Ethers-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 62415-74-1

Add 4-methoxy-o-dibromobenzene (1.0 mmol), thentBuOOH (1.2mmol), Cu (acac) 2 (0.08mmol), then add 2mL of solvent water, and react at room temperature for 8 hours,After the reaction was completed, the reaction solution was concentrated, and the corresponding product was separated by column chromatography, with a separation yield of 91%.

According to the analysis of related databases, 62415-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Institute of Technology; Yao Zijian; Qiao Xinchao; (6 pag.)CN110981702; (2020); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-(Benzyloxy)-1-ethanamine

General procedure: Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields.

According to the analysis of related databases, 38336-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Dongxing; Shi, Jinyu; Liu, Jing; Zhang, Xueying; Deng, Xiaoying; Yang, Yanyan; Cui, Shuang; Zhu, Qihua; Gong, Guoqing; Xu, Yungen; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 458 – 470;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37466-89-0, name is 3-Methoxybenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Recommanded Product: 37466-89-0

To a solution of Intermediate 7 (110 mg, 0.37 mmol), 3-methoxybenzene-1,2- diamine (50 mg, 0.34 mmol) and DIPEA (0.2 mL, 1 mmol) in DMF (2 mL) was added HATU (160 mg, 0.41 mmol). The reaction mixture was stirred at r.t. for 48 h, then partitioned between DCM and water. The organic phase was separated, then dried and concentrated in vacuo. The crude residue was purified by flash column chromatography (0-100% EtOAc/hexanes) to give the title compound (28.7 mg, 20%) as a white solid. LCMS (Method 5): [M+H]+ m/z 415, RT 1.31 minutes.

The synthetic route of 37466-89-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; FOULKES, Gregory; FROST, James Richard; HORSLEY, Helen Tracey; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; REUBERSON, James Thomas; SCHULZE, Monika-Sarah Elisabeth Dorothea; TAYLOR, Richard David; YAU, Wei Tsung; ZHU, Zhaoning; (246 pag.)WO2019/138017; (2019); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 592-55-2 as follows. COA of Formula: C4H9BrO

Example 65 Preparation of 2-[4-[2-(benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,6-diisopropyl-3-(2-ethoxyethyloxy)phenyl)acetamide: 2-Bromoethyl ethyl ether (2 ml) and potassium fluoride catalyst carried on alumina (40 wt %, 225 mg, 1.51 mmol) were added to a solution of 2-[4-[2-(benzoxazol-2ylthio)ethyl]piperazin-1-yl]-N-(2,6-diisopropyl-3-hydroxyphenyl)acetamide (150 mg, 0.30 mmol) in acetonitrile (3 ml) followed by stirring for 41 hours. The catalyst was filtered off and the filtrate was diluted with water and extracted with ethyl acetate. The organic layer was washed with a sodium chloride solution and dried over anhydrous sodium sulfate and the solvent was evaporated therefrom. The residue was purified by a preparative thin layer chromatography (developing solvent, chloroform:ammonia-saturated methanol=20:1) and the resulting crude crystals were recrystallized from ethyl acetate-hexane to provide 120 mg (yield 70%) of the desired compound as colorless powdery crystals. Melting point: 100-103 C. IR (KBr) cm-1: 3282, 2960, 1661, 1498, 1454. 1H-NMR (CDCl3) delta: 1.17 (6H, d, J=6.9 Hz), 1.23 (3H, t, J=7.0 Hz), 1.32 (6H, d, J=6.9 Hz), 2.62-2.79 (8H, m), 2.86 (2H, t, J=6.2 Hz), 2.93 (1H, sept, J=6.9 Hz), 3.19 (1H, sept, J=6.9 Hz), 3.21 (2H, s), 3.50 (2H, t, J=6.2 Hz), 3.59 (2H, q, J=7.0 Hz), 3.81 (2H, t, J=5.1 Hz), 4.09 (2H, t, J=5.9 Hz), 6.83 (1H, d, J=8.7 Hz), 7.09 (1H, d, J=8.7 Hz), 7.22-7.30 (2H, m), 7.43 (1H, m), 7.58 (1H, m), 8.56 (1H, br s). EIMSm/z (relative intensity): 568 (M+), 276 (100). Elementary analysis as C31H44N4O4S Calculated: C, 65.46; H, 7.80; N, 9.85; S, 5.64. Found: C, 65.16; H, 7.75; N, 9.81; S, 5.70.

