =methoxy). This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,4-dimethoxybenzene, its application will become more common.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5688810; (1997); A;,
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Related Products of 1836-62-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2-phenoxy-ethylamine (5 eq.) or 2-(2-methoxyphenoxy-)ethylamine (5 eq.) in 2-methoxyethanol(25 mL per mmol of amine) the appropriate aliphatic chloride33-39 (1 eq.) and KI (cat.) was added. The mixturewas refluxed for18-48 h and concentrated. The residue was suspended in CHCl3and washed with 1M NaOH, brine, dried over anhydrous Na2SO4and concentrated. The crude was purified by flash chromatographyto give the titled compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Methoxyphenoxy)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Franchini, Silvia; Sorbi, Claudia; Linciano, Pasquale; Carnevale, Gianluca; Tait, Annalisa; Ronsisvalle, Simone; Buccioni, Michela; Del Bello, Fabio; Cilia, Antonio; Pirona, Lorenza; Denora, Nunzio; Iacobazzi, Rosa Maria; Brasili, Livio; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 310 – 325;,
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Electric Literature of 36805-97-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,1-Di-teit-butoxy-N,N-dimethylmethanamine (6.77 ml, 28.3 mmol) was added to asuspension of 2-({[(benzyloxy)carbonyl]amino}methyl)- 1-ethyl-i H-i, 3-benzodiazole-6- carboxylic acid, Intermediate 4 (2.50 g, 7.08 mmol) in a,a,a-trifluorotoluene (50 ml). The reaction mixture was heated at 100 00 for 1 h. The reaction mixture was allowed to cool to RT then i,i-di-teit-butoxy-N,N-dimethylmethanamine (6.77 ml, 28.3 mmol) was added dropwise over 15 mm. The resultant mixture was heated at 100 00 for 45 mm. Thereaction mixture was cooled to 50 00 then i,i-di-teit-butoxy-N,N-dimethylmethanamine (3.38 ml, 14.2 mmol) was added dropwise over 5 mm. The resultant mixture was heated at 100C for 0.5 h then allowed to cool to RT. The reaction mixture was partitioned between EtOAc (50 ml) and water (50 ml). The phases were separated then the organic phase was washed with water (2 x 30 ml), saturated aqueous NaHCO3 solution (20 ml)and brine (10 ml) then dried over Na2504, filtered and concentrated in vacuo to afford a beige solid (2.5 g). The solid thus obtained was suspended in MeCN (10 ml). The solid was collected by filtration then dried under vacuum to afford the product as an off-white solid (2.30 g, 79%).1H NMR (500 MHz, DMSO-d6) O 8.07 (5, 1H), 7.97 (m, 1H), 7.76 (dd, J= 8.4, 1.5 Hz,1 H), 7.64 (d, J = 8.4 Hz, 1 H), 7.34 (m, 5H), 5.07 (5, 2H), 4.55 (d, J = 6.0 Hz, 2H), 4.38 -4.25 (m, 2H), 1.57 (5, 9H), 1.29 (m, 3H).LC/MS (System A): m/z (ESl) = 410 [MH], R = 1.17 mi UV purity = 99%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; MCCARTHY, Clive; (108 pag.)WO2019/77340; (2019); A1;,
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Related Products of 36805-97-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1-2; Synthesis of Compound 5 (di-tert-butyl ester of (2S, 3S)-N-(tert-butoxycarbonyl)-3-(3,5-dinitrobenzyloxy)aspartic acid) from Compound 3 in Figure 1; To a solution of Compound 3 (455 mg, 0.84 mmol) in methanol (3 mL), a catalytic amount of DL-camphorsulfonic acid was added and stirred at room temperature for 18 hours. After addition of saturated aqueous sodium bicarbonate to stop the reaction, the reaction mixture was extracted with ether and the organic layer was washed with saturated aqueous sodium chloride. After the organic layer was dried over magnesium sulfate, the solvent was distilled off and the resulting residue was dissolved in acetone (5 mL), followed by addition of Jones reagent until brown did not disappear. After stirring at room temperature for 30 minutes, 2-propanol was added to stop the reaction. The reaction mixture was extracted with ether and the organic layer was washed with saturated aqueous sodium chloride. The organic layer was dried over magnesium sulfate and the solvent was distilled off to give carboxylic acid (4) (26 mg, 72% for 2 steps). The thus obtained 4 was dissolved in methanol (2 mL) and 1 N NaOH (2.5 mL) was added thereto under ice cooling, followed by stirring at room temperature for 4 hours. The reaction mixture was adjusted with 2 N hydrochloric acid to pH 1 and extracted with ethyl acetate. The solvent was distilled off and the resulting residue was dissolved in N,N-dimethylformamide di-tert-butylacetal (5 mL) and heated at 90C for 15 minutes. The reaction mixture was cooled on ice and water was added thereto, followed by stirring for 18 hours. After extraction with ether, the organic layer was washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The solvent was distilled off the resulting residue was purified by silica gel column chromatography (ether/hexane = 1/3) to give the titled compound (257 mg, 77% for 2 steps). Oil; [alpha]D -4.2 (c 1.22, CHCl3) ; 1H-NMR (CDCl3, 400 MHz) delta1.39 (s, 9 H), 1.44 (s, 9 H), 1.47 (s, 9 H), 4.51 (d, 1 H, J = 2.5 Hz), 4.58 (d, 1 H, J = 12.5 Hz), 4.81 (dd, 1 H, J = 2.0, 10.5 Hz), 5.03 (d, 1 H, J = 12.5 Hz), 5.19 (d, 1 H, J = 10.5 Hz), 8.50 (d, 2 H, J = 2.0 Hz), 8.93 (t, 1 H, J = 2.0 Hz).

The synthetic route of 1,1-Di-tert-butoxy-N,N-dimethylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNTORY LIMITED; EP1849766; (2007); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2398-37-0, name is 1-Bromo-3-methoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 2398-37-0

Intermediate 1 l-AUyl-3-methoxy-benzene (Ha)A solution of 3-bromoanisole (4Og, 0.2138mol) dissolved in dry THF (220 rnL) was added dropwise to a solution of magnesium (7.9g, 0.328mol) activated by pinch of iodine in dry THF (20 ml) and the reaction was shortly heated with a heat -gun to get the reaction started. After 1 hr, when the solution was gray and most of the magnesium was dissolved, allyl bromide (28.4 mL, 0.328 mol) was added. After 3 h the reaction was quenched by a saturated NH4Cl solution and the organic layer was extracted with diethyl ether. The organic phase was dried over anhydrous Na2SO4, the solvent was evaporated and the crude product was subjected to flash chromatography on silica gel (230-400 mesh) using 3-4% ethyl acetate in petroleum ether which gave the allyl compound as yellow viscous liquid (24 g, 76%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MEDIVIR AB; WO2008/135488; (2008); A1;,
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