Ethers-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1484-26-0, name is 3-Benzyloxyaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Benzyloxyaniline

Anhydrous potassium carbonate (74 g, 0.535 mol) was sequentially added to benzyl alcohol (200 g, 1.86 mol, 192 ml).m-Dinitrobenzene (30g, 0.178mol),Stirring, reacting at 110 C for 24 h, cooling in an ice water bath, and filtering off inorganic salts by suction;Add Raney nickel (10g) to the filtrate.Passing hydrogen gas, pressure 2.5~3MPa, internal temperature 80C, reaction for 15h, and recovering nickel by filtration;The filtrate was distilled under reduced pressure, and after removing benzyl alcohol, 50 mL of ethanol was added to the residue, and the mixture was stirred for 2 hours in an ice water bath to precipitate a solid.Drying gives 9.3 g of aminophenol in an off-white solid.The yield was 48%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai University of Engineering Science; Xu Jingli; Shen Yongjia; Mao Yongjun; Wang Han; (7 pag.)CN109942441; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 887581-09-1, name is (2-Bromo-5-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H10BrNO

General procedure: A 25 mL Schlenk tube wascharged with a magnetic stirrer and DMSO (2.0 mL). Substituted(2-bromophenyl)methylamine (1) (0.5 mmol), amidine hydrochloride (2) (1.0 mmol),CuBr (0.1 mmol, 14.2 mg), and K2CO3 (1.5 mmol, 207 mg) were added to the tube.The mixture was stirred at 80-120 oC under nitrogen atmosphere for 24 h, and thenunder air for 0.5 h. The resulting mixture was cooled to room temperature and filtered,and the solid was washed with ethyl acetate for two times (3 ¡Á 3 mL). The combinedfiltrate was concentrated by the rotary evaporator, and the residue was purified bycolumn chromatography on silica gel using petroleum ether/ ethyl acetate as eluent togive the desired target product.

The synthetic route of 887581-09-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei; Synlett; vol. 24; 16; (2013); p. 2089 – 2094;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,2-Dimethoxy-4-methylbenzene

General procedure: To a solvent of (bisacetoxyliodo)benzene (DAIB) (4.75g, 14.75mmol) in dry THF (20-30mL) was added trifluoroacetic acid (1.12g, 9.83mmol) and acetic acid (0.29g, 4.92mmol). The mixture stirred for 30 min, after which the compound added for benzylic C-H oxidation (2.46mmol) and further reacted for 24h. The progress of the chemical reaction was monitored using thin-layer chromatography with precoated silica gel 60 (0.25mm thickness) plates. The reaction was quenched with 1mL of sat. NaHCO3 (aq), and the solvent removed in vacuo on a rotatory evaporator. The residue was extracted with ethyl acetate (30mL¡Á2) and water (20mL). The combined organic extracts were washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 494-99-5.

Reference:
Article; Lin, Chun-Yu; Yang, Ping-Shin; Chou, Pang-Yu; Ong, Chi Wi; Tetrahedron Letters; vol. 59; 4; (2018); p. 365 – 367;,
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33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 33170-72-8

A solution of methyl 5-amino-6-bromopyrazine-2-carboxylate (500 mg, 2.15 mmol, 1.00 equiv),2-bromo-i,i-dimethoxypropane (1.2 g, 6.56 mmol, 3.00 equiv), p-toluenesulfonic acid (76 mg,0.44 mmol, 0.20 equiv) in acetonitrile (20 mL) was stuffed for 12 h at 80 C. The mixture was concentrated under vacuum and the residue was purified by a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 400 mg (69%) of the title compound as a yellow solid. LC-MS (ES, mlz): 270 [M+H].

The synthetic route of 33170-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
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Electric Literature of 102503-23-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102503-23-1, name is 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: N-(2,4-dimethoxybenzyl)-N-methyl-3-phenylprop-2-yn-1-amine (5a). CuI (20 mg, 0.10 mmol) was added to a solution of phenylacetylene(510.6 mg, 5.0 mmol), HCHO (36% aq., 2 mL),N-methyl(2,4-dimethoxybenzyl)amine (1.09 g, 6.0 mmol) in DMSO (10.0mL). The resulting yellow green solution was stirred at room temperatureovernight and then diluted with H2O (10 mL), extracted with Et2O (15 mL x 3). The combined extractswas washed with H2O (2 x), brine (2 x) respectively, dried over Na2SO4, filtered, concentrated. Theresultant yellow oil was purified through flash column chromatography (silica gel, EtOAc/Hex = 1:6 to1:3) to give the product (5a, 1.14 g, 96%).