According to the analysis of related databases, 592-55-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kowa Company, Ltd.; US6969711; (2005); B2;,
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Electric Literature of 50742-37-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50742-37-5, name is (3-Phenoxyphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows.

(3-Phenoxyphenyl)methanamine (1.55 g, 7.79 mmol) was taken up in 60 mL of IPA, and 15 mL of volatile material was removed by distillation. The mixture was cooled, and TEA (1.50 mL, 10.7 mmol) and 4-chloroquinazoline (1.20 g, 7.32 mmol) in 15 mL of IPA were added. The mixture was heated at reflux for 5.5 hr, and then stirred at room temperature overnight. Then, the volatile components were evaporated, and the residue was partitioned between DCM (3×70 mL) and 5% Na2C03 (40 mL). The combined organic phases were dried over Na2S04, filtered, and concentrated. SPE, eluting with 25% and then 55% EA/Hex, gave product fractions that were combined and concentrated to yield an orange solid. Recrystallization from EA/Hex gave a pink solid, and then from MeOH gave 1.29 g of a light pink solid. R 0.19 (50% EA/Hex); mp 146.5- 148.0 C; 1H NMR (CDC13) delta 8.66 (s, 1H), 7.83 (d, 1H, J=8.5 Hz), 7.77 (d, 1H, J=8.1 Hz), 7.71 (m, 1H), 7.42 (m, 1H), 7.30 (m, 3H), 7.10 (m, 2H), 7.04 (br s, 1H), 6.99 (m, 2H), 6.90 (m, 1H), 6.44 (m, IH, NH), 4.84 (m, 2H, AB); C NMR (CDC13) delta 159.5, 157.9, 157.0, 155.5, 149.6, 140.4, 132.9, 130.3, 130.0, 128.7, 126.3, 123.7, 122.6, 120.9, 119.2, 118.3, 117.9, 115.1, 45.1.

The chemical industry reduces the impact on the environment during synthesis (3-Phenoxyphenyl)methanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; SIMPSON, David, M.; ZERBY, Dennis, Bryan; LU, Ming; VON BORSTEL, Reid, W.; LI, Rui; READING, Julian; WOLPE, Stephen; AMAN, Nureddin; WO2014/120995; (2014); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34967-24-3, name is 3,5-Dimethoxybenzyl amine, A new synthetic method of this compound is introduced below., Recommanded Product: 34967-24-3

N-methylacrylamide (ABCR; 500 mg, 5.87 mmol) and 3,5-dimethoxybenzylamine (Aldrich; 0.98 mL, 6.46 mmol) were dissolved in ethanol (4 mL) and heated in a microwave at 140 C. for 45 minutes. The mixture was poured onto a 20 g SCX-2 column, washed with methanol and eluted with 3.5N NH3 in methanol. The product fractions were evaporated to the title compound as a yellow oil (1.3 g, 88%).1H NMR (CDCl3) 2.36 (t, 2H), 2.78 (d, 3H), 2.88 (t, 2H), 3.72 (s, 2H), 3.79 (s, 6H), 6.36 (m, 1H), 6.45 (m, 2H), 7.31 (bs, 1H); MS m/z 253 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASTRAZENECA AB; US2008/9482; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 10541-78-3, name is 2-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10541-78-3, Formula: C8H11NO

