In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1579-40-4 as follows. category: ethers-buliding-blocks
Chlorosulfonic acid diluted (14.11g, 121.1mmol) in dichloromethane 30ml, was cooled in an ice water bath to 5 .This solution, di (para-tolyl) ether (10.0g, 50.44mmol) in dichloro-methane and then added dropwise to a solution (20ml), The reaction solution is warmed to room temperature was stirred for 2 hours.Was added dropwise distilled water (10ml) to the reaction solution was distilled off dichloromethane to the evaporator.Dropping the resulting solution into a saturated sodium chloride solution of 500ml, and then recovering the resultant precipitate was separated by filtration, and was dissolved by heating in distilled water 400ml.By cooling in ice water and this solution was filtered recovering the resulting precipitate.The resulting solid was dissolved in 50ml of methanol and adding Amberlite IR120 be small (Aldrich Co.) 20g, were stirred at room temperature for 30 minutes.Next, the reaction solution was filtered, concentrated by drying the obtained filtrate, to give a compound A1-1 (4.7g, 14.23mmol)
According to the analysis of related databases, 1579-40-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LG CHEMICAL CO., LTD; PARK, JONG HO; SAH, KONG CHUN; KIM, SUNG HYUN; BAEK, GYUNG LIM; RYU, CHANG HYUN; (91 pag.)KR2015/128789; (2015); A;,
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