Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: ((3-Bromopropoxy)methyl)benzene
To a suspension of NaH (55 wt percent in oil, 253 mg, 5.8 mmol) in DMF (12 mL) was added 3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepine (9) (1.4 g, 5.1 mmol) in DMF (12 mL) at 0 °C. After stirring for 10 min at room temperature, the mixture was cooled to 0 °C, and then benzyl 3-bromopropyl ether (1.37 g, 5.8 mmol) was added. The mixture was stirred for 1 h at room temperature, then 10percent aq NH4Cl and ethyl acetate were added to the reaction mixture. The mixture was extracted with ethyl acetate 2 times, and the combined extracts were washed with brine, dried over Na2SO4, and the solvent was removed under reduced pressure. The residual paste was chromatographed on silica gel (AcOEt/hexane) to afford (10) as a colorless oil (1.71 g, 79percent yield).1H NMR (CDCl3, delta ppm): 6.85-7.47 (12H, m), 4.43 (2H, s), 3.80 (2H, t, J = 6.4 Hz), 3.46 (2H, t, J = 6.0 Hz), 2.92-3.10 (4H, m), 1.77-1.92 (2H, m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 3005 – 3021;,
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Ether | (C2H5)2O – PubChem