Phosgene (5 mL, 20% in toluene) was added to a stirred suspension of 6′-hydroxy-4,4-dimethyl-4,5-dihydro-3/-/-[1,3′]bipyridinyl-2,6-dione (0.47 g, 2.00 mmol) and triethylamine(0.29 mL, 2.00 mmol) in dichloromethane (10 mL). After stirring for 0.75 h at room tempera- ture, the solvent and excess phosgene were evaporated under reduced pressure, yielding awhite solid. The residue was dissolved in dichloromethane (10 mL) followed by the additionof 1,4-diazabicyclo[2.2.2]octane (224 mg, 2.00 mmol) and 2-methoxy-/V-methylaniline (0.27g, 2.00 mmol) and stirring was continued for 0.75 hours at room temperature. The solutionwas extracted with water and evaporated in vacuo. The residue was purified by flash columnchromatography (SiO2, gradient of 0-15% ethyl acetate in dichloromethane), yielding the titlecompound (260 mg, 33% yield) as a white solid.1H NMR (300 MHz, CDC13): 8 = 1.19 (s, 6H), 2.66 (s, 4H), 3.29 + 3.40 (2 x s, 3H), 3.86 (s,3H), 6.94 (m, 2H), 7.04-7.54 (m, 4H), 8.03 + 8.12 (d + s, 1H); HPLC-MS (Method A): m/z =398 (M+H)+; Rt = 3.62 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVO NORDISK A/S; WO2004/111031; (2004); A1;,
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Reference of 1836-62-0, The chemical industry reduces the impact on the environment during synthesis 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, I believe this compound will play a more active role in future production and life.

To a solution of benzyl bromide (4100 mg, 23.92 mmol) in toluene(15 ml) was added triethylamine (6051 mg, 59.80 mmol)the temperature was lowered to 0 C .Toluene (10 ml) in which 2-(2-methoxyphenoxy)ethanamine (5000 mg, 29.90 mmol) was slowly added dropwise at 0 C,The temperature was increased to 25 C . After the reaction mixture was stirred at room temperature for 8 hours, water (25 ml) was added dropwise to the reaction mixture, and the mixture was stirred for 15 minutes. The organic layer was then separated, washed with water (15 ml), dried over sodium sulfate and concentrated in vacuo to give the crude product. The crude product was then purified by column chromatography on silica gel, 15-80% ethyl acetate / hexane to give the final compound as the final product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Methoxyphenoxy)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gachon University Industry Academy Cooperation Foundation; Kim Mi-hyeon; Kim Seon-yeo; Jang Cheong-yun; (29 pag.)KR2018/125090; (2018); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: ((3-Bromopropoxy)methyl)benzene

To a suspension of NaH (55 wt percent in oil, 253 mg, 5.8 mmol) in DMF (12 mL) was added 3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepine (9) (1.4 g, 5.1 mmol) in DMF (12 mL) at 0 °C. After stirring for 10 min at room temperature, the mixture was cooled to 0 °C, and then benzyl 3-bromopropyl ether (1.37 g, 5.8 mmol) was added. The mixture was stirred for 1 h at room temperature, then 10percent aq NH4Cl and ethyl acetate were added to the reaction mixture. The mixture was extracted with ethyl acetate 2 times, and the combined extracts were washed with brine, dried over Na2SO4, and the solvent was removed under reduced pressure. The residual paste was chromatographed on silica gel (AcOEt/hexane) to afford (10) as a colorless oil (1.71 g, 79percent yield).1H NMR (CDCl3, delta ppm): 6.85-7.47 (12H, m), 4.43 (2H, s), 3.80 (2H, t, J = 6.4 Hz), 3.46 (2H, t, J = 6.0 Hz), 2.92-3.10 (4H, m), 1.77-1.92 (2H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 3005 – 3021;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 366-99-4, name is 3-Fluoro-4-methoxyaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8FNO

Example 104 Synthesis of 6-Chloro-N,N’-bis-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine (E15) To 124 (1.09 g, 3.5 mmol) dissolved in acetone (25 mL) was added 3-fluoro-p-anisidine (0.54 g, 3.5 mmol) in acetone (5 mL) followed by addition of 2.5 N NaOH (1.4 mL, 3.5 mmol) and water (3.5 mL). The reaction mixture was stirred and heated at reflux for 3 hours. The reaction mixture was extracted three times using dichloromethane; the combined organic layers were washed with brine and dried over potassium carbonate. The sample was filtered, concentrated in vacuo, and the resulting solid was dried overnight under vacuum to yield white solid (E15) (1.332 g, 97percent); mp 194° C.; HPLC: Inertsil ODS 3V C18, 40:30:30 v:v:v [KH2PO4 (0.01 M, pH 3.2): CH3OH: CH3CN], 264 nm, Rt 33.2 min, 97.6percent purity; MS (TOF ES+) m/z 396 (35.0); 394 (M+H, 100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Reddy, Velagala Venkira Rama Murali Krishna; Sridevi, Bhatlapenumarphy Shesha; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/224950; (2004); A1;,
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