The synthetic route of 1-(2,4-Dimethoxyphenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Miao; Odelberg, Shannon J.; Tong, Zongzhong; Li, Dean Y.; Looper, Ryan E.; Tetrahedron; vol. 69; 27-28; (2013); p. 5744 – 5750;,
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Synthetic Route of 37895-73-1,Some common heterocyclic compound, 37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a Schlenk tube (20 mL) were added PdCl2(MeCN)2 (26 mg, 0.10 mmol) and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos, 0.16 g, 0.40 mmol). The Schlenk tube was capped with a rubber septum and then evacuated and purged with argon. The evacuation-purge operation was repeated twice. To the tube was added 1,4-dioxane (6.0 mL), 1,2-dibromobenzene (1.63 g, 0.82 mL, 5.0 mmol), NEt3 (3.04 g, 4.18 mL, 30.0 mmol), and pinacolborane (2.18 mL, 1.92 g, 15.0 mmol) in this order with syringes, respectively, through the septum. The reaction mixture was heated at 110 C and the progress of the reaction was monitored by gas chromatography. After the complete consumption of the dibromide was confirmed, the reaction mixture was then allowed to cool to room temperature. The resulting solution was filtered through a thin pad of Celite with EtOAc as the eluent. The organic solvent was removed under reduced pressure to give the crude product, which was purified by column chromatography on silica gel followed by recrystallization from hexane at -20 C, giving rise to 1,2-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (3h, 0.83 g, 51%) as a colorless solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dibromo-4,5-dimethoxybenzene, its application will become more common.

Reference:
Article; Shimizu, Masaki; Nagao, Ikuhiro; Tomioka, Yosuke; Kadowaki, Tsugumi; Hiyama, Tamejiro; Tetrahedron; vol. 67; 41; (2011); p. 8014 – 8026;,
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Synthetic Route of 123652-95-9, The chemical industry reduces the impact on the environment during synthesis 123652-95-9, name is (3-Fluoro-4-methoxyphenyl)methanamine, I believe this compound will play a more active role in future production and life.

To a screw-capped vial equipped with a magnetic stir bar were added 3,4- dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (Intermediate 2) (35 mg, 0.17 mmol), DMF (1 mL), DIEA (90 tL, 0.48 mmol), and HATU (77 mg, 0.20 mmol). This mixture was allowed to stir at ambient temperature for 30 minutes, and then excess (3-fluoro-4- methoxyphenyl)methanamine (2.1) was added. After stirring at room temperature for 30 minutes, purification by reversed-phase HPLC (eluting with water/0. 1% trifluoroacetic acid and acetonitrile) afforded the title compound. LCMS: RT = 0.81 mm, >99% 254 nm,>99% 215 nm; mlz (M + 1)= 346. ?H NMR (400 MHz, d6-DMSO) oe 9.5 (t, J= 5.8 Hz, 1H), 8.3 (s, 1H), 7.1-7.3 (m, 3H), 4.5 (d, J= 5.8 Hz, 2H), 3.8 (s, 3H), 2.7 (s, 3H), 2.6 (s, 3H); HRMS calculated for C,7H,6FN302S (M+H) mlz: 346.1026, measured: 346.1023.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Fluoro-4-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; POSLUSNEY, Michael, S.; TARR, James, C.; MELANCON, Bruce, J.; WO2015/27214; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 31576-51-9

In a round bottom flask under nitrogen 150 mg (0.35 mmol) of intermediate Awas dissolved in 5 mL ofCH2Ch and 0.18g of DIPEA (1.4 mmol) was added followed by 125 mg (1.05 mmol) of2-(2-Methoxy-ethoxy)-ethylamine. The mixture was allowed to stirovernight and then condensed in vacuo. The residue was dissolved in 20 mL of EtOAc andwashed with 2x 20 mL of water, 20 mL of brine, dried over Na2S04 and condensed in vacuo.Purification by biotage flash chromatography (Si02, MeOH/CH2Ch/Et3N gradient) affords 99mg of the title compound as a clear oil

The synthetic route of 31576-51-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZAFGEN, INC.; ZAHLER, Robert; VATH, James, F.; WO2013/169860; (2013); A1;,
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Related Products of 1515-89-5, A common heterocyclic compound, 1515-89-5, name is 1-Bromo-3-(methoxymethyl)benzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-bromo-3-methoxymethyl-benzene. (286 mg, 1.42 MMOL) and bis- (PINACOLATE) DIBORON. (397 mg, 1.56 MMOL) in DMSO (8 mL) are added KOAC (419 mg, 4.27 MMOL) and Pd (DPPF) CI2. CH2CI2 (58 mg, 0.071 MMOL). The reaction mixture is stirred at 80 C under nitrogen atomosphere for 1 h. After dilution with ether, the mixture is washed with water (x2) and brine. The organic layer is dried over MGS04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography (n-hexane: EtOAc=10: 1) to give the corresponding boron ester.

The synthetic route of 1515-89-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
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Related Products of 22236-10-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22236-10-8, name is 4-(Difluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 9; 2-ButyI-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenyIisothiazol-3(2H)-one 1,1-dioxide; 2-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide (0.63g, 2.1 mmol) and 4- (difluoromethoxy)-aniline (0.67g, 4.2mmol) were mixed in MeCN (4 mL, dry). The mixture EPO was put in the microwave reactor at 160 0C for 1 h, then additional 1 h and then 1 h more. It was evaporated to dryness. The residue was purified by column chromatography (ISOLUTE SI, 50 g/150 mL), eluting with DCM/heptane (50:50, then 75:25), to give the title compound (0.688g, 78%) as a yellow solid;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Difluoromethoxy)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2006/73363; (2006); A1;,
Ether – Wikipedia,
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